FCT 5 : Fractional laser-assisted topical imiquimod 5% cream treatment for recalcitrant common warts in children

( Hyun Chang Ko ),( Jeong Min Kim ),( Hyun Ho Cho1 ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Conventional destructive modalities for warts like cryotherapy or laser ablation have some limitations that are excruciating pain during procedure, in especially pediatric patients. Imiquimod is a topical immune response modifier that was approved for treating genital and perianal warts. But, thick stratum corneum of common warts may act as a barrier against drug permeation via the skin. Objectives: To evaluate efficacy and safety of above treatment. Methods: Eleven pediatric patients (6 female and 5 male, mean age 12.5 years) were included in this study. The lesions were treated by fractional 2940 nm Er:YAG laser for achieving the penetration of stratum corneum with 1 or 2 weeks intervals. Then, imiquimod 5% cream was self-applied once daily for 5 days a week. Assessment of response and adverse effects was performed every 2 weeks until complete clearance or up to maximum of 48 weeks. Pain during procedure was checked by VAS (0-10). Results: 8 out of 11 (72.7%) patients experienced complete clearance of all warts lesions. Mean duration of total treatment was 29.7 (16-48) weeks. Mean number of fractional laser treatment was 17.5 (8-37) times. No significant adverse effect was observed. VAS score of the pain during fractional laser treatment was 2.4 (1-4), comparing with 6.2 (5-8) during cryotherapy. Conclusion: Fractional ErYAG laser-assisted topical 5% imiquimod cream is an effective and safe treatment option for recalcitrant common warts of the children do not tolerate pain well.

White luminescence of Ho3+/Tm3+/Yb3+-codoped CaWO4 synthesized via citrate complex route assisted by microwave irradiation

CHO, Hyun,HWANG, Seok Min,LEE, Jae Bin,KA, Dong Hyun,KIM, Tae Wan,LEE, Bo Seul,LEE, Ji Young,LEE, Jung-Il,RYU, Jeong Ho Elsevier 2014 Transactions of Nonferrous Metals Society of China Vol.24 No.suppl1

참나무 群落地의 植物群集構造分析 : Ⅰ. 白雲山의 植物群集構造分析 Ⅰ. Plant Distribution and vegetation structure in Mt. Bakwoon

趙顯瑞,李喆浩 진주산업대학교 1998 論文集 Vol.37 No.-

백운산 내회지역과 지리산 대원계곡의 삼림군집구조를 파악하여 우량종 육성에 필요한 자료를 분석한 결과는 다음과 같다. 1. 백운산지역 95개 조사지를 TWINSPAN에 의하여 classification을 분석한 결과, 남사면에서는 양수인 소나무 군집으로 구분되었으며, 북사면에서는 활엽수흔효군집으로 구분되었다. 2. 백운산지역 조사지는 DCA에 의하여 1, 2축에 우측에서 좌측으로 소나무군집, 굴참무군집, 졸참나무-굴참나무군집, 졸참나무군집, 서어나무군집으로 분리되었고, 상, 하로 신갈나무군집, 활엽수흔효군집, 고로쇠나무군집 등의 8개 군집으로 분리되어 TWINSPAN보다 DCA방법이 효과적이었다. 3. 백운산 지역 군집간의 유사도지수를 분석한 결과, 소나군집과 졸참나무군집, 소나무군집과 서어나무군집, 소나무군집과 고로쇠나무군집, 신갈나무군집과 고로쇠나무군집의 유사도지수가 20%미만을 나타내어 이질적인 군집임을 알 수 있었고, 졸참나무-굴참나무군집과 굴참나무군집, 졸참나무군집, 활엽수흔효군집 그리고 굴참나무군집과 활엽수흔효군집간에는 55% 이상의 높은 값을 나타내었다. 4. 백운산지역 토양 환경인자의 DCA분석에서 토양산도를 제외하고 모든 인자의 A군집(소나무군집)에서 E군집(서어나무군집)으로 갈수록 증가하는 경향이었다. 5. 백운산지역 토양산도, 수분함량, 유기물함량 및 K^+, Ca^++, Mg^++ 등 토양환경요인을 DCA기법을 적용한 결과, 대부분의 요인에서 소나무, 신갈나무군집은 낮은 계급을 나타내었고, 서어나무군집, 활엽수흔효군집, 고로쇠나무군집 등에서는 높은 계급에 위치하고 있었다. This paper aims at analyzing the plant community in Mt. Bakwoon area. The plant community in Mt. Bakwoon was divided into 95 plots by clumped sampling method. According to DCA ordination, Mt. Bakwoon is composed of Pinus densiflora, Quercus variabilis, and Q. serrata communities. The similarity index between Quercus variabilis and mixed stands of broad leaved trees was more than 55%.

