고지혈증환자에서 Acipimox와 Fenofibrate의 효능 비교

김승미,조영환,오정미 대한임상약리학회 2002 Translational and Clinical Pharmacology Vol.10 No.2

Introduction : Hyperlipidemia is closely related to the generation of coronary heart disease (CHD). The objective of this study was to compare the efficacy of acipimox and fenofibrate for the treatment of hyperlipidemia. Methods : The study performed a retrospective comparison of acipimox (250 mg TID) and fenofibrate (200 mg/day) by comparing the means of changes in total cholesterol, triglyceride, HDL-C, LDL-C levels, and TC/HDL-C ratio at 3, 6, and 9 months of the treatments. Results : A total of 103 patients (41 in acipimox group and 62 in fenofibrate group) were evaluated. Acipimox- and fenofibrate-treated group were comparable with respect to patient demographic characteristics. After treatments both acipimox and fenofibrate produced a significant reduction in total cholesterol(9.7% with acipimox; 11.3% with fenofibrate), triglyceride levels (52.6% with acipimox, p<0.001; 54.3% with fenofibrate, p<0.001) and TC/HDL-C ratio(15.2% with acipimox; 18.0% with fenofibrate) from baseline. HDL-C levels after treatments increased by 8.4% and 9.3% with acipimox and fenofibrate, respectively. Both drugs did not produce a significant reduction in LDL-C levels (4.4% with acipimox; 2.0% with fenofibrate) after treatments. The mean changes of total cholesterol, triglyceride, LDL-C, HDL-C levels and TC/HDL-C ratio were not significantly different between the two drugs. Conclusion : Both acipimox- and fenofibrate- treated groups experienced significant changes in total cholesterol, triglyceride, HDL-C, and TC/HDL-C ratio from the baseline after treatments.

멀티밴드 합성을 이용한 실시간 워터 렌더링

김승미,손유익,임충재 한국컴퓨터게임학회 2010 한국컴퓨터게임학회논문지 Vol.21 No.-

한국인 말단흑색종에서 Yes-Associated Protein의 면역조직화학적 발현 양상

김승미,김도연,권인선,신정민,홍동균,정경은,김창덕,이영,서영준,박상현 대한피부과학회 2022 대한피부과학회지 Vol.60 No.10

Background: Acral melanoma is the most common subtype of melanoma among Koreans, and regional or distantmetastasis is an indicator of poor prognosis. Yes-associated protein (YAP), a key effector of the Hippo pathway, isknown to induce tumor progression and metastasis in various cancers. Objective: We aimed to analyze the clinical and histopathological characteristics of acral melanoma among Koreansand to evaluate their association with YAP expression. Methods: This retrospective review included 27 patients with acral melanoma. Clinical features including age, sex, lesionsite, and stage were obtained from the medical records and images. Biopsy slides of patients with acral melanoma werereviewed, and immunohistochemical staining for YAP was performed. Results: The rate of YAP expression was significantly higher in patients having acral melanoma with regional ordistant lymph node (LN) metastasis than in those without metastasis (n=4/5, 80.0% vs. n=2/22, 9.1%; p=0.004). Histopathologically,the rate of YAP expression was higher in patients having acral melanoma with lymphovascularinvasion than in those without lymphovascular invasion (n=4/8, 50.0% vs. n=2/19, 10.5%; p=0.044). Among the 27lesions, 14 (51.9%) were on stress-bearing sites such as the forefoot and heel. However, the rate of YAP expressiondid not differ significantly between weight-bearing and non-weight-bearing locations (p=0.834). Conclusion: YAP expression is significantly associated with metastasis, especially LN metastasis, in patients with acralmelanoma. Therefore, YAP expression may be used as a prognostic factor for LN metastasis and a target for noveltreatments in patients with melanoma.

고지혈증환자에서 Acipimox와 Fenofibrate의 효능 비교

김승미,조영환,오정미 大韓臨床藥理學會 2002 臨床藥理學會誌 Vol.10 No.2

The effect of resin cements and primer on retentive force of zirconia copings bonded to zirconia abutments with insufficient retention

