간질성 및 다낭성 폐질환이 동반된 쇼그렌 증후군 1례

장대용,신병철,정기영,김종오,양종태,주유철,이승일,Jang, Dai-Yong,Shin, Byung-Chul,Jung, Ki-Young,Kim, Jong-O,Yang, Jong-Tae,Joo, Yoo-Chul,Lee, Seung-Il 대한결핵및호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.51 No.6

A 47-years-old woman presented with a 2-month history of a dry mouth and dry cough. The patient had been taking medication for Sj$\ddot{o}$gren's syndrome for approximately 7 years. The chest radiography showed multiple cystic lesions and a hazy density in both lower lung fields. The HRCT showed a diffuse ground glass like appearance and multiple variable sized cystic lesions in both lung fields. After medication, the symptoms were aggravated. Bronchoscopy was preformed with a transbronchial lung biopsy. The biopsies showed an infiltration of lymphocytes, neutrophils, monocytes and histiocytes through the interstitial space of the alveola and a widening of the alveolar septa. However, the histological findings of the cysts were not obtained. Sj$\ddot{o}$gren's syndrome is a slowly progressive inflammatory autoimmune disease, which is characterized by lymphocyte mediated destruction of the exocrine glands, with pulmonary involvement in approximately 19-65%, High-resolution CT is a sensitive technique for assessing the pulmonary involvement in patients with Sj$\ddot{o}$gren's syndrome. Although a lung biopsy is not always necessary for establishing a diagnosis of an interstitial lung disease in Sj$\ddot{o}$gren's syndrome. A lung biopsy may reveal a wide spectrum of changes ranging from a mild inflammatory response to end stage fibrosis with honeycombing. Because of the predominantly peribronchiolar inflammatory infiltration and inspissated secretions the cysts were suspected to have been formed by the ball-valve phenomen. However, no definite evidence was obtained.

오디오 앰프의 측정법에 관하여

장대용,강경옥 한국음향학회 1992 韓國音響學會誌 Vol.11 No.4

사회적기업가정신이 조직가치일치를 매개로 협조적행동에 미치는 영향 : 사회복지기관 구성원을 중심으로

장대용,김태현 한국창업학회 2013 한국창업학회 Conferences Vol.2013 No.1

간질성 및 다낭성 폐닐환이 동반된 쇼그렌 증후군 1례

장대용 ( Jang Dae Yong ),신병철 ( Sin Byeong Cheol ),정기영 ( Jeong Gi Yeong ),김종오 ( Kim Jong O ),양종태 ( Yang Jong Tae ),주유철 ( Ju Yu Cheol ),이승일 ( Lee Seung Il ) 대한결핵 및 호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.51 No.6

국내 유통 식품용 플라스틱 기구 및 용기, 포장의 중금속 위해도 평가

이경연,김형수,장대용,구예지,이승하,여혜빈,윤지수,임경민,최재윤 한국포장학회 2022 한국포장학회지 Vol.28 No.3

중금속은 첨가제 성분이나 오염으로 인해 식품용 플라스 틱 기구 및 용기, 포장 제품에 유입되어 식품을 통해 인체 로 노출될 수 있다. 따라서 본 연구에서는 독성을 가진 7종 의 중금속(납, 카드뮴, 니켈, 크롬, 안티몬, 구리, 망간)을 선 정하고 국내 유통되는 16재질 137개 제품들에서의 이행량 을 파악하여 위해도 평가를 수행하였다. 대상 검체들은 4% 초산을 식품모사용매(70oC, 30분)로 적용하여 이행시험을 수행하였다. 동시분석을 위해 유도결합플라즈마 질량분석법 (ICP-MS)을 적용했으며 선형성, 검출 한계(LOD), 정량 한 계(LOQ), 회수율, 정밀도를 측정하고 확장불확도를 산출하 여 정량결과의 신뢰성을 확보하였다. 모니터링 결과, 전체 적으로 불검출 (ND) ~ 8.76 ± 11.87 μg/L의 수준으로 검출되 었으며, 대부분이 평균 1 μg/L 미만의 미량으로 확인되었다. 또한 안티몬이 PET 재질에서 다른 재질들에 비해 통계적 으로 유의하게 높게(p < 0.05) 측정되었다. 마지막으로 위해 도를 평가한 결과, 국내 유통되는 제품들의 중금속들은 인 체안전기준 대비 모두 안전한 수준으로 유지되고 있는 것을 확인하였다. Heavy metals can be intentionally or unintentionally introduced into plastic food utensils, containers, and packaging (PFUCP) as additives or contaminants, which can be ingested with food by humans. Here, seven-heavy metals (lead, cadmium, nickel, chromium, antimony, copper, and manganese) with toxicity concerns were selected, and risk assessment was done by establishing their migration from 137 PFUCP products made of 16 materials distributed in Korea. Migration of heavy metals was examined by applying 4% acetic acid as a food simulant (70oC, 30 minutes) to the PFUCP products. Inductively coupled plasma mass spectrometry (ICP-MS) was employed for the analysis of migrated heavy metals, and the reliability of quantitative results was confirmed by checking linearity, LOD, LOQ, recovery, precision, and expanded uncertainty. As a result of monitoring, heavy metals were detected at a level of non-detection to 8.76 ± 11.87 μg/L and most of the heavy metals investigated were only detected at trace amounts of less than 1 μg/ L on average. However, antimony migrated from PET products was significantly higher than other groups. Risk assessment revealed that all the heavy metals investigated were safe with a margin of exposure above 311. Collectively, we demonstrated that heavy metals migrated from PFUCP products distributed in Korea appear to be within the safe range.

