Clinical Practice Guideline for Accurate Diagnosis and Effective Treatment of Gastrointestinal Stromal Tumor in Korea

강윤구,김경미,손태성,최동일,강혜진,류민희,김우호,양한광 대한의학회 2010 Journal of Korean medical science Vol.25 No.11

Despite the rarity in incidence and prevalence, gastrointestinal stromal tumor (GIST) has emerged as a distinct pathogenetic entity. And the clinical management of GIST has been evolving very rapidly due to the recent recognition of its oncogenic signal transduction pathway and the introduction of new molecular-targeted therapy. Successful management of GIST requires a multidisciplinary approach firmly based on accurate histopathologic diagnosis. However, there was no standardized guideline for the management of Korean GIST patients. In 2007, the Korean GIST study group (KGSG) published the first guideline for optimal diagnosis and treatment of GIST in Korea. As the second version of the guideline,we herein have updated recent clinical recommendations and reflected changes in diagnosis, surgical and medical treatments for more optimal clinical practice for GIST in Korea. We hope the guideline can be of help in enhancing the quality of diagnosis by members of the Korean associate of physicians involving in GIST patients’ care and subsequently in achieving optimal efficacy of treatment.

삼각형 메시와 사각형 메시 사이의 영에 가까운 하우스도르프 거리 계산

강윤구,윤승현,경민호,김명수 한국정보과학회 2019 정보과학회논문지 Vol.46 No.2

두 물체 사이의 하우스도르프 거리는 유사성의 척도로 사용될 수 있지만 하우스도르프 거리의 정확한 계산은 매우 어려운 문제이며 두 물체가 유사할수록 더욱 복잡해진다. 하우스도르프 거리가 나타나는 위치를 쉽사리 특정 짓기가 어렵기 때문이다. 본 논문에서는 이러한 장애를 극복하고 삼각형 메시 모델과 사각형 메시 모델 사이의 하우스도르프 거리를 빠르고 정확하게 계산하는 알고리즘을 소개한다. 모델을 작은 조각으로 분할하고 영향력이 없는 조각들을 제거하는 작업을 반복해 하우스도르프 거리가 발생하는 위치를 좁혀나간다. 각 조각에 대해 “대응 곡면”을 생각하고 그에 따른 하우스도르프 거리 상한을 계산함으로써 그 조각의 보존 여부를 판단할 수 있다. 이렇게 구한 하우스도르프 거리를 활용하면 삼각형 메시를 근사하는 사각형 메시의 유사도를 평가할 수 있다. The Hausdorff distance between two objects can be used as a measure for their similarity, but its precise computation is a significantly challenging problem that is as complex as the objects are similar, since it is more difficult to locate where the Hausdorff distance occurs. In this paper, we solve this obstacle and present an algorithm that precisely computes the Hausdorff distance between a triangle mesh model and a quad mesh model. We narrow down where the Hausdorff distance occurs by iteratively partitioning the models into smaller pieces and removing irrelevant ones. The “match” that we set for each piece and its corresponding upper bound for the Hausdorff distance enable us to decide whether to keep the piece. The Hausdorff distance thus computed can be used to evaluate quad meshes that approximate triangle meshes.

이야기 속으로

강윤구 서울여자대학교 조형연구소 2017 조형연구 Vol.23 No.-

레벨 좌표 기반 연속적 폐 변형

강윤구,김용준,김명수,김종효 한국컴퓨터그래픽스학회 2012 한국컴퓨터그래픽스학회 학술대회 Vol.2012 No.6

영상문화사업전망에 대한 고찰

姜潤九 연세대학교 언론홍보대학원 1994 연세 커뮤니케이션즈 Vol.1994 No.1

태풍내습시 연안역의 침수재해를 야기시키는 해일.파랑에 의한 월류.월파 특성

강윤구 한국방재학회 2007 한국방재학회지 Vol.7 No.1

Phase 1/2a Study of Rivoceranib, a Selective VEGFR-2 Angiogenesis Inhibitor, in Patients with Advanced Solid Tumors

강윤구,류민희,홍용상,최창민,김태원,류백열,김정은,John R. Weis,Rachel Kingsford,Cheol Hee Park,Seong Jang,Arlo McGinn,Theresa L. Werner,Sunil Sharma 대한암학회 2024 Cancer Research and Treatment Vol.56 No.3

Purpose This study aimed to report the results from an early-phase study of rivoceranib, an oral tyrosine kinase inhibitor highly selective for vascular endothelial growth factor receptor 2, in patients with advanced solid tumors. Materials and Methods In this open-label, single-arm, dose-escalating, multicenter three-part phase 1/2a trial, patients had advanced solid tumors refractory to conventional therapy. Part 1 evaluated the safety and pharmacokinetics of five ascending once-daily doses of rivoceranib from 81 mg to 685 mg. Part 2 evaluated the safety and antitumor activity of once-daily rivoceranib 685 mg. Part 3 was conducted later, due to lack of maximum tolerated dose determination in part 1, to evaluate the safety and preliminary efficacy of once-daily rivoceranib 805 mg in patients with unresectable or advanced gastric cancer. Results A total of 61 patients were enrolled in parts 1 (n=25), 2 (n=30), and 3 (n=6). In parts 1 and 2, patients were white (45.5%) or Asian (54.5%), and 65.6% were male. The most common grade ≥ 3 adverse events were hypertension (32.7%), hyponatremia (10.9%), and hypophosphatemia (10.9%). The objective response rate (ORR) was 15.2%. In part 3, dose-limiting toxicities occurred in two out of six patients: grade 3 febrile neutropenia decreased appetite, and fatigue. The ORR was 33%. Conclusion The recommended phase 2 dose of rivoceranib was determined to be 685 mg once daily, which showed adequate efficacy with a manageable safety profile (NCT01497704 and NCT02711969).

