폐색전증과 동반된 동맥류 파열에 의한 뇌지주막하출혈

이형중,김동원,고용,김광명,오석전 한양대학교 의과대학 2003 한양의대 학술지 Vol.23 No.1

백서 허혈 모형에서 D,L-6,8-Thioctic Acid가 뇌경색의 용적에 미치는 영향

이형중,이상구,이우택,김광명,김영수,고용 대한신경외과학회 2002 Journal of Korean neurosurgical society Vol.32 No.4

Objective:The authors demonstrate neuroprotective effects of antioxidant in reperfusion injury using ischemic rat model and evaluate the clinical eligibility of this agent to ischemic cerebrovascular diseases. Methods:Rat model was made according to Longa method. Thirty-six Sprague-Dawley rats were used and were equally divided into three groups;A) treated subcutaneously with D,L-6,8-Thioctic acid 30 minutes before occlusion, B) within one hour after occlusion, and C) with vehicle only. Neurologic examination was performed immediately and 24 hours after reperfusion. Twenty-four hours after reperfusion, brains were extracted and stained with 2% 2,3,5-Triphenyltetrazolim chloride in 2mm-thickness section. Then, fixed sections were digitalized and used for infarct area calculation. Results:There was no significant statistical difference in recorded hemodynamic and physiologic parameters between three groups. The neurologic status taken immediately following reperfusion were A) 2.67±0.492, B) 2.75±0.452, and C) 2.83±0.389, and were improved to A) 1.67±0.898, B) 1.92±0.900, and C) 2.08±0.793 just before sacrificing. However, there was no statistically significant difference between three groups. Mean volume of cerebral infarction was A) 9.5±1.67%, B) 10.4±1.58%, and C) 11.3±1.12% with no significant difference. Any specific correlation between the neurologic status and the mean infarction volume was not observed. Conclusion:Any single agent does not seem to reduce the infarction volume holistically, therefore, the incoming therapeutic target should be the development of versatile neuroprotective agents or the selection of preexisting synergistic compounds without compromising patients' safety. Key words:Antioxidant;Reperfusion;Rat model;D,L-6,8-Thioctic acid;Cerebral infarction;Neuroprotective agents.

전이성 뇌종양의 1년간 추적 관찰연구-불량한 예후와의 연관성

이형중,김충현,김재민,백광흠,오석전,Yi, Hyeong Joong,Kim, Choong Hyun,Kim, Jae Min,Bak, Koang Hum,Oh, Suck Jun 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.9

Objective : Prognostic factors of metastatic brain tumors have been widely reported and their operative indications also have been extended gradually even to the poor grade patients. Authors intended to analyze the causative factors for the clinical outcome of metastatic brain tumors, especially with relevant to the poor prognosis by one year follow-up evaluation. Patients and Methods : The authors retrospectively studied the clinical characteristics of 46 cases(35 patients) with metastatic brain tumors among 466 cases(437 patients) which were operated on due to the brain tumor, during the period between January 1994 to June 1999. Statistical analysis was performed by using SPSS 8.0$^{(R)}$. A p-value of less than 0.05 was considered clinically significant. Result : Among the variable clinical factors in patients with metastatic brain tumors, Karnofsky Performance Scale (KPS) score of less than 70(16 patients), uncontrolled primary tumor(8 patients), and surgical resection without further adjuvant therapy(9 patients) showed statistically significant poor prognosis ; p value of 0.002, 0.032, and 0.001, respectively. Other tested variables, such as old age(greater than 65 years ; 10 patients), gender(male ; 20 patients), type of primary cancer(primary undefined ; 6 patients, lung cancer ; 15 patients), location(infratentorial ; 9 patients, sellar ; 5 patients), number of lesion(multiple ; 12 patients), and number of operation(multiple craniotomy ; 7 patients) were not related to the poor prognosis. Conclusions : The most common primary site of distant metastasis was lung. The poorer prognosis was highly correlated with various factors including low KPS score(<70), no postoperative adjuvant therapy, and uncontrolled primary tumors.

朱子語類의 ‘史’인식과 朝鮮의 수용

이형중 동양고전학회 2020 東洋古典硏究 Vol.0 No.78

This paper aims to examine Zhuzi(朱子)'s perception of history centered on 『Zhuziyulei(朱子語類)』 and consider how Zhuzi's perception influenced Joseon. At first, this paper study on Zhuzi's view and perception of history. Zhuzi's said that men who studied history had to study scriptures(Chinese Classics) because of set a standard in one’s mind. He thought that history was a thing which just written down the result so historical result could nothing to do with the law of nature. If someone who didn’t know the reason could suspect the law of nature. Zhuzi worried about this situation. However, Zhuzi didn’t reject the history. He sought to consider from scriptures and gain knowledge from history which was written correctly. Joseon accepted most of zhuzi's perception of history through dissemination of 『Zhuziyulei』. Actually, Joseon pursued Neo-confucian rule since its founding. So a lot of sholars in Joseon studied on Zhuzi's Neo-confucian. And then, 『Zhuziyulei』 could further deepen Joseon’s philosophy including historical perception. The scholar of Joseon accepted Zhuzi's perception of history and the King of Joseon studied it also. Most of all, Zhuzi's historical perception influenced method of historical presentation which like modification and alteration of Sillok(實錄).

