남성의 신체 크기 인식에 따른 디자인 선호도

이정임,조장현,김종서,이연심,노영미 배재대학교 자연과학연구소 2006 自然科學論文集 Vol.17 No.1

The purpose of this study is to analyze the design preference according to the body consciousness for 20∼26 years old male. The consciousness of body size and the satisfaction with body proportion were investigated. And the relationship between the body consciousness and the design preference was analyzed. Most subjects thought their body size was proper generally and their body proportion was proper or a little unsatisfied. The subjects preferred 'Round neckline', 'loose sleeve', and 'loose and long tops'. They didn't like the style that tops are under pants on the waist. They also preferred 'loose and long pants'. When the subjects chose clothing design, especially 'V-neckline tops' and 'short pants', they considered their height. They also considered their girth size and it meant they thought much of looseness. There was not any preference in clothing design according to the consciousness of height. The most significant relationships between the size consciousness and the preference in design was found in tops more than pants. The higher satisfaction with their body proportion was connected with the higher preference in some design. From all these results, it was found that the preference of clothing design could vary according to the consciousness of body size. The results from this study could give the important tips to improve the satisfaction with the clothing for each person.

여성 하부요관석환자에서 무마취하 요관경하 배석술

박영호,송윤섭,임용순,김영호,이남규,구자현,서병욱,김민의,전윤수 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Although ureteroscopy(URS) has been used widely to remove ureteral calculi, there is an argument against the belief that anesthesia or admission is needed for URS. We evaluated the experience of URS without anesthesia in female patients. From September 1997 to July 1998, URS was performed in 31 female patients without anesthesia. EHL(Electrohydraulic Lithotripsy) was used in 21 patients with impacted or large stone over 5mm. All patients were given oral antibiotics for 3 days and follow-up KUB was taken to confirm successful removal of the stone one week after the procedure. Successful treatment was defined as complete removal of the stone or residual fragments less than 2mm. Overall success rate was 96.7%(30 cases among 31 cases). All but one patient tolerated with analgesia through the entire procedures. There were only minimal complications such as mild flank pain and hematuria. So, we recommend that non-anesthetic ureteroscopic removal of stone as the first choice for treatment of lower ureteral stones in female based on the minimal morbidity, high success rate and low cost.

독성물질의 세포사 기전 및 세포사 유발물질의 검색법 개발에 관한 연구(Ⅰ) : 독성물질로 인한 파킨슨병 모델에서의 세포사 기전 연구 Study on the cell-death mechanisms of toxin-induced parkinsonism

강태석,김종민,서경원,김영옥,김준규,오재호,이윤동,김규봉,오정자,송연정,임종준,전범석,문전옥,최광식 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

MPTP 독성물질이 도파민성 신경세포에 선택적으로 작용하여 산화성 손상에 의한 신경세포사를 일으키는 것을 이용하여 파킨슨병의 동물모델을 만들고, 이를 통해서 아폼토시스를 비롯한 포사의 기전에 대한 연구 및 너코틴의 신경세포 보호효과 여부를 판정하는 실험을 병행하고자 하였다. 파킨슨꾐의 동물모델을 MPTf 독성 물질을 이용하여 확립하였으며, MPTP(30mgag, i.p.)를 투여한 후 1, 2,3, 4, 5일째 흑질 조직을 채춰하여 tarm로 박걸하여 tyrosine hydroxylase 면역조직화학염색을 수행하여 cell countif우한 결과, control은 57.635ce11s, 1일째 친.OfDells,2일째 57.9±6cells,3일릴 없.3±죠ells, 4일째 49.0츠3cells, 5일째 39.4±Scells료 4, 3일째 뚜렷한 신경세포 수의 감소를 보였다. 신경세포사 기전 규명을 위한 아폼토시스 분걱에서는 벼PTP 투여 후 1, 2, 3, 4, 5일째 조직을 채취하여 Hoechst staining, TUNEL staining을 수곡하였는데 양성 반응을 보인 신경세포는 관찰되지 않아. 아폼토시스로 인한 세포사가 관찰되지 않았다. bIPTP 파킨슨병 동물모델에서 nicotine 보호효과 탐색에 관한 실험은 nicat푸e 0.2mgAg을 5일 퐁안 투여 후 리『fP(30mgag)를 CS7Bt/6 마은스에 복강 내주사로 nicotine과 병용 투여한 후 1, 2, 3, 4, 5일째 뇌를 적출하땄다. 신경세포사가 뚜렷이 관찰되기 시작하는 4, 5일째의 신경세포 수의 감소 정도를 20. 30% 정도 약화시키는 경향을 보였으나, nicotine 보호효과에 대한 추가 실헝이 현재 수행 중에 있다. The cause of Parkinson's disease (PD) is largely unknown. However, free radical toxicit? may plaf a role ip. the degeneration of substantia nigra, which is the Hajorfocus of pathological damages in PD. Recently, a neuroprotective effect of nicotine in PD has been suggested. Therefore, the mechanism of neurodegenerafion and protective potential o( nicotine in PD were investigated in the experimental modeB of Pll using a neurotoxin, C57BL/6mice were administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg,j.p.). The degree of neurodegenerafion was determined by immunohistochemical stainiHB oftyrosine hydroxylase (TH). TH-positive cells on nigral sections were found 56.0 ±4, 57.9 ±6,52.315ce11s, 49.0±3cells, and 39,4±Scells at days 1, 2, 3, 4, 5, respectively (controls : 57.6±Scells). Hoechst and TUNEL staining showed no evidence of apoptosis. The exandnation on themice co-adrunistered with nicotine(0.2mgAg) and MPTP(30mgag) revealed a tendency ofnicotine protective effects. At days 4 and 5, the degree of TH-positive cells was decreased by20-30%, In corclusiffn, the role of apoptosis was not evidenced in this MPTP modeB of PB.The possible proteccon by nicotine should be elucidated with further studies.