시클러 캡슐(세파클러 250㎎)에 대한 경보세파클러 캡슐의 생물학적동등성

조혜영,강현아,김세미,박찬호,오인준,임동구,문재동,이용복 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1

The purpose of the present study was to evaluate the bioequivalence of two cefaclor capsules, Ceclor (Lilly Korea Co., Ltd.) and Kyongbocefaclor (Kyongbo Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of cefaclor from the two cefaclor formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media (pH 1.2. 4.0. 6.8 buffer solution and water). Twenty four healthy male subjects. 22.96±1.52 years in age and 67.03±7.90 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After one capsule containing 250 mg of cefaclor was orally administered, blood was taken at pre-determined time intervals and the concentrations of cefaclor in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. In addition. the pharmacokinetic parameters such as AUC_(t), C_(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t). C_(max) and untransformed Tmaa. The results showed that the differences between two formulations based on the reference drug, Ceclor. were -1.90%, 2.68% and -7.60% for AUCt, C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.91-log 1.06 and log 0.92-log 1.18 for AU', and C_(max), respectively). Thus. the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kyongbocefaclor capsule was bioequivalent to Ceclor capsule.

리스페달 정(리스페리돈 2㎎)에 대한 리스펜 정의 생물학적 동등성

조혜영,박은자,강현아,백승희,이석,박찬호,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

The purpose of the present study was to evaluate the bioequivalence of two risperidone tablets, Risperdal (Janssen Korea Co., Ltd) and Rispen (Myung In Pharm. Co., Ltd), according to the guidelines of Korea Food and Drug Administration (KFDA). The risperione release from the two risperidone formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with various of dissolution media (pH 1.2, 4.0, 6.8 butter solution and water). Twenty four healthy male subjects, 23.33±2.10 years in age and 69.24±8.05 kg in body weight, were divided into two groups and a randomized 2×2 crossover study was employed. After one tablet containing 2 ㎎ as risperidone was orally administered, blood was taken at predetermined time intervals and the concentration of risperidone in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Risperdal were 0.20, -1.29 and -11.09% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.90)∼log(1.03) and log(0.84)∼log(1.09) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Rispen tablet and Risperdal tablet were bioequivalent.

참나무 幼齡化 접수에 의한 接木法 開發에 관한 연구

趙顯瑞,李喆浩,秋甲喆 진주산업대학교 1999 論文集 Vol.38 No.-

To obtain effective grafting propagation method, grafted rejuvenation shoots at seedlings of Q. acutissima, Q. aliena and Q. dentata, respectively. The result investigated at April and October are as follows: The survival ratio of Q. acutissima, Q. aliena and Q. dentata in grafting at April were 75%, 58% and 51%, and at October were 87%, 76% and 71%, respectively. The height of Q. acutissima which grafted cuttings growth highest, was 120㎝, Q. aliena and Q. dentata were 80㎝ and 71㎝. Grafting method by rooted cuttings at seedlings at Q. acutissima is most effective.

