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( You-sub Kim ),( Kyung-sub Moon ),( Gun-woo Kim ),( Sang Chul Lim ),( Kyung-hwa Lee ),( Woo-youl Jang ),( Tae-young Jung ),( In-young Kim ),( Shin Jung ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2015 Brain Tumor Research and Treatment Vol.3 No.2
Background Craniofacial resection (CFR) has been regarded as a standard treatment for various tumors involving the anterior skull base. The purpose of this study was to evaluate the results of CFR for the patients with anterior skull base malignancies in our hospital. Methods We retrospectively analyzed 17 patients with anterior skull base malignancies treated with CFR between 2001 and 2012. Mean follow-up duration was 41 months (range, 2-103 months). Results Intracranial involvement was found in 11 patients (65%) and orbital extension in 6 patients (35%). Classical bifrontal craniotomy was combined with endoscopic endonasal approach in 14 patients and external approach in 3 patients. Vascularized flap was used for reconstruction of the anterior fossa floor in 16 patients (94%). The most common pathological type was squamous cell carcinoma (6 patients). Gross total resection was achieved in all cases. Postoperative complications developed in 4 patients (24%) and included local wound problem and brain abscess. One patient with liver cirrhosis died from unexpected varix bleeding after the operation. Although postoperative treatment, such as radiotherapy or chemotherapy, was performed in 14 patients, local recurrence was seen in 6 patients. The mean overall survival time after the operation was 69.0 months (95% confidence interval: 47.5-90.5 months) with a 1-, 2-, and 5-year survival rate of 82.3%, 76.5%, and 64.7%, respectively. Postoperative radiotherapy was found to be the powerful prognostic factor for favorable survival. Conclusion Considering the higher local control rate and acceptable complication or mortality rate, CFR with adjuvant radiotherapy is a gold standard treatment option for malignant tumors involving anterior skull base, especially with extensive intracranial involvement.
Lateral Ventricular Meningioma Presenting with Intraventricular Hemorrhage
( Ji Soo Moon ),( Seung Heon Cha ),( Won Ho Cho ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2019 Brain Tumor Research and Treatment Vol.7 No.2
A 35-year-old female visited emergency department for a sudden onset of headache with vomiting after management for abortion at local department. Neurological examination revealed drowsy mentality without focal neurological deficits. CT showed 3.2×3.4 cm hyperdense intraventricular mass with intraventricular hemorrhage. The intraventricular hemorrhage was found in lateral, 3rd, and 4th ventricles. MRI showed well enhancing intraventricular mass abutting choroid plexus in the trigone of the right lateral ventricle. CT angiography showed tortuous prominent arteries from choroidal artery in tumor. Her neurological status deteriorated to stupor and contralateral hemiparesis during planned preoperative workup. Urgent transtemporal and transcortical approach with decompressive craniectomy for removal of intraventricular meningioma with hemorrhage was done. Grossly total removal of ventricular mass was achieved. Pathological finding was meningotheliomatous meningioma of World Health Organization (WHO) grade I. The patient recovered to alert mentality and no motor deficit after intensive care for increased intracranial pressure. However, visual field defect was developed due to posterior cerebral artery territory infarction. The visual deficit did not resolve during follow up period. Lateral ventricular meningioma with spontaneous intraventricular hemorrhage in pregnant woman is very uncommon. We report a surgical case of lateral ventricular meningioma with rapid neurological deterioration for intraventricular hemorrhage.
