자궁내 태아사망의 임상적 고찰

이권해,이정재,조현철,이석민,이임순,이해혁,김권대,이순곤,남계현 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Objective: This study was designed to evaluate diagnosis and complication, prognosis during clinical study of cases of intrauterine fetal death. Methods and materials: This is a clinical study of 56 cases of the intrauterine fetal death among 8064 deliveries at Seoul Sunchunhyang university hospital during 5 years from January, 1994 to December, 1998. Results: The incidence was 0.7%. The age distribution of mothers was 18 - 44 years and was highest in the 25 - 29 years range(46.4%). The parity was the most highest in the nulliparous group(51.8%). The most common gestational weeks was 20 - 28 weeks gestational period(46.4%), and most common presentation was cephalic(73.5%). The most common weights of the intrauterine fetal death was from 5,00gm to 1,000g(48.2%). The mode of the most common delivery was the induction of delivery(57.2%). The etiologic factors were: unknown(42.9%), preeclampsia(17.9%), chorioamnionitis(14.3%), congenital anomaly(12.5%), abruptio placenta(7.1%), cord complication(3.6%), placenta previa, death of one for twin. There were 2 cases of maternal complication(DIC, Uterine atony). Conclusion : Intrauterine fetal death should be diagnosised early and treated properly to reduce risk of the maternal complication.

위에 발생한 유암종 (Carcinoid Tumor) : 1예 보고

김남재,김진희,이경태,서광식,정현용,이승민,김석현,이병석,이헌영 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.3

A carcinoid tumor of the stomach is uncommon, has no clinical symptoms, and is regarded as a benign. It is also incidentally found in most cases. 48-year-old woman with gastric carcinoid tumor was admitted. She had suffered from a anorexia and a dry mouth for 4-months. A gastroscopy revealed a polypoid mass on the greater curvature of the mid-body of the stomach which was subsequently thought to be an adenocarcinoma. An endoscopic mucosectomy revealed however, that it was a carcinoid tumor. A case of carcinoid tumor of the stomach is here by presented with a brief literature review.

조산의 예측 지표로서의 fetal fibronectin의 유용성

정집광,이해혁,이정재,이석민,이순곤,남계현,이임순,이권해 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Objective: The purpose of this study was to evaluate clinical efficacy of fetal fibronectin as a marker to predictor of preterm labor. Materials & Methods: The study group consisted of sixty-eight healthy pregnant women, at gestational age between 24 and 36 weeks, who visited our department with vaginal discharge from April, 1995 to December, 1997. For comparison, we divided all of the pregnant women into two groups by the result of ROM-Check^®, positive groups(N=21) and negative groups(N=47). When preterm labor appeared, 50mg of ritodrine hydrochloride(Yutopar^®) mixed I liter of 5% dextrose solution was administered slowly intravenously. Results: 1) The gestational age at delivery and the interval time from admission to delivery in the positive groups were significantly shorter than those of the negative groups(p<0.05). 2) The positive groups had significantly lower birth weight and Apgar scores than the negative groups(p<0.05). 3) Among the negative groups, in case of tocolytics administration, the interval time from admission to delivery significantly delayed more than that time in case of no tocolytics administration(p<0.05). Conclusions: The detection of the fetal fibronectin in vaginal discharge had a useful method as a predictor of preterm labor. Tocolytics was more effective in the negative groups than in the positive groups.

The Safety and Efficacy of Daclatasvir and Asunaprevir with Chronic HCV Genotype 1 Infection and Hemodialysis

