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FBW7 Upregulation Enhances Cisplatin Cytotoxicity in Non-small Cell Lung Cancer Cells
Yu, Hao-Gang,Wei, Wei,Xia, Li-Hong,Han, Wei-Li,Zhao, Peng,Wu, Sheng-Jun,Li, Wei-Dong,Chen, Wei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Introduction: Lung cancer is extremely harmful to human health and has one of the highest worldwide incidences of all malignant tumors. Approximately 80% of lung cancers are classified as non-small cell lung cancers (NSCLCs). Cisplatin-based multidrug chemotherapy regimen is standard for such lesions, but drug resistance is an increasing problem. F-box/WD repeat-containing protein 7 (FBW7) is a member of the F-box protein family that regulates cell cycle progression, and cell growth and differentiation. FBW7 also functions as a tumor suppressor. Methods: We used cell viability assays, Western blotting, and immunofluorescence combined with siRNA interference or plasmid transfection to investigate the underlying mechanism of cisplatin resistance in NSCLC cells. Results: We found that FBW7 upregulation significantly increased cisplatin chemosensitivity and that cells expressing low levels of FBW7, such as NCI-H1299 cells, have a mesenchymal phenotype. Furthermore, siRNA-mediated silencing or plasmid-mediated upregulation of FBW7 resulted in altered epithelial-mesenchymal transition (EMT) patterns in NSCLC cells. These data support a role for FBW7 in regulating the EMT in NSCLC cells. Conclusion: FBW7 is a potential drug target for combating drug resistance and regulating the EMT in NSCLC cells.
ON THE LAGRANGIAN TIDAL RESIDUAL CIRCULATION IN THE BOHAI SEA
Hao Wei,Liang Zhao,Shi Zuo Feng 한국해안해양공학회 1999 학술강연회 발표논문초록집 Vol.1 No.1
Tidal residual is very important to the transport in the coastal sea. In our point of view Lagrangian time averaged residual is relevent to the Eulerian one to embody the coastal circulation. Tidal system of Bohai Sea is simulated by HAMSOM and both of two kinds of tidal residual are calculated at the mean time. There are significant differences between them in some area.
Kinetics and optimization of L-tryptophan separation with ion-exchange chromatography
Wei Luo,Limei Fan,Peilian Wei,Hao Chen,Limei Fang,Jin Huang,Zhinan Xu,Peilin Cen 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.5
Adsorption and desorption of L-tryptophan (L-trp) on strong acid cation exchange resin were investigated in a fixed-bed column. L-trp was effectively adsorbed onto the resin HZ-001, with the loading capacity and breakthrough time determined. Four kinetic models, including Adams-Bohard, Wolborska, Thomas, and Yoon-Nelson models,were adopted to determine the kinetic parameters of adsorption and to predict the breakthrough curves. The results showed that the models used described the breakthrough well. Desorption of L-trp from the column bed was performed using aqueous ammonia as the eluant. Optimum procedure was obtained with 2.0M aqueous ammonia at the elution velocity of 6 BV/h. Five cycles of adsorption-elution-regeneration were conducted to evaluate the column reutilization.
Research on Encryption Key Extraction From Iris Feature
Wei Hao,Yong Wei 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.5
The current encryption algorithm has some problems that key length is long, which is difficult to be memorized and kept so that a potential threat is caused to information security. The encryption key extracted from the biological feature is used for the encryption method, which has become a hotspot of the research. The Haar wavelet decomposition is carried out to the iris image, to extract the third-layer high frequency coefficient as the iris feature code. The random mapping function is used to generate a 128 - bit key. chi-square (χ2) test is used to analyze the key safety extracted. The results show that the key extracted from iris feature can meet requirements of the randomness and security of the encryption algorithm.
Numerical Method with High Real-time Property Based on Shortest Path Algorithm for Optimal Control
Wei Liao,Xiaohui Wei,Jizhou Lai,Hao Sun 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.6
A numerical method consisting of an off-line part and an on-line part for optimal control problems is proposed in this paper. In the off-line part, the state space is discretized into a Cartesian grid structure and then define a graph over all grid points by connecting two points if the Euclidean norm between them is closer than a positive number called adjacent radius, the minimum cost between them is estimated using difference method and stored in a matrix. After that the matrix is updated by a shortest path algorithm and a matrix holding the information of the shortest paths between any two grid points is generated. In the on-line part, the optimal control vector at each time step can be generated by reading data from the matrix according to the current state and target state and doing some simple calculations. Since there is no need to do a lot of calculation in the on-line part, this method can satisfy the real-time requirements in some engineering control problems. We prove that the solution of the proposed method converge to the analytical solution when the adjacent radius and the grid size tend to zero and the grid size tend is a higher order infinitesimal of the adjacent radius. At the end of this paper, some numerical examples are taken to illustrate the effectiveness of the proposed method.
