담낭종양에서 CD24의 역할

임성철,이용,김동출,강길,변익건,박정희,최석민 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

CD24 is a small heavily glycosylated glycosylphosphatidylinosito-linked cell surface protein, which is expressed in hematologic malignancies as well as in a large variety of solid tumors, It appears to function as a ligand of PUselectin, an adhesion molecule that is present in activated platelets and endothelial cells. The authors aimed to evaluate CD24 protein expression in adenoma and adenocarcinoma of gallbladder to correlate to clinicopathologic data. The staining- was evaluated as stainability (negative, weak-, moderate-, strong-positive) and staining' patterns (membranous vs. intracytoplasmic) for statistical analysis. A highly significant association of cytoplasmic CD24 expression with adenocarcinoma compared to the adenoma of gallbladder was demonstrated. The present study demonstrates that CD24 was abundantly expressed on adenocarcinoma rather than on adenoma, but it was not statistically significant, Interrelation between the stainability or intracytoplasmic staining of CD24 and lymph node metastasis was not statistically significant. The authors conclude that CD24 is involved in tumorigenesis of gallbladder mucosa and intracytoplasmic expression of CD24 is an important molecular marker for malignant transformation.

폐철을 이용한 크롬(VI)의 환원적 제거

임우택,정용식,유건상,김종현,김영훈 7개 국립대학교 환경연구논문집 공동발행 위원회 2005 공업기술연구 Vol.5 No.-

Cr(VI) is a known toxic heavy metal which is found frequently in many industrial sites. Contaminates soil and ground water with Cr(VI) is a big enviromental concern due to the high toxicity. Permeable Reactive Barrier(PRB)is an innovative remedial technology intensively studied and developed recenty. The most popular PRB material is zero-valent iron which is environmentally favorable and cheap. Scrapped steels and precleaned scrapped steels were tested in this study for Cr(VI). Scrapped steels were precleaned wuth detergent, acetone, hexane.The precleaned scrapped steel showed relatively high reactivity for Cr(VI). The results indicate that the scrapped steel could be used as PRB material after proper pretreatments.

運動選手의 身體構成과 體型 및 最大有酸素性 能力에 關한 縱斷的 硏究 : 蹴球選手를 中心으로 Emphasised on soccer Players

林相鶴,金豪敏,崔成根,韓泰龍 서울市立大學校 1989 論文集 Vol.23 No.-

This study attempts to find the change and the relationship of body composition somatotype and maximum aerobic power according to the age on the based of result of the survey performed to 69 subjects who attended in the K college, D high school, K middle school. The result were as follows : 1. The percent of fat of all the subjcets was lower than that of ordinary people. 2. Somatotype of subjects was higher mesomorph and lower endomorph. 3. Maximum oxygen uptake was increasing and maximum oxygen uptake per kilogram of body weight was decreasing according to growth. 4. Endomorph and maximum oxygen uptake was sure to have certain correlation.

중앙심벽형댐의 응력전이에 관한 연구

임희대,임찬수,이성용 忠南大學校 産業技術硏究所 1995 산업기술연구논문집 Vol.10 No.2

Various modes of load transfer may exist in rockfill dams. If the core is softer than the shells, load is transferred from the core onto the shells as a result of greater downward displacement of the core with respect to the shells. But if the core is stiffer than the shells, load transfer occurs from the shells onto the core. In this study, the mechanisms of load transfer in rockfill dams have been outlined and load transfer of Juam main and regulation dam with central core are evaluated by load transfer ratio. The load transfer ratio is defined as the ratio of computed values of major principal stresses in the core to the core overburden stresses. The vertical stresses are determined by the FEM, which use hyperbolic model and incremental method to simulate placement of successive layers of fill. The hyperbolic paramaters for the core was estimated from a series of conventional triaxial tests carried out during construction. From the results of this analyses and its comparison with the values measured by soil pressure meters, it has been shown that significant load transfer from the core to the shells was observed in two dams and that the load transfer ratios predicted are higher than the values measured.

