서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

TLD를 이용한 X-선 수중 흡수선량 측정 및 해석

오장진,전재식,하석호,김원식,황선태 대한방사선 방어학회 1988 방사선방어학회지 Vol.13 No.2

LiF : PTEE를 사용하여 중경 X-선(HVL : 0.29, 0.84, 1.60, 2.62mmCu)영역에 대한 수중 흡수선량을 측정 해석하였다. 이때 선량계(0.4mm × Φ12.5mm, hot-pressed LiF TLD-700)는 루사이트로 둘러 싸여 있고 물의 흡수선량은 각각의 TL출력 값에 Burlin의 공동이론을 적용하여 해석하였다. 그 결과 물 팬텀 속 깊이 5㎝에서 흡수선량률의 측정 오차는 최대 ±5%로 나타났다. 이 측정값을 측정 오차가 ±2%의 간접절대측정방법인 이온화법에 의한 측정값과 비교한 결과 두 값의 차이는 LiF : PTFE의 측정오차 범위 내에서 일치하였다. 이와 같은 결과로 LiF : PTFE를 이용한 수중 흡수선량 측정의 신뢰성을 확인할 수 있게 되었으며 이는 중경 X-선 영역에 대한 선량당량 평가의 근거로 활용 될 수 있을 것이다. Absorbed dose in water was analyzed by Burlin's general cavity theory for medium X-ray energy region (HVL : 0.29, 0.84, 1.60, 2.62mm Cu) using LiF : PTFE TL dosimeter(0.4mm x Φ 12.5mm, hot-pressed LiF TLD-700) which was enclosed in Lucite capsule. The absorbed dose rate at 5㎝ depth in water phantom was determined with measurement error of ±5%. This result was compared to that of the ionization method, indirectly absolute measurement method, of which measurement error of ±2%. The difference between these two results lies within measurement error of LiF : PTFE method. Therefore, the absorbed dose in water obtained by LiF : PTFE is reliable, and this result suggests the base to estimate dose-equivalent for medium X-rays.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

Surgical Clues of Distal Anterior Cerebral Artery(DACA) Aneurysms

김승범,이형중,김재민,백광흠,김충현,오석전,Kim, Sung Bum,Yi, Hyeong Joong,Kim, Jae Min,Bak, Koang Hum,Kim, Choong Hyun,Oh, Suck Jun The Korean Neurosurgical Society 2000 Journal of Korean neurosurgical society Vol.29 No.12

목 적 : 원위부 전대뇌 동맥에 발생하는 동맥류는 모동맥의 확보가 힘들고 재출혈 및 수술중 조기출혈의 빈도가 높으며, 익숙치 않은 수술적 접근법이 필요하다든지 하는 몇 가지 독특한 문제점이 있다. 따라서 전대뇌 반구간열 주변의 해부학적 구조물과 박리 시작점에 대한 수술전 지식을 요한다. 저자들은 박리 시작점에 대한 일관된 외부표식자를 이용하여 전두 기저부 대뇌반구간열 접근법 수술을 시행하였고 이를 심부 구조물들에 대한 접근 지표로 삼고자 하였다. 대상 및 방법 : 1995년 11월부터 1999년 6월까지 동맥류경을 결찰한 총 131명의 뇌동맥류파열 환자 중에서 원위부 전대뇌 동맥류 9명에 대하여 혈관조영술, 의무기록지, 수술소견을 통해 임상적, 수술소견을 조사하였다. 결 과 : 원위부 전대뇌동맥류의 빈도는 6.3%였고, 6례에서 뇌량 연변 동맥이 기시하는 뇌량 주위 동맥에서 발생하였고, 3례에서는 전두극동맥이 기시하는 뇌량 주위 동맥에서 발생하였다. 동반된 다른 혈관기형 및 다른 동맥류는 각각 3예에서 발견되었다. 술전 환자 상태는 일반적으로 불량했다. 조기수술은 7예에서 실시되었으며, 전두 기저부 대뇌반구간열 접근법으로 동맥류 결찰을 시행한 경우도 7예였다. 술후 심한 혈관연축과 흡인성 폐렴으로 인한 사망이 각각 1례씩이었으며 그 이외에는 신경학적 소견은 정상이었다. 결 론 : 원위부 전대뇌 동맥류의 조기수술시에 전두 기저부 대뇌반구간열 접근법이 유용하였다. 이 방법으로 뇌견인을 최소화할 수 있었으며 동맥류의 조기파열을 방지할 수 있었다. 저자들은 대뇌반구 간열의 박리 시작점으로 첫번째 교정맥(전두극 정맥)이 상시상 정맥동으로 유출되는 지점을 기준으로 하여 뇌량 및 뇌량 주변부 원위부 전대뇌동맥류에 접근할 수 있었다. Objects : Surgical management of the distal anterior cerebral artery(DACA) aneurysms presents several unique problems to surgeons, such as difficulty in early identification of parent arteries, high incidence of rebleeding and premature rupture, and requirement of unfamiliar approach other than conventional frontotemporal craniotomy. Therefore, preoperative anatomical knowledge of anterior interhemispheric fissure and entry point of dissection is prerequisite. Authors utilized a frontobasal approach for DACA aneurysms by using consistent external landmark for guidance to the deep structure. Materials and Methods : From Nov. 1995 to Jun. 1999, a surgical clipping of DACA aneurysms was carried out in 9 patients among a total 131 patients with intracranial aneurysms. In each case, the clinical and aneurysmal features were carefully reviewed through the angiograms, medical records, and intraoperative findings. Results : The incidence of DACA aneurysms was 6.9% from our series. All cases were arisen from juxtacallosal por-tion ; 6 cases from pericallosal-callosomarginal(PC-CM) junction and 3 from pericallosal-frontopolar(PC-FP) junction. Associated vascular anomalies were noted in 3 cases and multiple aneurysms in 3 cases, respectively. The preoperative clinical grades were generally poor. An early surgery was performed in 7 cases and frontobasal interhemispheric approaches in 7 cases. Postoperatively, two patients died of complications ; one delayed ischemic vasospasm and one aspiration pneumonia but remaining patients recovered well. Conclusion : The frontobasal interhemispheric approach was useful for DACA aneurysms in early surgery. Division of superior sagittal sinus(SSS) enabled a minimal retraction of brain on both sides, and prevention of intraoperative rupture was possible. Authors suggest the frontopolar(first frontal bridging) vein as a constant external landmark for approaching the genu of the corpus callosum and juxtacallosal DACA aneurysms.

