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        High Precision Indoor Positioning System Based on UWB/MINS Integration in NLOS Condition

        Yao Surui,Su Yan,Zhu Xinhua 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.2

        Targeting a seamless and precise indoor localization in NLOS condition, a high-precision positioning system based on UWB/MINS integration is designed in this work. The proposed system is a low-cost and small-size multi-sensor platform in which an MIMU is added to a classical UWB indoor positioning system that implements the TOA algorithm. Particularly, when the lack of suffi cient anchor nodes occurs, compared with the single UWB system, the enhanced performance of this system mainly benefi ts from the eff ective NLOS identifi cation for every node and the tightly-coupled fusion strategy based on extended Kalman fi lter. The former prevents this system from the interference caused by erroneous indirect-path signal, which utilizes the power strength of UWB received signal to distinguish LOS and NLOS condition. The latter takes full advantage of the kinematic constraints to maintain positioning accuracy. Remarkably, when there are only two valid TOA signals, experimental results validate that the performance of the proposed system which provides centimeter-level positioning accuracy outperforms that of traditional UWB positioning system which fails in NLOS condition.

      • KCI등재

        Anti‑infammatory and antioxidant activities of acteoside isolated from Acanthus ilicifolius var. xiamenensis

        Zhang Yifan,Shen Jinhuang,Ma Xinhua,Yao Mingshuang,Zhang Yonghong,Cao Dairong 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.3

        Acanthus ilicifolius var. xiamenensis (Acanthaceae), a mangrove found in southeastern China, is an herb with strong antiinflammatory property. Phytochemical study of the mangrove showed that the plant has a high content of phenylethanol glycoside acteoside (AC). In this research, the anti-inflammatory activity of acteoside on dextran sodium sulphate (DSS)-mediated mouse ulcerative colitis model were studied. For DSS- mediated colitis in mice, AC can reduce weight loss and DAI score in UC mice, suppress colon shortening and alleviate colon pathological injury. Moreover, AC treatment notably up-regulates IL-10, down-regulates the levels of IL-1β and TNF-α, and inhibits the protein expression of JAK2/STAT3, NF-κB p65, IKKα/β and IKB of colon. In addition, after AC treatment, the level of MDA and NO in colonic tissue were remarkably decreased, while the levels of GSH, SOD, and Nrf2 and HO-1 protein expression levels were significantly increased. These results indicate that AC can activate the Nrf2 signaling pathway by inhibiting the JAK/STAT, iNOS/eNOS and NF-κB signaling cascades, enhance the intestinal barrier function, and effectively reduce DSS-induced UC in mice.

      • KCI등재

        Seroprevalence of Dirofilaria immitis in Cats from Liaoning Province, Northeastern China

        Honglie Hou,Lili Cao,Wenzhi Ren,Dansheng Wang,He Ding,Juan You,Xinhua Yao,Hang Dong,Yanbing Guo,Shuxian Yuan,Xi-Chen Zhang,Pengtao Gong 대한기생충학ㆍ열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.6

        The present study was performed to investigate the seroprevalence and risk factors for Dirofilaria immitis infection in cats from Liaoning province, northeastern China. From October 2014 to September 2016, sera of 651 cats, including 364 domestic cats and 287 feral cats (332 females and 319 males) were assessed. They were tested for the presence of D. immitis antigen using SNAP Heartworm RT test kit. In this population, the average prevalence was 4.5%. Age and rearing conditions (feral or domestic) were found to be associated with the prevalence of D. immitis. The prevalence was significantly higher in feral cats compared with domestic cats (8.4% vs 1.4%, P<0.01). There was no significant difference between males and females (4.7% vs 4.2%, P>0.05), but older cats (≥3 years old) showed a statistically higher prevalence compared with younger cats (<3 years old) in feral populations (16.8 vs 2.4%, P<0.01), while the difference between the age groups was not statistically significant in domestic cats (2.4% vs 0.51%, P>0.05), all these results suggest that outdoor exposure time may be one of the most important factors for D. immitis prevalence in cats. Results reveal that D. immitis are prevalence in domestic and feral cats in northeastern China, which indicates that appropriate preventive measures should be taken to decrease the incidence of feline heartworm disease in Liaoning province, northeastern China.

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        A Novel Anti-Microbial Peptide from Pseudomonas, REDLK Induced Growth Inhibition of Leishmania tarentolae Promastigote In Vitro

        Yanhui Yu,Panpan Zhao,Lili Cao,Pengtao Gong,Shuxian Yuan,Xinhua Yao,Yanbing Guo,Hang Dong,Weina Jiang 대한기생충학ㆍ열대의학회 2020 The Korean Journal of Parasitology Vol.58 No.2

        Leishmaniasis is a prevalent cause of death and animal morbidity in underdeveloped countries of endemic area. However, there is few vaccine and effective drugs. Antimicrobial peptides are involved in the innate immune response in many organisms and are being developed as novel drugs against parasitic infections. In the present study, we synthesized a 5-amino acid peptide REDLK, which mutated the C-terminus of Pseudomonas exotoxin, to identify its effect on the Leishmania tarentolae. Promastigotes were incubated with different concentration of REDLK peptide, and the viability of parasite was assessed using MTT and Trypan blue dye. Morphologic damage of Leishmania was analyzed by light and electron microscopy. Cellular apoptosis was observed using the annexin V-FITC/PI apoptosis detection kit, mitochondrial membrane potential assay kit and flow cytometry. Our results showed that Leishmania tarentolae was susceptible to REDLK in a dose-dependent manner, disrupt the surface membrane integrity and caused parasite apoptosis. In our study, we demonstrated the leishmanicidal activity of an antimicrobial peptide REDLK from Pseudomonas aeruginosa against Leishmania tarentolae in vitro and present a foundation for further research of anti-leishmanial drugs.

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