Taxanes: Paclitaxel과 Docetaxel

강윤구 가톨릭중앙의료원 가톨릭암센터 1998 암심포지움 Vol.- No.1

인도메타신의 투여가 치아 맹출 시 기질금속단백분해 효소의 분포에 미치는 영향

강윤구,남종현,이기수 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.2

이 연구는 치낭과 그 주위 조직 세포에서 matrix metalloproteinase (MMP)-3과 -9의 발현에 대한 인도메타신의 영향을 관찰하여 인도메타신이 치아의 맹출에 미치는 영향의 일단을 규명하기 위해 시행되었다. 생후 10-12주된 10마리의 개를 실험군 8마리와 대조군 2마리로 나누고 실험군은 인도메타신을 체중에 대하여 통상적 복용량인 인도메타신 2㎎/㎏/day을 7일간 및 14일간 투여한 군과 과량의 8㎎/㎏/day을 7일간 및 14일간 투여한 군으로 나누고 대조군은 빈 캅셀을 placebo로 투여한 후 희생하고 맹출 중인 영구치 치배를 적출하여 조직 처리하고 H-E 염색 및 MMP-3과 -9에 대한 면역염색 시행 후 광학현미경으로 검경하였다. 관찰결과 대조군에서는 파골세포, 조골세포, 치주인대 세포, 법랑모세포 및 상아모세포에서 모두 MMP-3과 -9의 발현이 뚜렷하게 관찰되었다. 대조군에 비해 인도메타신 투여군에서 파골세포, 조골세포, 치주인대 세포는 MMP-3과 -9의 발현이 억제된 소견이 관찰되었으며 인도메타신의 투여기간이 길수록 투여량이 많을수록 더 뚜렷하게 관찰되었다. 법랑모세포와 상아모세포는 대조군과 실험군의 MMP-3과 -9의 발현의 차이가 관찰되지 않았다. 이상의 결과에 의하면 prostaglandin (PG) 생합성 억제제인 인도메타신은 치낭의 파골세포, 조골세포 및 치주인대 세포에서 MMP-3과 -9의 발현을 억제하였으며 이는 인도메타신 투여로 치아 맹출이 억제될 수 있음을 시사한다. Tooth eruption requires remodeling of surrounding tissues. This study was aimed to investigate the effect of indomethacin on the dental follicle and paradental tissues during tooth eruption by observing the distribution and expression of MMP by the immunohistochemical method. Ten mongrel dogs of ten to twelve weeks old were divided into 5 groups: four experimental groups administered indomethacin 2㎎/㎏/day 8㎎/㎏/day and orally 2 times a day for 14 days and 7 days respectively, and the control group was administered a placebo. Permanent teeth before eruption and their surrounding tissues were selected and excised. H & E staining and immunohistochemical stainings of MMP-3 and -9 were performed and examined under the light microscope. Osteoclasts, osteoblasts, periodontal ligament cells, ameloblasts and odontoblasts of the control group all expressed MMP-3 and -9. In the experimental group, osteoclasts, osteoblasts and periodontal ligament cells showed reduced expression of MMP-3 and -9. Magnitude of MMP reduction in the experimental group showed a time and dose of indomethacin administration dependent manner. These results show that indomethacin inhibited MMP-3 and -9 expression in the dental follicle and surrounding tissues and suggest that when indomethacin is administered for long periods, tooth eruption could be delayed.

Effects of organic amendments on lettuce (Lactuca sativa L.) growth and soil chemical properties in acidic and non-acidic soils

강윤구,이준영,김준호,오택근,윤여욱 충남대학교 농업과학연구소 2023 Korean Journal of Agricultural Science Vol.50 No.4

Soil acidification challenges global food security by adversely influences soil fertility and agricultural productivity. Carbonized agricultural residues present a sustainable and ecofriendly way to recycle agricultural waste and mitigate soil acidification. We evaluated the effects of organic amendments on lettuce growth and soil chemical properties in two soils with different pH levels. Carbonized rice husk was produced at 600℃ for 30 min and rice husk was treated at 1% (w·w-1). Carbonized rice husk increased soil pH, electrical conductivity, total carbon content, and nitrogen content compared with untreated and rice husk treatments. Furthermore, this study found that lettuce growth positively correlated with soil pH, with increasing soil pH up to pH 6.34 resulting in improved lettuce growth parameters. Statistical correlation analysis also supported the relationship between soil pH and lettuce growth parameters. The study findings showed that the use of carbonized rice husk increased the constituent elements of lettuce, such as carbon, nitrogen, and phosphate content. The potassium content of lettuce followed a similar trend; however, was higher in acidic soil than that in non-acidic soil. Therefore, improving the pH of acidic soil is essential to enhance agricultural productivity. It is considered advantageous to use agricultural residues following pyrolysis to improve soil pH and agricultural productivity.