Running Exercise Test with Esophageal pH and Manometry : A Useful Test for Evaluating Chest Pain of Undetermined Origin

(Suck Chei Choi),(Tae Hyeon Kim),(Yong Ho Nah),(Suck Jun Choi),(Chang Soo Choi),(Suck Kyu Oh),(Jin An Kim),(Young Sung Kim),(Kyoung Hoon Yoo),(Jin Hee Kim),(Yang Kyu Park) 대한소화관운동학회 1999 대한소화관운동학회 춘계학술대회 Vol.8 No.-

DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-alpha-induced IL-8 and CCL20 production by inhibiting p38 kinase and NF-kappaB pathways in human gastric epithelial cells.

Choi, Suck-Chei,Choi, Eun-Ju,Oh, Hyun-Mee,Lee, SungGa,Lee, Jeong-Kun,Lee, Meung-Su,Shin, Yong-Il,Choi, Suck-Jun,Chae, Jeong-Ryong,Lee, Kang-Min,Lee, Won-Jung,Park, Jae-Sik,Shin, Chang-Yell,Oh, Tae-You WJG Press 2006 WORLD JOURNAL OF GASTROENTEROLOGY Vol.12 No.30

<P>To investigate whether, or how, DA-9601, which is a new gastroprotective agent, inhibits TNF-alpha-induced inflammatory signals in gastric epithelial AGS cells.</P>

변화하는 부동산 산업의 환경과 국제윤리

오준석(Oh, Jun Suck),이창석(Lee, Chang Suck) 한국부동산학회 2008 不動産學報 Vol.35 No.-

1.CONTENTS (1) RESEARCH OBJECTIVES New changing trend in real estate comes in the name of corporate socal responsibility(CSR), which will apparently give a big impact to the decision making of real estate business in the future. (2) RESEARCH METHOD In the paper, we start to deal with the recent trend of CSR in the form of literature study as well as case analysis. Then, with the help of analytic data, we will let you know how the managers try to implement the concept of CSR in the business decision making. (3) RESEARCH FINDINGS In the results of this survey, the most important problem is the Changing environment of business from the perspective of CSR & international business ethics in real industry. 2. RESULTS The overall environment of Korean real estate industry has been very weak and feeble comparing to that of advanced countries. Though there seems to be a variety of reasons, more than that, real estate industry doe not considered as one of major industry to propel our economy but as a socially necessary evil, which causes to set up policy to minimize the impact of real estate industry rather than to maximize the efficiency of resource allocation. In addition, industry participants also show little respect for the social value creation in real estate industry. For the last, we derive the ethics of real estate industry, which can be implementable, and we raise the issue that real estate industry also should prepare for the changing new environment of CSR as well as globalized business of real estate industry, where CSR will be a main concern.

