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애엽추출물 , DA-9601 의 실험적 위궤양 모델에 대한 항궤양 효과 및 기전 연구
양중익(Junn Ick Yang),이상득(Sang Deuk Lee),이은방(Eun Bang Lee),오태영(Tae Young Oh),류병권(Byung Kweon Ryu),박정배(Jeong Bae Park) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.2
Antiulcer effects of Artemisia herbs extract (DA-9601) were evaluated in various types of experimental gastric ulcer induced in rats. And the effects of DA-9601 on mucus, basal and stimulated gastric acid secretion were also investigated in rats. DA-9601 (12.5∼400 ㎎/㎏, p.o.) prevented the formation of gastric ulcers induced by 60% EtOH in 150 mM HCl, restraint water immersion stress, platelet activating factor (PAF), aspirin in 150 mM HCl with Pylorus-ligation and indomethacin. DA-9601 (4∼400 ㎎/㎏, p.o.) significantly accelerated the healing rate of acetic acid-induced gastric ulcer and significantly stimulated mucus secretion in a dose-dependent manner. DA-9601 (20∼200 ㎎/㎏, i.d.), however, did not inhibit basal gastric acid secretion in pylorus ligated rats and DA-9601 (200 ㎎/㎏, i.d.) failed to influence histamine-, pentagastrin- and carbachol- stimulated gastric acid secretion. These results suggest that DA-9601 has inhibitory action on gastric lesion and ulceration through increasing mucus secretion in the stomach of rats without influencing basal and stimulated gastric acid secretion.
약-약 상호작용 연구(IV) Warfarin의 혈장단백 결합에 대한 Niflumic Acid 및 Phenylbutazone의 영향 비교
조윤성,양중익 대한약학회 1980 약학회지 Vol.24 No.2
To determine in vitro effects of phenylbutazone and niflumic acid on warfarin binding to rabbit serum protein, warfarin was added to the rabbit plasma, and the bound fraction was determined by warfarin-protein complex fluorescence. The bound fraction was decreased by phenylbtazone and niflumic acid. From this effect niflumic acid was found to have the more potent ability to displace warfarin from protein binding sites than phenylbutazone.
새로운 항암성 항생물질 DA-125의 심장독성에 대한 평가
김원배,양중익,이순복,안병옥,백남기,도변준언 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.1
DA-125, a new anthracycline antibiotic, showed antitumor activity against animal tumors and human tumors. Therefore we studied the cardiotoxic potential of DA-125 in hamsters and rats as a part of safety research, and compared it with that of doxorubicin(DXR). In acute cardiotoxicity test model used hamsters DA-125 was administered intravenously at a dose of 6, 9, 12 ㎎/㎏, and DXR at 3 ㎎/㎏ was given. The electrocardiogram(ECG) of hamsters was recorded for 30 minutes after administration. The DA-125 caused slight ECG alterations at a dose of 6 ㎎/㎏. At a dose of 12 ㎎/㎏ DA-125 induced moderate to remarkable changes in ECG like decrease of heart rate, widening of PR interval and QT interval, and A-V block in 3 out of 5 animals. The severity of ECG alteration at 12 ㎎/㎏ of DA-125 was similar to that at 3 ㎎/㎏ of DXR and these changes caused by DA-125 and DXR recovered within 10 minutes after injection. In chronic cardiotoxicity test model used rats, DA-125 was administered intravenously once a week for three weeks at a dose of 6, 9 ㎎/㎏ and DXR was given at a dose of 6 ㎎/㎏. Electrocardiogram was recorded every week from the start of administration to 2 weeks after the last administration and the animals were sacrificed for histological heart examination at 1 week or 2 weeks after the last administration. DA-125 did not cause any abnormal changes in ECG and in histological heart examination due to administration, but DXR caused widening of ST segment, QRS complex, and QT interval from 1 week after administration and these changes were continued to necropsy. These alterations in ECG were accompanied by cardiac histological lesions such as vacuolation in myocardiac cells, interstitial edema and necrosis of myocytes. These results suggest that DA-125 is less cardiotoxic than DXR.
A New Format for Agarose Solid-Phase Enzyme Immunoassay
김학주,양중익,민신홍,변시명,Kim, Hack-Joo,Yang, Jung-Ick,Min, Shin-Hong,Byun, Si-Myung 생화학분자생물학회 1989 한국생화학회지 Vol.22 No.1
B형 간염 표면항원의 모노크로날 항체를 CNBr로 활성화시킨 agarose에 결합시켜 만든 고상 agarose-anti-HBs를 사용하여 측정하고자 하는 시료, 효소결합체, 효소반응을 1회용 플라스틱 주사기에서 이루어지도록 하는 진단방법을 연구하였다. 이 방법으로 실온에서 3시간 이내에 간단한 조작으로 측정이 완료될 수 있었으며 민감도는 기존의 상품화 되어 있는 진단시약과 동일수준을 보여주었고 B형 간염 표면항원 1 ng/ml의 농도를 측정할 수 있었다. A new format for agarose solid-phase enzyme immunosassay (ASEIA) has been developed in which a monoclonal antibody-coupled agarose, packed into a 1-ml disposable plastic syringe, regulates the sample and the enzyme reaction. The assay can be completed in less time at room temperature and in a simpler maner by use of this single-syringe system. The sensitivity of the technique is equivalent to a commercially available enzyme immunoassay kit and was able to detect $1{\mu}g/L$ of hepatitis B surface antigen in this study.
김원배,양중익,이종권,이순복,김대병,김부영,안병옥,백남기 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.1
DA-125, a new anthracycline derivative, shows significant anticancer activities. We conducted a study to examine the local irritating effect of DA-125 using mice and rabbits. In the skin test in mice, intradermal injection of 0.4 ㎎ of DA-125, compared to a dosage of 0.2 ㎎ of adriamycin, had weak irritating potentials to induce skin ulceration and erythematous induration. A dosage of 0.6 ㎎ of DA-125 produced similar degree of lesions in perivascular irritation model to that of 0.2 ㎎ of adriamycin, but the healing time was shorter in the case of mice treated with DA-125. In ocular irritation study in rabbit, the highest M.O.I.(mean ocular irritation index) of 0.5% DA-125 solution was 0.67, therefore DA-125 could be considered as a practically non-irritating anticancer agent. These results suggest that substitution of DA-125 for Adriamycin would reduces the possibility of outbreaks of local irritation and the severity of the lesions.