H9c2 심근 세포주에서 외인성 nitric oxide가 허혈에 의한 세포 독성에 미치는 영향

정성구,장현용,김명천,고영관,정주호,배영미,박원서,김대중,유영민,김성수,임성빈 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Nitric oxide(NO) is known to have protective effects on an ischemic heart and to exert triggering effects on ischemic preconditioning. However, the effects of NO during the ischemic period have not been investigated. To investigate the role of exogenous nitric oxide in a model of ischemic heart cell death, we studied the effects of ischemic preconditioning and ischemia in a normal and an ischemic buffer. Methods: Rat cardiac myoblast cells(H9c2) were cultured in a normal and an ischemic buffered medium. For the ischemic culture of heart cells, the cells were cultured in a dessicator with GasPak for 5 hrs. In ischemic preconditioning, the cells were pretreated with ischemic buffer for 5 min and then perfused with normal medium for 30 min. For the measurement of the cytotoxicity, a MTT(3-4-Sdimethylthiazol-2-yl-2,5-diphenyl tetrazolium bromide) assay was performed. A DAPI(4',6-diamidino-2-phenylindole dihydrochloride) staining procedure and a flow cytometry analysis were performed to confirm apoptotic cell death by ischemia. Results: Cell viability, as determined by using a MTT assay, showed that the preconditioned group treated with NO showed more cell death than with the not-preconditioned groups in both normal and ischemic buffers. But, In normal medium and not-preconditioned groups, NO showed protective effect according to the concentrations(100,1000μM) . No treatment with NO produced the different results. In normal medium, the protective effect of ischemic preconditioning was demonstrated, but no protective effect of ischemic preconditioning could be seen in the case of the ischemic buffer. The DAPI staining and flow cytometry analysis of heart cells showed characteristic apoptotic features. Conclusion: NO added in the ischemic phase had deterious effects on heart cells. Ischemic preconditioning was more harmful than ischemia alone. The toxicity of the cells was characteristic apoptosis.

Poster Session : DNA Damage Response and Genetic Instability ; P53-dependenet chemopreventive mechanism for SeMet in normal cells exposed to methyl methanesulfonate

( Hwa Jin Jung ),( Ju Han Lee ),( Seok Won Jeong ),( Young Ju Lee ),( Sung Vin Yim ),( Seung Joon Park ),( Joo Ho Chung ),( Jee Chang Jung ),( Young R. Seo1 ) 한국생화학분자생물학회 (구 한국생화학회) 2007 생화학분자생물학회 춘계학술발표논문집 Vol.2007 No.-

Infiltrative Type HCC Has Prognostic Impact in Patients with Hepatocellular Carcinoma: Comparison of Modified AJCC Staging System versus Latest AJCC Staging System