An Updated Nationwide Epidemiology of Primary Brain Tumors in Republic of Korea
( Kyu Won Jung ),( Johyun Ha ),( Seung Hoon Lee ),( Young Joo Won ),( Heon Yoo ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2013 Brain Tumor Research and Treatment Vol.1 No.1
Objective: The aim of this report is to provide accurate nationwide epidemiologic data on primary brain and central nervous system (CNS) tumors in Republic of Korea. In 2010, we had reported first nationwide epidemiologic data on primary brain tumors diagnosed in 2005. In this report, we updated the data by analyzing primary brain and CNS tumors diagnosed in 2010 using the data from national cancer incidence database. Methods: Data on primary brain and CNS tumors diagnosed in 2010 were collected from the Korean Central Cancer Registry. Crude and age-standardized rates were calculated in terms of gender, age, and histological type. Results: A total of 10,004 patients diagnosed with primary brain and CNS tumors in 2010 were included in this study. Brain and CNS tumors occurred in females more often than in males (female to male, 1.59 : 1). The most common tumor was meningioma (35.5%). Pituitary tumors (18.7%), gliomas (15.1%), and nerve sheath tumors (10.3%) were followed in incidence. Glioblastoma accounted for 34.6% of all gliomas. In children (<20 years), sellar region tumors (pituitary and craniopharyngioma), embryonal/primitive/medulloblastoma, and germ cell tumors were the most common tumors. Conclusion : Data from this study should provide valuable information regarding the primary brain tumors epidemiology in Republic of Korea.
뇌종양으로 오인될 수 있는 단락관과 관련된 반응성 신경교증
위승복 ( Seung Bok Wee ),김승민 ( Seung Min Kim ),정성삼 ( Sung Sam Jung ),박기석 ( Ki Seok Park ),정승영 ( Seung Young Jung ),박문선 ( Moon Sun Park ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2008 대한뇌종양학회지 Vol.7 No.2
There are several pathologic conditions which can be around the shunt catheter. But, reactive gliosis related to shunt catheter is uncommon. We report a case of reactive gliosis which has been suggested to catheter-related tumorous condition such as glioblastoma. The authors report a 45-year-old man who had a history of ventriculoperitoneal shunt placement for hydrocephalus after traumatic intracranial hemorrhage 10 years ago. General weakness and dementic mentality developed recently. MRI revealed multi-lobulating contoured dark signal lesion on T2 weighted image and MR spectroscopy suggest tumorous condition such as meningioma or lymphoma. The stereotacxic biposy was performed under navigation guide. Histopathologically, the specimen showed strong positive reaction on glial cells. There was no remarkable results on microbiologic study. After steroid medication, patient`s condition was improved and enhancing mass was subsided. There are several diseases related to shunt catheter that to be ruled out, we must note the possibility of reactive gliosis mimicking brain tumor, like this case.
Central Neurocytoma: A Review of Clinical Management and Histopathologic Features
( Seung J. Lee ),( Timothy T. Bui ),( Cheng Hao Jacky Chen ),( Carlito Lagman ),( Lawrance K. Chung ),( Sabrin Sidhu ),( David J. Seo ),( William H. Yong ),( Todd L. Siegal ),( Minsu Kim ),( Isaac Yan 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2016 Brain Tumor Research and Treatment Vol.4 No.2
Central neurocytoma (CN) is a rare, benign brain tumor often located in the lateral ventricles. CN may cause obstructive hydrocephalus and manifest as signs of increased intracranial pressure. The goal of treatment for CN is a gross total resection (GTR), which often yields excellent prognosis with a very high rate of tumor control and survival. Adjuvant radiosurgery and radiotherapy may be considered to im-prove tumor control when GTR cannot be achieved. Chemotherapy is also not considered a primary treatment, but has been used as a salvage therapy. The radiological features of CN are indistinguishable from those of other brain tumors; therefore, many histological markers, such as synaptophysin, can be very useful for diagnosing CNs. Furthermore, the MIB-1 Labeling Index seems to be correlated with the prognosis of CN. We also discuss oncogenes associated with these elusive tumors. Further studies may improve our ability to accurately diagnose CNs and to design the optimal treatment regimens for patients with CNs.
양경훈 ( Kyung Hoon Yang ),남도현 ( Do Hyun Nam ),공두식 ( Doo Sik Kong ),김종현 ( Jong Hyun Kim ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2009 대한뇌종양학회지 Vol.8 No.2
Pleomorphic xanthoastrocytoma(PXA) is a superficially located, rare glial tumor first described in 1979. It affects young patients, who often present with seizures. The tumor has a relatively favorable prognosis, but 15-20% progress to malignancy. We describe a case of PXA which was benign features at presentation, but underwent anaplastic transformation. Surgery remains the mainstay of treatment. Factors influencing clinical outcome include extent of resection, and histological features such as mitotic index, necrosis and lymphocytic infiltration. The roles of radiotherapy and chemotherapy remain undefined. We advocate lifelong follow-up and establishment of a central registry in order to further understanding of this infrequently encountered tumor.
