秋史 金正喜의 濟州流配文學 硏究

梁淳珌,金奉玉 제주대학교 1991 논문집 Vol.32 No.1

The purpose of this study is to understand Choosa's literature by analyzing 20 exile chinese poems and 48 exile letters(27 Chinese letters and 21 Korean letters), which was written for nine years of his exille. Conclusions of this study are as follows: (Ⅰ) Exile chinese poetry expresses emotion in the exile's life, such as affection for the kings, repent of individual situation, life in seclusion, love for nature, nostalgic reminiscence, great sarrow, lament for the world, tast, and transience. This proves that while living in seclusion, Choosa not only eulogized the nature but also devoted himself to an artistic life with the inspiration obtained from probing nature. (Ⅱ) In analyzing exile letters, I quoted Busemann's emotional and intentional phase replacement theory and through this method, I concluded the followig. 1) His fraternity with his brother and elder cousin when he was exiled shows emotional phase. This derived its origin from environmental factors of an isolated island and from his inner state of mind covered with hopelessness and solitude. 2) His emotional phase for his wife when he was exiled to Cheju-do, was his confirmed love and respect, which we can't find in a traditional and noble family. But I found out this in his letters sent to his wife. He wrote the letters to his wife using honorific expressions and unique words. I could reconfirm this in a mourning poem and a funeral address expressing his regret over his wife's death. Especially, more attention should be paid to use creative words for his wife. 3) His emotional phase for his children twmed out to be a stern father. He said that mountains and streams couldn't break affecti on between them son, even though they lived at a long distance each other. I could find his emotional phase in taking attitude toward his son's reading. And he has an intellectual and conservative phase, from the viewpoint of advising his adopted son, Sang-moo to observe his family precepts "To behave oneself decently". 4) He regarded sacrificial rites as a sincerity, and he was glad to take a descendant. In this sence, we can claim that his intention to be anxious about his family shows us his distinct learning toward conservatism. 5) He struggled not to lose his moral sense of a classical scholar during his exiled life to Cheju-do. He devoted all his energies to all things. He always carried about books with him, and his action was sincere. He completed "CHOOSA-CHE; his unique style of penmanship" and "SAEHAN-DO; his painting showing one's true value when he is in adversity", while in Cheju-do. In view of this, we contend that he was great scholar who acted up to his principles and that he overcome difficulties, frustrations, and despairs during his exiled life. 6) He realized his rational intention, by maintaining the relation of teacher and pupil. Only if the pupils devoted themselves to their studies, he taught them with ail his might. Surely he was looked up to as their true preceptor. Letters are materials showing personal aspects such as ways of thinking and ways of life. From this point of view, this study aims to understand Choosa's letters written when he was in exile. For this purpose, I made an concrete analysis of the letters based on the phase-replacement theory. It is highly valued that Choosa wrote 21 letters to his wife and daughter-in-law, which reflects his real life-style and practical conscionsness of his languge and literaure as a means of communication.

Streptozotocin 유도 당뇨쥐에서의 Phospholipase A₂, Cyclooxygenase 활성과 Thromboxane 및 Prostacyclin합성