칼슘제 수관살포가 참다래의 과실 품질과 저장에 미치는 영향

임경호,나양기,임동근,마경철,조윤섭,김월수,이상현,박용서 全南大學校 農業科學技術硏究所 2001 農業科學技術硏究 Vol.36 No.-

This study were carried out to improve Kiwifruit quality and storage life. Three kinds of calcium compound were sprayed and calcium content of fruits, weight loss during fruit storage and fruit quality were investigated. Calcium contents within leaves and fruit were lower in Clef-non treatment than that of control. The calcium content in fruit pericarp of Kalk-H and CaCl2 was 0.04 to 0.05% higher than that of control. Fruit weight and soluble solids content at harvest was a little higher but acidity and fruit hardness was lowered. Fruit weight loss of Kalk-H and CaCl2 treatment was 1.39 to 1.53% lower than that of control during storage. The soluble solids of ripen fruit was 1.0 to 1.3% higher in all treatment and 0.8% higher in Kalk-H treatment in 120 of after storage. Fruit hardness of control fruit was higher at harvest but that of CaCl2 treatmented fruit was 0.39㎏/φ 5㎜ higher in 120 days of storage.

관상동맥질환의 중증도와 혈중지질치 및 아포지단백과의 상관관계

임현주,황종현,류재근,정병천,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

목적 : 관상동맥질환의 위험인자로서 혈청지질 및 혈장 지단백에 대한 관심이 높아지고 있고 또 아포지단백이 관상동맥 질환을 일으키는데 다른 지질보다 더 중요하다는 연구가 많이 발표되고 있으나 우리나라에서는 아포지단백에 대한 연구가 그리 많지 않은 편이다. 이에 저자등은 혈중지질치와 새로운 위험인자로 알려지고 있는 아포지단백치를 측정하고 이들과 관상동맥질환 중증도와의 상관 관계를 알아보았다. 대상 및 방법 : 관상동맥질환이 의심되어 관상동맥조영술을 실시한 69명의 환자를 대상으로 하였으며 12시간 이상 공복후 혈청을 채취하여 총콜레스테롤, 중성지방, HDL-콜레스테롤, 아포지단백 AI (ape AI), 아포지단백 B (ape B)를 측정하였다. 관상동맥조영상 50%이상의 협착이 있는 혈관의 수 (lesion number), 최대협착을 합한 값 (lesion score), 각 분절의 최대협착을 합한 값 (total score), 가장 심한 협착 값 (peak stenosis) 등으로 관상동맥 중증도를 알아본 다음 이들과 혈청지질치, 아포지단백과의 상관 관계를 비교해 보았다. 상관 관계는 Spearman's correlation coefficient를 구하였다. 결과 : 관상동맥질환의 중증도와 각 지질치 간의 상관 관계를 비교해 보았을때 lesion number와 관계있는 것은 연령 (r=0.2789), 중성지방치 (r=0.2829)이며 lesion score와 관계있는 것은 연령(r=0.2911), 중성지방치0 (r=0.3316), 총콜레스테롤과 HDL-콜레스테롤의 비 (r=0.2361), apo B 치(r=0.2759), apo AI과 apo B의 비 (-0.3154)로 나타났다. Total score는 연령 (r=0.3100), 총콜레스테롤치 (r=0.2452), 중성지방치 (r=0.3022), 총콜레스테롤과 HDL-콜레스테롤의 비 (r=0.2770), apo B치 (r=0.2927), apo AI과 apo B의 비 (r=-0.3408)와 연관이 있었고 peak stenosis는 중성지방 치(r=0.3305), ape B 치 (r=0.2968), apo AI과 apo B의 비 (r=-0.3977)와 관계가 있었다. 연령으로 조정하여 partial correlation을 좌면, 관상동맥조영술상 중증도는 중성지방치 (r=0.3408), apo B 치(r=0.2877), apo AI과 apo B의 비 (r=-0.3460)와 유의한 상관 관계가 있었다. 이중 ape AI과 ape B의 비는 lesion score (r=-0.2640), total score (r=-0.3057), peak stenosis (r=-0.3460)와 유의한 상관관계를 보였다. 결론 : 이상의 결과로 보아 apo B치 그리고 apo AI과 apo B의 비가 관상동맥 중증도의 예견인자로 다른 혈중 지질 치보다 더 유용하다는 것을 알 수 있었다. Objectives : Recently, it was reported that the measurements of apolipoprotein levels may be valuable in the clinical assessment of coronary artery disease severity. However there are a few reports regarding to the relationship between coronary artery disease severity and apolipoprotein levels in Korea. Thus, we measured serum lipid and apolipoprotein levels and studied the relationship between coronary artery disease severity and serum lipids and apolipoproteins levels. Subjects and Methods : The 69 patients who underwent coronary angiography to evaluate chest pain were subjected to this study. We measured the levels of serum cholesterol, triglycerides, HDL cholesterol, apolipoprotein AI(apo AI) and apolipoprotein B(Apo B) and measured the severity of coronary artery disease by lesion number, lesion score, total score and peak stenosis. Then, we studied the relationship between coronary artery disease severity and apolipoproteins and calculated the correlation coefficient. Results : The results were as follows. There are significant correlation(r=0.3) between age, triglycerides, apo B levels, apo AI/B ratio and coronary artery disease severity. In controlling for age, tyiglycerides, apo B levels and apo AI/B ratio shows significant correlation(r=0.3) with coronary artery disease severity. Especially, apo AI/B ratio shows significant correlation(r=0.3) with lesion number, total score and peak stenosis. Conclusion : These results suggest that the apo B levels and the ratio of apo AI/B can be used as significant independent predictor for coronary artery disease severity rather than other serum lipid levels.

