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Hitach-7600 P-module을 이용한 Methotrexate 정량분석 평가
김민의,차경호,김승희,김남주,채효진 대한임상검사과학회 2009 대한임상검사과학회지(KJCLS) Vol.41 No.4
Methotrexate (MTX) in one of the antineoplastic drug and it is known to effective to management of acute lymphoblastic leukemia in children, management of choriocarcinoma and related trophoblastic tumors in women, management of carcinomas of the breast, tongue, pharynx, and tests, maintenance of remission in leukemia and treatment of serve, debilitating psoriasis. Intermediate to high-dose methotrexate administration followed by leucovorin rescue is effective in treatment of carcinoma of the lung and osteogenic sarcoma. Intrathecal administration is effective in treating meningeal leukemia or lymphoma.There are FPIA (Fluorescence polarization immunoassay) and EMIT (Enzyme multiplied immunotechique) methods that measure for MTX. We evaluated the FPIA and EMIT methods. MTX were measured by Hitachi-7600 P-module using EMIT and FPIA using TDX in the sera 60 patients. The performance characteristics evaluated were, light influence, linearity, comparison with FPIA. Also, precision evaluated were three level controls through put following CLSI evaluation protocols (EP10-A). When the MTX value of 4.16±5.78 μμmol/L (mean, SD) by the Hitachi-7600 P-module was compared with that of 4.05±5.47 μμ mol/L by FPIA, coefficients of correlation of 0.988 was obtained. The regression equation was Y (Hitachi-7600 P-module) = 0.9408 x (FPIA) + 0.1316 (r=0.9885, n=60). CVs of MTX measured by Hitachi 7600 P-module was 6.78% at 0.33 μμmol/L, 0.96% at 1.16 μμmol/L, and 0.96% at 8.04 μμmol/L. The precision was excellent in each group. The linearity was acceptable. We evaluated that MTX is light-sensitive on prolonged exposure to direct sunlight. Comparing with the FPIA using TDX, the Hitachi-7600 P-module using EMIT showed good coefficient of correlation and precision. Therefore the Hitachi-7600 P-module can replace the FPIA for quantitative analysis of MTX.
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김민의 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Hydatid disease is a parasitic infestation caused by the larval stage of the tapeworm genus Echinococcus. Usually, alveolar echinococcosis occurs in the liver. Rarely, other localizations, such as the lungs or brain, have been reported. We report a case of alveolar echinococcosis of the bilateral testis.
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Cost-Effectiveness of Rate- and Rhythm-Control Drugs for Treating Atrial Fibrillation in Korea
김민,김우진,김창수,정보영 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.12
Purpose: Although the economic and mortality burden of atrial fibrillation (AF) is substantial, it remains unclear which treatmentstrategies for rate and rhythm control are most cost-effective. Consequently, economic factors can play an adjunctive role inguiding treatment selection. Materials and Methods: We built a Markov chain Monte Carlo model using the Korean Health Insurance Review & AssessmentService database. Drugs for rate control and rhythm control in AF were analyzed. Cost-effective therapies were selected using acost-effectiveness ratio, calculated by net cost and quality-adjusted life years (QALY). Results: In the National Health Insurance Service data, 268149 patients with prevalent AF (age ≥18 years) were identified betweenJanuary 1, 2013 and December 31, 2015. Among them, 212459 and 55690 patients were taking drugs for rate and rhythm control,respectively. Atenolol cost $714/QALY. Among the rate-control medications, the cost of propranolol was lowest at $487/QALY,while that of carvedilol was highest at $1363/QALY. Among the rhythm-control medications, the cost of pilsicainide was lowest at$638/QALY, while that of amiodarone was highest at $986/QALY. Flecainide and propafenone cost $834 and $830/QALY, respectively. The cost-effectiveness threshold of all drugs was lower than $30000/QALY. Compared with atenolol, the rate-control drugspropranolol, betaxolol, bevantolol, bisoprolol, diltiazem, and verapamil, as well as the rhythm-control drugs sotalol, pilsicainide,flecainide, propafenone, and dronedarone, showed better incremental cost-effectiveness ratios. Conclusion: Propranolol and pilsicainide appear to be cost-effective in patients with AF in Korea assuming that drug usage orcompliance is the same.
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김민,Kim, Min 대한타이어공업협회 1984 타이어 고무 Vol.114 No.-
본자료는 세계 11개 주요 고무제품제조업체 (그 중 10개사는 82년도 매출액이 각각 10억 달러 이상임)의 재무상황과 최근의 영업실적을 분석한 것이다. 조사편의상 기업체들을 미국ㆍ유럽ㆍ일본의 3개 그룹으로 나누어 자료비교가 가능한 지난 82년도를 기준으로 분석했는데, 동년 총매출액 370억달러 중 미국이 53%, 유럽이 36%, 일본이 11%를 점하였다. 11개 업체는 Goodyear, Michelin,Pirelli, Firestone,Bridgestone, BF Goodrich, Dunlop, General Tire, Uniroyal, Continental, Yokohama 등인데, 이들이 모두 고무산업만을 하는 것은 아니다. 일본의 Sumitomo 사는 1983년에 Dunlop의 영국공장과 서독의 타이어공장을 사들이고, 84년에도 프랑스의 공장을 매입했지만 82년도 매출액이 7억 5,000만 달러에 불과하여 이번 분석대상에서 제외되었다. 각기업체 자료는 가급적 동일한 조건으로 취급하려 했지만, 각사의 정책상비밀로 하는 정보 때문에 제한을 받았다. 비교하기 쉽도록 하기 위하여 모든 금약은 미화 달러 기준으로 하였고, 자료는 대부분 각사의 결산보고서에 따른 것이다.
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김민,김태훈,유희태,Eue-Keun Choi,Hyung-Seob Park,Junbeom Park,Young Soo Lee,Ki-Woon Kang,Jaemin Shim,Jung-Hoon Sung,Il-Young Oh,정보영 대한심장학회 2021 Korean Circulation Journal Vol.51 No.3
Background and Objectives: Atrial high-rate episodes (AHREs) can be continuously detected by cardiovascular implantable electronic devices (CIEDs); however, the predictors of clinically relevant AHREs are unclear. Methods: This prospective multicenter study monitored 816 patients (median age 73 years, 40.4% male) without atrial fibrillation (AF) from September 2017 to July 2020. AHREs was defined as a programmed atrial detection rate >220 beats/min. The reference values of 6 minutes and 6 hours were set to analyze clinical implication of AHREs based on previously published data that the 6 minutes excluded most episodes of oversensing. Results: During a median follow-up of 18 months (interquartile interval 9–26 months), AHREs with the longest durations of >15 seconds, >6 minutes, and >6 hours and clinically documented AF by electrocardiography were noted in 246 (30.1%), 112 (13.7%), 49 (6.0%), and 24 (2.9%) patients, respectively. Among patients developing AHREs >6 minutes, 102 (91.1%) of 112 patients were identified at the 6-month visit. Patients with AHREs >6 minutes had higher proportions of sick sinus syndrome, subjects with atrial premature beat >1% on Holter monitoring, and larger left atrium (LA) size than patients with AHREs ≤6 minutes. Multivariable logistic regression analysis showed that LA diameter >41 mm (odds ratio [OR], 2.08; 95% confidence interval [95% CI], 1.25–3.45), and sick sinus syndrome (OR, 3.22; 95% CI, 1.91–5.43) were associated with AHREs >6 minutes. Conclusions: In patients with LA diameter >41 mm, and sick sinus syndrome before CIEDs implantation is associated with risk of developing AHREs >6 minutes.
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