중학교 가정과 교육의 가족생활관련 영역(인간발달과 가족관계)의 효과적인 교수-학습 방법

이신숙,조혜정 목포대학교 생활과학연구소 2000 생활과학논집 Vol.3 No.-

The purpose of the study is to develop effective and practical Teaching-Learning method for family life area of Home Economics in the middle school. In the method of the research, literature review related to the family life area of Home Economics in the middle school, which are Home Economics system and Home Economics goals. The results are summarized as follows. : First, Effective and practical Teaching-Learning method is catalogue from media and had advertisement or columns of journals or newspaper, Second. Multi-media material(TV. VTR, etc...) is produced to help the students learn the family life area. Thirds. Employing practical reasoning and teaching models such role play, to be effectively played, is improve the physical class room environment. It is necessary for Home Economics teachers to make effort to develop educational materials and to engage in Teaching-Learning method.

닭에서 Ethanol의 中樞作用이 血漿內 葡萄糖 濃度에 미치는 影響

李神雄,姜仁淑 충남대학교 의과대학 지역사회의학연구소 1975 충남의대잡지 Vol.2 No.1

The present experiments were undertaken in an attempt to elucidate the central effect of ethanol on the plasma glucose level in the hen. After intravenous administration of 30mg/kg ethanol to control group, plasma glucose concentration was not affected but over 100mg/kg, it induced hypoglycemia. Hypoglycemic effect of intravenous ethanol was potentiated by adrenergic blocking agents. Intraventricular administration of 30mg/kg ethanol resulted in a significant increase in the plasma glucose level, and this hyperglycemic effect of intraventricular ethanol was inhibited by regitine, propranolol, or reserpine. It suggests that metabolic effect of ethanol on the plasma glucose concentration in the hen is mediated partially by the activation of sympathetic center.

자기 진술에 의한 유·무배우 여자노인의 생활실태

이신숙 한국가정과학회 2004 한국가정과학회지 Vol.7 No.2

The purpose of this study is to investigate the living status of widowed and unwidowed elderly women by means of the case study employing in depth interviews. The main results are following: First, In the case of economic status of elderly women was very low: widowed, it was significantly low. The allowances were provided by their children. And they were spent for medical expenses- Second, Most elderly women have one or two chronic diseases, mostly Arthritis, Gastritis, Hyperpiesia. Third, The emotional relationship of the elderly women centered around their children. Fourth, Leisure activities of the elderly women were not partially formed, usually T.V. watching, chatting, playing Korea cards. Fifth, The elderly women wanted most to work for house chores, do light exercises, and to earn pocket money. Sixth, The wish for the goverment was financial support/ health support/ and emotional welfare support.

Euonymus alatus 추출뭉의 실험적 간 손상 억제

신숙정,이병용,신동근,이정호 Official Journal of the Korean society for immunol 2001 Immune Network Vol.1 No.3

항 Histamine와 Muscarinic Receptor 와의 상호작용 (Ⅱ) : 대뇌 Muscarinic M1 Receptor 에 대한 작용 Action on the cerebral muscarinic M₁ Receptor

이신웅,박영주,박인숙,이정수 영남대학교 약품개발연구소 1991 영남대학교 약품개발연구소 연구업적집 Vol.1 No.-

A single uniform population of specific, saturable, high affinity binding site of [³H] guinuclidinyl benzilate(QNB) was identified in the rat cerebral microsomes. The Kd value(37.2 pM) for [³H]QNB calculated from the kinetically derived rate constants was in agreement with the Kd value(48.9 pM) determined by analysis of saturation isotherms at various receptor concentrations. Dimenhydrinate(DMH), histamine H₁-blocker, increased Kd value for [³H] QNB without affecting the binding site concentrations and this effect resulted from the ability of DMH to slow [³H]QNB-receptor association. Pirenzepine inhibition curve of [³H]QNB binding was shallow(nH = 0.52) indicating the presence of two receptor subtypes with high (M₁-site) and low(M₂-site) affinity for pirenzepine. Analysis of these inhibition curves yielded that 68% of the total receptor populations were of the M₁-subtype and the remaining 32% of the M₂-subtype. Ki values for the M₁- and M₂-subtypes were 2.42 nM and 629.3 nM, respectively. Ki values for H₁-blockers that inhibited [³H]QNB binding varied with a wide range (0.02-2.5μM). The Pseudo-Hill coefficients for inhibition of [³H]QNB binding by most of H₁-blockers examined except for oxomemazine inhibition of [³H]QNB binding were close to one. The inhibition curve for oxomemazine in competition with [³H]QNB was shallow(nH = 0.74) indicating the presence of two receptor populations with different affinities for this drug. The proportion of high and low affinity was 33:67. The Ki values for oxomemazine were 0.045±0.016 μM for high affinity and 1.145±0.232 μM for low affinity sites. These data indicate that muscarinic receptor blocking potency of H₁-blockers varies widely between different drugs and that most of H₁-blockers examined are nonselective antagonist for the muscarinic receptor subtypes, whereas oxomemazine might be capable of distinguishing between subclasses of muscarinic receptor.