( Myeong Jun Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Tae Hee Lee ),( Young Woo Kang ),( Ji Woong Jang ),( Seok Hyun Kim ),( Byung Seok Lee5 ),( Sea Hwan Lee ),( Hong Soo Kim ),( Ji Hoon Kim ),( S 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: We aimed to evaluate the efficacy and safety of Daclatasvir (DAV) and Asunaprevir (ASV) in patients with chronic hepatitis C virus (HCV) and chronic renal failure (CRF). Methods: 22 chronic hemodialysis patients with HCV infection at 12 medical centers have prospectively enrolled from Feb, 2016 to Feb, 2017 (NCT02580474). Of those, 9 patients who were followed 12 weeks after treatment ended were included. We evaluated the virological responses at each week 4, 12, 24 and the 12-week sustained virologic response (SVR12). The tolerability and safety of patients were also evaluated. Results: Of these 20 patients, there had no resistance-associated variant of NS5A (NS5A RAVs) and 2 patients showed indeterminate NS5A RAVs. 12 patients (54.5%) completed the 24 weeks treatment of DAV and ASV. 6 patients (27.2%) have continued, but 4 patients discontinued study prior to 12 weeks. Overall, all patients (n=9) achieved SVR12. Virologic response at week 4, 12 and 24 showed 94.4% (17/18), 93.3% (14/15), and 100% (12/12) respectively. DCV and ASV were well tolerated among the majority of patients and discontinuation of the treatment due to adverse events (hypertension, bradycardia, leukemia) was occurred in 3 patients. In two patients with indeterminate NS5A RAVs, one achieved SVR12 but the other showed viral breakthrough and discontinued treatment. Conclusions: In this study, DAV and ASV combination therapy for chronic hemodialysis patients with HCV infection achieved high sustained virological response with few adverse events. Close monitoring of safety and tolerability may be necessary when treating chronic hepatitis C patients with CRF receiving DCV and ASV.

자가 면역성 간염에서 자가항체의 발현 양상과 스테로이드 치료의 효과

박기오,채경훈,허원석,강윤세,정재훈,김연수,문희석,이엄석,김선문,이병석,김남재,이헌영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

목적 : 최근 8년간 본원에서 경험한 자기면역성 간염의 혈액학적 특징과 스테로이드의 치료효과를 알아보고자 본 연구를 시행하였다. 방법 : 1996년 이후부터 2002년까지 충남대학교 병원에서 1999년 International Autoimmune Hepatitis Group(LAHG)에서 제시한 수정 진단 기준안에 의거하여 총 진단점수가 probable 이상에 해당하는 환자들을 대상으로 임상적 특징, 검사실 및 조직 소견과 스테로이드와 azathioprine의 치료 효과를 후향적으로 조사하였다. 결과 : 9예의 환자들은 여성이 78%, 40대가 많았고, 급성 발병이 33.3%, 피로감, 식욕부진 및 황달 등이 나타났으며, 항핵항체가 55.6%에서 그리고 항평활근 항체가 77.8%에서 양성이었고, 동반 질환은 류마치스 관절염이 2예, 특발성 혈소판 감소증 1예, Henoch-Sch nlein 자반증 및 그레브스병이 각각 1예 씩이었다. 7예에 대해서 스테로이드와 azathioprine으로 치료하여 생화학적 임상적 완해가 이루어져서 유효한 치료 결과를 얻었다. 결론 : 자가면역성 간염은 우리 나라에서 원인을 찾을 수 없는 만성 간질환의 경우, 특히 중년여성에서 다른 자가면역성 질환이 동반되었을 때 자가면역성 간염을 의심하여 자가항체 선별검사를 시행해 보아야 할 것으로 생각된다. 향후 다기관 연구를 통하여 좀 더 많은 증례를 모으고 전향적인 연구를 시행하여야 할 필요가 있다. Although autoimmune hepatitis(AIH) is common in western contries, some studties have been reported in Korea. The aim of the study was to analyze the clinical and histological features and expression pattern of the autoantibody and to examine clinical course of AIH in Korea. For 9 patients diagnosed as having AIH in our hospital since 1996, we reviewed medical records and analyzed clinical and laboratory findings retrospectively. They had a probable or definite AIH according to the revised criteria of International AIH group. The mean age was 42.7(21∼68)years and 7(77.8%) were female. Three of them(33.3%) showed acute hepatitis and five of them showed cirrhosis. Fatigue and anorexia were the most frequently complained symptoms(55.6%). Four patients(44.4%) were accompanied with other autoimmune diseases. Antinuclear antibody was detected in 5(55.6%) and anti-smooth muscle antibody was detected in 7(77.8%). Three patients showed focal picemeal necrosis and four showed periportal fibrosis. Among 7 patients who received immunosuppressive therapy, six patients(85.7%) showed initial response. and biochemical and serologic remission were achived in 5(71.4%) and 3(42.8%) patients, AIH seems to be partly responsible for chronic liver disease of unknown etiology in Korea. AIH should be suspected in female patients with unknown chronic liver disease of unknown etiolgy, especially accompanied with other autoimmune disease. The clinical characteristics of AIH may not be quite different from those of Western countries.

