Carbon-Ion-Implanted Nd, MgO-Codoped Near-Stoichiometric Lithium-Niobate Optical Waveguides

Ning-Ning Dong,Yang Tan,Yan-Xia Kong,Feng Chen,Hong-Ji Ma 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.6

Nd, MgO codoped near stoichiometric lithium niobate (Nd:MgO:SLN) is a promising laser gain crystal for infrared laser generations. We report on, to our knowledge for the first time, the planar waveguide formation in Nd:MgO:SLN crystal by MeV carbon ion implantation at dose of 1014 ions/cm2. The guiding properties are investigated by using the well-known m-line technique and end-face arrangement. The refractive index profiles of the waveguides show a typical “well + barrier” distribution, which could confine the light propagation in a non-leaky way. In addition, a numerical simulation of the light propagation shows that the waveguide modal distributions are in good agreement with the experimental data, which means potential applications for the formation of designable devices in Nd:MgO:SLN by using carbon ion implantation. Nd, MgO codoped near stoichiometric lithium niobate (Nd:MgO:SLN) is a promising laser gain crystal for infrared laser generations. We report on, to our knowledge for the first time, the planar waveguide formation in Nd:MgO:SLN crystal by MeV carbon ion implantation at dose of 1014 ions/cm2. The guiding properties are investigated by using the well-known m-line technique and end-face arrangement. The refractive index profiles of the waveguides show a typical “well + barrier” distribution, which could confine the light propagation in a non-leaky way. In addition, a numerical simulation of the light propagation shows that the waveguide modal distributions are in good agreement with the experimental data, which means potential applications for the formation of designable devices in Nd:MgO:SLN by using carbon ion implantation.

Expression of Translationally Controlled Tumor Protein (TCTP) Gene of Dirofilaria immitis Guided by Transcriptomic Screening

Yan Fu,Jingchao Lan,Xuhang Wu,Deying Yang,Zhihe Zhang,Huaming Nie,Rong Hou,Runhui Zhang,Wanpeng Zheng,Yue Xie,Ning Yan,Zhi Yang,Chengdong Wang,Li Luo,Li Liu,Xiaobin Gu,Shuxian Wang,Xuerong Peng,Guangy 대한기생충학열대의학회 2014 The Korean Journal of Parasitology Vol.52 No.1

Effect of a Novel Intracycle Motion Correction Algorithm on Dual-Energy Spectral Coronary CT Angiography: A Study with Pulsating Coronary Artery Phantom at High Heart Rates

Yan Xing,Yuan Zhao,Ning Guo,Cun-Xue Pan,Gulina Azati,Yan-Wei Wang,Wen-Ya Liu 대한영상의학회 2017 Korean Journal of Radiology Vol.18 No.6

Objective: Using a pulsating coronary artery phantom at high heart rate settings, we investigated the efficacy of a motion correction algorithm (MCA) to improve the image quality in dual-energy spectral coronary CT angiography (CCTA). Materials and Methods: Coronary flow phantoms were scanned at heart rates of 60−100 beats/min at 10-beats/min increments, using dual-energy spectral CT mode. Virtual monochromatic images were reconstructed from 50 to 90 keV at 10-keV increments. Two blinded observers assessed image quality using a 4-point Likert Scale (1 = non-diagnostic, 4 = excellent) and the fraction of interpretable segments using MCA versus conventional algorithm (CA). Comparison of variables was performed with the Wilcoxon rank sum test and McNemar test. Results: At heart rates of 70, 80, 90, and 100 beats/min, images with MCA were rated as higher image scores compared to those with CA on monochromatic levels of 50, 60, and 70 keV (each p < 0.05). Meanwhile, at a heart rate of 90 beats/min, image interpretability was improved by MCA at a monochromatic level of 60 keV (p < 0.05) and 70 keV (p < 0.05). At a heart rate of 100 beats/min, image interpretability was improved by MCA at monochromatic levels of 50 keV (from 69.4% to 86.1%, p < 0.05), 60 keV (from 55.6% to 83.3%, p < 0.05) and 70 keV (from 33.3% to 69.3%, p < 0.05). Conclusion: Low-keV monochromatic images combined with MCA improves image quality and image interpretability in CCTAs at high heart rates.

Cloning, Expression, and Characterization of Thermostable Manganese Superoxide Dismutase from Thermoascus aurantiacus var. levisporus

Ning-Ning Song,Yan Zheng,Shi-Jin E,Duo-Chuan Li 한국미생물학회 2009 The journal of microbiology Vol.47 No.1

A superoxide dismutase (SOD) gene of Thermoascus aurantiacus var. levisporus, a thermophilic fungus, was cloned, sequenced, and expressed in Pichia pastoris and its gene product was characterized. The coding sequence predicted a 231 residues protein with a unique 35 amino acids extension at the N-terminus indicating a mitochondrial-targeting sequence. The content of Mn was 2.46 µg/mg of protein and Fe was not detected in the purified enzyme. The enzyme was found to be inhibited by NaN3, but not by KCN or H2O2. These results suggested that the SOD in Thermoascus aurantiacus var. levisporus was the manganese superoxide dismutase type. In comparison with other MnSODs, all manganese-binding sites were also conserved in the sequence (H88, H136, D222, H226). The molecular mass of a single band of the enzyme was estimated to be 21.7 kDa. The protein was expressed in tetramer form with molecular weight of 68.0 kDa. The activity of purified protein was 2,324 U/mg. The optimum temperature of the enzyme was 55°C and it exhibited maximal activity at pH 7.5. The enzyme was thermostable at 50 and 60°C and the half-life at 80°C was approximately 40 min.

