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      • 일개 대학병원에서 일년간 분리된 반코마이신 내성 장구균의 임상 분자역학적 연구

        송진영,김창억,김성욱,우흥정,김미란,이규만,이란,장미화,정희진,김우주 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.4

        목적 : 한강성심병원에서는 2000년 3월 반코마이신내성 장구균이 처음 분리되어, 원내전파를 막기 위한 노력을 하였으나, 분리가 지속되었다. 따라서 이에 대한 좀더 자세하고 객관적인 자료를 얻기 위해 본원에서 분리된 반코마이신내성 장구균에 대한 임상분자 역학적 연구를 시행하게 되었다. 방법 : 2000년 3월부터 2001년 2월까지 한림대학교 한강성심병원에서 분리된 장구균을 대상으로 디스크 확산법, 최소발육억제 농도등의 측정을 통해 반코마이신 내성여부를 확인하였으며, 반코마이신내성 장구균을 대상으로 PFGE를 시행하여 형별 분석을 하였다. 결과 : 분리된 균주는 총 32균주로 모두 E. faecium이었다. 항생제 내성 검사 결과 모두 Van A형이었다. PFGE 결과 1a형이 8검체, 1b형이 5검체, 2a형이 4검체, 2b형이 4검체, 3a형이 2검체, 3b형이 5검체였고, 그 외 4, 5, 6형이 각각 1검체씩이었다. 총 32균주 중 56%(18/32)의 균주가 같은 시기, 같은 병실에서 동일한 PFGE 형을 보이면서 분리되었다. 결론 : 반코마이신내성 장구균의 PFGE 분석 결과 여러 종류의 반코마이신내성 장구균이 유행하였음을 알 수 있다. 그러나 같은 기간, 같은 병실에서 분리된 균주의 PFGE 형이 같은 것이 상당수 있었다. 이는 반코마이신내성 장구균의 원내 전파가 있었음을 의미한다. 따라서 반코마이신내성 장구균의 전파의 발생 및 전파 방지를 위해서는 보다 효과적인 감염관리 활동이 필요할 것으로 생각된다. Background: Vancomycin-resistant enterococci(VRE) have been a rising problem worldwide. In March 2000, VRE was first isolated from a patient in Hangang Sacred Heart hospital. Although efforts to prevent transmission of VRE were performed, isolations continued. So molecular epidemiological study of VRE was done. Method : The minimal inhibitory concentration(MIC) to vancomycin and teicoplanin, and pulsed field gel electrophoresis(PFGE) pattern of VRE isolated from March 2000 to February 2001 were evaluated. Results : 32 VRE were isolated. All of the VRE were Enterococcus faecium and showed Van A resistance phenotype. We found out that a significant number of VRE isolated during same period and in same room, were same PFGE patterns. (18 cases/ 32 isolates= 56%) Conclusion: This study demonstrated the spread of VRE of same PFGE patterns. It suggests the nosocomial spreads of VRE.