( Sun Young Yim ),( Chung Gyo Seo ),( Yoo Jin Lee ),( Jihwan Lim ),( Tae Hyung Kim ),( Young Sun Lee ),( Na Yeon Han ),( Yeon Seok Seo ),( Ji Hoon Kim ),( Hyung Joon Yim ),( Young Dong Yu ),( Dong Sik 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: The American Joint Committee on Cancer (AJCC) 8th edition staging manual introduced several significant changes to the staging system for hepatocellular carcinoma (HCC). However, the revised staging system still does not consider tumor gross morphology when staging, which is considered to be an important predictive factor of survival in HCC patients as previously reported. Firstly, we aimed to compare the diagnostic efficacy of 8th edition of AJCC staging system to 7th edition. Secondly we evaluated the impact of infiltrative type HCC and propose new staging system to improve the diagnostic efficacy of current staging system. Methods: We retrospectively reviewed database of 992 patients with pathologically confirmed HCC between year 2004 and 2016 from three institutes. The infiltrative type HCC was defined as a mass with foci varying in size which fuse to form a larger foci without a distinct margin or a mass with a permeative appearance which blends into the background of the cirrhotic liver with an indistinct margin. Overall survival analysis (OS) were performed using Kaplan-Meier method and compared using log-rank tests. The Harrell concordance index (c index) and Akaike information criterion (AIC) were calculated to compare prognostic powers. Results: A total of 774 patients who had undergone hepatic resection were available for the analysis. The cohort was comprised of T1 (55.6%), T2 (32.8%), T3a (5%), T3b (4.7%) and T4 (1.9%) stages according to AJCC 7^th staging system while T1a (21.4%), T1b (37%), T2 (30%), T3 (5%) T4 (6.6%) stages according to AJCC 8^th staging system (Fig. 1). The OS did not differ between the advanced stages (T3a vs T3b; T3b vs T4 in AJCC 7^th edition similarly between T2 vs T3; T3 vs T4 in 8^th edition). Among all patients, 56 patients had infiltrative type HCC and OS analysis was performed after reclassifying the infiltrative type HCC separately. The OS of the patients with infiltrative type HCC was similar to OS of T4. After excluding infiltrative type HCC, sub-analysis was performed according to tumor sizes (≤2cm, >2-4cm, >4cm) for single and multiple tumors respectively as survival rate did not differ between the stages as shown above. Since the OS rate differed significantly among tumors with different sizes, we modified the T-stages as shown in Table 1. The modified AJCC T-staging system efficiently stratified patients according to survival as shown in Fig.1. Furthermore, modified staging system showed highest diagnostic performance followed by AJCC 8^th edition and AJCC 7^th edition (AIC 3074.4 vs 3087.8 vs 3103.4 and C-index 0.701 vs 0.67 vs 0.65, all P<0.01). Conclusions: The AJCC 8^th T-staging system showed improved prognostic efficacy compared to 7^th edition. However, modified AJCC staging system presented finer stratification of patients compared to previous staging systems by reclassifying sizes within single or multiple tumors and reassigning infiltrative type HCC to T4. The AJCC staging system requires surgical specimen for analysis and this study includes a large number of patients who undergone hepatectomy which is believed to have clinical impact with further validation in other cohorts.

Comparison of Daily Norfloxacin versus Weekly Ciprofloxacin for the Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients: A Randomized Controlled Trial

( Hyung Joon Yim ),( Sang Jun Suh ),( Young Kul Jung ),( Sun Young Yim ),( Yeon Seok Seo ),( Soo Young Park ),( Jae Young Jang ),( Young Seok Kim ),( Hong Soo Kim ),( Byung Ik Kim ),( Kwang-hyub Han ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: For the prevention of spontaneous bacterial peritonitis (SBP) in cirrhotic patients with ascites, norfloxacin 400mg per day is a standard regimen. However, ciprofloxacin 750 mg per week is also known to be effective. In addition, ciprofloxacin once weekly administration is more convenient and less costly. This study aims to prove that ciprofloxacin once weekly administration is as effective as norfloxacin once daily administration for the prevention of SBP. Methods: Liver cirrhosis patients with ascites between 20-75 years old were screened, and enrolled in this randomized controlled trial if 1) ascitic polymorphonucleated cell count < 250/mm3 2) ascitic protein is equal or less than 1.5 g/dL or 3) the presence of history of SBP. Patients were randomly assigned into norfloxacin daily or ciprofloxacin weekly group, and followed-up for 12 months. Primary end point was the prevention rate of SBP, and the secondary end points were 1 year mortality, incidence of infectious events, hepatorenal syndrome, and hepatic encephalopathy. Results: 124 patients were enrolled and allocated into each group by 1:1 ratio (62:62). Male patients were 90% and the mean age was 55.2 ± 10.1. The mean Model for End stage Liver Disease (MELD) score was 14.6 ± 4.8. There was no difference in baseline characteristics between the groups. SBP developed in 2 patient of ciprofloxacin group, and in 3 patients of norfloxacin group (3.2% vs. 4.8%, P = 0.643). Cumulative transplant free survival rate were comparable between the groups (80.6% vs. 82.3%, P = 0.863). Incidence of infectious complication, hepatorenal syndrome, hepatic encephalopathy, and variceal bleeding rates were not significantly different (all P = ns). The only factor related to survival was underlying liver function MELD, P = 0.001). Conclusions: Once weekly ciprofloxacin was as effective as daily norfloxacin for the prevention of SBP in cirrhotic patients with ascites. NCT01542801]