液體種菌 接種에 의한 표고톱밥裁培 效果

이태수,민두식,조남석 충북대학교 농업과학기술연구소 1998 農業科學硏究 Vol.15 No.-

For cultivation on sawdust-bed of oak-mushroom until present time, inoculation of spawn on sawdust bed has been performed by sawdust spawn. But, liquid spawn may have advantages for rapid mass production of spawn, and now, sawdust-cultivation by liquid spawn inoculation should be applied instead of sawdust spawn. Therefore, investigations were performed to evaluate the effect of sawdust-cultivation by liquid spawn inoculation. The results were as follows : 1.When 11 kinds of liquid media were applied, the oak-mushroom culture medium was the most excellent in growth. Most suitable temperature at PDA was 25℃, and 22.5-27.5℃ in range were optimal for liquid culture. In liquid culture, amount of mycelial growth increases rapidly up to 40 days of cultivation. Incubation at fermentor brought yield of 106㎎ dry mycelia per 40㎖ media after 17 days. 2.In 1ℓ -spawn bottle, growth of mycelium by inoculation of 20㎖-liquid spawns were faster than 6g-sawdust spawn in spread of mycelia. On 2kg-bag culture, inoculations of 10㎖-, 20㎖- and 30㎖-liquid spawns were all slower than 20g-sawdust spawn in mycelial spread. So, amount increasement in ampunt of liquid spawn should be discussed. Yields of mushrooms until third sproutings of 2kg-bag culture were 580g in 30㎖-liquid spawn inoculation, but 510g, 486g and 470g from 20g-sawdust spawn, 20㎖-liquid spawn and 10㎖-liquid spawn, respectively. Thus, 30㎖-liquid spawn inoculation was highest in yield. Key words : oak-mushroom, sawdust-bed, liquid spawn.

비정형 기관지 유암종에 의한 이소성 ACTH 증후군 1례

이창훈,천남일,홍세인,정진욱,윤인석,조동혁,강호철,정동진,정민영 全南大醫大 2001 전남의대학술지 Vol.37 No.2

움직씨 "가다"의 분석을 위한 지시이론적 접근 : 이동의 물리적 현상과 상징적 현상에 관한 비교연구

이남석 한국독일어문학회 2000 독일어문학 Vol.11 No.-

In dieser Arbeit geht es darum. innerhalb der deiktischen Kategorie das Verb gehen ada¨quat zu beschreiben. Ganz anders als solche Verben wie fliegen. laufen. oder fahren, tragen kommen und gehen keine Information mit Bezug auf das Wie und das Mittel einer Bewegung. Andererseits hat es auch kein Merkmal Direktionalita¨t, fu¨r das doch ein Valenzstudierter pla¨diert. Sie drucken zwar einfach eine Bewegung von einer Stelle zur anderen aus. aber damit geben sie Hinweise auf den Ausgangspunkt und das Ziel der Bewegung. Das ist nicht vom linguistischen Kontext hergeleitet. sondern von der Sprechsituation. in der der Satz ausgedru¨ckt wurde. Diese deiktische Information geht die Identita¨t des Sprechers an. die Position des Sprechers. Kodierungszeit vom lokutiona¨ren Akt und die Identita¨t des Angesprocheners. wenn die Kommunikation durch einen Brief oder ein Ferngespra¨ch stattfindet. dann ist auch Dekodierungszeit und die Position des Angesprochen wichtig. Fillmore (1972: 1975) ist uns tatsa¨chlich mit Bezug auf die Studie der deiktischen Natur in kommen und gehen vorangegangen. Er hat jedoch im wesentlichen nur die physikalische Bewegung der Verben beschrieben; er hat die symbolischen Gebrauchsweise der Verben vo¨llig auβer Acht gelassen. Ich habe schon das Thema durch Eine deiktische Interpretation u¨ber die Bewegung mit Bezug auf die Verben gehen und kommen in Korean linguistics 9 (1999) dargestellt. Aber es fehlt dabei daran. dass das Verb GEHEN besonders mit Bezug auf die symbolische Funktion systematisch beschrieben wurde: Also generell gesprochen entspricht das Deutsche gehen und kommen gar nicht den Verben im Englischen sowie im Koreanischen in bezug auf den Wechsel des Zustandes; das deiktische Merkmal der koreanischen Verben und der englischen ist resistent eben auch im fiktiven Kontext. wa¨hrend das der deutschen neutralisiert ist. So tragen die deutschen Verben gehen und kommen keine Information u¨ber den Normalzustand oder den Gesichtspunkt der Bewertung. Mit entweder gehen oder kommen kann man auf die Vera¨nderung zum Normalzustand oder weg davon verweisen. Kommt gehen dabei vor. dann sagt es vorher, dass die Person. die die Wechselung betrifft. also die Ursache der Wechselung ist. Mit kommen konnen wir in Bezug auf die Ursache nichts mehr vorhersagen. kommen ist vielmehr charakterisch fu¨r eine Situation, in der man auβerhalb seiner Entscheidung unvermeidlich in die Wechselung des Zustandes hineingezogen wurde. Andererseits bringt kata (gehen) im Koreanischen sowohl den Bewertungswechsels wie auch den NormalzustandswechseIs zum Ausdruck. Dabei habe ich das Pha¨nomen immer noch aus der deiktischen Theorie der Perspektive interpretiert.