RAPD分析法에 의한 참나무 優良種의 PCR反應 分析

趙顯瑞,李喆浩,李正煥 진주산업대학교 1999 산업과학기술연구소보 Vol.- No.6

RAPD를 이용한 참나무류의 band pattern은 primer의 종류에 따라 공시 수종별로 구분이 가능한 표식인자(marker)를 가지고 있었고, 상수리나무 (lane 1-11) band pattern에서는 고유 band를 보였다. Primer OPA-10, OPA-16에서 갈졸참나무 (lane 28)은 갈참나무(lane 22-25) 및 졸참나무 (lane 12-17)와 공유 band가 있었으마, 갈참나무와 유사한 band pattern을 보여 갈참나무와 유사한 경향을 보였다. 촐참나무 (lane 12∼17), 갈참나무 (lane23∼27)와 갈졸참나무(lane28) 집단 간에는 유사한 band pattern을 보여 갈졸참나무가 갈참나무에 근접한 교잡종으로 인식되었다. 군집분석결과 28개 집단은 7개 Grpup로 분류되었는데, 제1 집단은 상수리나무, 제 2 집단은 갈참나무, 제 3집단은 졸참나무 등으로 집단간 종의 구분이 가능하였다. In the Polymerase Chain Reaction (PCR) - Random Amplified Polymerase (RAPD) DNA analysis was performed on DNA samples obtained from leaf collected from wild Quercus spp. in Kyeongnam Province. PCR - DNA markers were used as a predictor of superior tree in future Quercus spp. breeding development. Eight primers were used for PCR and generated a total of 122 RAPD markers. According to the PCR products bands of Q. acutissima (lane 1-11), Q. serrata (lane 12-17), Q. uariabilis (lane 18-22), Q. aliena (lane 23-27) a n d Quercus x urticaefolia (lane28) were detected in all samples. Genetic relationships among the 28 individual samples were analyzed by the cluster analysis of 122 RAPD markers, which divides seven groups. According to the cluster analyses, First group are contains Q. acrtissima. Second group are Q. aliena, third group Q. serrata and so on. And close relationship between Quercus x urticaefolia and Q. aliena were ascertained by cluster analysis.

면역억제제를 사용치 않은 동소성 간이식 실험견의 조직병리소견

조원현,최순옥,김인호,임태진,김성수,박준희,김우석,김현철,최규택,김진모,권건영 大韓移植學會 1994 Korean Journal of Transplantation Vol.8 No.1

Latex Modified Concsdrete 교면공법을 이용한 포장공법의 Life Cycle Cost 분석

조효남,최현호,정평기,이상윤 漢陽大學校 工學技術硏究所 2001 工學技術論文集 Vol.10 No.-

라텍스 개질 콘크리트(Latex Modified Concrete : 이하 LMC라 약칭함)는 방수성, 동결성 등에서 뛰어난 재료이기 때문에 과거 35년 전부터 전 세계적으로 널리 이용되고 있는 포장재료이다. 그러나 아직 국내에서는 고가의 초기공사비 부담으로 인하여 시공실적이 전무한 실정이다. 따라서, 본 연구에서는 현재 우리나라에서 초기도입단계에 있는 라텍스 개질 콘크리트 교면 포장공법을 위한 LCC 분석 절차 및 사용자비용 모델을 제안하고자 하였고, 이러한 절차 및 모델에 기초하여 실제 대상교량의 포장공사에 적용하여 LMC의 LCC 측면에서의 비용 절감효과를 정량적으로 조사하고자 한다. Latex Modified Concrete(LMC) has been widely used for the pavement of highway bridges over the past 35years around the world since it is more resistant to the intrusion of chloride ions, has higher tensile, compressive, and flexural strength, and has greater freeze-thaw resistance. However, in Korea, it has not been introduced to fields due to higher initial construction cost for its overlay than conventional pavement materials. Due to durable characteristics, it should be noted that the LMC may be more cost-effective than conventional pavements such as asphalt pavement considering life-cycle cost(LCC) concept. The objective of this study is intended to suggest a practical LCC analysis model for pavement projects and to demonstrate relative cost-effectiveness of the LMC overlays in comparison with conventional pavement techniques. It may be stated that the procedure proposed in this study may be utilized for making optimal decision on cost-effective pavement design.