분리장소에 따른 황색포도구균의 항생제 내성

임용,이강길,신성희 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

본 연구의 결과를 요약하면 다음과 같다. 1. 임상 분리주 총 70주의 황색 포도구균의 9가지 항생제에 대한 내성율을 조사한 결과, OXAC 내성율 즉 MRSA 분리율은 54.3%이었다. PCV에는 92.9%의 균주가 내성을 보인 반면, SXT 5.7%의 내성율을 보여서 좋은 항균효과를 보였으며, VM에는 모든 실험균주가 감수성을 보였다. 2. 임상 분리주 중 87%(61주)에 해당되는 균주가 2가지 이상의 항생제에 다제내성을 보였다. 3. 대상균주를 환자 분리주(56주), 의료인 분리주(7주), 병원환경 분리주(7주)로 나누어 각 항생제의 내성율을 비교한 결과 통계적 차이를 보이지 않았으나 CLM, SXT 등의 항생제는 환자 분리주에서 보다 병원환경 분리주에서 더욱 높은 내성율을 보였다. 4. 환자 분리주를 외래환자 분리주(16주)와 입원환자분리주(40주)로 나누어 항생제 내성율을 비교한 결과, SXT와 VM을 제외한 모든 항생제에서 통계학적으로 의미 있는 차이를 보였다(p<05). 즉 외래환자 분리주는 기타 환자 분리주에 비해 항생제에 대해 매우 높은 감수성을 보였다. 또한 OXAC에 전부 감수성이 있는 MSSA이었다. 이상과 같은 결과를 토대로 환자 분리주, 의료인 분리주, 병원환경 분리주에서 항생제에 대한 내성율에 큰 차이를 보이지 않고 비슷한 내성율을 보인 점은 이러한 비교군 간의 황색 포도구균 감염의 연쇄고리가 있음을 알 수 있으며 외래환자 분리주가 입원환자 분리주에 비해 항생제 감수성이 높은 것은 외래 환자들의 감염원이 병원내에 있지 않고 자연환경이나 건강인의 피부나 비강에서 비롯된 것이었기 때문으로 생각해 볼 수 있다. Objectives: Staphylococcus aureus showing multi-drug resistance is one of the major human pathogens causing nosocomial infection. The aim of this study is to investigate the difference of antimicrobial resistance according to the isolation sites and to offer the latest information of antimicrobial chemotherapy and reappraisal. Materials and Methods: We isolated and identified seventy stains of S. aureus from community hospitals and the isolated strains were classified according to the isolation sites. Disk diffusion test was used for the determination of antibiotic resistance. Results: The obtained results were as the follows. (1) Methicillin-resistant S. aureus was 54.3% of the total seventy strains. 92.9% were susceptible against sulphamethoxazole and trimethoprim and 100% against vancomycin. (2) When the total isolates were divided into the three groups including the isolates from patients (56 strains), those from doctors and nurses (7 strains) and those from a hospital environment (7 strains), there was a slight, but not significant difference in the resistance ratio against the tested antimicrobial agents. (3) There was a striking difference in the resistance ratio between the isolates obtained from the outpatient department (OPD, 16 strains) and those from the hospitalized patients (40 strains). Isolates obtained from OPD showed a higher susceptibility than those from the hospitalized patients (p<0.05) and all the isolates obtained from OPD proved MSSA (methicillin-susceptible S. aureus). Conclusion: Taken together, these findings suggest that there is an intimate circuit for bacterial transmission among the three groups. The higher susceptibility in the isolates from OPD suggests that they may be less frequently exposed to antimicrobial agents and originated from either a natural environment or the nares of normal persons but not from the hospital environments.