양정아,김성옥,최정화,곽오계,이순재,장현욱 영남대학교 약품개발연구소 1998 영남대학교 약품개발연구소 연구업적집 Vol.8 No.-

당뇨병에서의 혈전생성 기전에 관련된 주된 요인을 관찰코져 흰쥐를 4주간 사육한 후 streptozotocin(STZ)으로 당뇨를 유발한 후 6일째에 희생하여 당뇨쥐에 있어서의 phospholipase A₂ 활성변화에 따른 조직의 과산화적 손상과 혈소판 응집능 등의 변화를 관찰한 결과는 다음과 같다. 체중증가는 STZ를 투여한 후에는 STZ 투여군에서 현저하게 감소하였다. 식이섭취에 있어 STZ injection 후, DM군은 16% 증가하였다. 식이효율은 STZ injection 후 DM군은 정상군에 비해 유의적으로 감소하였다. 혈청 중의 총 지질과산화물가는 정상군에 비해 DM군은 2.5배 높았다. HDL 중의 TBARS는 정상군에 비해 DM군은 약 1.6배 정도 높았고 LDL 중의 TBARS는 정상군에 비해 DM군에서 4.8배의 높은 증가를 보였다. 혈소판 phospholipase A₂ 활성은 DM군은 정상군에 비해 42% 증가하였다. 혈소판 cyclooxygenase 활성은 정상군에 비해 DM군이 2배 정도 높은 수준이었다. 혈소판 중의 TXA₂ 농도는 정상군과 비교하여 DM군에서 169%로 현저하게 높았고 대동백 PGI₂의 농도는 정상군에 비해 DM군은 낮은 수준을 보였으며 대동맥 PGI₂와 혈소판 TXA₂의 비는 DM군에서 정상군에 비해 55% 낮았다. 결론적으로 STZ 유발 당뇨쥐에 있어서는 혈청 지질과산화물 수준의 증가와 더불어 phospholipase A₂ 활성이 증가되었으며 따라서 cyclooxygenase가 유도하는 AA cascade 활성화에 의해 TXA₂ 생성증가 및 PGI₂/TXA₂ ratio의 감소가 관찰되었다. 이러한 결과는 당뇨병 질환에서 나타나는 동맥경화증, 심혈관계 질환 등의 여러 혈관계의 병리적 현상들이 당뇨 상태에서의 지질대사 이상으로 인한 지질과산화물의 증가와 그의 독성으로 인한 여러 혈소판 관련 인자들의 활성화와 밀접하게 연관되어 나타나는 것을 시사하는 것이라 하겠다. The relation between lipid peroxidation and thrombotic reaction were investigated in streptozotocin (STZ)-induced diabetic rats. Sprague-Dawley male rats weighing 100±10gm were randomly assigned to normal and STZ-induced diabetic group(DM). Diabetes was experimentally induced by intravenous injection of 55mg/kg of body weight of STZ in citrate buffer(pH 4.3) after 4 weeks feeding of basal diet. Animals were sacrificed at the 6th day of diabetic states. Body weight gains were lower in diabetic group after STZ injection. Serum levels of thiobarbituric acid reacting substances(TBARS) that were markedly increased in DM group compared with of normal group. TBARS levles of HDL and LDL were similar patterns to total TBARS of serum. Activities of platelet phospholipase A₂(PLA₂) were higher in diabetic group than those of normal group. Activities of platelet cyclooxygenase were 106% in DM group than normal group. Platelet thromboxane A₂(TXA₂) formation was increased in DM group than normal group. Production of aortic prostacyclin(PGI₂) was lower in diabetic group than that of normal group. PGI₂/TXA₂ ratios were decreased by 55% in DM groups than those of normal group. The present results indicate that STZ-induced diabetic rats are more sensitive to oxidative stess which leads to acceleration of lipid peroxidation and platelet aggregability. In conclusion, accelerating effect of lipid peroxidation and thrombogenesis in diabetic state is regarded to be resulted from enhancement of PLA₂ activity and arachidonic acid metabolism, inhibition of antiaggregating agent and aortic PGI₂ formation.

老人女性의 운동에 대한 認識 및 與件과 實態에 관한 調査硏究

梁順子,權永玉,元周淵 忠南大學校體育科學硏究所 1988 體育科學硏究誌 Vol.6 No.1

The purpose of this study was to provide a fundamental information for plan for positive and active participation or execution of exercise in Female elderly. Questionaire about the Leisure activities, the understanding for exercise and health, the actual and given condition of exercise participation and facilities was used for this study. 330 Aged women (over 60 year-old) who live in Seoul city were answered the Questionaire. Following conclusions were obtained were obtained : 1. Aged women's main daily works are managing house hold duties, attending a lecture in College for elderly, Seeing and Hearing of T. V. or Radio. And their Leisure activities are very simple (not various) and Static, for example seeing and Hearing of T. V. or Radio, gardening, reading, chess and Korean playing cards etc. 2. Aged women are very interested in Health and they point out illness and lack of exercise as a factor of weakness. Furthermore they understand the necessity of exercise for health and their daily life in old age, and also have a lot of intention to do exercise. 3. Exercises that aged women are enjoying or want to enjoy are taking a walk, mountain climbing, physical exercises, Aerobic dance, Badminton, and Jogging. 4. Almost aged women are doing exercise sometimes or usually, and also are seeing and hearing a T. V. or Radio for sports game. 5. Places that aged women are doing excercise are generally not well equipped place (e. g. medicinal water fountain, low hill, and around their house). Besides almost doing exercise alone or just with intimate friends and family. Club sports activities are not general. 6. As inconvinient factor for exercise, a lot of aged women pointed out the not specially equipped or established sports facilities for elderly, lack of number of equipment, and the long distance from home to facilities.