朝鮮 謄錄記錄의 類型과 그 管理體系에 관한 硏究

이형중 서울대학교 규장각한국학연구원 2018 한국문화 Vol.0 No.83

This study focused on the types and the managing system of Deung-rok(謄錄). The word of ‘Deung-rok’ primarily has meant ‘copy’ or ‘retranscription’. In Joseon Dynasty, however, the word ‘Deung-rok’ had different meanings which include ‘document files’ and ‘records & archives management system’. The definition of Deung-rok needs to be clarified in the field of Korean history to avoid confusion. The Deung-rok documents were studied by separating them into five major types - ‘daily business logs’, ‘quasi law books’, ‘register or account books’, ‘administrative transactional document files’ and ‘reports & manuals’. Each type has different characteristics in structure, compiling and utilities. In addition, this study investigated the whole process of Deung-rok system, including the creation, preservation and management of Deung-rok. The Deung-rok documents were created by officials who evaluated original records and extracted and copied selected records. The Deung-rok documents were dispersed and preserved at each place based on their utilization and importance.

대기 부하량에 제한이 있는 M/G/1 시스템의 근사법

이형중,김정기,허선 대한산업공학회 2003 대한산업공학회 춘계학술대회논문집 Vol.2003 No.5

조선 大典類에 나타난 기록관리제도의 성립과 변화 양상

이형중 서울대학교 규장각한국학연구원 2021 한국문화 Vol.- No.95

Joseon was a country that pursued the rule of law. Early on, Joseon solidified its administrative system based on the establishment of the law 『經國大典』. The records and archives management system was also constituted and operated in accordance with this law. 『經國大典』 was considered as permanent law by the rulers, however, in reality it needed change because of responding to political, economic, and social variation. To overcome this legal problem, Joseon continued to supplement and compile the law like 『續大典』, 『大典通編』 and 『大典會通』. As the laws were supplemented and compiled, the records and archives management system was also reorganized ans supplemented. Joseon’s records and archives management rules which including form of official document were maintained until the late period. However the legal obligations and penalites which related records and archives were continuously enacted and supplemented in the latter. This means that records and archives were actively used in a wider public area, and then legal control of records ans archives was required in this situation in Joseon. .

경추부에 발생한 골막성 연골종의 증례 보고 : Case Report

이형중,김영수,이형석,이승로,함창곡,고용,오성훈,오석전,김남규,김광명 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.5

The authors experienced a case of cervical periosteal chondroma presenting with symptom of spinal cord compression in 26-year-old woman. The diagnosis was based on the characteristic features of computed tomographic scan and magnetic resonance imaging scan. Total surgical removal in two-staged operation was followed by full neurological recovery. column was observed and rarely reported in this literature.

Threaded Fusion Cage(TFC)를 이용한 척추 전전위증 수술환자에서의 임상 및 방사선학적 소견의 분석

이형중,김남규,이승로,김영수,고용,오성훈,오석전,김광명 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.7

The indications for surgical treatment of spondylolisthesis are as follows : pain unrelieved by conservative treatment persistent neurologic signs. progression of the slip or slip greater than 50 per cent. postural deformity or walking difficulty due to tight hamstring muscles. The goal of operation for spondylolisthesis is to relieve radiculopathy and low back pain. and to prevent further progression of the slip through decompression of neural elements and fusion for pseudoarthrosis. The authors performed the posterior lumbar interbody fusion using Threaded Fusion Cage(TFC) on 23 patients with spondylolisthesis. All patients have been followed for 3 to 12 months. We then studied the clinical and radiological outcomes of these patients and verified the relationship between clinical outcomes and radiological findings. Summaries of the results are as followings. 1) Successful bone fusion was achieved in 20 out of 23 cases(87%). 2) Neurological signs were improved in 20 out of 23 cases(87%). 3) The majority of cases which demonstrated radiologic bone fusion also showed clinical improvement. Posterior lumbar interbody fusion using TFC was useful in the treatment of mild degree spondylolisthesis.

두개강내 원발성 간엽성 종양에 대한 임상 고찰

이형중,김충현,백광흠,김영수,김재민,고용,오석전,김광명,Yi, Hyeong Joong,Kim, Choong Hyun,Bak, Koang Hum,Kim, Young Soo,Kim, Jae Min,Ko, Yong,Oh, Suck Jun,Kim, Kwang Myung 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.1

Objective : A few anecdotal cases of mesenchyme-derived tumors which grow into a cranial cavity have been reported that disclosed a dismal prognosis, due to their critical location, aggressive biological behavior, and high rate of surgical morbidity. The aim of this study is to search clinical factors related to these tumors. Methods : Eight patients who underwent surgical removal of intracranial mesenchymal tumors between January 1993 and December 1997 were studied retrospectively. The tumors included are three chordomas, two chondrosarcomas, two rhabdomyosarcomas, and one hemangiopericytoma. Authors compared clinical features, treatment, and results of our cases with reported cases. The mean follow-up period was 20.5 months. Results : All cases showed nonspecific, location-related clinical findings and arose from sphenopetroclival region. Single stage operation was performed in 4 cases, and skull base approaches in 3 cases. Adjuvant therapies were done in 2 cases. Recurrence was seen in 3 cases(37.5%), and 3 patients died. Interdisciplinary approach with otologic surgeon was done in 2 cases. Conclusion : Recent advancement of refined tactics has made these tumors amenable and provides prolongation of progression-free survival. These are modified skull base approaches, multi-modality treatment options, and inter-disciplinary team approaches. Good results may be expected for these mesenchymal tumors by aggressive resection and adjuvant therapies according to their biological nature.