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고재경,한중수,김영미,김영식,계세협 한양대학교 의과대학 1996 한양의대 학술지 Vol.16 No.2
Activities of nucleases (acid DNase and neutral RNase) known to be involved in carcinogenesis and suppressionof cancer were determined in cancer tissue, serum and ascitic fluid of patients withhepatocellular carcinoma and were compared with those ofthe controls. Also studied were nucleases and nuclease-inhibitors isolated from hepatocellular carcinoma tissue and ascitic fluid of the cancer patients to evaluate the properties and interactions between them. Activites of DNase, RNase and RNase inhibitor were significantly increased, suggesting the use of the nucleases and the inhibitor as biochemical markers for the hepatocellular carcinoma. DNase activity was not detected, RNase activity was increased and RNase inhibitor activity was unchanged in both serum and ascitic fluid of the hepatocellular carcinoma patients. The results indicated that RNase was released into the body fluid from the cancer tissue and that the RNase could be used as a diagnostic marker for the hepatocellular carcinoma. DEAE-cellulose column chromatographical analyses revealed that DNase was isolated as a single enzyme and RNase as seven isozymes from the hepatocellular carcinoma tissue. The DNase isolated was perferentially cleaved ds DNA over ss DNA and was endonuclease in nature (majority of hydrolytic products of DNA by the DNase were oligodeoxyribonucleotides), suggesting an important role of the DNase in carcinogenesis of the liver. Of seven RNase isozymes isolated from the hepatocellular carcinoma tissue, isozyme I exhibited nonsecretory nature of RNase and other six isozymes secretory nature of the enzyme. Activity of RNase isozyme V was greatly increased and the activity of inhibitory complexed with the isozyme V was also increased in the cancer tissue. RNase in ascitic fluid of the cancer patient was separated into four isozymes, of which isozyme I exhibited mixed form of secretory and nonsecretory nature and greatly increased in its activity. RNase isozyme V isolated in the hepatocellualr carcinoma tissue was not detected in the ascitic fluid. The results indicated that RNase isozyme V was limited in the cancer tissue and that RNase isozyme I and V and inhibitors associated with these isozymes might be involved in carcinogenesis processes, supression of cancer and maintenance of hepatocellular carcinoma through their interactions.
간세포암 환자에서 DNase , RNase 및 Rnase inhibitor 측정의 의의
계세협(Sea Hyub Kae),정유선(Yoo Sun Chung),장현주(Heon Ju Jang),정선화(Sun Wha Jung),김용태(Yong Tae Kim),강승식(Seung Sik Kang),이진(Jin Lee),곽상택(Sang Taek Kwak),주상언(Sang Aun Joo),유재영(Jae Young Yoo) 대한내과학회 1998 대한내과학회지 Vol.54 No.5
Objective Activities of nucleases (acid DNase and neutral RNase) and RNase inhibitor 1mown to be involved in carcinogenesis and suppression of cancer were determined in cancer tissue, serum and ascitic fluid of patients with hepatocellular carcinoma and were compared with those of the controls. Also studied were nucleases and RNase inhibitor isolated from hepatocellular carcinoma tissue and ascitic fluid of the cancer patients to evaluate the properties and interactions between them. Method: Activities of nucleases and RNase inhibitor were measured in cancer tissue, serum and ascitic fluid of patients with hepatocellular carcinoma by ultraviolet spectrophotometry. Nucleases and RNase inhibitor were isolated from hepatocellular carcinoma tissue and ascitic fluid of the cancer patients by DEAE-cellulose column chromatography. As controls, normal tissue of the cancer patients, serum of healthy persons and ascitic fluid of cirrhotic patients were used. Result: Activities of DNase, RNase and RNase inhibitor were significantly increased in hepatocellular carcinoma tissue. DNase activity was not detected, RNase activity was increased and RNase inhibitor activity was unchanged in both serum and ascitic fluid of the hepatocellular carcinoma patients. DNase was isolated as a single enzyme and RNase as seven isozymes from the hepatocellular carcinoma tissue. The DNase isolated preferentially cleaved ds DNA over ss DNA and was endonuclease in nature (majority of hydrolytic products of DNA by the DNase were oligodeoxyribonucleotides). Of seven RNase isozymes isolated from the hepatocellular carcinoma tissue, isozyme I exhibited nonsecretory nature of RNase and other six isozymes secretory nature of the enzyme. Activity of RNase isozyme V was greatly increased and the activity of inhibitor complexed with the isozyme V was also increased. RNase in ascitic fluid of the cancer patient was separated into four isozymes, of which isozyme I exhibited mixed form of secretory and nonseretory nature and greatly increased in its activity. RNase isozyme V isolated in the hepatocellular carcinoma tissue was not detected in the ascitic fluid, Conclusion: The use of the nucleases and the inhibitor in the cancer tissue as biochemical markers for the hepatocellular carcinoma was suggested. RNase was released into the body fluid from the cancer tissue and could be used as a diagnostic marker for the hepatocellular carcinoma. An important rale of the DNase in carcinogenesis of the liver was suggested. RNase isozyme V was limited in the cancer tissue and RNase isozyme I and V and inhibitors associated with these isozymes might be involved in carcinogenesis processes, suppression of cancer and maintenance of tocellular carcinoma through their interactions.
이성록,이철우,오인택,주상언,계세협,진학구,이호순 대한내과학회 1989 대한내과학회지 Vol.37 No.1
Familial polyposis coli is a rare hereditary disease characterized by the appearance of numerous polyps in the large intestine with a high potential for malignant transformation. The disease has considerable value in the elucidation of many problems of gastrointestinal disease, especially in the fields of genetics, histopathology and cancer control, as one of the sources for evidence supporing the adenoma-carcinoma sequence. In Korea, several cases were reported, but there were none which showed malignant transformation after a considerable period. We experienced a case of familial polyposis coli which transformed to adenocarcinoma after aperiod of a year and two months, and we report this with a brief review of the literature.