엘라스타제의 토끼에 대한 최기형시험

안병옥,백남기,이순복,김원배,양중익,이영순,임윤규 A.R. Liss 1990 ENVIRONMENTAL MUTAGENS AND CARCINOGENS Vol.10 No.2

자기 효능의 개념 분석

서순림,이은남,박송자,양영희,이동숙,최은옥,구미옥,김인자,이인숙,김성재,박영임,이은옥 서울대학교 간호대학 간호과학연구소 1997 간호학 논문집 Vol.11 No.1

Today human needs for health promotion and maintenance are increasing. The nursing progression has a great responsibility for helping clients to practice good health behavior. self efficacy was found to be potent predictor in initiating and maintaining the health-related behavior. Therefore, the concept is important in nursig intervention for change of health behavior. The purpose of this paper was to analyze and clarify the meaning of the concept, self efficacy. This study used Walder & Avant's process of concept analysis. Critical attributes of self efficacy were : 1) positive perception of his won capability; 2) intrapersonal strength; 3) possibility of being learned; 4) individuality; 5) specificity; 6) generalizability. Antecedents of self efficacy consist of those facts that 1) new situation occurs; 2) individuals have needs to change the new situation; 3) there are some required actions in new situation. Consequences occurring as a result of self efficacy consist of those facts that 1) individual initiates the of failure; 5) cope with the situation; 6) controls the situation; 7) the level of self efficacy is enhanced; 8) the level of self-esteem is enhanced.

STZ 유발 당뇨쥐에서 시간에 따른 생리적 항산화계의 변화

이순재,양정아,김성옥,최정화,신주영,채영미,차복경 대구효성가톨릭대학교 응용과학연구소 1997 응용과학연구논문집 Vol.5 No.-

The purpose of this study was to investigate change of physiological antioxidative system according to the time in streptozotocin-induced diabetic rats. Sprague-Dawley male rats weighing 150±10gm were randomly assigned to one normal and five STZ-induced diabetic groups. Diabetic groups were classified to experimental period. Diabetes was experimentally induced by intravenous injection of 55 mg/kg of body weight of STZ in citrate buffer(PH 4.3) after 6 weeks feeding of three experimental diets. Animals were sacrificed at 0, 3, 6, 12, 18th days of diabetic states. 1. Activity of superoxide dismutase(SOD) in liver was increased in that of diabetic mellitus(DM) groups at 3th day but that of DM groups was not significant from 6th day according to period. Glutathion peroxidase(GPX) was significantly decreased in DM groups from 6th day 2. Reduced glutathione(GSH) contents in liver significantly decreased in diabetic groups from 3rd day compared with those of DM groups according to the period. Oxidized glutathione(GSSG) was higher from 6th day. GSH/GSSG ratio was significantly lower than that of normal group from 3rd day to all experimental period 3. Contents of vitamin E in liver of DM groups were significantly decreased compared with that of normal group from 6th day. 4. Lipid peroxide(LPO) contents in liver of DM groups were significantly increased compared with that of normal group from 3rd day. The present results indicate that STZ-induced diabetic rats were reduced by antioxidative defense system and taken by peroxidate damage in tissue compared with normal group from 3rd day or 6rd day after injection STZ. It lended to acceleration all diabetic groups but no significance according to the experimental time.

