A New Multi-objective Evolutionary Algorithm for Inter-Cloud Service Composition

( Li Liu ),( Shuxian Gu ),( Dongmei Fu ),( Miao Zhang ),( Rajkumar Buyya ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.1

Service composition in the Inter-Cloud raises new challenges that are caused by the different Quality of Service (QoS) requirements of the users, which are served by different geo-distributed Cloud providers. This paper aims to explore how to select and compose such services while considering how to reach high efficiency on cost and response time, low network latency, and high reliability across multiple Cloud providers. A new hybrid multi-objective evolutionary algorithm to perform the above task called LS-NSGA-II-DE is proposed, in which the differential evolution (DE) algorithm uses the adaptive mutation operator and crossover operator to replace the those of the Non-dominated Sorting Genetic Algorithm-II (NSGA-II) to get the better convergence and diversity. At the same time, a Local Search (LS) method is performed for the Non-dominated solution set F{1} in each generation to improve the distribution of the F{1}. The simulation results show that our proposed algorithm performs well in terms of the solution distribution and convergence, and in addition, the optimality ability and scalability are better compared with those of the other algorithms.

Tea consumption is associated with a reduced risk of coronary heart disease in female but not male populations in Guangzhou, China

Chen, Ying,Ye, Yanfang,Zhang, Zhen,Zhang, Chi,Chen, Minyu,Pang, Jun,Zhou, Shuxian,Xiang, Qiuling The Korean Nutrition Society 2019 Nutrition Research and Practice Vol.13 No.5

BACKGROUND/OBJECTIVES: The association between tea consumption and risk of coronary heart disease (CHD) remains controversial. This study aimed to determine whether tea consumption has an effect on CHD risk in Chinese adults. SUBJECTS/METHODS: In this hospital-based case-control study, 267 cases of CHD and 235 non-CHD controls were enrolled. Blood samples from all cases were examined. Cardiac function indices (left ventricular ejection fraction, left ventricular end-diastolic dimension, lactate dehydrogenase, and creatine kinase of the muscle or brain type), blood lipid index (high-density lipoprotein cholesterol), and blood coagulation function indices (fibrinogen and activated partial thromboplastin time) were recorded. Tea consumption of study participants was assessed by a specifically designed questionnaire. The baseline characteristics of the study populations were recorded, and CHD-related biomarkers were detected. Differences in baseline characteristics of the study participants were examined using t-tests for continuous variables and chi-squared tests for categorical variables. Unconditional logistic regression was used to measure the association between tea and CHD. RESULTS: There were significant differences in cardiac function indices, blood lipid index, and blood coagulation indices between CHD cases and controls (P < 0.05). We found tea consumption reduced CHD risk in female participants (adjusted odds ratio (OR) = 0.484, 95% CI: 0.242-0.968, P = 0.0403). Regarding the type of tea consumed, the risk of CHD was reduced in women who drank partially fermented tea (adjusted OR = 0.210, 95% CI: 0.084-0.522, P = 0.0008). Analytic results for the amount of tea consumed per unit time showed CHD risk was reduced in women who consumed 1-2 cups of tea per day (adjusted OR = 0.291, 95% CI: 0.131-0.643, P = 0.0023). A tea-drinking frequency of > 6 days/week was beneficial for CHD prevention (adjusted OR = 0.183, 95% CI: 0.049-0.679, P = 0.0112). When analyzed according to the duration of tea consumption, the risk of CHD was reduced in participants who had been drinking tea for 10-20 years (adjusted OR = 0.360, 95% CI: 0.137-0.946, P = 0.0382). CONCLUSIONS: Tea consumption is associated with a reduced risk of CHD in female but not male populations in Guangzhou.

