Retraction: Saccharomyces cerevisiae와 Hanseniaspora uvarum 효모 혼합발효를 이용한 증류식 소주의 휘발성 향기성분 및 아미노산 함량 변화

최규택,박춘우,이수현,이예나,오지윤,최준수,최덕영,이새벽 한국식품저장유통학회 2024 한국식품저장유통학회지 Vol.31 No.1

한국식품저장유통학회지 30권 6호(2023년 12월 30일 발행), p 1029-1042에 게재된 “Changes in the volatile aromatic compounds and amino acid contents of distilled soju using co-fermentation by Saccharomyces cerevisiae and Hanseniaspora uvarum yeasts” 논문을 교신저자의 요청에 따라 철회합니다(최규택 등, 2023). 저자들은 본 논문의 유리 아미노산 실험에 오류가 있는 것을 발견하고 모든 저자의 동의를 얻어 자발적으로 논문의 게재를 철회합니다. 저자는 이로 인해 편집위원회와 독자들에게 불편을 끼쳐 드린 점에 대해 깊이 사과드립니다. In the published article “Changes in the volatile aromatic compounds and amino acid contents of distilled soju using co-fermentation by Saccharomyces cerevisiae and Hanseniaspora uvarum yeasts. Korean J Food Preserv, 30, 1029-1042” has been retracted upon request of the corresponding author (Choi et al., 2023). The authors found an error in the results of the free amino acid analysis, and voluntarily withdraw publication of this article with the consent of all authors. The authors deeply apologize for any inconvenience this may have caused to the editorial board and readers.

아로니아 첨가형태에 따른 Muscat Bailey A 와인의 품질 특성 및 항산화 활성

최규택,이새벽,전성현,이우창,최준수,박희동 한국식품저장유통학회 2020 한국식품저장유통학회지 Vol.27 No.1

To improve the functionality and palatability of Muscat Bailey A (MBA) wine, MBA was fermented with three types of preprocessed aronia: Aronia fruit (AF), extract (AE), and powder (AP); aronia was chosen for its strong acerbity. The fermentation characteristics of the wines did not differ greatly, except that the pH of the AP wine was slightly higher than that of the other wines. The hue and intensity values of all the MBA wines with aronia were higher than those of the control, except for the hue value of the AE wine. In the Hunter’s color value result, the L* value of the AE wine and the a* value of the control were the highest among all the wines; the b* values of all the MBA wines with aronia were higher than that of the control. The total phenolic compounds, total anthocyanin compound, total flavonoid content, DPPH free radical scavenging activity, ABTS radical scavenging activity, and FRAP of the AF and AP wines were considerably higher than those of the control, whereas those of the AE wine were slightly lower than those of the control. In a sensory evaluation, the AE wine obtained the highest color, sweetness, bitterness, sourness, body, and overall preference scores among all the wines, the whereas AF and AP wines obtained lower scores than the control for most criteria except color and body. This study suggests that different types of aronia can be used to improve the quality of Korean MBA wine.

간 체외절제술(Ex Situ Resection of the Liver)을 위한 마취관리

최규택,박종연,전인구,황규삼 대한마취통증의학회 2004 Korean Journal of Anesthesiology Vol.46 No.1

Ex situ resection of the liver is an alternative surgical procedure for patients with conventionally unresectable hepatic tumors, and with contraindications to liver transplantation. We experienced a case of ex situ resection of the liver in a 40-year-old female patient suffering from sclerosing hepatocellular carcinoma. Preoperative liver function was normal. The duration of the anhepatic period was 2 hours and 55 minutes. No severe hemodynamic or pulmonary complications, and no significant metabolic or coagulatory disorders occurred. To obtain good results by ex situ resection of the liver, anesthesiologist should understand the physiology of the anhepatic period and guard against possible problems during the operation. (Korean J Anesthesiol 2004; 46: 127~130)

Saccharomyces cerevisiae와 Hanseniaspora uvarum 효모 혼합발효를 이용한 증류식 소주의 휘발성 향기성분 및 아미노산 함량 변화