The Function of Dimeric Structure of Soluble Intercellular Adhesion Molecule-1 (sICAM-1): Inhibition of Leukocyte Function Associated Antigen-1 (LFA-1) Binding to ICAM-3

Choi, Suck-Chei,Han, Weon-Cheol,Park, Do-Sim,Kim, Eun-Cheol,Oh, Hyun-Mee,Oh, Jung-Mi,Jun, Chang-Duk The Korean Society for Microbiology 2002 Journal of Bacteriology and Virology Vol.32 No.1

Intercellular adhesion molecule-1 (ICAM-1) is a membrane protein, exists as a dimer on the cell surface, and interacts with leukocyte function associated antigen-1 (LFA-1), a member of ${\beta}_2$-integrin family. A soluble circulating form of ICAM-1 (sICAM-1) is also detected in human serum, and has been implicated as a regulator for LFA-1-dependent cell-cell interaction in vivo. However, previous reports demonstrated that sICAM-1 shows little inhibitory effect on LFA-1 binding to ICAM-1, indicating that sICAM-1 is unlikely to antagonize LFA-1/ICAM-1-mediated cellular events in vivo. Here, we investigated the property of the dimeric sICAM-1 as an inhibitor of LFA-1 interaction with ICAM-3, since the lower avidity of LFA-1 for ICAM-3 compared with ICAM-1 or ICAM-2 had been speculated. Using recently constructed heterodimeric sICAM-1 joined at the C terminus via an ${\alpha}$-helical coiled coil (ACID-BASE) (Jun, CD. et al., 2001, Proc Natl Acad Sci 98, 6830-6835), we also tested whether the structural integrity in dimer could affect the inhibitory action of sICAM-1. Engineered sICAM-1 dimer that contained intact ectodomain (E34/E34) significantly blocked SKW3 cell (LFA-$1^+$) binding to ICAM-3, but not to ICAM-1 and ICAM-2, indicating the lower avidity of LFA-1 to ICAM-3 than that of both ICAM-1 and ICAM-2. A one binding site knock out mutant (E34/K34) showed ${\sim}2$-fold reduction in efficiency compared with E34/E34 to inhibit cell binding. Interestingly, a one binding domain deletion mutant (E34/${\Delta}D1$-D2) showed significant reduction (${\sim}5$-fold) compare with E34/K34, suggesting that structural integrity, which is precluded in E34/${\Delta}D1$-D2, is necessary for optimal binding of dimeric sICAM-1 to LFA-1, thereby inhibiting LFA-1/ICAM-3-dependent adhesion. Furthermore, BIAcore affinity measurements revealed that E34/${\Delta}D1$-D2 bound to immobilized soluble open LFA-1 I domain with an ${\sim}3$-fold reduced affinity compared with E34/K34. Overall, our results demonstrate that maintaining the structural integrity in dimer is necessary for optimal binding of sICAM-1 to LFA-1, and further suggest the therapeutic potential of dimeric sICAM-1 to antagonize LFA-1/ICAM-3-mediated cellular events in vivo.

뇌량 경유 접근법

오석전 ( Suck Jun Oh ) 대한뇌종양학회 2002 대한뇌종양학회지 Vol.1 No.1

Evidence for the Association of Ce11u1ar Iron Loss in Nitric Oxide-induced Apoptosis of HL-60 Cells: Involvement of p38 Kinase, c-Jun N-terminal Kinase, Cytochrome C Release, and Caspases Pathways

Choi, Suck-Chei,Kim, Beom-Su,Yoon, Kwon-Ha,Song, Moon-Young,Oh, Hyun-Mee,Han, Weon-Cheol,Kim, Tae-Hyeon,Kim, Eun-Cheol,Jun, Chang Duk The Korean Society for Integrative Biology 2002 Korean journal of biological sciences Vol.6 No.2

Nitric oxide has high affinity for iron, and thus it can cause intracellular iron loss. We tested the idea that intracellular iron can be the primary target of NO toxicity by comparing the signaling mechanisms involved in cell death caused by iron depletion and that caused by NO. Treatment of HL-60 cells with a NO donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP), decreased the intracellular iron level rapidly as that observed with the iron chelator deferoxamine (DFO). Iron chelators such as DFO and mimosine could induce death of human leukemic HL-60 cells by a mechanism requiring activation of p38 kinase, c-Jun N-terminal kinase, caspase-3 and caspase-8. DFO and SNAP also caused release of cytochrome c from mitochondria. Inhibition of p38 kinase by a selective inhibitor, SB203580, abolished the NO and DFO-induced cell death, release of cytochrome c, and activation of caspase-3 and caspase-8, thus indicating that p38 kinase lies upstream in the cell death processes. In a parallel situation, the cells that are sensitive to NO showed similar sensitivity to DFO. Moreover, simultaneous addition of ferric citrate, an iron-containing compound, inhibited the SNAP and DFO-induced activation of caspases and also blocked the NO-mediated cell cycle arrest at $G_1$ phase. Collectively, our data implicate that the NO-induced cell death of tumor cells including HL-60 cells is mediated by depletion of iron and further suggest that activation of p38 kinase lies upstream of cytochrome c release and caspase activation involved in this apoptotic process.