돼지 췌장 유래 엘라스타제의 항원성 시험

김순회,백남기,안병옥,이상득,이순복,김원배,양중익 A.R. Liss 1990 ENVIRONMENTAL MUTAGENS AND CARCINOGENS Vol.10 No.2

갑상선 질환에서 혈청 Microsome 항체 측정의 의의

윤영옥,장순모,박호자,이준열,양기화,정인숙,강석진 대한임상병리사협회 1984 임상병리사회지 Vol.16 No.1

한국인 본태성 고혈압환자에서 Angiotensinogen M235T 유전자 다양성

양동호(Dong Ho Yang),홍세용(Sea Yong Hong),김홍수(Hong Soo Kim),방차옥(Cha Ok Bang),김철현(Chul Hyun Kim),최종순(Jong Soon Choi),하권수(Kwun Soo Ha) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.3

N/A Background: Potential involvement of the angio-tensinogen gene(M235T) in the pathogenesis of essen-tial hypertension has been suggested by some inves- tigators. However, an association between M235T gene polymorphism and essential hypertension has been reported by some, but not by others. Since genetic diversity exists among different ethnic population, we addressed the question of whether there is an association between M235T gene poly-morphism and essential hypertension in the Korean. Methods: 100 patients with essential hypertension and 100 control subjects were recruited from out- patients at the Department of Internal Medicine, Soon-chunhyang Hospital, Chunan City. The criteria for hypertension was defined as systolic blood pressure higher than 160mmHg and/or diastolic blood pressure higher than 95mmHg. For detection of the M235T polymorphism at the angiotensinogen locus, the primer sequences were: sense primer : 5'-TGAAGGAG- AAGGTGTCTGCGGGA-3' and antisense primer : 5'- AGGACGGTGCGGTGAGAGTG-3'. The PCR product mixture was exposed to restriction enzyme Tthlll I and then submitted to electrophoresis in polyacryl-amide gel. Differences between the molecular variants of the gene in hypertensives and normotensives were com- pared by using the X²test. p<0.05 was considered statistically significant. The odds ratio and 95% confidence interval were calculated using Woolf's method. Results: Compared with the control subjects, hypertensives had higher values of three established risk factors for hypertension : age, BMI cholesterol (total and LDL). X analysis showed no difference in the distribution of genotype or allele frequency between the hypertensives and normotensives(X²=1.14, p=0.29). The crude odds ratio was 0.73 for CC over CT(95% confidence interval 0.41-1.30). The adjusted odds ratio with age, sex, lipid profilcs and BMI was 0.68 for CC over CT(9596 confidence interval 037-1,23). Conclusion : The molecular varient M235T of the angiotensinogen gene is not associated with essential hypertension in Korean population.

S-상 심실중격의 임상적 고찰

이동민,장경식,양종태,장대용,김종오,서영욱,고영엽,홍순표 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background: The sigmoid septum described an anatomical variation in the contour of the left ventricular outlet. It is related to degenerative change with aging. We observed clinical significance of sigmoid septum in Korean. Methods: Echocardiographic examination was performed in 434 patients. Sigmoid septum is defined as discrete bulging of the proximal interventricular septum with that thickness is greater than 1.3cm or the thickness is grater 1.5 times than adjacent mid interventricular septum in apical 3 chamber view. Result: The incidence of patient with sigmoid septum(septum patient) is 24.8% (male 8.4%, female 16.3%) . The incidence increases with age and is more common in women. The patients with sigmoid septum were compared with targeted groups, there was no significant difference in blood pressure between them, but in height and weight, the former were lower. (p<001, p<03). In the patients with sigmoid septum, weight and the surface area of a body have an opposite correlation with increase of age (p<03, r=-0.34) (p<04, r=-0.31) , but no decrease of height was found according to age increase (p=0.47, r=-0.11) The main reason patients with sigmoid septum ask echocardiolography and its clinical symptoms were abnormal results of previous electrocardiography and/or usual chest pain. Compared with control group, interventricular septal thickness is larger in septum patients (p<001). The thickness of interventricular septum located in subaortic left ventricular outflow tract is 1.6±0.3cm. There is another web like structure that continued from interventricualr septum to anterior free wall of left ventricle and the width is 1.6±0.4cm. A sign of insignificant obstruction due to left ventricular outflow was observed from three sigmoid septum patients. Conculusion: Septum patient is largely found in older age group and the body weight and body surface area are lower than control group. The body weight and body surface area are opposite correlation with age. So sigmoid septum is considered as structural change by weight reduction with aging. It is assumed that septum patients are related with asymptomatic ischemia because they have more abnormal ECG finding such as T wave inversion on precordial leads or standard leads, nonspecific ST-T change, LBBB etc. Sigmoid septum is not only proximal interventricular septal bludging but also another web like structure continuing to anterior wall of left ventricle.