도시주거단지에서 노인특성을 고려한 주택의 유니버설 디자인에 관한 연구

안상녕(Yan, Xiang-ning),남경숙(Nam, Kyoung-sook) 한국실내디자인학회 2019 한국실내디자인학회 학술대회논문집 Vol.21 No.1

Since the very beginning of the 21st century, more and more people are focusing on the issue of providing for the aged. Right now, home-based care is the mainstream for the aged in Korea, according to the current situation, provide a suitable living housing dwelling for old solitary people is one important job of care for the aged. In this paper, the people above 65 or elder who live alone in Seoul is the main object of investigation, and the affordable residential district in Seoul is the investigation scope. On the basis of the sustainable design principles, this paper summarized the living housing dwelling, which meet the needs of the solitary people in Seoul, and reveal the basic laws of such residential from the environmental psychology, behavioral science, architecture and other multidisciplinary perspective.

Adaptive Approaches to Identify the Interface in Low Frequency Vibration-Assisted Drilling of CFRP/Ti6Al4V Stacks

Chaoren Yan,Yan Chen,Ning Qian,Nan Guo,Yongqing Wang,Haojun Yang,Biao Zhao 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.23 No.8

Low frequency vibration-assisted drilling (LFVAD) of CFRP/Ti stacks is a promising method of one-shot drilling to increase efficiency and extend tool life while adaptive approaches are applied to adjust the cutting parameters in each layer. Thus, the interfacial recognition method is significant to automatically change the cutting parameters. In this paper, two recognition methods are proposed based on the analysis of the features of cutting forces under the LFVAD process in both time and frequency domains. With the recorded thrust force signals at different wear stages, both the proposed methods identify the transition point when the drill bit starts to contact the Ti layer within allowable time delay. Compared with the traditional threshold method, the time domain method and the frequency domain method respectively increase the identifying speed by 19.8% and 46.7%, besides the reduction of implementation cost. In contrast, the time domain method reduces the programming and calculation time, while the frequency domain method improves the average recognition speed. Furthermore, an adaptive drilling system embedded with the established time-domain method is designed and the accuracy of the method is proved of 100% in a drilling test of all 20 CFRP/Ti stack holes. Moreover, the effect of the adaptive LFVAD process in improving tool wear and increasing machining efficiency is verified by reducing the force growth rate by 11.7% and time decrease of 37% in a hole-making cycle compared with the traditional LFVAD process.

청년 여행자를 고려한 게스트하우스의 커뮤니케이션 스페이스 특성

안상녕(Yan, Xiang-Ning),류정(Liu, Ting),유단경(Liu, Dan-Qiong),황연숙(Hwang, Yeon-Sook) 한국실내디자인학회 2018 한국실내디자인학회 학술대회논문집 Vol.20 No.1

With the development of tourist industry and diversification of a traveling way, the guesthouse seems to be a standard organization of the international hotel chain, different from the general hotels. Moreover, its unique spaces for communications attract a large number of young tourists to the guesthouse. However, with some problems learned from the communication spaces in some guesthouses, it is necessary to research characteristics of particular guesthouses and then vitalize those characteristics for young tourists’ interests. Therefore, a case study was conducted on three guesthouses located in Seoul. Analysis results are as follows: First, five design characteristics of communication spaces are interactivity, regional culture, variability, openness, and sensory stimulation. Second, based on the research from arrangement types, interactivity ranks the highest in intensive type and blended type, and in stand-alone type, regional culture shows the highest. Third, with the design characteristics examined from three places, interactivity is well-reflected in Jung-gu and Mapo-gu, and regional culture is effectively expressed in Jongro-gu.

연구논문 : 문화유산관광지 선택속성이 만족도에 미치는 영향 -지각가치를 매개변수로-

녕수연 ( Xiu Yan Ning ) 한국관광산업학회 2012 Tourism Research Vol.37 No.-

This study examined the impacts of selection attributes of tourist attractions with cultural heritage on satisfaction with the tourists who visited Gyeongbokgung as the subject. In addition, this study grasped the impacts of perceived value on the relationship between the selection attributes of tourist attractions with cultural heritage and satisfaction and also identified if this could play the role of medium. The results of analysis are as follows. First, the selection attribute factors of tourist attractions with cultural heritage such as attraction, peculiarity, educational characteristic, information and so on have a significant positive impact on satisfaction, but convenience showed a result which was not significant. Second, the selection attribute factors of tourist attractions with cultural heritage all have a significant positive impact on perceived value. Third, as a result of examination on the impacts of perceived value on satisfaction, it was found that perceived value has a significant positive impact on satisfaction. Fourth, as a result of examination on mediated effect of perceived value in between selection attributes and satisfaction, it was found that perceived value has a partial mediated effect in between attraction and peculiarity and satisfaction, and has a complete mediated effect in between educational characteristic and information and satisfaction. In addition, it was found that perceived value has no mediated effect in between convenience and satisfaction.