최규택,박춘우,이수현,이예나,오지윤,최준수,최덕영,이새벽 한국식품저장유통학회 2023 한국식품저장유통학회지 Vol.30 No.6

This study aimed to apply the technology of increasing the volatile aromatic compounds in wine through mixed fermentation of Saccharomyces cerevisiae and non-Saccharomyces yeasts to make distilled soju. The expectation was to induce changes in metabolites such as volatile aromatic compounds before the distillation process, followed by concentrating these compounds through distillation to enhance the odor property of distilled soju. Additionally, the study aimed to examine the impact of mixed fermentation with S. cerevisiae and non-Saccharomyces yeasts on distilled soju’s free amino acid content. As a result, when Hanseniaspora uvarum yeast was used, there was an increase in the content of low molecular weight volatile aroma compounds, particularly esters. Distilled soju co-fermented with S. cerevisiae and H. uvarum SJ69 exhibited similar amino acid content to distilled soju single-fermented with S. cerevisiae. However, distilled soju co-fermented with S. cerevisiae and H. uvarum S6, a decrease in amino acid content. Sensory evaluation results indicated a higher odor score in distilled soju co-fermented with S. cerevisiae and H. uvarum S6, suggesting that the mixed fermentation technology utilizing H. uvarum could contribute to improving the quality of distilled soju in the future.

신장이식수술에서 수액 요법의 지침으로써 경식도도플러의 유용성

최규택,조인숙,이지용,손수창 대한마취통증의학회 2005 Korean Journal of Anesthesiology Vol.49 No.1

Background: Maximizing renal blood flow during reperfusion of the transplanted kidney could be the key factor to prevent acute tubular necrosis (ATN). To achieve such a goal, augmentation of circulating blood volume is necessary. We evaluated stroke volume monitored or CVP guided volume expansion method and, which method would be better for the outcome. Methods: Forty three patients (Group I) of 79 patients received maximum hydration guided by CVP maintaining 12-15 mmHg, other 36 patients (Group II) received fluid to achieve maximum SV using esophageal doppler monitor. All patients received albumin (maximal dose < 1 g/kg), mannitol (20%, 200 ml), and furosemide (40 mg) before renal artery reperfusion. Postoperative tests for evaluation of renal function, incidence of ATN and morbidity and hospital stay in patient were investigated. Results: Amount of fluid infused were 3,891 ± 1,145 ml in Group I and 2,981 ± 936.4 ml in Group II. Incidence of ATN (Group I; 9.3% and Group II; 8.3%), tests for renal function were not statistically significant in both Group, but two patients in Group I was administered in intensive care unit (ICU). Conclusions: Lesser fluid was administered in the Group used with SV augmentation than conventional CVP guided group and there was no difference in the incidence of ATN between two group. In kidney transplantation, esophageal doppler monitoring may be better in fluid management than CVP monitoring. (Korean J Anesthesiol 2005; 49: 59~66)