PREPARATION AND CHARACTERIZATION OF ELECTRIC ZAO NANOPARTICLES
HAO-WEI SHI,HONG-ZHEN XIE,JIN-KU LIU,YAN WANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2010 NANO Vol.5 No.4
The white good dispersion zinc aluminium oxide (ZAO) nanoparticles were efficiently prepared by solid phase synthesis method. The morphologies, structures, photoelectricity of the ZAO nanoparticles and the thermochemistry behavior of the precursor were analyzed by TEM, XRD, UV-vis and TG, etc. The phytotoxicity properties of the ZAO nanoparticles were researched for the first time. The results show that the ZAO nanoparticles have a strong inhibition of seed germination and root growth. The biological toxicity of ZAO nanoparticle reduces along with the enlargement of nanoparticle size.
Effect of Relative Humidity on Physiology and Antioxidant Metabolism of Grafted Watermelon Seedlings
Hao Wei(위호),Abinaya Manivannan,Sowbiya Muneer,SooHoon Kim(김수훈),Liu Ya(유아),Ji Eun Park(박지은),Byoung Ryong Jeong(정병룡) (사)한국생물환경조절학회 2016 생물환경조절학회지 Vol.25 No.4
본 연구는 수박 접목묘의 활착에 미치는 상대습도의 영향을 알아보고자 수행하였다. 2품종(‘스피드’, ‘삼복꿀’)의 수박(Citrullus vulgaris Schrad.)을 ‘RS-동장군’ 박 대목(Lagenaria siceraria Stanld.)에 접목하고, 접목묘는 주간 25℃/야간 18oC, 광주기는 1일 16시간 기준으로 몰리어다이어그램을 따라 3수준의 상대습도, 95-96%[1.1-0.8(주간) 또는 0.8-0.6(야간) g·m<SUP>-3</SUP>수분부족분(VPD)], 97-98%[0.7-0.4(주간) 또는 0.5-0.3(야간) g·m<SUP>-3</SUP> VPD], 또는 99-100%[0.3-0.0(주간) 또는 0.2-0.0(야간) g·m<SUP>-3</SUP> VPD]로 유지하였다. 상대습도 처리 중 97-98% 처리는 대목과 ‘스피드’ 접수의 생체중과 초장을 가장 크게 증가시키며 접목 2일 후에 접합부의 연결을 향상시켰다. 그러나 ‘삼복꿀’의 경우 상대습도 99-100% 처리에서 경경과 초장이 증가하였다. 또한 상대습도 95-96%와 97-98% 처리에서 재배한 2 품종 모두 과산화수소가 덜 발생하고 산화적 스트레스의 지표인 항산화 효소의 활성이 덜 나타났다. 따라서 이 연구의 결과는 수박묘의 접목활착에 가장 적절한 상대습도는 97-98%였다. This study investigated the effect of different relative humidity (RH) regimes on graft healing of grafted seedlings of watermelon (Citrullus vulgaris Schrad.). Two watermelon cultivars (‘Speed’ and ‘Sambok Honey’) were grafted onto the ‘RS-Dongjanggun’ bottle gourd rootstock (Lagenaria siceraria Stanld.) and the grafted seedlings were maintained under one of three relative humidity regimes, 95-96% [1.1-0.8 (day) or 0.8-0.6 (night) g·m<SUP>-3</SUP> vapor pressure deficit (VPD)], 97-98% [ 0.7-0.4 (day) or 0.5-0.3 (night) g·m<SUP>-3</SUP> (VPD)], or 99-100% [0.3-0.0 (day) or 0.2-0.0 (night) g·m<SUP>-3</SUP> (VPD)] according to the Mollier diagram based on the air temperature of 25℃ day/18℃ night with 16 h photoperiod per day. Among the RH treatments, 97-98% significantly increased plant height and fresh weight of the rootstock and scion of the ‘Speed’ and it also enhanced the graft union connection of both cultivars after two days of grafting. However, plant height and thickness of the scion of ‘Sambok Honey’ was increased by the 99-100% RH treatment. Furthermore, both cultivars grown in the 95-96 and 97-98% RH treatments consisted of lower levels of endogenous H₂O₂ and less activities of antioxidant enzymes which illustrated the occurrence of less oxidative stress. Hence, the results of this study identified the optimal RH level for the graft healing of watermelon seedlings.