Tea consumption is associated with a reduced risk of coronary heart disease in female but not male populations in Guangzhou, China

Ying Chen,Yanfang Ye,Zhen Zhang,Chi Zhang,Minyu Chen,Jun Pang,Shuxian Zhou,Qiuling Xiang 한국영양학회 2019 Nutrition Research and Practice Vol.13 No.5

BACKGROUND/OBJECTIVES: The association between tea consumption and risk of coronary heart disease (CHD) remains controversial. This study aimed to determine whether tea consumption has an effect on CHD risk in Chinese adults. SUBJECTS/METHODS: In this hospital-based case-control study, 267 cases of CHD and 235 non-CHD controls were enrolled. Blood samples from all cases were examined. Cardiac function indices (left ventricular ejection fraction, left ventricular end-diastolic dimension, lactate dehydrogenase, and creatine kinase of the muscle or brain type), blood lipid index (high-density lipoprotein cholesterol), and blood coagulation function indices (fibrinogen and activated partial thromboplastin time) were recorded. Tea consumption of study participants was assessed by a specifically designed questionnaire. The baseline characteristics of the study populations were recorded, and CHD-related biomarkers were detected. Differences in baseline characteristics of the study participants were examined using t-tests for continuous variables and chi-squared tests for categorical variables. Unconditional logistic regression was used to measure the association between tea and CHD. RESULTS: There were significant differences in cardiac function indices, blood lipid index, and blood coagulation indices between CHD cases and controls (P < 0.05). We found tea consumption reduced CHD risk in female participants (adjusted odds ratio (OR) = 0.484, 95% CI: 0.242-0.968, P = 0.0403). Regarding the type of tea consumed, the risk of CHD was reduced in women who drank partially fermented tea (adjusted OR = 0.210, 95% CI: 0.084-0.522, P = 0.0008). Analytic results for the amount of tea consumed per unit time showed CHD risk was reduced in women who consumed 1-2 cups of tea per day (adjusted OR = 0.291, 95% CI: 0.131-0.643, P = 0.0023). A tea-drinking frequency of > 6 days/week was beneficial for CHD prevention (adjusted OR = 0.183, 95% CI: 0.049-0.679, P = 0.0112). When analyzed according to the duration of tea consumption, the risk of CHD was reduced in participants who had been drinking tea for 10-20 years (adjusted OR = 0.360, 95% CI: 0.137-0.946, P = 0.0382). CONCLUSIONS: Tea consumption is associated with a reduced risk of CHD in female but not male populations in Guangzhou.

Fabrication and Characterization of Multiple Herbal Extracts-loaded Nanofibrous Patches for Topical Treatment of Acne Vulgaris

Ying Tang,Lei Liu,Jinju Han,Zhaolun Zhang,Shuyan Yang,Shuxian Li,Shuxian Li,Zhanhua Fan,Hua Zhao 한국섬유공학회 2021 Fibers and polymers Vol.22 No.2

Herbal extracts have recently received considerable interest in acne therapy owing to their enhanced skincompatibility compared with antibiotics and synthetic agents. In this study, electrospun poly (vinyl alcohol)/chitosan (PVA/CS) fibrous patch incorporating a combination of herbal extracts with complementary mechanisms of action was developedas an alternative acne therapy for patients with resistance to the conventional treatments. The herbal extracts-loadedelectrospun fibers displayed uniform and smooth-surfaced nanofibers (dia. 100-300 nm), high drug loading efficiency (89.5-97.7 %) and good water absorbing properties. Results of the in vitro release and antibacterial studies suggest the patches arecapable of sustained release of polyphenol-rich extracts, which may, together with the chitosan present in the fiber, endow thepatch with potent bacterial inhibition of Propionibacterium acnes. The herbal extracts-loaded patches exhibited pronouncedclinical therapeutic efficacy in treating mild-to-moderate facial acne by rapidly reducing inflamed lesions and restoringepidermal barrier. Also, the herbal patches demonstrated improved biocompatibility or tolerability in comparison with thesynthetic drug benzoyl peroxide. Overall, the present study has provided a facile approach to develop biocompatiblepolymers based electrospun fibrous patch for the efficient delivery of herbal extracts for topical skin therapy, opening newperspectives for a new generation of cosmetotextiles.

