이공의 위치 및 형태에 관한 방사선학적 연구

손정익 경북대학교치과대학 1995 慶北齒大論文集 Vol.12 No.2

방사선조사에 따른 백서 악하선내 혈관 내피세표 미세구조의 조기변화

손정익,최갑식,류정수,배용철 大韓口腔顎顔面 放射線學會 1995 Imaging Science in Dentistry Vol.25 No.1

The purpose of this study was to investigate the early irradiation changes on the ultrastructure of the capillary endothelial cell in the rat submandibular glands. For the study, 110 Sprague-Dawley strain male rats were singly irradiated to their neck regions with the doses of 2Gy, 5Gy, and 10Gy by 6MV X-irradiation, and sacrificed on the 3 hours, 6 hours, 12 hours, 1 day, 3 days, 7 days, and 14 days after irradiation. The authors observed the histologic and ultrastructural changes of the capillary endothelial cell using the light and electron microscopes. The results were as follows: 1.In the light microscopic examination, the capillary dilation was observed on the 6 hours group and the capillary density was slightly increased on the 12 hours group after 2Gy and 5Gy irradiation. And luminal size and capillary density were decreased on the 3 days and the 7 day groups after irradiation, after then, they were recovered. But capillary density was still decreased on the 14 days group after 10Gy irradiation. 2.In the transmission electron microscopic examination, the mild proliferation of cytoplasmic process of the endothelial cell and reduction in luminal size were observed on the 3 hours group after irradiation. After then, endothelial swelling, marked proliferation of cytoplasmic process, thickened basal lamina, and numerous pinocytotic vesicles were observed after the 1 day group after irradiation. Thickened basal lamina and numerous pinocytotic vesicles were still observed until the 7 days group after irradiation. These changes were recovered to normal on the 14 days group after 2Gy and 5Gy irradiation, but not after 10Gy irradiation. 3.In the scanning electron microscopic examination, the dilation of conduits and constriction, and meandering were observed on the 1 day group after 10Gy irradiation. These changes were observed with increased coarseness of the surface of the vascular resin casting on the 3 days group after irradiation. 4.From the above results, endothelial swelling, proliferation of cytoplasmic process, and thickening of the basal lamina appeared before the 6 hours group after irradiation. And these changes may also induce the increase of the capillary number and luminal size, after then, capillary permeability was increased via the increase of the number of pinocytotic vesicles. The changes were observed earlier and more apparent with the increase of the irradiation doses under the dose of 10Gy irradiation.

결체증식성 법랑모세포증

손정익,최갑식,김동윤 大韓口腔顎顔面 放射線學會 1995 Imaging Science in Dentistry Vol.25 No.1

Desmoplastic variant of ameloblastoma is a new and unusual variant of ameloblastoma with extensive stromal desmoplastic proliferation. The authors experienced a case of desmoplastic variant of ameloblastoma with moderate-defined radiolucency on the right maxillary anterior area in 62-year-old female. As a result of careful analysis of clinical, radiological, histopathological examinations, we diagnosed it as desmoplastic variant of ameloblastoma, and the following results were obtained : 1. Main clinical symptoms were nontender bony swelling with normal intact overlying mucosa on the right maxillary anterior area. 2.Radiographically, moderate-defined, multilocular radiolucency on the right maxillary anterior area were shown, and severe cortical bony thinning and expansion to labial and palatal sides were also observed. And this lesion was shown to be extended to the right nasal cavity. 3.Histopathologically, follicle-like epithelial island with densely abundant collagenous stroma were morphologically compressed.

