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Comparison of Serum CRP and Procalcitonin in Patients after Spine Surgery
Chung, Yeon-Gu,Yu, Sam-Won,Kwon, Young-Joon,Shin, Hyun-Chul,Choi, Chun-Sik,Yeom, Joon-Sup The Korean Neurosurgical Society 2011 Journal of Korean neurosurgical society Vol.49 No.1
Objective: Classical markers of infection cannot differentiate reliably between inflammation and infection after neurosurgery. This study investigated the dynamics of serum procalcitonin (PCT) in patients who had elective spine surgeries without complications. Methods: Participants were 103 patients (47 women, 56 men) who underwent elective spinal surgery. Clinical variables relevant to the study included age, sex, medical history, body mass index (BMI), site and type of surgery, and surgery duration. Clinical and laboratory data were body temperature, white blood cell count (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and PCT, all measured preoperatively and postoperatively on days 1, 3, and 5. Results: PCT concentrations remained at <0.25 ng/mL during the postoperative course except in 2 patients. PCT concentrations did not correlate with age, sex, DM, hypertension, BMI, operation time, operation site, or use of instrumentation. In contrast, CRP concentrations were significantly higher with older age, male, DM, hypertension, longer operation time, cervical operation, and use of instrumentation. Conclusion: PCT may be useful in the diagnosing neurosurgical patients with postoperative fever of unknown origin.
정연구(Yeon Gu Chung),이해숙(Hae Sook Lee),이경애(Kyung Ae Lee),정옥(Ok Joung),오원근(Won Keun Oh),김광동(Kwang Dong Kim),임종석(Jong Seok Lim),문자영(Ja Young Moon),조용권(Yong Kweon Cho),박순희(Sue Nie Park),윤도영(Do Young Yoon) 대한약학회 2002 약학회지 Vol.46 No.6
Cervical cancer is one of the leading causes of female death from cancer worldwide with about 500,000 deaths per year, A strong association between certain human papilloma viruses (HPV type 16 and 18) and cervical cancer has been well known. An extract of Saururus chinensis, named as PE-46, has been used to investigate whether this agent has the ability of inhibiting the oncogenes E6 and E7 of HPV type 16, PE46 inhibited the proliferation of human cervical cancer cell lines in a dose response manner, PE46 also inhibited the in vitro binding of E6 and E6AP which are essential for the binding and degradation of the tumor suppressor p53. In addition, PE-46 inhibited the in vitro binding of E7 and Rb which is essential tumor suppressor for the control of cell cycle. The levels of MRNA for E6 and E7 were also decreased by PE-46. SiHa cells treated with PE46 induced GO/G1 arrest, resulting in inhibition of growth. Our study showed that the PE-46 can inhibit the cervical carcinomas via both inhibition of bindings between oncogenes and tumor suppressors, and inhibition of G1->S S transition. PE-46 inhibited the oncogenecity of E6 and E7 of HPV 16 type, thus could be used as a putative modulating agent for the treaoent of cervical Carcinomas caused by HPV.
원발성 폐 수막종과 지연성으로 발생된 뇌수막종 -증례보고-
정연구 ( Yeon Gu Chung ),양재영 ( Jae Young Yang ),최천식 ( Chun Sik Choi ),채승완 ( Seoung Wan Chae ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2009 대한뇌종양학회지 Vol.8 No.1
Primary extracranial and extraspinal meningiomas are rare tumors that usually occur in the head and neck region, and few cases have been reported in the chest. In the described case, a complete central nervous system evaluation eliminated meningioma at other locations, and allowed a diagnosis of primary pulmonary meningioma. We describe a case of primary pulmonary meningioma(PPM) treated by excision. A complete central nervous system evaluation eliminated the possibility of multiple involvement. However, 9 years later meningioma developed in the brain. Solitary primary pulmonary meningioma is rare, and delayed onset brain meningioma is extremely rare. A search of the literature failed to reveal a similar case. Accordingly, this may be the first description of a primary pulmonary meningioma associated with the delayed development of brain meningioma.