Randomly Amplified Polymorphic DNA 분석을 이용한 Streptococccus Group B의 분자유전형에 대한 연구

이승관,신숙희 高麗大學校 倂設 保健大學 保健科學硏究所 2002 保健科學論集 Vol.28 No.2

40 strains of group B Streptococcus isolated from clinical specimens were characterized by randomly amplified polymorphic DNA (RAPD) analysis. Among 40 Streptococcus Group B strains, 39 isolates fell into a single cluster at the similarity level of 90% when the primer OPS 11 was used. In case of using the primer OPS 16, 34 out of 40 strains fell into a single cluster at the similarity of 90%.

오미자(Schizandra chinensis)의 구성 유기산이 L. monocytogenes의 생육에 미치는 영향

이신호,임용숙 경산대학교 생명자원개발연구소 1999 생명자원과 산업 Vol.3 No.-

오미자의 구성 유기산은 L. monocytogenes scott A, L. monocytogenes Brie Ⅰ 및 L. monocytogenes ATCC 19111에 대해서 항균 효과를 나타내었다. 오미자의 주된 유기산인 fumaric acid, malic acid, citric acid 및 itaconic acid와 같은 0.1% 수준의 유기산에 의해서 L. monocytogenes의 성장이 억제되었다. 오미자의 구성 유기산 중 fumaric acid가 가장 효과가 우수하였다. 오미자의 구성 유기산 중 가장 효과가 뛰어난 fumaric acid에 의한 미생물 형태 변화를 살펴본 결과 대조구는 그 모양이 smooth한 반면에 처리구는 그 모양이 불규칙하고 부푼 형태학적인 변화를 보였다. The organic acid of Schizandra chinensis showed antimicrobial activty against three strains of L. monocytogenes scott A, L. monocytogenes Brie Ⅰ and L. monocytogenes ATCC 19111. The growth of L. monocytogenes was inhibited by 0.1% of various organic acids such as fumaric acid malic acid, citric acid, succinic acid and itaconic acid which were major components of Schizandra chinensis. The fumaric acid of Schizandra chinensis showed more strong inhibitory activity activity than the other acids of Schizandra chinensis. Cell surface of L. monocytogenes Scott A was irregular, swell and disrupted in fumaric acid of Schizandra chinensis treated cell but smooth in normal cell.