파노라마방사선사진상의 이공에 관한 연구

배용철,손정익,최갑식,김동윤 大韓口腔顎顔面 放射線學會 1997 Imaging Science in Dentistry Vol.27 No.1

22세에서 25세의 남녀 각각 100명씩 200명을 대상으로 표준 위치에서 촬영된 파노라마 방사선사진사에서 이공의 정상적 형태 및 위치를 분석하고, 다시 남녀 각각 50명씩 100명을 선별하여 두부를 10mm 전방 이동, 10mm 후방이동, 10˚하방 이동, 그리고 10˚상방 이동시킨 후 촬영된 각각의 파노라마 방사선사진상에서 피사체의 위치변화에 따른 이공의 형태 및 수평, 수직적 위치의 변화를 평가하여 다음과 같은 결과를 얻었다. 1. 이공의 형태는 elliptical형(43.3%), round 또는 oval형(42.5%), unidentified형(7.5%), diffuse형(6.7%)의 순으로 관찰되었다. 2. 이공이 치아에 대한 수평적 위치는 제2소구치부위(54.2%)와 제1소구치와 제2소구치 사이(43.1%)에서 대부분 관찰되었으며, 제2소구치와 제1대구치 사이(2.7%)의 순으로 관찰되었고, 제1소구치 부위, 견치와 제1소구치 사이, 제2대구치 부위에서는 관찰되지 않았다. 3. 이공의 수직적 위치는 치근단 하방(88.2%)에서 대부분 관찰되었으며, 치근단에 접하는 경우(9.7%), 치근단과 겹쳐 나타난 경우(1.9%), 치근단에 비해 상방에 위치하는 경우(0.2%)의 순으로 관찰되었다. 4. 피사체 두부 위치의 변화에 따른 이공의 형태변화는 표준 위치에서 나타난 결과와 비교해 볼 때 표준 위치에서 두부를 10mm 전방 이동시킨 위치에서 unidentified 형(9.0%)이 증가하였고, 두부를 10mm 후방 이동시킨 위치와 피사체의 턱을 10˚상방 이동시킨 위치에서는 round 또는 oval형 (57.5%, 52.5%)이 각각 증가하였으며, 피사체의 턱을 10˚하방 이동시킨 위치에서는 diffuse형(3.5%)이 감소한 것외에는 표준위치에서 나타난 결과와 유사하였다. 5. 피사체 두부 위치의 변화에 따른 이공의 수평적 위치의 변화는 표준 위치에서 두부를 10mm 전방 이동시킨 위치에서 제1소구치와 제2소구치 사이에 위치한 경우(35.2%)가 감소한 반면 제2소구치와 제1대구치 사이에 위치한 경우(8.8%)는 더 많이 관찰되었으며, 두부를 10mm 후방 이동시킨 위치와 피사체의 턱을 10˚상방 이동시킨 위치에서는 제2소구치와 제1대구치 사이에 위치한 경우(6.1%, 7.5%)가 더 많이 관찰되었으며, 피사체의 턱을 10˚하방 이동시킨 위치에서는 표준 위치에서 나타난 결과와 유사하였다. 6. 피사체 두부 위치의 변화에 따른 이공의 수직적 위치변화는 치근단에 비해 하방에 위치한 경우가 약 90%로 대부분이었으며, 치근단에 접하는 경우, 치근단과 겹쳐 나타난 경우의 순으로 관찰되었으며, 치근단에 비해 상방에 위치하는 경우는 관찰되지 않았다. The purpose of this study was to evaluate the position and shape of mental foramen in panoramic radiographs. For this study panoramic radiographs were obtained from the 200 adults and evaluated the position and shape of mental foramen. According to various positional changes in panoramic radiographs of the patients. the author also obtained panoramic radiographs from the 100 adults and then evaluated the positional and shape changes of mental foramen. The following results were obtained: 1. Shapes of mental foramen were observed elliptical(43.3%), round or oval(42.5%), unidentified(7.5%) and diffuse(6.7%) type in descending order of frequency. 2. Horizontal position of mental foramen were most frequently observed at the 2nd premolar area(54.2%), and area between the 1st premolar and 2nd premolar(43.1%), area between the 2nd premolar and 1st molar(2.7%) in descending order of frequency. 3. Vertical position of mental foramen were most frequently observed at the inferior of apex(88.2%), and at apex(9.7%), overlap with apex(1.9%), superior of apex(0.2%) in descending order of frequency. 4. According to various positional changes in panoramic radiographs of the patients shape changes of mental foramen were more obviously observed at the forward 10mm and chin down 10˚positioned panoramic radiographs. And changes of horizontal and vertical position were observed in similar to compared with normal positioned panoramic radiographs.