Effect of Freeze-Thaw Cycles on Dynamic Characteristics of Undisturbed Silty Clay

Gao Hang Cui,Zhuo Cheng,Daili Zhang,Shuxian Ma,Zhiqiang Liu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.9

We conducted dynamic triaxial tests of undisturbed soil samples under different control parameters using the Global Digital Systems (GDS) dynamic triaxial instrument. We investigated the dynamic and engineering characteristics of undisturbed soil under a freeze–thaw cycle. When the dynamic load amplitude and the number of freeze–thaw cycles were adjusted, we explored the cumulative plastic strain, dynamic elastic modulus, and dynamic strength of undisturbed soil, and we then proposed appropriate fitting formulae to compute the cumulative plastic strain, dynamic elastic modulus, and dynamic strength. The findings revealed that as the number of freeze–thaw cycles increased, the cumulative plastic strain grew, the dynamic strength progressively fell, and the dynamic elastic modulus dropped first, but then increased. The critical physical and dynamic features of soil changed dramatically during one to six freeze–thaw cycles. This study’s suggested formula for the average growth ratio can directly reflect the cumulative plastic strain fluctuation of soil throughout freeze–thaw cycles. The formula has a good fitting effect on undisturbed soil, according to the test findings, and the accumulative plastic strain, dynamic elastic modulus, and dynamic strength may be computed within a specified range. The findings of this study contribute to a better understanding of the effect of the freeze–thaw cycle on the dynamic characteristics of undisturbed silty clay, as well as a theoretical foundation for the design and construction of silty clay highway subgrade in seasonally frozen regions as well as the dynamic analysis of vehicle simulation in seasonally frozen regions.

Inhalation of panaxadiol alleviates lung infl ammation via inhibiting TNFA/ TNFAR and IL7/IL7R signaling between macrophages and epithelial cells

Yifan Wang,Hao Wei,Zhen Song,Liqun Jiang,Mi Zhang,Xiao Lu,Wei Li,Yuqing Zhao,Lei Wu,Shuxian Li,Huijuan Shen,Qiang Shu,Yicheng Xie 고려인삼학회 2024 Journal of Ginseng Research Vol.48 No.1

Background: Lung inflammation occurs in many lung diseases, but has limited effective therapeutics. Ginseng andits derivatives have anti-inflammatory effects, but their unstable physicochemical and metabolic propertieshinder their application in the treatment. Panaxadiol (PD) is a stable saponin among ginsenosides. Inhalationadministration may solve these issues, and the specific mechanism of action needs to be studied. Methods: A mouse model of lung inflammation induced by lipopolysaccharide (LPS), an in vitro macrophageinflammation model, and a coculture model of epithelial cells and macrophages were used to study the effectsand mechanisms of inhalation delivery of PD. Pathology and molecular assessments were used to evaluate efficacy. Transcriptome sequencing was used to screen the mechanism and target. Finally, the efficacy andmechanism were verified in a human BALF cell model. Results: Inhaled PD reduced LPS-induced lung inflammation in mice in a dose-dependent manner, includinginflammatory cell infiltration, lung tissue pathology, and inflammatory factor expression. Meanwhile, the dose ofinhalation was much lower than that of intragastric administration under the same therapeutic effect, which maybe related to its higher bioavailability and superior pharmacokinetic parameters. Using transcriptome analysisand verification by a coculture model of macrophage and epithelial cells, we found that PD may act by inhibitingTNFA/TNFAR and IL7/IL7R signaling to reduce macrophage inflammatory factor-induced epithelial apoptosisand promote proliferation. Conclusion: PD inhalation alleviates lung inflammation and pathology by inhibiting TNFA/TNFAR and IL7/IL7Rsignaling between macrophages and epithelial cells. PD may be a novel drug for the clinical treatment of lunginflammation.

Expression of Translationally Controlled Tumor Protein (TCTP) Gene of Dirofilaria immitis Guided by Transcriptomic Screening

Yan Fu,Jingchao Lan,Xuhang Wu,Deying Yang,Zhihe Zhang,Huaming Nie,Rong Hou,Runhui Zhang,Wanpeng Zheng,Yue Xie,Ning Yan,Zhi Yang,Chengdong Wang,Li Luo,Li Liu,Xiaobin Gu,Shuxian Wang,Xuerong Peng,Guangy 대한기생충학열대의학회 2014 The Korean Journal of Parasitology Vol.52 No.1

— Invited Review — Understanding the functionality of the rumen microbiota: searching for better opportunities for rumen microbial manipulation

Qi Wenlingli,Xue Ming-Yuan,Jia Ming-Hui,Zhang Shuxian,Yan Qiongxian,Sun Hui-Zeng 아세아·태평양축산학회 2024 Animal Bioscience Vol.37 No.2