Clinical Aspect of Coronavirus Disease 2019 (COVID-19) on HBV Infected Patient

( Young Kul Jung ),( Gi Hyeon Seo ),( Tae Hyung Kim ),( Sun Young Yim ),( Young-sun Lee ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ),( Soon Ho Um ) 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1

Comparison of Sorafenib versus Hepatic Arterial Infusion Chemotherapy-Based Treatment for Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis

( Young Eun Ahn ),( Sang Jun Suh ),( Hyung Joon Yim ),( Yeon Seok Seo ),( Eileen L. Yoon ),( Tae Hyung Kim ),( Young Sun Lee ),( Sun Young Yim ),( Hae Rim Kim ),( Seong Hee Kang ),( Young Kul Jung ),( 대한소화기학회 2021 Gut and Liver Vol.15 No.2

Background/Aims: Sorafenib is the first approved systemic treatment for advanced hepatocellular carcinoma (HCC). However, its clinical utility is limited, especially in Asian countries. Several reports have suggested the survival benefits of hepatic arterial infusion chemotherapy (HAIC) for advanced HCC with main portal vein tumor thrombosis (PVTT). This study aimed to compare the efficacy of sorafenib-based therapy with that of HAIC-based therapy for advanced HCC with main PVTT. Methods: Advanced HCC patients with main PVTT treated with sorafenib or HAIC between 2008 and 2016 at Korea University Medical Center were included. We evaluated overall survival (OS), time-to-progression (TTP), and the disease control rate (DCR). Results: Seventy-three patients were treated with sorafenib (n=35) or HAIC (n=38). Baseline characteristics were not significantly different between groups, except the presence of solid organ metastasis (46% vs 5.3%, p<0.001). The median OS time was not significantly different between the groups (6.4 months vs 10.0 months, p=0.139). TTP was longer in the HAIC group than in the sorafenib group (2.1 months vs 6.2 months, p=0.006). The DCR was also better in the HAIC group than in the sorafenib group (37% vs 76%, p=0.001). Subgroup analysis, which excluded patients with extrahepatic solid organ metastasis, showed the same trends for the median OS time (8.8 months vs 11.1 months, p=0.097), TTP (1.9 months vs 6.0 months, p<0.001), and DCR (53% vs 81%, p=0.030). Conclusions: HAIC-based therapy may be an alternative to sorafenib for advanced HCC with main PVTT by providing longer TTP and a better DCR. (Gut Liver 2021;15:284-294)

The Change of Suicidal Ideation Over a 12-Week Naturalistic Treatment of Depression: Comparison Between Young People and Older Adults

Young-Eun Jung,Tae-Youn Jun,Young Sup Woo,Hyeon Woo Yim,Jung-Bum Kim,Jae-Min Kim,Ho-Jun Seo 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.1

Objective We investigated the differences in suicidality between young people and older adults with depression over the course of 12-week naturalistic treatment with antidepressants. Methods A total of 565 patients who had moderate to severe depression (Hamilton Depression Rating Scale [HAM-D] score ≥14) and significant suicidal ideation (Beck Scale for Suicide Ideation [SSI-B] score ≥6) were recruited from 18 hospitals. Participants were classified into two groups: the younger group (13–24 years of age, n=82) and the older group (≥25 years of age, n=483). Total scores over time on the SSI-B, HAM-D, and Hamilton Anxiety Rating Scale (HAM-A) were assessed and compared between the two groups. Results At baseline, the younger group had lower HAM-D scores (21.0 vs. 22.2; p=0.028) but higher SSI-B scores (19.4 vs. 15.6; p<0.001) compared with the older group. The overall 12-week proportion of patients with resolved suicidality was 44.1% in the younger group and 69.2% in the older group. Although the improvement in the HAM-D and HAM-A scores did not differ between the groups, suicidal ideation in the younger group remained more severe than in the older group throughout the treatment. The ratio of the subjects who achieved HAM-D remission or response but did not achieve SSI-B remission was significantly higher in the younger group than in the older group. Conclusion These data suggest that in depressed youths, suicide risk is a serious concern throughout the course of depression even when favorable treatment outcomes are obtained.