방사선조사에 따른 구개점막상피의 형태학적 변화에 관한 실험적 연구

이강숙,손정익,최갑식,안상희 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.2

The purpose of this study was to investigate the irradiation effects on the palatal mucosa. For this study, Sprague-Dawley strain rats were irradiated to their head and neck region with the dose of 5Gy and 10Gy by 6MV X-radiation and sacrificed on the experimental periods after irradiation. The authors observed the histological changes of the hard and soft palatal mucosae. The results were as follows: In the light microscopic examination, hydropic change on the basal cells, increased cell size of the epithelium, and decreased epithelial cell layers were observed on the 3hours, 6hours, and 12hours groups after irradiation. But, basal cell hyperplasia, increased epithelial cell layers, and elongated rete pegs were observed on the 3days group after irradiation. After then, these changes were recovered in the mucosa of the hard palate on the 7days and 14days groups, and in the mucosa of the soft palate on the 14days and 28days groups after irradiation. And such changes were greater in the mucosa of the soft palate than in that of the hard palate, and more prominent in 10Gy irradiated groups than in 5Gy irradiated groups.

다발성 골수종

최갑식,하춘호,손정익 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.1

Multiple myeloma is a malignant plasma cell tumor that is thought to originate proliferation of a single clone of abnormal plasma cell resulting production of a whole monoclonal paraprotein. The authors experienced a case of multiple myeloma with severe mandibular osteolytic lesions in 46-year-old female. As a result of careful analysis of clinical, radiological, histopathological features, and laboratory findings, we diagnosed it as multiple myeloma, and the following results were obtained ; 1. Main clinical symptoms were intermittent dull pain on the mandibular body ares, abnormal sensation of lip and pain due to the fracture on the right clavicle. 2. Laboratory findings revealed M-spike, reversed serum albumin-globulin ratio, markedly elevated ESR and hypercalcemia. 3. Radiographically, multiple osteolytic punched-out radiolucencies were evident on the skull, zygoma, jaw bones, ribs, clavicle and upper extremities. Enlarged liver and increased uptakes on the lesional sites in RN scan were also observed. 4. Histopathologically, markedly hypercellular marrow with sheets of plasmoblasts and megakaryocytes were also observed.

방사선조사가 악하선 미세혈관과 내피세포에 미치는 영향에 관한 실험적 연구

최갑식,최미,손정익,유영아,배용철 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.1

The purpose of this study was to investigate the irradiation effects on the capillary and endothelial cell in the submandibular gland. Sprague-Dawley strain male rats were singly irradiated to their neck region with the dose of 5Gy and 10Gy by 6MV X-irradiation and sacrificed on the 6 hours, 12 hours, 1,3,7, and 14 days after irradiation. The authors observed the histological changes of the capillary at H & E and PAS staining under a light microscope, and also observed the ultrastructural changes of the endothelial cell using a transmission electron microscope. The obtaining results were as follows: 1. In the light microscopic examination, the capillary density was slightly increased on the 1 day after irradiation, and increased until the 7 days after irradiation. After then, capillary density was apparently decreased. 2. The reaction to PAS staining at acinar cells was decreased on the 6 hours after irradiation, and recovered on the 7 days after irradiation. But reaction was decreased on the 14 days after irradiation again, after then, gradually recovered with days. 3. In the transmission electron microscopic examination, mild proliferation of cytoplasmic process of the endothelial cell and reduction in luminal size were observed just after irradiation. After then, nuclear degeneration, marked proliferation of cytoplasmic process, thickened basal lamina, and numerous cytoplasmic vesicles were observed on the 1 day after irradiation. These changes were recovered to normal on the 14 days after 5GY group, but not with 10GY irradiation group. And destruction of endothelial cell and loss of basal lamina were not observed in both groups. 4. From the above results, reduction in luminal size, proliferation of cytoplasmic process and thickening of basal lamina were observed as the irradiation effects on the capillary and endothelial cell of the submandibular gland. And also, these changes may induce increase in capillary number and endothelial permeability by means of increase of cytoplasmic vesicle formation. The changes appeared earlier and more prominent in 10Gy irradiated group than in 5Gy irradiated group.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Intravenous and Intra-arterial Delivery of Plasmid DNA/Cationic Lipiodol Emulsion Complexes

Jeong Seo Young,Sohn Young Taek,Park Jae Hyung,Chung Jin Wook,Kwon Ick Chan,Chung Hesson,Chae Min Jung 大韓藥學會 2003 大韓藥學會 總會 및 學術大會 Vol.2003 No.2

Cyclo(Dehydrohistidyl-L-Tryptophyl), an Inhibitor of Nitric Oxide Production from a Fungal Strain, Fb956

( Hyun Jeong Noh ),( Mi Jin Sohn ),( Hyung Eun Yu ),( Ick Dong Yoo ),( Won Gon Kim ) 한국미생물생명공학회 2007 Journal of microbiology and biotechnology Vol.17 No.10