PLCE1 rs2274223 Polymorphism and Susceptibility to Esophageal Cancer: a Meta-analysis

Guo, Li-Yan,Yang, Ning,Hu, Die,Zhao, Xia,Feng, Bing,Zhang, Yan,Zhai, Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Purpose: To investigate and study the relationship between the PLCE1 rs2274223 gene polymorphism and susceptibility to esophageal cancer by meta-analysis. Materials and Methods: The literature was searched in Wanfang, CNKI, PubMed, CBM, Web of Science, MEDLINE, EMBASE, Springer, Elsevier and Cochrane databases from the date of January $1^{st}$ 2004 to April $1^{st}$ 2014 to collect case-control studies on the PLCE1 polymorphism and susceptibility to esophageal cancer. For the population genotype distributions of both esophagus cancer and control groups, their odds ratios (ORs) and 95% confidence intervals (CIs) were taken as effect indexes. Disqualified studies were excluded. Odds ratios of PLCE1 rs2274223 genotype distributions in the group of patients with esophageal cancer and the group of healthy control were calculated. The metaanalysis software, RevMan5.0, was applied for heterogeneity test, pooled OR and 95% confidence intervals. Sensitivity analysis and publication bias were also explored. Results: A total of twelve case-control studies were included, covering a total of 9, 912 esophageal cancer cases and 13, 023 controls were included. The pooled odds ratio of PLCE1 rs2274223 genotype GA vs AA was 1.29 (95%CI=1.17~1.43), p<0.01, GG vs AA was 1.65 (95%CI=1.32~2.05), p<0.01, GG/GA vs AA was 1.30 (95%CI=1.16~1.46), p<0.01 and GG vs GA/AA was 1.48 (95%CI=1.22~1.80), p<0.01. The PLCE1 rs2274223 polymorphism was thus associated with risk of esophageal cancer in all genetic models. In the stratified analysis by ethnicity, and source of controls, no significantly increased risk was observed for white persons. There was no obvious publication bias detected. Conclusions: This meta-analysis showed there was a significantly association between PLCE1 rs2274223 polymorphism and esophageal cancer in yellow race populations. Due to some minor limitations, our findings should be confirmed in further studies.

Comparison of Liver Transplantation and Liver Resection for Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus Type I and Type II

Jia-Yu Lv,Ning-Ning Zhang,Ya-Wei Du,Ying Wu,Tian-Qiang Song,Ya-Min Zhang,Yan Qu,Yu-Xin Liu,Jie Gu,Ze-Yu Wang,Yi-Bo Qiu,Bing Yang,Da-Zhi Tian,Qing-Jun Guo,Li Zhang,Ji-San Sun,Yan Xie,Zheng-Lu Wang,Xin 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.1

Purpose: The aim of this study was to compare the efficacy of liver transplantation (LT) and liver resection (LR) for hepatocellularcarcinoma (HCC) patients with portal vein tumor thrombus (PVTT) and to investigate risk factors affecting prognosis. Materials and Methods: A total of 94 HCC patients with PVTT type I (segmental PVTT) and PVTT type II (lobar PVTT) were involvedand divided into LR (n=47) and LT groups (n=47). Recurrence-free survival (RFS) and overall survival (OS) were comparedbefore and after inverse probability of treatment weighting (IPTW). Prognostic factors for RFS and OS were explored. Results: Two treatment groups were well-balanced using IPTW. In the entire cohort, LT provided a better prognosis than LR. Among patients with PVTT type I, RFS was better with LT (p=0.039); OS was not different significantly between LT and LR(p=0.093). In subgroup analysis of PVTT type I patients with α-fetoprotein (AFP) levels >200 ng/mL, LT elicited significantly longermedian RFS (18.0 months vs. 2.1 months, p=0.022) and relatively longer median OS time (23.6 months vs. 9.8 months, p=0.065). Among patients with PVTT type II, no significant differences in RFS and OS were found between LT and LR (p=0.115 and 0.335,respectively). Multivariate analyses showed treatment allocation (LR), tumor size (>5 cm), AFP and aspartate aminotransferase(AST) levels to be risk factors of RFS and treatment allocation (LR), AFP and AST as risk factors for OS. Conclusion: LT appeared to afford a better prognosis for HCC with PVTT type I than LR, especially in patients with AFP levels>200 ng/mL.