長期間 Ethanol 投與가 家兎의 心搏數, 體溫 및 血中乳酸濃度에 미치는 效果

崔圭澤,金亨鎭,黃樹寬,朱永恩 慶北大學校 醫科大學 1975 慶北醫大誌 Vol.22 No.2

長期間의 ethanol 投與가 家兎의 心搏數, 體溫 및 血中乳酸濃度에 미치는 效果를 알아보기 위해 試圖한 本 硏究의 結果를 要約하면 다음과 같다. Ethanol 이 心搏數를 增加시키는 效果는 長期間의 ethanol 投與時에도 變함 없이 나타났으나, ethanol 投與前의 心搏數는 長期間의 ethanol 投與가 繼續됨에 따라 繼續하여 減少하는 傾向을 보였다. Ethanol 의 體溫下降 效果는 長期間의 ethanol 投與에 따라 약간 弱化되는 傾向을 보였으나 有意한 變化없이 나타났다. Ethanol 의 單回投與後 血中乳酸濃度는 增加하였으며, ethanol 의 長期間投與를 繼續함에 따라 ethanol 投與前의 血中乳酸濃度도 繼續하여 增加하였다. In order to elucidate the chronic effect of ethanol on the heart rate, body temperature and blood lactate concentration, the author administered ethanol orally to 25 albino rabbits for 8 weeks and measured the heart rate by recording lead I electocardiogram, the oral temperature with a mercury thermometer and blood lactate concentration by Barker-Summerson method before and 30, 60 and 120 min after ethanol ingestion every other week. The results are summarized as follows. Heart rate showed a gradual decrease through the 8 weeks period of chronic ethanol ingestion, from 258.83±8.80 to 203.50±8.32/min, though it was always increased after each dose of ethanol ingestion. Oral temperature was always decreased after ethanol ingestion and showed no significant change due to chronic ethanol ingestion except that the degree of hypothermia was gradually lessened. Blood lactate showed an increase after every dose of ethanol and a gradual increase, from 21.66±3.51 to 66.20±7.55 mh/dl, through the 8 week period of ethanol ingestion. It was therefore concluded that the cardioacceleration effect of ethanol is not affected but the hypothermic effect of ethanol tends to be weakened by chronic ethanol ingestion and the blood lactate is increased by both a single dose and a chronic ingestion of ethanol.

體育特技者의 肺機能과 運動後 恢復期의 血液가스의 變化

崔圭澤,朴載植,黃樹寬,朱永恩 慶北大學校 1985 論文集 Vol.39 No.-

The pulmonary function and changes of blood gas tensions and pH in the athletes have been reported but are fragmentary as to require more complete studies including all the pulmonary parameters and blood gas tensions especially at the early part of 20 years of age. This study was aimed to elucidate the pulmonary function at the rest and the changes of venous blood gas tension and pH after the exercise in the athletes of physical education students. The subjects chosen for this study were 15 athletes of physical education students (special group) of 21-25 years of age. The athletes had at least four years of exercise careers, and were compared with 12 non-athletes of physical education students (general group) who had not been subjected to any form of rigorous training program. All the subject were directed to perform running on the treadmill for three minutes under the condition of 15% grade and 5 MPH. The venous blood samples were taken at the rest as well as at 0, 5, 10 and 20 minutes after the exercise to check the changes of Pco_2, Po_2 and pH during the recovery period. The venous blood Pco_2, Po_2 and pH were determined using the Model 175 Automatic Blood Gas Analyzer by Corning Co., and the pulmonary function using the computerized spirometer. The results obtained were compared with the general group and summarized as follows: The special group exhibited higher values of the pulmonary function except FVC compared with the general group, and particularly FEV_0·5% and FEV_1% were significantly different. The venous Po_2 was decreased immediately after the exercise, but increased during the recovery period. The special group generally showed higher oxygen partial pressure than the general group. The venous Pco_2 in contrast to the oxygen increased immediately after the exercise, but decreased during the recovery period. The special group showed lower carbon dioxide partial pressure. Blood pH was significantly decreased from the resting value after the exercise and returned to the resting value at 20 minutes. In the special group, however, the change of pH was less than in the general group.