김승미,윤지영,이명현,오남식 대한치과보철학회 2013 The Journal of Advanced Prosthodontics Vol.5 No.2

PURPOSE. The purpose of this study was to investigate the effect of resin cements and primer on the retentive force of zirconia copings bonded to zirconia abutments with insufficient retention. MATERIALS AND METHODS. Zirconia blocks (Lava, 3M ESPE, St. Paul, MN, USA) were obtained and forty sets of zirconia abutments and copings were fabricated using CAD/CAM technology. They were grouped into 4 categories as follows, depending on the types of resin cements used, and whether the primer is applied or not:Panavia F2.0 (P), Panavia F2.0 using Primer (PRIME Plus, Bisco Inc, Schaumburg, IL, USA) (PZ), Superbond C&B (S), and Superbond C&B using Primer (SZ). For each of the groups, the cementation was conducted. The specimens were kept in sterilized water (37℃) for 24 hours. Retentive forces were tested and measured, and a statistical analysis was carried out. The nature of failure was recorded. RESULTS. The means and standard deviations of retentive force in Newton for each group were 265.15 ± 35.04 N (P), 318.21 ± 22.24 N (PZ), 445.13 ± 78.54 N (S) and 508.21 ± 79.48 N (SZ). Superbond C&B groups (S & SZ) showed significantly higher retentive force than Panavia F2.0 groups (P & PZ). In Panavia F2.0 groups, the use of primer was found to contribute to the increase of retentive force. On the other hand, in Superbond C&B groups, the use of primer did not influence the retention forces. Adhesive failure was observed in all groups. CONCLUSION. This study suggests that cementation of the zirconia abutments and zirconia copings with Superbond C&B have a higher retentive force than Panavia F2.0. When using Panavia F2.0, the use of primer increases the retentive force.

교실수업에 나타난 발도르프 교사의 역사교육관과 그 실천

김승미 한국사회교과교육학회 2019 한국사회교과교육학회 학술대회지 Vol.2019 No.0

교실수업에 나타난 발도르프 교사의 역사교육관과 그 실천

김승미 한국역사교육학회 2019 역사교육연구 Vol.- No.35

The purpose of this study is to explore how the history education perspective of teachers based on the philosophy of the Waldorf is implemented in the content and method of the history class, and to derive implications of the teaching and learning activities of the Waldorf School for the composition of the contents of the history education of the institution. To this end, the researcher observed and analyzed history classes of two teachers at Garam Waldorf School and one teacher at Narae Waldorf School, and interviewed them to refine the analysis and interpretation of the data. The feature of observed and analyzed history classes are as follows. First, The various activities at Waldorf School's teacher showed in their periodic concentration class helped students' historical understanding. They led classes with poetry, recorder performance, play, story and art. Second, teachers wanted to link history lessons to students' lives. They included historical facts and topics that students could experience in their lives in their study, and worked to solve conflicts or solve problems. Third, they tried to select the right learning content for the inner consciousness' development of the student. They included class subjects and related historical figures in their study based on their understanding of the students' development stage. This practice of history lessons by teachers was basically based on the principles of Waldorf education. In the meantime, teachers took classes that were different from the interpretation and application of the principle. This is a result of the respect of the autonomy of the teachers of the Waldorf education, and of the nature of the history class. The following are the implications of the history classes at Waldorf School for organizing the elementary history syllabus and for effective doing history. First, in order for elementary school history education to function properly as the beginning of history education, it needs to be organized into content that students can realize that studying history is an understanding of humans through topics related to their lives. Second, teachers who teach history should actively practice their autonomy in the practice of history education, through the integrated classes with history and other subjects, the operation of block time, and others systems by using the contents of textbooks as material that interprets from various perspectives, rather than blindly conveying them. Third, in order to teach students a alive history, a history class of emotional approach through storytelling and art activities must be conducted. 본 연구는 발도르프 철학에 기반을 둔 교사의 역사교육관이 역사 수업의 내용과 방법으로 어떻게 구현되는지를 탐색하고, 발도르프학교의 역사 수업이 제도권 역사교육의 내용 구성과 교수・학습활동에 주는 시사점을 도출하는 데 목적이 있다. 이를 위해 가람발도르프학교 교사 2명의 역사수업과 나래발도르프학교 교사 1명의 역사 수업을 관찰・분석하였고, 자료의 분석과 해석을 정교화하기 위해 교사 면담을 병행하였다. 관찰・분석한 역사 수업의 특징은 다음과 같다. 첫째, 발도르프학교 교사들이 주기집중수업에서 보여준 다양한 활동은 학생들의 역사이해를 도왔다. 그들은 시 낭송, 리코더 연주 및 놀이 활동, 이야기와 예술 활동 등으로 수업을 이끌어갔다. 둘째, 교사들은 역사학습을 학생들의 삶과 연결하고자 했다. 학생들이 살아가면서 경험할 수 있는 역사적 사실이나 주제를 학습 내용에 포함하고, 갈등의 해소나 문제해결을 고민할 수 있는 활동을 했다. 셋째, 그들은 학생 내면의 의식발달에 맞는 학습내용을 선정하기에 힘썼다. 학생들의 발달단계에 대한 이해를 바탕으로 수업 주제 및 관련 역사 인물을 학습 내용에 포함시켰다. 교사들의 이런 역사 수업 실천은 기본적으로 발도르프교육의 원리에 기초를 두고 이루어졌다. 그러면서도 다른 한편으로, 그 원리를 해석하고 적용하는 측면에서는 교사에 따라 차이를 보였다. 이는 발도르프교육이 가지고 있는 교사의 자율성 존중의 측면, 그리고 역사 수업이 가지는 성격에 의한 결과이다. 발도르프학교의 역사 수업이 초등학교 역사교육 내용 구성 및 교수・학습활동에 주는 시사점은 다음과 같다. 첫째, 초등학교 역사교육이 역사교육의 시작으로서 그 역할을 제대로 하기 위해서는 학생들의 삶과 관련 있는 주제를 통해 역사를 공부한다는 것이 인간을 이해하는 것임을 학생들이 깨달을 수 있는 내용으로 구성할 필요가 있다. 둘째, 역사를 가르치는 교사들은 교과서 내용을 맹목적으로 전달하기보다는 역사를 다양한 관점으로 해석하는 자료로 활용함으로써, 역사와 타 교과의 통합적 수업 구성과 블록 타임제 운영 등 역사교육의 실천에 있어서 자율성을 적극적으로 실천해야 한다. 셋째, 학생들에게 살아 숨 쉬는 역사를 가르치기 위해서는 이야기와 예술 활동 등을 통한 정서적 접근의 역사 수업이 이루어져야 한다.

