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조선,류소연,박종,강명근,김은숙,김형철,박광희,윤혜은,노희송 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2
Objectives: This study was performed to find the association of cigarette smoking and blood lipid profiles in healthy young adults. Methods: The data was collected by a self-administered questionnaire and health examination in 489 professional soldiers from 6 to 12 May, 2004. The status of cigarette smoking was classified by non-smoking, ex-smoked, ≤4.9, 5-9.9, and ≥10 pack-years. The statistical analysis were used by chi-square test, analysis of variance and analysis of covariates. Results: In status of subjects cigarette smoking, current smoking, ex-smoked, and non-smoking were 71.8%, 11.2%, and 17.0%, respectively, In distribution by amount of smoking, non-smoking, ex-smoked, ≤4.9 pack-years, 5-9.9 pack-years, and ≥10 pack-years were 17.0%, 11.2%, 37.4%, 21.3%, and 13.1%, respectively. At other confounding variables were controlled, total cholesterol and LDL-cholesterol were increased significantly when amount of smoking was increased. However, triglyceride and HDL-cholesterol did not showed statistically significant differences, Conclusion: Smoking has relevant to total cholesterol and LDL-cholesterol and it is need to perform the further study for finding how blood lipid profiles are affected its level by cigarette smoking and to find an influence of cigarette smoking on cardiovascular disease.
박혜연,전소분,김선아,정금선,조종기,송근호,이영원 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-
A two years old intact female Minature Schnauzer was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with an intermittent seizure by traffic accident. No specific finding was found by radiography and computer tomography (CT). Hematologic and blood chemical examination revealed that PCV (62.5%), BUN (72.6 mg/dl), CK (1769 U/l), ALT (169 U/l) and ALP (353 U/l) were increased. This dog was recovered by medical treatment.
Perspectives of Integrative Cancer Genomics in Next Generation Sequencing Era
Kwon, So-Mee,Cho, Hyun-Woo,Choi, Ji-Hye,Jee, Byul-A,Jo, Yun-A,Woo, Hyun-Goo Korea Genome Organization 2012 Genomics & informatics Vol.10 No.2
The explosive development of genomics technologies including microarrays and next generation sequencing (NGS) has provided comprehensive maps of cancer genomes, including the expression of mRNAs and microRNAs, DNA copy numbers, sequence variations, and epigenetic changes. These genome-wide profiles of the genetic aberrations could reveal the candidates for diagnostic and/or prognostic biomarkers as well as mechanistic insights into tumor development and progression. Recent efforts to establish the huge cancer genome compendium and integrative omics analyses, so-called "integromics", have extended our understanding on the cancer genome, showing its daunting complexity and heterogeneity. However, the challenges of the structured integration, sharing, and interpretation of the big omics data still remain to be resolved. Here, we review several issues raised in cancer omics data analysis, including NGS, focusing particularly on the study design and analysis strategies. This might be helpful to understand the current trends and strategies of the rapidly evolving cancer genomics research.
서울 시내 4년제 남자 대학생의 우울과 흡연량, 흡연기간, 니코틴 의존도와의 관계
박지영,박소영,이미숙,백수진,신의경,예혜련,오승진,장윤정,조혜진,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37
Background: With reports on the relation between smoking and depression appearing since 1980, it has become clear that depression is one of the psychodynamics of smoking, though there has been little or no progress made in the study of whether or not there is indeed a relation between depression and nicotine dependence. Purpose: The purpose of the study was to investigate the effects of depression on the amount and period of smoking and nicotine dependence among university man student smokers. Method: In periodical examination between 14 and 21, May, 2003, using 170 university male. The CES-D(Center for Epidemiologic Studies Depression) Scale and the FTQ(Fagerstrom Tolerance Qustionnaire) were utilized to measure the level of depression and nicotine dependency. The amount of smoking was calculated based on the number of cigarette used. Result: Results indicated that depression had something to do with amount of smoking. Nicotine dependence also was related to depression but total value was relatively low. finally the period of smoking had nothing to do with depression. Conclusion: The results of this study revealed that the amount of smoking of university man student smokers was very high. Both the amount of smoking and nicotine dependence were affected by levels of depression. Accordingly psychiatric nursing access such as emotional support is needed to manage depression and decrease smoking.
20대 여성의 정장의류 상표군 선호도와 구매시 평가기준
권수애,장현주,한정혜,조소영,손지희,김선화,안경은 충북대학교 교육 ·생활연구소 생활과학연구센터 2002 생활과학연구논총 Vol.6 No.2
This study is to analyze the compitition structure and the brand image of the formalwear and the preferance of the brand group among the age of 20's females. The 207 samples of 20's females who live in Cheong-Ju city. The results of this study are followed as: The market competition structre appeared in positioning map have been constituted into four groups of the "Tomboy y'sb","lollol·selly·besti-belly","VOV·o.z.o.c·Joinus",EnC·i.n.v.u". The brand-trasfer of each group may easily be taken place as each compition among these groups was much feeble. By investigating the image of the formalwear brands appeared in positioning map, it may be presented that horizontality dimrnsion is "cute-ellegance image", and verticality dimension is "mannish-feminine image". Group Ⅳ such as EnC·i.n.v.u is brand which are prefered and purechaseed by the age of 20's females, whereas the preferance and puechase of brand such as VOV·o.z.o.c·Joinus.