      • SCOPUSSCIEKCI등재
      • KCI등재

        컴포머에 대한 복합레진의 전단결합강도에 관한 연구

        정송란,최남기,양규호,김선미,송호준 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3

        컴포머(compomer) 충전물이 파절될 경우 즉, 컴포머 수복이 실패했을 때 기존 컴포머의 파절된 부분(aged compomer)을 복합레진으로 수복해야 하는 경우를 고려해야 한다. 본 연구에서는 컴포머의 표면처리 방법에 따른 수리(repair)를 위한 복합레진과의 전단결합강도 변화를 알아보기 위해 두 개의 mold를 만들어서 Dyract AP, F2000를 컴포머 수복재료로, Z250을 수리용 복합레진 재료로 사용하여 컴포머와 레진을 부착시킨 시편을 제작하였다. 컴포머와 복합레진의 종류 조합, 본딩레진 사용유무, 열순환 처리 유무, 표면거칠기 부여 유무, 기존 수복물의 시효(aging)에 따라 10개의 군으로 나누어, 컴포머와 복합레진간의 전단결합강도를 측정하고 그 파절양상을 관찰하여 다음과 같은 결과를 얻었다. 1. 컴포머의 복합레진에 대한 전단결합강도를 측정한 결과, Dyract AP가 F2000 보다는 높은 전단강도 값을 보였으나 통계적으로 유의한 차이는 없었으며 (p>0.05), fresh 컴포머군이 aged 컴포머군보다 결합강도가 높았다(p<0.05). 2. 각 군간의 전단결합강도를 측정한 결과 Dyract AP에 접착제를 도포하고 Z250을 접착시킨 제 5군이 가장 높았으며, Dyract AP를 충전하고 1주일간 물에 보관한 후 건조시켜 표면을 roughening 한 후 Z250을 충전시킨 제 9군에서 가장 낮았다(p<0.05). 3. 열순환을 시행한 군이 시행하지 않은 군보다 전단결합강도가 낮게 나타났으나 통계적으로 유의한 차이는 없었다. 4. 각 재료들의 결합실패가 일어난 파절단면을 조직학적으로 관찰한 결과, 전반적으로 접착파괴를 보였으나, 접착제를 도포한 군에서는 응집파괴가 우세하게 나타났다. 이상의 결과 fresh 컴포머 위에 접착제를 도포한 다음 수리용 복합레진 재료를 사용함으로써 컴포머와 복합레진간의 결합력을 증가시킬 수 있음을 알 수 있었다. 그리고 fresh 컴포머 위에 복합레진을 즉시 충전한 경우가 높은 결합력을 얻을 수 있었다. Aged 컴포머와 복합레진간의 성공적인 결합력을 얻으려면 aged 컴포머의 표면을 mechanically roughening하고 접착제를 도포한후 복합레진을 충전해야 할 것으로 사료된다. For the purpose of comparing the bond strengths of compomers to composite resin, composite 2250, and two polyacid modified composite resin, Dyract AP and F2000, were selected and investigated using universal testing machine for measuring the shear bond strengths. Additionally, the failure modes were examined by observing the fractured surfaces of each specimen. The following results were obtained. 1. The shear bond strength of Dyract AP to Z250 were higher than those of F2000, but there was no statistically significant difference between group 1 and group 3(p>0.05), and groups using fresh compomers showed higher bond strength than those using aged compomers(p<0.05). 2. After measuring the shear bond strength of each group, it was highest in group 5 and was lowest in group 9(p<0.05). 3. Although there was no statistically significant difference, groups treated with thermocycling showed lower bond strengths than those of non-thermocycling groups. 4. Overall compomer/composite resin failures were adhesive. Cohesive failures occurred mainly in groups using bonding agent. Based on these results, the application of a bonding agent on fresh polyacid-modified resin composite increases the bond strength between polyacid-modified resin composite and composite resin. Additionally, the surface of aged polyacid-modified resin composite has to be roughened mechanically and a bonding agent has to be used in combination with composite resin.

      • 정신보건관련인력의 정신질환자에 대한 태도 연구

        사공정규,송창진,손인기 東國大學校 2000 東國論叢 Vol.39 No.-

        Attitudes of the health personnel toward the mentally ill affect the development and utilization of the community mental health program and reintegration of the mentally ill into society. Therefore the authors carried out a survey of attitudes toward mentally ill in the health personnel by measuring Community Attitudes to the Mentally Ⅲ Inventory(CAMI). The purpose of this survey was to get basic data to develop plan and strategy of community mental health in Pohang city. The results were as follows : (1) The health personnel of Pohang community showed positive attitude of 'Benevolence' and 'Community mental health ideology' and negative attitude of "Authoritarianism' and 'Social restrictiveness'. Therefore community mental health project in Pohang city will be established and activated easily. (2) The male group had more authoritative, less community mental health oriented attitude. (3) the more aged group had more authoritative, social restrictive attitude. (4) the unmarried group had less authoritative, social restrictive attitude. (5) The lower educated group had more authoritative, social restrictive and less benevolent, community mental health oriented attitude. (6) Monthly income 1-2 million Won group had more authoritative, social restrictive attitude, less community mental health oriented attitude. (7) The respondents who have never met mentally ill had less community mental health oriented attitude. (8) The respondents who themselves had used mental health services more benevolent, less authoritative, social restrictive attitude. From the above results, authors propose that planning of mental health project be necessary containing information and education for negative group and making resource for positive attitude group.