Rumen microbiota play a central role in the digestive process of ruminants. Their remarkable ability to break down complex plant fibers and proteins, converting them into essential organic compounds that provide animals with energy and nutrition. Research on rumen microbiota not only contributes to improving animal production performance and enhancing feed utilization efficiency but also holds the potential to reduce methane emissions and environmental impact. Nevertheless, studies on rumen microbiota face numerous challenges, including complexity, difficulties in cultivation, and obstacles in functional analysis. This review provides an overview of microbial species involved in the degradation of macromolecules, the fermentation processes, and methane production in the rumen, all based on cultivation methods. Additionally, the review introduces the applications, advantages, and limitations of emerging omics technologies such as metagenomics, metatranscriptomics, metaproteomics, and metabolomics, in investigating the functionality of rumen microbiota. Finally, the article offers a forward-looking perspective on the new horizons and technologies in the field of rumen microbiota functional research. These emerging technologies, with continuous refinement and mutual complementation, have deepened our understanding of rumen microbiota functionality, thereby enabling effective manipulation of the rumen microbial community.

In Situ Growth of MOF-Derived NaCoPO4@Carbon for Asymmetric Supercapacitive and Water Oxidation Electrocatalytic Performance

Peng Guo,Zhaojie Wang,Hongyu Chen,Shaohui Ge,Chen Chen,Haowei Wang,Jinbao Zhang,Minglei Hua,Shuxian Wei,Xiaoqing Lu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.15 No.01

The increasing energy crisis promotes the study on novel electrode materials with high performance for supercapacitive storage and energy conversion. Transition metal phosphates have been reported as a potential candidate due to the unique coordination and corresponding electronic structure. Herein, we adopted a facile method for preparing NaCoPO4@C derived from a metal organic framework (MOF) as a bifunctional electrode. ZIF-67 was synthesized before a refluxing process with Na2HPO4 to form a precursor, which is transformed into the final product via calcination in different atmospheres. Specifically, the resultant NaCoPO4@C exhibits a high specific capacitance of 1178.7 F g -1 at a current density of 1 A g -1 for a supercapacitor. An asymmetric supercapacitor (ASC) assembled with active carbon displays a high capacitance of 163.7 F g -1 at 1 A g -1. In addition, as an oxygen evolution reaction (OER) catalyst, the NaCoPO4@C electrode requires only 299 mV to drive a current density of 10 mA cm -2. These results suggest that the rational design of MOF-derived NaCoPO4@C provides a variety of practical applications in electrochemical energy conversion and storage.

Seroprevalence of Dirofilaria immitis in Cats from Liaoning Province, Northeastern China

Honglie Hou,Lili Cao,Wenzhi Ren,Dansheng Wang,He Ding,Juan You,Xinhua Yao,Hang Dong,Yanbing Guo,Shuxian Yuan,Xi-Chen Zhang,Pengtao Gong 대한기생충학ㆍ열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.6

The present study was performed to investigate the seroprevalence and risk factors for Dirofilaria immitis infection in cats from Liaoning province, northeastern China. From October 2014 to September 2016, sera of 651 cats, including 364 domestic cats and 287 feral cats (332 females and 319 males) were assessed. They were tested for the presence of D. immitis antigen using SNAP Heartworm RT test kit. In this population, the average prevalence was 4.5%. Age and rearing conditions (feral or domestic) were found to be associated with the prevalence of D. immitis. The prevalence was significantly higher in feral cats compared with domestic cats (8.4% vs 1.4%, P<0.01). There was no significant difference between males and females (4.7% vs 4.2%, P>0.05), but older cats (≥3 years old) showed a statistically higher prevalence compared with younger cats (<3 years old) in feral populations (16.8 vs 2.4%, P<0.01), while the difference between the age groups was not statistically significant in domestic cats (2.4% vs 0.51%, P>0.05), all these results suggest that outdoor exposure time may be one of the most important factors for D. immitis prevalence in cats. Results reveal that D. immitis are prevalence in domestic and feral cats in northeastern China, which indicates that appropriate preventive measures should be taken to decrease the incidence of feline heartworm disease in Liaoning province, northeastern China.