( Yeon Suk Cha ),( Jae Gu Seo ),( Myung Jun Chung ),( Chung Won Cho ),( Hyun Joo Youn ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.10
Lactic acid bacteria (LAB) are probiotics that provide numerous beneficial effects on the host body, especially on the intestine. Combining several strains of LAB, we prepared a formulation containing four different LAB and studied its anti-inflammatory activity both in vitro and in vivo. The formulation significantly reduced NO production from RAW 264.7 cells treated with bacterial lipopolysaccharide, indicating that the formulation might include antiinflammatory activity. The formulation also suppressed inflammatory change induced by trinitrobenzene sulfonic acid (TNBS) in mice, where oral or rectal administration of the formulation protected the colon tissue from the damage by TNBS. Expressions of the IL-6 and FasL genes appeared to be down-regulated by the formulation in TNBS-treated colon tissues, suggesting that the suppression of those genes may be involved in the anti-inflammatory activity of the formulation.
( Ji Yeon Choi ),( Moo Suk Park ),( Song Lee Kim ),( Sang Hoon Lee ),( Eun Young Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Joon Chang ),( Jin Gu Lee ),( Hyo Chae P 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Lung transplantation (LTX) has been established as a current therapy for patients with end-stage lung disease. Despite year of experience with LTX, the rate of mortality still remains high. Calcineurin inhibitors sometimes have induced reactive hemophagocytic syndrome and influenced on mortality. Objective of this study was to search prognostic factors using modified reactive hemophagocytic syndrome diagnostic score (mrHScore) associated with mortality after LTX. Methods We conducted a retrospective analysis of 100 patients who underwent LTX at Severance Hospital from October 2012 to July 2018. We classified into two groups by high (n=52, mrHScore ≥78.5) and low mrHScore (n=48, mrHScore <78.5). The optimal cut-off value of mrHScore for the prediction of postoperative overall survival was set at 78.5 using receiver operating characteristics analysis. Five biologics (i.e., triglyceride, ferritin, serum glutamic oxaloacetic transaminase, fibrinogen and cytopenia) were used in calculating mrHScore. We analyzed the basal characteristics and mortality rates in low and high mrHScore groups as prognostic factors of LTX outcomes. Results The primary lung disease was idiopathic pulmonary fibrosis (n=51, 51%), interstitial lung disease (n=14, 14%), and bronchiectasis (n=5, 5%). High mrHScore group showed significantly cytopenia, hyperferritinemia, hypertriglyceremia, high LDH levels and high C-reactive protein levels compare to those of low mrHScore group. On Kaplan-Meier analysis, mortality rate was significantly increased in high mrHScore group than in low mrHScore group (hazard ratio: 2.074, p=0.015). Multivariate regression analysis showed that high mrHScore was significantly associated with postoperative mortality, even after adjusting for other confounding factors. Conclusion Our Results show that high mrHScore provides clues for adverse outcome during follow up period in LTX patients. The mrHScore can be used to estimate prognosis of post LTX patients, and provide useful information for predicting postoperative mortality.
장애인생활시설의 인적자원관리가 서비스 품질에 미치는 영향에 관한 연구
정무성(Chung, Moo Sung),구자연(Gu, Ja Yeon) 한국비영리학회 2011 한국비영리연구 Vol.10 No.1
본 연구는 전국의 장애인생활시설의 인적자원관리가 서비스 품질에 어떠한 영향을 미치는지를 살펴보았다. 조사대상은 보건복지부가 시행하는 2010년 장애인생활시설평가에 참여하였던 전국의 187개 시설이었다. 분석 결과 인사평가요소와 슈퍼비전요소가 가장 영향력이 높은 요인으로 나타났다. 그 다음으로는 직원 복리후 생과 인력의 충분성, 인력의 전문성으로 관찰되었다. 이러한 결과는 장애인생활시설에서 전문인력을 확보하는 것이 중요하며, 서비스의 품질 향상을 위하여 슈퍼비전실시를 강화하는 것이 필요함을 제시하고 있다. 나아가서 인사평가도 체계적으로 실시하는 것이 바람직하다는 함의를 제시하고 있다. 충분한 인력을 확보하기 위해서는 최소한 법정 직원 수대로는 각 시설에 배치될 수 있도록 정책적 · 제도적 지원이 뒷받침되어야 한다. The purpose of this study is to examine effects of the human resources management on service quality in residential facilities for the disabled. For the study, 187 facilities were analyzed using 2007 evaluation data and the results showed that the factors of personnel evaluation and supervision have significant effects on service quality in residential facilities for the disabled. It was found that fringe benefits for employees, sufficient numbers of employees, and the professional quality of the employee also have effects on service quality. The implication of these findings shows that it is important for the facility to secure qualified professional workers and to have systematic supervision system to improve the service quality. And a fair personnel evaluation system is also required. For the facilities to secure qualified workers, the proper grant from the government should be provided.