      • 위암세포에 의한 종양침윤 림프구의 면역반응 억제기전에 관한 연구

        박정규,송규상,서광선,최정목,배진선,장일성,윤완희,노승무,조은경,백태현 大韓免疫學會 1995 大韓免疫學會誌 Vol.17 No.3

        Tumor-infiltrating lymphocytes ('1°ILs) interact most closely with tumor cells and thus are more likely to reflect tumor host interactions accurately. But it is unknown whether such T cells are nonspecific inflammatory cells or a subset of specific host immune responses. In this study, there was no clear correlation between the infiltration of T lymphocytes in stomach cancer and the overexpression of c-ErbB-2 or increasing class I MHC expression on tumor cells. A positive correlation was seen between the presence of TILs in the tumor and tumors with diploidy by flow cytometric DNA analysis. The proliferative responses of Ills stimulated with IL-2, anti-CD3 mAb, or both were examined. When compared to normal mucosal-associated lymphoid tissue lymphocytes, the proliferative response of TILs to high dose IL-2 was minimal. A similarly poor response to anti-CD3 mAb plus IL-2 was also observed. The freshly isolated TILs exhibit reduced ability to proliferate in response to IL-2, anti-CD3 mAb or both. The microenvironment of the tumor suppresses the proliferative capacity of the TILs. The mechanism of this suppression remains unknown. It could be mediated by suppressor cells, by soluble substances within the tumor, or both. To examine this question, supernatants of stomach cancer cells (SNSNU-1) were tested for the presence of immunosuppressive factors. Human peripheral blood T-cells and tumor-draining lymph node lymphocytes (TDLNL) were incubated for 3 days with SNSNU-1 and then assessed for proliferative responses to PMA, anti-CD28 mAb, or both and for the inducibility to express IFN- r or IL-4 mRNA to PMA. Peripheral blood T-cells pretreated with SNSNU-1 were unable to proliferate in response to PMA, anti-CD28 mAb or both. SNSNU-1 also produces inhibitory activities of TDLNL proliferative response to PMA or anti-CD28 mAb and PMA (49%, 52%, respectively). In contrast, culture supernatants obtained from HEp-2, K562 or Daudi showed normal proliferative responsiveness of peripheral blood T-cells and TDLNL by PMA, anti-CD28 mAb or both.

      • HL-60 세포주를 이용한 결핵균항원의 세포성면역반응의 분석

        박정규,강윤중,김운옥,임재현,송창화,조은경,김화중 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

        Most persons who become infected with M. tuberculosis mount a protective immune response and remain clinically well, the only evidence of infection being development of a positive tuberculin skin test. Five to 10% develop tuberculosis disease within the first 2 years after infection (primary tuberculosis) or thereafter (reactivation tuberculosis). Acquired resistance against tuberculosis paradigmatically rests on cell-mediated immunity, with the major factors being mononuclear phagocytes and T Lymphocytes. While the former cells act as the principal effectors, the latter ones serve as the predominant inducers of protection. The usefulness of the single dose of BCG routinely given in childhood in many developing countries in preventing far more commonly occurring tuberculosis in adults is in doubt. An effective and safe vaccine against tuberculosis is sorely needed. A subunit vaccine are capable of inducing protective immunity and could have substantial advantages over BCG or other whole-bacterium vaccines. The human promyelocytic cell line HL-60 adopted characteristic macrophage-like properties, including adherence and CD14 expression after a period of continuous culture at high ambient CO_(2) concentration. When HL-60 cells were cultured with 1,25-dihydroxyvitamin D_(3) for 4 days, the cells acquired the activity to potentiate T cell proliferation by the 30 kDa or 38 kDa antigen of Mycobacterium tuberculosis H37Rv Therefore, vitamin D-treated HL-60 cells showed the function of the antigen presenting cells.

      • 대학생들의 자기이미지가 의복 혁신성과 동조성에 미치는 영향

        서민정;김연희;윤송이;서문숙;이규혜 한양대학교 2008 韓國 生活 科學 硏究 Vol.28 No.1

        The purpose of this study was to examine self images as antecedents of clothing innovativeness and conformity. A survey questionnaire was made for the empirical research. 206 university students living in Seoul metropolitan area participated in the study. The data were analyzed using factor analysis, Chi-square, t-test, ANOVA, and stepwise regression. The self image measures were classified six factors (free, affirmative, self-centered, traditional, sensual, and feminine image). According to regression analysis, fashion innovativeness was affected by free, traditional, sensual image, and conformity was only influenced by traditional image. Respondents were classified into four groups by innovativeness and conformity scores; Low innovativeness/Low conformity group(LI/LC), Low innovativeness/High conformity group(LI/HC), High innovativeness/Low conformity group(HI/LC), and High innovativeness/High conformity group(HI/HC). For LI/LC consumers, innovativeness was affacted by the sensual self image. For LI/HC consumers, and innovativenss was affected by the feminine self image. The conformity of HI/LC were influenced by traditional self image.