엄민식,박원우,서승철,이진호,조주연,최혜영,이찬희,임소덕 白中央醫療院 2005 仁濟醫學 Vol.26 No.1
Relapsing polychondritis is an uncommon multisystemic disease which is characterized by recurrent episodes of inflammation and progressive destruction of cartilaginous tissue. The cause of relapsing polychondritis is unclear and suspected to be autoimmune pathophysiology. It involves cartilage of nose, vertebra, trachea, peripheral joint as well as structures of eye, heart, blood vessels or inner ear. Auricular chondritis is present in almost all patients, and multiple arthritis, nasal chondritis, saddle nose, eye involvement, laryngotracheal involvement and skin manifestations are also present. We report a case of relapsing polychondritis presented a arthritis with review of literatures.
김민경,이인환,신애숙,김나희,김혜미,심소라,나병조,조승연,박성욱,정우상,문상관,박정미,고창남,조기호,김영석,배형섭,Kim, Min-kyung,Lee, ln-whan,Shin, Ae-sook,Kim, Na-hee,Kim, Hye-mi,Shim, So-ra,Na, Byung-Jo,Cho, Seung-yeon,Park, Seong-uk,Jung, Woo Sang 대한중풍순환신경학회 2010 대한중풍.순환신경학회지 Vol.11 No.1
Object : This study was conducted as part of the national project to standardize stroke diagnosis in Korean medicine. In this study, we aimed to evaluate the characteristics of acute stroke between heat pattern group and cold pattern group. Methods : We recruited stroke patients from 5 universities(Kyung-Hee University oriental medical center, Kyung-Hee University East-West Neo medical center, Kyungwon university lncheon oriental medical center, Kyungwon university Songpa oriental medical center and DongGuk university llsan oriental medical center) from April, 2007 until February, 2010. We diagnosed them and selected 463 heat pattern patients and 182 cold pattern patients. Results : We find that the risk factor of smoking, alcohol, diet(prefer to meat) are more associated with the heat pattern group. On the other hand, inflammation history in recent 3 months and diet(prefer to sea food) are more associated with the cold pattern group. RBC, Hg, Hct, TG, CK and Cl are more related to the heat pattern group. CPT, total cholesterol and HDL are more related to the cold pattern group. Tae-eum type takes high distribution of the heat pattern group, and So-eum type takes high distribution of the cold pattern group. Conclusions : This study provides evidence that the heat pattern group have more risk factor than the cold pattern group.
( Hye Jeong Cho ),( Hee Jin Hong ),( So Dam Hong ),( Jae Kyoung Shin ),( Bo Hye Kim ),( So Young Chong ),( Do Youn Oh ),( Ji Su Oh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Metastatic lesions to the oral region are uncommon and account for 1% of all malignancies of the jaw. The current study describes a rare case of a 74-year-old woman who presented with a painful swelling of right facial area. She was a non-smoker and the family history was unremarkable. Computed tomography (CT) and magnetic resonance imaging (MRI) of neck showed about 5.5*5cm sized mass in the right mandible condyle and ramus with total destuction of condyle and invasion into right masseter and lateral pterygoid muscle. It looked like osteosarcoma. Sono-guided biopsy of the mass was performed. The results of the tissue indicated well-differentiated adenocarcinoma. Immunohistochemical (IHC) analysis showed positive for cytokeratin 7, thyroid transforming factor 1 but negative for cytokeratin 20, vimentin. A contrast enhanced chest CT, which was performed to detect the primary cancer, revealed about 4.2cm sized mass in left upper lobe lingular segment and left lower lobe anterobasal segment. The results of IHC stain and images favored metastatic adenocarcinoma from the lung. Moreover, activating mutation of epidermal growth factor receptor (EGFR) was detected (c.2573T>G (p.L858R) in exon 21). Subsequent PET-CT also confirmed other metastatic disease in left humeral head and neck, right level II cervical lymph nodes, and right lower paratracheal lymph node. This case indicates that possible metastatic disease should be suspected in patients presenting with a mandibular mass or swelling although metastatic mandibular tumor is even rare. Because their diagnosis may be the first indication of an undiscovered malignancy at a distant primary site, the clinicians need to pay attention to this point, and evaluate patients who present unusual clinical symptoms thoroughly.
( So Dam Hong ),( Hye Jeong Cho ),( Jae Kyoung Shin ),( Hee Jin Hong ),( Bo Hye Kim ),( So Young Chong ),( Do Youn Oh ),( Ji Su Oh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
The incidence of metastases to the thyroid gland demonstrates a 1% in unselected autopsy series to 25% in patients with widespread metastatic lesions. Most recurrent uterine cervical cancer patients have metastatic lesions in intra-pelvis and adjacent lymph node involvement, while a distant metastasis alone is extremely rare. We report a case of a 79-year-old woman with recurrent uterine cervical cancer, presenting thyroid mass without intra-pelvic recurrence four year after initial curative treatment. 4 years ago, the patient was diagnosed uterine cervical cancer (invasive squamous cell carcinoma, non-keratinizing type). She had undergone a course of concurrent chemoradiotherapy to the pelvis. She had lived without any other symptoms and evidence of recurrence for 4 years. Several weeks ago she had noticed foreign body sensation in throat, a palpable mass in the left side of her neck and a swelling in the region of the thyroid gland. Sono-guided biopsy of thyroid mass was performed and revealed metastatic squamous cell carcinoma, clinically from the uterine cervix. She had undergone total thyroidectomy and treated with 4 cycles of chemotherapy and radiotherapy. We conclude that patients who present swelling or palpable nodules in the thyroid side and have a history of a previous malignancy must be considered for metastatic disease although metastasis from the uterine cervical carcinoma to the thyroid gland is even rare.