http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국인 본태성 고혈압환자에서 Angiotensinogen M235T 유전자 다양성
양동호(Dong Ho Yang),홍세용(Sea Yong Hong),김홍수(Hong Soo Kim),방차옥(Cha Ok Bang),김철현(Chul Hyun Kim),최종순(Jong Soon Choi),하권수(Kwun Soo Ha) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.3
N/A Background: Potential involvement of the angio-tensinogen gene(M235T) in the pathogenesis of essen-tial hypertension has been suggested by some inves- tigators. However, an association between M235T gene polymorphism and essential hypertension has been reported by some, but not by others. Since genetic diversity exists among different ethnic population, we addressed the question of whether there is an association between M235T gene poly-morphism and essential hypertension in the Korean. Methods: 100 patients with essential hypertension and 100 control subjects were recruited from out- patients at the Department of Internal Medicine, Soon-chunhyang Hospital, Chunan City. The criteria for hypertension was defined as systolic blood pressure higher than 160mmHg and/or diastolic blood pressure higher than 95mmHg. For detection of the M235T polymorphism at the angiotensinogen locus, the primer sequences were: sense primer : 5'-TGAAGGAG- AAGGTGTCTGCGGGA-3' and antisense primer : 5'- AGGACGGTGCGGTGAGAGTG-3'. The PCR product mixture was exposed to restriction enzyme Tthlll I and then submitted to electrophoresis in polyacryl-amide gel. Differences between the molecular variants of the gene in hypertensives and normotensives were com- pared by using the X²test. p<0.05 was considered statistically significant. The odds ratio and 95% confidence interval were calculated using Woolf's method. Results: Compared with the control subjects, hypertensives had higher values of three established risk factors for hypertension : age, BMI cholesterol (total and LDL). X analysis showed no difference in the distribution of genotype or allele frequency between the hypertensives and normotensives(X²=1.14, p=0.29). The crude odds ratio was 0.73 for CC over CT(95% confidence interval 0.41-1.30). The adjusted odds ratio with age, sex, lipid profilcs and BMI was 0.68 for CC over CT(9596 confidence interval 037-1,23). Conclusion : The molecular varient M235T of the angiotensinogen gene is not associated with essential hypertension in Korean population.
허혈성 뇌졸중과 응고인자 XIII Val 34 Leu 다형성과의 무관성
방차옥,최종순,박형국,안무영,홍세용 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
Background and purpose: Although a common G to T point mutation (FXIII Val34Leu) in exon 2 of the alpha-subunit of the FXIII is protective against myocardial infarction and venous thrombosis, there are few reported the association of FXIII Val34Leu and ischemic stroke. The aim of this study was to investigate the protective role of the FXIII Val34Leu against ischemic stroke and its suggested interaction with the plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism. Methods: We carried out genotype analyses for FXIII Val34Leu using single-stranded conformation polymorphism and 4G/5G polymorphism in the promoter region of the PAI-1 gene in 53 patients with ischemic stroke and in 82 race-matched control subjects. Results: Age, hypertension, diabetes, and low-density lipoprotein were significantly higher in ischemic stroke patients. However, genetic distributions of FXIII A subunit and promoter region of PAI-1 were not different on both groups. Even adjusting for age, sex, hypertension, diabetes, and total cholesterol, there were not significantly associated between FXIII Val34Leu or 4G/4G genotype of PAI-1 and ischemic stroke. Conclusion: FXIII Val34Leu and the 4G/4G genotype of the PAI-1 gene are not significantly associated with an increased or decreased risk of ischemic stroke.
뇌경색 환자에서 PAI-1 유전자의 다형성에 대한 연구
방차옥,안무영 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
Background : Decreased fibrinolysis due to increased plasminogen activator inhibitior-1 (PAI-1) activity has been associated with hypertension or cerebral infarction. The aims of this study were to observe associations of the genetic polymorphism for PAI-1 with hypertension and cerebral infarction, and to elucidate whether impaired fibrinolytic activity in cerebral infarction was related to atherothrombosis or to risk factors such as hypertension. Methods : Patients with cerebral infarction (n=60), hypertension (n=100), and control subjects (m=100) were enrolled. We genotyped all subjects for 4G/5G polymorphism in the promoter region of the PAI-1 gene. Results : The frequency of 4G/4G genotype of PAI-1 was significantly higher in the patients of cerebral infarction than the control subjects (41.7% versus 21.0%; P=0.005), but not in the hypertensive subjects. There was a significant association between 4G/4G genotypes of PAI-1 and cerebral infarction (adjusted odds ratio=3.11, 95% confidence interval, 1.18-8.15), adjusting for age, sex, total cholesterol, low-density lipoprotein, triglyceride, and body mass index. Conclusion : Our results suggest that the 4G/4G genotype of the PAI-1 gene is significantly associated with an increased risk of cerebral infarction.
알코올 금단 발작 환자에서 진전 섬망 예방에 대한 Nimodipine과 Chlordiazepoxide의 효과 비교
정두신,양광익,이보람,방차옥,이태경,성기범,안무영,박형국 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1
Background & objectives : An increase of calcium influx during alcohol withdrawal state may contribute to neuronal hyperexitability, which cause delirium tremens(DT). Some investigators have found calcium channel blockers effects in prevention of DT in experimental animals. Therefore we evaluated the preventive effects of calcium channel blocker(nimodipine) and benzodiazepine(chlordiazepoxide) on the development of DT in alcohol withdrawal seizure(AWS) patients. Method : A total 59 patients with AWS were divided into three groups according to the management nimodipine-treated, chlordiazepoxide-treated, and control(no specific medication) groups. We compared the incidence rates of DT in the three groups. Results : Total incidence rate of DT was 30.5%(18 of 59 patients). There were 6 DTs of 18 patients(33.5%) in nimodipine-treated group, 4 of 21 patients(22.5%) in chlordiazpoxide-treated group, and 8 of 20 patients(44.0%) in control. Conclusion : The control group(44.0%) showed the highest incidence rate of DT. And nimodipine-treated(33.5%) and chlordiazepoxide-treated group(22.5%) were followed. However, this result failed to demonstrated statistically significant differences due to small numbers size.