반응성애착장애아의 어머니-아동 관계

신의진,이경숙,박숙경 대한소아청소년정신의학회 1997 소아청소년정신의학 Vol.8 No.1

본 연구는 반응성 애착 장애 아동(Reactive Attachment Disorder, 이하 'RAD')의 혼란된 부모-아동 관계를 애착이론의 입장에서 체계적으로 살펴보고자 하였다. 이를 위해 1994년 8월에서 1995년 8월 사이 소아정신과에 내원한 RAD 아동과 어머니 20쌍과 비교집단으로 정상 아동과 어머니 20쌍을 대상으로, 아동에 대한 내적 실행 모델 면접(Working Model of Child Interview, 1986)과 낯선 상황 절차(Strange Situation Procedure, 1978), 부모-아동 상호작용 척도(Dyadic Parent-child Interaction Coding Scales, 1983)을 실시하여 어머니의 아동에 대한 내적 표상과 어머니의 내적 표상 유형과 아동의 애착 유형과의 관계, 내적 표상 유형에 따른 어머니-아동 상호작용 양상을 살펴보았다. 1) 대상 어머니들을 3가지 내적 표상 유형으로 분류해 본 결과, 비교 집단 어머니는 모두 균형된 표상으로 분류되었고 RAD 집단 어머니는 비개입된 표상(55%), 왜곡된 표상(45%)으로 분류되었다. 2) 어머니의 아동에 대한 내적 표상 유형은 아동의 애착 유형과 체계적으로 연관되었다. 균형된 표상의 어머니의 아동은 모두 안정 애착이었고 비개입된 표상 어머니의 82%는 그 아동이 불안/회피 애착으로 분류되었고 왜곡된 표상 어머니는 56%가 그 아동이 비조직/비일관 애착, 33%는 불안/저항 애착으로 분류되었다. 3) 어머니-아동 상호작용에서, 비개입된 표상의 어머니는 아동 중심 놀이에서 균형된 표상의 어머니에 비해 묘사적 진술, 반영적 진술, 묘사/반영적 질문을 적게 사용하였고 왜곡된 표상의 어머니는 균형된 표상의 어머니에 비해 직접 명령과 간접 명령을 많이 사용하였다. 장난감 정리하기 과제에서 비개입된 표상과 왜곡된 표상의 어머니는 균형된 표상의 어머니보다 직접명령, 간접명령을 더 많이 사용하였다. 위의 결과를 통해서 볼 때, 어머니의 아동에 대한 내적 실행 모델은 아동과의 애착 관계와 어머니-아동 상호작용에 중요한 요인으로서 혼란된 어머니-아동 관계를 이해하는데 효율적인 접근을 제공하며 아동에 대한 치료적 개입에 유용한 정보를 제공해 줄 것으로 생각된다. The objective of this study is to understand disordered parent-child relationships of Reactive Attachment Disorder(RAD) systematically through the mother's internal working model of child. In this study, RAD mothers' internal representations of the child were compared with mothers' of control group and association between mothers' representation classifications and children's attachment classifications was examined. Also individual differences in mother-child interaction by mothers' representation classifications was observed. The subjects of this study were 40 2-5 year-old children and their mothers, 20 attachment disordered dyads and 20 normal dyads of control group. Mothers were interviewed using the Working Model of the Child(Zeanah, Benoit & Barton 1986) to classify internal representations of child. Children's attachment patterns were assessed by the Strange Situation Procedure. for observation of mother-child interaction, Each dyad was seen in DPICS devised by Eyberg and Robinson(1983). The results of the study were as follows : 1) Among RAD group, 55% of mothers were classified as disengaged and 45% classified as distorted, while all mothers of control group were classified as balanced. In rating scales, there were significant differences in all 3 representation classifications in Intensity of involvement and Coherence. In Intensity of involvement disengaged representations had the lowest score and distorted representations had the lowest score in Coherence. 2) Mothers' representation classifications were related to children's attachment classifications. All mothers of control group whose children were classified as secure were classified as balanced. Among RAD's mothers, by contrast, 82% of mothers classified as disengaged had children classified as anxious-avoidant, 56% of mothers classified as distorted had children classified as disorganized/disoriented and 33% of mothers classified as distorted had children classified as anxious-resistant. 3) There were individual differences in mother-child interactions by mothers' representation classifications. In the child-centered play, mothers classified as disengaged used discriptive statement, reflective statement and discriptive-reflective question less than balanced mothers. Mothers classified as distorted used direct command and indirect command more than balanced mothers. In the clean-up task, mothers classified as disengaged and distorted used direct command and indirect command more than balanced mothers. The results of this study suggest that parents' working model of the child is an important factor to understand parent-child attachment relationships and their interactions. The understanding of parents' working model of the child is thought to enrich our understanding of disordered parent-child relationships and to provide useful informations for specific and successful treatments.