5次 敎育課程에 의한 中學校 科學 敎科書 比較分析 : 化學領域 Chemistry Contents

林性美,李甲龍 대구효성가톨릭대학교 자연과학연구소 1992 基礎科學硏究論集 Vol.1992 No.1

The contents for the chemistry parts in the five textbooks of middle school science 1, 2, 3 based on 5th middle school new curriculum were analyzed and compared with each other. The results showed as follows : (1) Most of textbooks were well organized in accordance with objectives and contents based on the new curriculum. (2) The contents of the textbooks had a little difference according to authors. (3) The quantity of space increased as the grade is moved up. (4) Most of textbooks dealt with observation and measurements, conditional controls, performance of laboratory equipments and discussion of results exceedingly in the content of experiments, but sefety educations were somewhat neglected.

스틸벤의 치환기 효과에 대한 분자궤도함수론적 해석

林性美,朴柄珏,李甲龍 대구효성가톨릭대학교 자연과학연구소 1992 基礎科學硏究論集 Vol.1992 No.1

치환 시틸벤 계열에 대해 HMO법으로 Hammett 치환기 상수를 해석하였다. 이 계열에서 치환기 상수에 대한 유도효과와 공명효과의 기여를 양자화학적 지수로 취하여 계산한 이론값이 Hammett 치환기 상수 σ_p와 병행성이 있음을 알았으며 이 이론값으로 치환 스틸벤의 쌍극자능률에 미치는 치환기 효과를 설명할 수 있었다. 아울러 이 화합물의 전자전이에 대한 최대 흡수파장(λ_max)은 HOMO와 LUMO 에너지의 차에 의존됨이 확인되었다. The Hammett's substituent constants were interpreted for substituted stilbenes by HMO method. The appropriate quantum chemical indices are chosen as independent contribution of the inductive and the resonance effects for substituent constants. It has been found that theoretical values, σ_p^th, defined as sum of the net charge, self atom polarizability and difference in HOMO energy between substituted- and unsubstituted stilbenes, correlated with experimental Hammett's substituent constants. The dipole moments were found to be correlated with differences in σ_p^th between two substituents for disubstituted stilbenes. It has been also found that transition optical spectra, λ_max of the substituted stilbenes depend on difference between the HOMO and the LUMO energy as expected.

조선대학교 의과대학 의학과 학사편입제도의 전향적 검토

임성철,박상기,도남용,박상학,이승일,송창훈,박종 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

There are many advantages and disadvantages under the limited bachelor's admission system. To diminish the demerits and to increase the merits of this system, the authors posed questions to the faculties and students of the Department of Medicine. Chosun University College of Medicine and other colleges in Korea. The questionnaire was made according to trends and feelings in this system. We received a lot of information and suggestions as to how to improve the system, in the following paper we discuss and report the prospective aspects of the bachelor's admission system.