배양 흰쥐 인슐린종세포에서 싸이클로스포린에 의한 세포독성에 미치는 글루타치온의 영향

최동헌,이병래,장대용,김종오,김병수,정기영,임태영,신병철,배학연 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.1

연구배경:Cycloporine A는 장기이식 환자에게 면역거부 반응을 억제할 목적으로 사용되고 있는데 이는 당뇨병, 고혈압, 신장세포 손상 등 여러 가지 부작용을 초래한다. Cyclosporine A의 이런 부작용에 대한 독성 기전은 아직 명확치 않으나 산화적 세포손상이 한 요인으로 생각되고 있다. 본 실험에서는 Cyclosprine A에 의한 췌장 베타세포의 독성이 미치는 GSH의 영향을 알아 보았다. 방법:흰쥐 인슐린종(RIN5mF)세포를 배양한 후 배양액에 글루타치온 합성효소 억제제인 buthione sulfoximine(BSO)과 cyclosporine A(CsA)및 GSH을 첨가하여 배양한 후 생존한 세포를 MTT법으로 측정하였다. 결과:CsA 용량이 증가함에 따라서 흰쥐 인슐린종 세포의 생존율은 감소되었다. BSO+CsA 투여군의 MTT 환원율은 CsA 단독 투여군보다 감소되었다. GSH+CsA 투여군의 MTT 환원율은 CsA 단독 투여군보다 증가되고, GSH+CsA+BSO 투여군의 MTT 환원율은 CsA+BSO 투여군보다 증가되었다. 결론:CsA는 췌장 베타세포에 직접적인 손상을 유발할 수 있으며, GSH은 CsA에 의한 베타손상방지 기능이 있는 것으로 추측된다. Background : Cyclosporin A (CsA) is a immunosuppressive agent that is most widely used in organ transplanted patients to prevent immunorejection, However, it has some side effects, including diabetes mellitus, nephrotoxicity and hypertension. The mechanism of CsA cytotoxicity is unclear but it has been suggested that reactive oxygen species are involved in the cytotoxic reactions. The purpose of this study was to determine the effects of glutathione, as a physiological antioxidant on CsA induced β-cell toxicity. Methods : Rat insulinoma (RINm5F) cells were incubated with culture media (RPMI1640) in the presence of CsA and/or buthionine sulfoximine (BSO), which is an inhibitor of r-glutamyl cysteine synthetase, and reduced glutathione. The viable cells were examined using 3-〔4,5-dimethylthiazol-2-yl〕-2,5-diphenyl tetrazolium bromide (MTT) and was determined by a spectrophotometer at a wavelength of 570 nm. Results : Incubating the RINm5F cells with CsA resulted in a decrease in cell viability with increasing dose. This deceased cells viability, induced by CsA was potentiated by BSO treatment. The CsA and BSO induced cells toxicity was reduced significantly by the reduced glutathione. Conclusion : The results suggest that pancreatic β-cell may be injured by CsA and glutathione may have some role in cytotoxicity (J Kor Diabetes Asso 26:57~63, 2002).

배양 흰쥐 인슐린종세포에서 싸이클로스포린에 의한 세포독성에 미치는 글루타치온의 영향

최동현,이병래,장대용,김종오,김병수,정기영,임태영,신병철,배학연 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.1

비세포폐암 세포주에서 고용량 Cisplatin 세포독성에 대한 Glutathione의 효과

이승일,부귀범,장대용,정기영,서정균,이병래,정종훈 대한결핵및호흡기학회 2002 Tuberculosis and Respiratory Diseases Vol.52 No.5

S-상 심실중격의 임상적 고찰

이동민,장경식,양종태,장대용,김종오,서영욱,고영엽,홍순표 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background: The sigmoid septum described an anatomical variation in the contour of the left ventricular outlet. It is related to degenerative change with aging. We observed clinical significance of sigmoid septum in Korean. Methods: Echocardiographic examination was performed in 434 patients. Sigmoid septum is defined as discrete bulging of the proximal interventricular septum with that thickness is greater than 1.3cm or the thickness is grater 1.5 times than adjacent mid interventricular septum in apical 3 chamber view. Result: The incidence of patient with sigmoid septum(septum patient) is 24.8% (male 8.4%, female 16.3%) . The incidence increases with age and is more common in women. The patients with sigmoid septum were compared with targeted groups, there was no significant difference in blood pressure between them, but in height and weight, the former were lower. (p<001, p<03). In the patients with sigmoid septum, weight and the surface area of a body have an opposite correlation with increase of age (p<03, r=-0.34) (p<04, r=-0.31) , but no decrease of height was found according to age increase (p=0.47, r=-0.11) The main reason patients with sigmoid septum ask echocardiolography and its clinical symptoms were abnormal results of previous electrocardiography and/or usual chest pain. Compared with control group, interventricular septal thickness is larger in septum patients (p<001). The thickness of interventricular septum located in subaortic left ventricular outflow tract is 1.6±0.3cm. There is another web like structure that continued from interventricualr septum to anterior free wall of left ventricle and the width is 1.6±0.4cm. A sign of insignificant obstruction due to left ventricular outflow was observed from three sigmoid septum patients. Conculusion: Septum patient is largely found in older age group and the body weight and body surface area are lower than control group. The body weight and body surface area are opposite correlation with age. So sigmoid septum is considered as structural change by weight reduction with aging. It is assumed that septum patients are related with asymptomatic ischemia because they have more abnormal ECG finding such as T wave inversion on precordial leads or standard leads, nonspecific ST-T change, LBBB etc. Sigmoid septum is not only proximal interventricular septal bludging but also another web like structure continuing to anterior wall of left ventricle.

문서의 효율적인 검색을 위한 HTML 문서 변환 시스템

김수희(Su-Hee Kim),장대용(Dae-Yong Chang) 한국정보과학회 2000 한국정보과학회 학술발표논문집 Vol.27 No.2Ⅰ

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