위내시경 검사환자에 대한 정신의학적 연구 : BDI와 STAI를 중심으로

신동균,조숙행,이성근 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.6

The authors studied the emotinal status of the medical outpatient who underwent gastroscopy for gastrointestinal complaints by means of BDI(Beck Depression Inventory) and STAI(State-Trait Anxiety Inventory). Also, the authors compared the degree of anxiety and depression according to each factors of demographic and other data which might influence emotional status. The subjects were 674 patients who underwent gastroscopy at Guro Hospital, College of Medicine, Korea University. from March 1 to September 30, 1986. The results are as follows : 1) There were no statistically significant differences in BDI and STAI between the negative group and positive group, and between the ulcer group and gastritis group. 2) There were no statistically significant differences in BDI and STAI between the gastric ulcer group and duodenal ulcer group, and among the chronic superficial group and erosive gastritis group and atrophic gastritis group. In atrophic gastritis group, there was no statistically significant difference in BDI and T-A among patients with mild, moderate or severe pathology. But in S-A, patients with severe pathology showed higher degree of anxiety than patients with mild or moderate pathology. 3) 25% of the positive group and 13% of the ulcer group and 23% of the gastritis group were rated as depressed by BDI(a score of 21 was used as criterion). 4) In the negative group, according to sex, there was significant difference in BDI and STAI. According to economic state, there was significant difference in BDI, but not in STAI. According to sleep pattern, there were significant difference in BDI and S-A, but not in T-A. 5) In the ulcer group, according to sex, education level, and sleep pattern, there were significant differences in BDI and S-A, but not in T-A. According to economic state, there was significant differences in T-A, but not in BDI or S-A. 6) In the gastritis group, according to age, there was significant differences in BDI but not in STAI. According to marital state, there was significant differences in BDI and T-A, but not in S-A. According to sex, economic state, educational level, early parental death, and sleep pattern, there was significant differences in BDI and STAI.

화살나무 추출물에 의한 Doxorubicin-유도 조직손상의 억제

이정호,신숙정,문용,이동근 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.2

Doxorubicin(DR), a potent antineoplastic drug, is effective in adult and childhood solid tumors and hematologic cancer. However, it has minor(mucositis, nausea, vomiting and alopecia) and major(myelosuppression, cumulative dose-related cardiomyopathy, and skin and subcutaneous ulcers) clinical toxic effects. Accidental subcutaneous DR-extravasation may provoke a prolonged and severe cutaneous inflammatory reaction for which there is currently no simple and effective treatment method. Because of this, apart from measures to prevent paravenous extravasation, many methods of preventing these ulcers have been tried clinically or experimentally, but the efficacy is uncertain. The present study was undertaken to exploit Euonymus alatus extract(EA) as an antidote for DR-induced skin ulceration, using animal model, and to evaluate the effects of EA on the pharmacological activity of DR. Sprague-Dawley rats and ICR mice were intradermally injected DR(0.5 mg/rat and 0.2 mg/ mouse) with or without EA(10 mg/rat and 5 mg/mouse). In rat model, intradermal injection of DR alone produced predictable uniform skin necrosis and ulceration involving the deep dermis. These ulcers developed within 3-7 days, remained stable for 2-4 weeks, and all rats died in 55 days of observation. However, intradermal injection of DR plus EA into rat developed only minor transient edema, erythema and mild inflammation involving the superficial dermis, which healed quickly, and all rats survived throughout the experimental periods. In mouse model, intradermal injection of DR alone produced an ulcer approximately 15.2 mm2 at 5 days. This ulcer was progressively aggravated in size until 15 days, and regressed and healed after that. But, when mice were intradermally injected DR plus EA, the ulcers were reduced in size and healed quickly. These results suggest significant efficacy for EA as a DR-extravasation antidote. B16 cells, 3LL cells and human tonsillar lymphocytes were cultured in the presence of DR with or without EA, and the proliferation responses of these cells were evaluated. DR alone de-creased remarkably the proliferation of malignant cells as well as normal cells, in a dose-dependent fashion. On the other hand, the EA itself reduced weakly the responses of tumor cells but increased those of normal cells. And EA also slightly enhanced the DR- induced inhibition of the tumor cell-proliferation, but it restored the DR-derived decrease of the lymphocyte-prol-iferation. These results suggest that EA itself has no side effects, and also suggest that EA may possibly diminish the systemic toxic effects of DR-administration. Taken together, the present study reveals that EA has an antidotic activity against DR-ex-travasations and systemic DR. And these results suggest the possibility that EA could be developed and used in a form of DR-annex as an antidotic and reinforcing agent of DR.