홍제범 ( Je Beom Hong ),홍창기 ( Chang Ki Hong ),이규성 ( Kyu Sung Lee ),윤선옥 ( Sun Och Yoon ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2011 대한뇌종양학회지 Vol.10 No.2
We present a case of spinal accessory nerve cavernous hemangioma. A 44-year-old male patient visited our hospital because a mass at his foramen magnum had been found during a medical checkup. A magnetic resonance (MR) image revealed a well-enhanced mass in the foramen magnum, with displacement of the medulla oblongata to the left side by this mass. The lesion was resected using a far-lateral approach, and the pathological diagnosis was a cavernous hemangioma. Although cranial nerve cavernous hemangioma is a rare condition, it should be considered when making differential diagnoses of foramen magnum masses.
례악성 송과체 종양의 연수막 파종과 유사한 발현을 가진 송과체 세포종 환자에서 발생한 유방암의 종양성 뇌수막염 -증례보고-
장지환 ( Ji Hwan Jang ),김규홍 ( Kyu Hong Kim ),양근영 ( Geun Young Yang ),김영준 ( Young Zoon Kim ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2012 대한뇌종양학회지 Vol.11 No.1
Neoplastic meningitis is a relatively rare, but serious late-stage complication of brain metastasis from systemic cancer. A 37-year-old woman presented with complaints of altered mentation, nausea and vomiting. Computed tomography (CT) and magnetic resonance imaging of brain revealed a patchy enhancement with gadolinium contrast of leptomeninges over the cerebral convexities and in basilar cistern, insulae, all the recesses, and ventricular walls. By neuroendoscopy, we performed third ventriculostomy and biopsy of pineal mass, which revealed a histopathologically-pure pineocytoma. The unexpected observation of cells floating in the ventricle was consistent with adenocarcinoma. In systemic work up, Cancer Antigen (CA) 15-3 was markedly increased in serum, and multiple enhanced masses were found in the breast, lung, axial lymph node, and vertebrae on positron emission tomography-CT. Ultrasonography-guided biopsy of breast mass suggested poorly differentiated adenocarcinoma. Herein, we report a rare case of neoplastic meningitis of breast cancer in the patients with a pineocytoma.
박철웅 ( Chul Woong Park ),권택현 ( Taek Hyun Kwon ),박윤관 ( Youn Kwan Park ),정흥섭 ( Heung Seob Chung ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2008 대한뇌종양학회지 Vol.7 No.2
The schwannomas from the lower cranial nerves have rarely been described, because the determination of lower cranial nerve`s origin is not always possible. The authors report a case of glossopharyngeal schwannoma, where the selective nerve origin was validated by microsurgical findings. A 35-year-old female presented with gait ataxia and headache. The preoperative MRI revealed a large cystic mass in the left cerebello-pontine angle, compressing the brain stem. Via the suboccipital route operation, it was demonstrated that the mass was adhered to the paper-like thinned glossopharyngeal nerve near the jugular foramen without association to other lower cranial nerves. In the cisternal portion, the glossopharyngeal nerve could be identified by its rostral entrance to the jugular foramen. A subtotal tumor removal was achieved to avoid damage of the paper-like thinned glosspharyngeal nerve. After surgery, the patient was discharged without any neurological symptoms and has received stereotactic radiation surgery for small remnant tumor.
정성훈 ( Sung Hoon Jung ),손은익 ( Eun Ik Son ),김인수 ( In Soo Kim ),김상표 ( Sang Pyo Kim ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2005 대한뇌종양학회지 Vol.4 No.2
Symptomatic lateral ventricular subependymomas are rare. A 34-year-old man presented with a 3-year history of progressive headache and seizure. Computed tomography and magnetic resonance imaging demonstrated inhomogenous well-enhancing, mass with calcification and chronic hemorrhagic component. A gross total resecton was performed via inferior temporal approach and the patient did well postoperatively. This report presents an introduction of subependyma and surgical strategy for lateral trigonal tumor.