Raynaud증후군을 위한 Reserpine, Procaine의 동맥주사와 성상교감신경절 차단

최규택,전재규 啓明大學校 醫科大學 1983 계명의대학술지 Vol.2 No.2

Efforts from many different approaches have been made to cure Raynaud's phenomenon, such as dorsal sympathectomy, toopical injection of nitroglycerin, phentolamin and procaine, and oral or parentr al administratioin of various drugs. However, there has been no successful management proven yet. In recent years, it was reported that intra-arterial administration in normal subjects as well as patients with Raynadu's syndrome has demonstrated a significant rise in blood flow to the hands. We used intermittent stellate ganglion blocks in conjunction with intra-arterial injections of reserpine and procaine in one patient suffering from bilateral finger necrosis. The stellate ganglion block was performed in a paratracheal approach by injection of 0.75% bupivacaine without epinephrine mixed and followed by the administration of reserpine I mg and procaine 50 mg through a butterfly needle inserted in the radial artery. The administration of reserpine and procaine was done only one time. The stellate ganglion block was carried out once in a 5 days for abut I month, then once in a 2 weeks as needed for 2 months. As the procedure was carried out and the necrotic tissue sloughed off, oozing appeared and new granulation tissue was observed. Now the patient was healed completely and he is waiting for revision of the stump. We concluded that the intra-arterial administratioin of resrepine and procaine helped initiate and accelerate increasing blood flow to the hand and the stellate ganglion block continued to help revascularization by dilating the peripheral beds.

상복부 수술을 위한 흉추 경막외 마취와 술후 통증관리

최규택(Kyu Taek Choi),전재규(Jae Kyu Jeon) 대한통증학회 1989 The Korean Journal of Pain Vol.2 No.1

N/A It has been standard practice in many institutions to use a combination of a light general anesthesia and an epidural block for lower abdominal and pelvic surgery. This combination of a balanced anesthesia can provide various benefits to the patient such as less bleeding in the surgical field, the use of a lower concentration of general anesthetics, less muscle relaxant, and post operative pain management. However there are several problems associated with hemodynamics such as bradycardia and hypotension etc. In order to block the pain of the high surgical area with a lumbar epidural puncture postoperatively, a large volume of local anesthetic is required and consequently an extensive blockade of sympathetic, sensory and motor functions can occur causing motor weakness, numbness and postural hypotension. Therefore, the patient is unable to have early ambulation postoperatively. In this study, thoracic epidural catheterization was undertaken to locate the tip of the catheter exactly at the surgical level for upper abdominal surgery, and was followed by general anesthesia. Twenty-one patients scheduled for upper abdominal surgery were selected. Fifteen of them had he-patobiliary operations and the remaining 6 had gastrectomies. Thoracic epidural punctures were performed mostly at T9 - T10 (57.1%) and TS- T9. Neuromuscular blocking agents were not used in half of the cases and the, mean doses of relaxant were 3.5±1.0mg in gastrectomies, and 2.7±0.9mg in cases of hepatobiliary operation. Epidural morphine was injected 1 hour before the end of the operation for postoperative pain control. Eight patients did not require additional analgesics and the mean dose of epidural morphine was 2.2±0.9mg, and 13 cases were given 0.125% epidural bupivacaine when patients complained of pain. Their initial doses of epidural morphine were 1.9+0.4mg and the mean duration of bupivacaine was 6 hours 20 minutes+40 minutes. In conclusion, thoracic epidural analgesia is valuable to reduce postoperative pain in patients with upper abdominal surgery, However, it is not easy to maintain this balanced anesthesia with high epidural analgesia and light general anesthesia for upper abdominal surgery because of marked hemodynamic changes. Therefore, further practice will be required.

좌전폐적출술중 발생한 심한 무기폐

최규택,전재규,김명한 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.2

Pulmonary atelectasis is a common complication following surgery under general anesthesia. It is well documented for the anesthetic procedure to incur diffuse microatelectasis. However profound pulmonary collapse are rare. Total or segmental lung collapses are usually resulted from the obstruction of bronchial pathway by secretions such as mucus, blood and pus etc. We had a case of profound atelectasis developed during the left pneumonectomy of bronchiectasis. Secretions with copious pus was noticed which the lungs were surgically manipulated and vigorous suction through the endotracheal tube was carried out. However a spillage of pus into the dependent lung could not be prevented. We assumed that the cause of the atelectasis was an obstruction of the left bronhus by pus drained from the surgical lesions. With a conventional single-lumen endotracheal tube it is very difficult to separate two lungs and prevent a spillage of pus into a healthy dependent lung. Therefore we recommend the use a double-lumen tube to prevent such a complication and also facilitate better surgical field.