      • 결핵균 30 kDa 항원과 Triton X-100 Solubilized Protein 항원에 의한 대장암 주변 림프절 단핵구의 활성화

        박정규,김광호,조은경,임재현,민들레,송영자,김화중,백태현 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

        Tumor-draining lymph node mononuclear (TDLMN) cells are specifically sensitized to the growing tumor but such cells are deficient for mediating an antitumor response. In this study, we examined the feasibility of using mycobacterial 30 kDa or Triton X-100 solubilized protein (TSP) antigen to stimulate mononuclear cells of colon cancer-draining lymph node for the generation of cell mediated immune effector cells. The proliferative response of TDLMN cells stimulated with mycobacterial 30 kDa or TSP antigen was determined by ^(3)H-thymidine incorporation assay. The proliferation of TDLMN cells to mycobacterial 30 kDa or TSP antigen was significantly increased in PPD (+) patients, but a poor response to the 30 kDa or TSP antigen was observed in PPD (-). The expression on γδ T cells to mycobacterial 30 kDa or TSP antigen was assessed by flow cytometry. The γδ T cells from PPD ( + ) patient responded only to 30 kDa antigen but to TSP antigen. An investigation of cytokine mRNA expression was undertaken using reverse transcription-polymerase chain reaction (RT-PCR) to follow TDLMN cells stimulated with the 30 kDa or TSP antigens for 5 days. The IFN-γ and TNF-α mRNA expression was only induced in TDLMN cells of PPD ( + ) patient in response to the 30 kDa or TSP antigen. The IL-2 mRNA expression was induced in both PPD (+) and PPD (-) in response to the 30 kDa or TSP antigen. But the IL-4 mRNA expression was not induced in response to the 30 kDa or TSP antigen. These results suggest that the 30 kDa and TSP antigens may serve as biologic response modifier for the generation of cell mediated immune effector cells.

      • Vitamin D_(3)가 RAW 세포에 감염된 Mycobacterium marinum의 증식억제에 미치는 기전 연구

        박정규,정샛별,이길수,김수영,송창화,박종호,조현구,조은경,김화중 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

        The natural resistance-associated macrophage protein 1(Nramp1) has been proposed to directly regulate bactericidal or bacteriostatic activity of the macrophage toward pathogens or participate in macrophage activation that lead to microbial elimination in the host. The relationship between Nramp1 and nitric oxide(NO) as an antimicrobial factor has not been precisely defined to date. To devise an in vitro assay for Nramp1 function, this study introduced a wild type Nramp1^(G169) cDKA transfected RAW264.7 macrophages(A8) which bear a homozygous mutant Nramp1^(D169) allele and are permissive to replication of specific intracellular parasites. RAW264.7 and A8 macrophages did not produce NO, but vitamin D_(3)-activated-Mycobacterium marinum-infected RAW264.7 and A8 macrophages pretreated with vitamin D_(3) leaded to the increase of NO production and growth inhibition of M. marinum. Inhibition of NO production by a NO inhibitor, L-NAME, abolished the above effects. The mRNA expression of iNOS in infected macrophages with costimulated vitamin D_(3) was increased. IFN-γ activated macrophages also showed the same results with vitamin D_(3) activated macrophages. These results suggest that bactericidal or bacteriostatic activity in RAW264.7 and A8 macrophages correlated with the production of NO, although NO might not be the only factor responsible for controlling M. marinum infection. The Nrampl gene is considered to be a cofactor in the controlling the replication of M. marinum infection.

      • SCOPUSSCIEKCI등재

        지방척수수막류 14례의 임상 분석 : Clinical Analysis of 14 Cases

        이정호,신규만,김명현,송준혁,박향권,김성학,박동빈 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.6

        Lipomyelomeningocele is the most common malformation leading to spinal cord tethering. Nonetheless, these lesion continues to pose a challenge in patient management. The purpose of this study was to identify the clinical feature, candidate for surgical repair, and outcome of lipomyelomeningocele in young children and adults. We studied the magnetic resonance images and/or lumbar myelo-CT of lipomyelomeningocele performed between January 1987 and September 1995 at our institutions and reviewed the pertinent medical records and radiologic studies to determine clinical feature, surgical candidate, and outcomes of these patients. Of the 14 cases(11 female and 3 males) studied, the most common factor that caused these patients to seek help was the cosmetic effect of the mass on their back, followed by urinary incontinence, and weakness of lower extremities. The patients' age ranged from 2 months to 21 years(mean, 5.0 years). All the patients underwent immediate surgical management that consisted of removal of lipoma, untethering of the cord, and complete dural sac repair. Follow up for these patients ranged from 6 to 82 months(median, 54 mo). None of the patients that underwent surgical correction before the emergence of neurological deficit had ever developed neurological deficits at the end of the follow up. However a few of the patients, despite presented with neurological deficits or urinary incontinence at the time of surgery, improved significantly. In conclusion, early detection and prophylactic surgery is imperative to prevent permanent neurological deficits and urinary dysfunction.

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