임신 전 체질량지수와 임신 중 체중증가가 출산결과에 미치는 영향

김승미,박인혜 전남대학교 간호과학연구소 2013 Nursing and Health Issues(NHI) Vol.18 No.1

Purpose: This research is to provide baseline data on proper childbirth management based on the birth outcome of BMI before pregnancy and weight gain during pregnancy will influence. Method: The subjects were women who delivered a child and newborns hospitalized in the department of obstetrics in C university general hospital. The following has been obtained: The women’s age, weight before pregnancy, weight gain during pregnancy, childbirth history, types of childbirth, educational standards and job existence and the newborns’ weight in birth, gender, fetal period and hospitalization in an intensive care unit. Result: The higher the index of body mass of pregnancy women are, the more they gained the weight just before the childbirth, the more weight newborns have, and the shorter the child-bearing period is. Related to weight gain during the child-bearing period, it ranked the highest(first) in the group of under weight gain. The birthrate of premature, low birth weight, and small for gestational age(SGA) have been ranked high in the group of under weight gain. And birthrate of large for gestational age(LGA) has been ranked high in the group of over weight gain. Conclusion: The study shows that pre-pregnancy BMI and Weight Gain during Pregnancy affected the newborn birth outcome. Therefore More active prenatal program that improve the nutritional status of maternal and practice is needed for appropriate weight gain. Consequently, this study can contribute to positive newborn birth outcome of maternal and neonatal.

Down증후군 환아의 임상적 고찰

김승미,이상범,이건수 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.2

The clinical characteristics, karyotypes and associated illnesses were evaluated in 151 children with Down syndrome who had been cytogenetically confirmed during 10 years from 1981 in the Cytogenetic Laboratory, Department of Pediatrics, Kyung-Pook National University Hospital. Seventy percent of the patients were under 1 year of age and male to female ratio was 1.4 to 1. Karyotyping revealed regular trisomy 21 in 134 cases(88.7%), translocation in 9 cases(6.0%), and mosaic in 8 cases(5.3%). The maternal age over 35 years old was in 12 cases which were consisted with 10 cases of trisomny 21 and 2 cases of mosaicism. Of the clinical characteristics flat nasal bridge and upward slanting palpebral fissures were found in 91% of cases respectively, epicanthal fold in 73% and hypotonia in 70%. The atd angle was greater than 57˚ in all observed cases and the mean was 62.7˚. The ulnar loop in fingerprints was observed in 80% and the hallucal arch tibial in 62%. The 78% of patients was below the 10th percentile in head circumference. The height and weight were also below the 10th percentile in 42% and 65% respectively. Of an associate anomalies congenital heart diseases were observed in 53 cases(41%) of 128 cases, unblical hernia in 7 cases and acute megaloblastic leukemia in 2 cases. Ventricular septal defect with an associated anomalies was observed in 39%, endocardial cushion defect in 27% and patent ductus arteriosus in 15% by echocardiogram.

진로적응성에 대한 연구동향과 메타분석연구

김승미,손은령,배선희 한국상담학회 2021 한국상담학회 학술대회 논문집 Vol.2021 No.8