多收性도토리의 遺傳資源과 優良種의 選拔에 관한 硏究

趙顯瑞,李喆浩,安相烈 진주산업대학교 1998 論文集 Vol.37 No.-

상수리나무, 굴참나무, 졸참나무, 갈참나무, 신갈나무 및 떡갈나무를 중심으로 우수한 형질을 나타내는 48개체 중 선발된 수종의 형질 특성을 농촌진흥청 원예시험장 과수조사 기준에 따라 果樹化를 위한 주요 형질인 葉長, 葉幅, 新梢長, 節間數, 新梢莖, 果重, 과종경, 과횡경 및 熱期를 각 지역별로 조사한 결과를 요약한다. 가. 선발 1년차 1. 굴참나무의 개체선발 결과 평균 흉고직경이 21㎝, 수고10m, 수관폭 4m 정도이고 수령은 20-25년생으로 그 중 우량종으로 개체선발된 굴참나무는 흉고직경 23㎝, 수고 12m, 수령 25년생이었으며, 떡갈나무는 평균 흉고직경 20㎝, 수고 8-9m, 수관폭 4m, 수령 20년생으로 그 중 우량종으로 개체선발된 떡갈나무는 흉고직경 20㎝, 수고 8m, 수령 20년생으로 수간이 곧고 수관폭이 4m 정도였다. 2. 졸참나무는 평균 흉고직경 25㎝, 수고 13m, 수관폭 4m, 수령 25년생 정도로 그 중 우량종은 흉고직경 25㎝, 수고 10m, 수령 20년생으로 수간이 곧고 수관의 폭은 5m였다. 3. 농가 탐문조사에 의한 개체선발 결과 우수종의 신초장 생육은 함양선발종Ha-6, 7, 14호가 가장 크게 신장했고, 잎의 형태는 수종별로 다양한 것으로 나타났으며, 종실의 무게는 산청선발종S-2, 9호가 7.2g과 5.7g으로 가장 무거운 것으로 나타났고, 종실의 형태는 난형, 장타원형 등 수종에 따라 다양하였다. 나. 선발 2년차 1. 상수리나무의 과중이 무겁고, 졸참나무류의 과종경이 횡경에 비해 길었으며 다수종의 평균 과중은 3.1g이고 과종경은 평균 20.4㎜인 것으로 나타났다. 2. 평균 과중이 무거운 종은 산청선발종S-2, 9호등이고, 가벼운 종은 함양선발종H-7, 19호등이며, 숙기 조사 결과 함양선발종H-4, 진주금곡면수집종JS-1, 구례종G-1 등이 조생종이고 함양종H-10, 산청종S-7, 합천종Ha-1 등은 중생종, 함양종H-7, 산청종S-3, 산청생비락면종SS-0 등은 만생종이었다. To improve the genetic resources of acorn, we selected some genetically desirable ones among a population of acorn trees. The survey sites for this study were natural forests where mother trees were growing, and where their genetic characteristics were developed through natural selection. According to the standard list of elite tree collection, 6 species(48 individual Fagaceae trees) were selected, among which 21 were in their 1st year and 27 in their 2nd year. The extension of shoot length was longest in Hamyang line(H-6, H-7 and H-14). The weight of acorn was heavier than others in Sancbung line(Sa-2 and Sa-9), and the acorn type was ovate and oblong. The average weight of individual acorn was 3.1g and its average diameter was 20.4㎜. With respect to fruit maturing period, H-4 of Hamyang variety, CK-1 of Kumgok line and G-1 of Gurye line were precocious species; H-10 of Hamyang line, Sa-7 of Sancbung line and WH-1 of Hapcbun line were intermediate ripening species; H-7 of Hamyang line, Sa-3 of Sancbung line and Ss-0 of Sangbirak line were late ripening species.