Sharing of Asymmetric Information for a Collusion

이남순,서옥석 충북대학교 산업경영연구소 1995 産業과 經營 Vol.8 No.1

本論文의 目的은 각 기업이 非協助的인 게임에서는 각자가 보유하고 있는 私的情報의 非對稱性이 존재하는한 競爭企業과 私的情報를 결코 서로 共有하지 않을 것이라는 Clarke(1983)의 주장이 협조적인 게임에서는 성립될 수 없다는 점을 理論的으로 밝히는데 있다. 협조적인 게임에서는 期待談合利潤이라는 추가적인 要因 때문에 情報의 限界價値가 매우 크므로 각 기업의 정보에 대한 反應度가 민감해진다. 따라서 협조적인 게임에서는 각 기업이 서로 비대칭적인 정보를 가지고 있더라도 平均市場需要가 크거나 또는 市場需要의 不確實性이 작을 경우에 情報共有가 일어날 수 있다는 사실을 본 논문은 明示的으로 보여 준다. 이러한 본 논문의 硏究結果는 旣存硏究의 결과와 正反對의 결과이며 동시에 각 市場에서 일어나고 있는 實際現狀과 부합하는 매우 重要한 硏究結果라고 사료된다.

한 대학 신입생의 우울수준과 관련변인에 관한 연구

이명학,남해성,손석준,이정애,김병우 대한보건협회 1994 대한보건연구 Vol.20 No.2

1994년도 한 대학 1년생을 대상으로 8개항목의 생활만족지수(LSI-W) 그리고 20개항목의 우울지수(CES-D) 및 관련변인들을 조사하여 각각의 점수와 우울증의 유병률을 계산하고 서로간의 관련성을 조사하여 다음과 같은 결과를 얻었다. 1. 생활만족지수의 평균점수는 9.98이었고 비흡연군, 비음주군, 운동을 하는 군에서 평균점수가 유의하게 높았다(p<0.01). 2. 우울지수의 평균점수는 17.2였고 여학생에서 남학생보다 유의하게 높았고, 우울증의 유병률은 19.8%이었고 여학생에서 남학생보다 유의하게 높았다(p<0.01). 3. 우울증세 고위험군과 저위험군에 있어서 건강에 대한 본인의 생각과 본인이 인지하는 체중에서 차이가 있었으며, 생활만족지수, 가족수, 체중, 신장에서 유의한 차이를 보였다(p<0.05). 4. 우울지수와 생활만족지수, 연령, 종교활동기간, 신장, 체중등과는 음의 상관을 나타내고(p<0.01), 가족수, 수면시간, 경제수준과는 양의 상관을 보였다(p<0.01). 5. CES-D에 영향을 미치는 변수를 알아보기 위한 단계적 로지스틱 회귀분석에서 생활만족도, 성별, 건강에 대한 본인의 생각, 본인이 인지하는 체중, 흡연, 음주가 CES-D에 의한 우울증 발현에 있어서의 유의한 요인으로 나타났다(p<0.05). The questionnaire survey using the Center for Epidemiological Studies-Depression Scale(CES-D) and 8-items Life Satisfaction Index Well-being(LSI-W) and other variables was conducted to determine the prevalence of depression and to identify the correlation among CES-D and related factors. Study population was the whole freshman group newly enrolled in a university. The results were as follows; 1. Mean score of LSI-W was 9.98 and that score was higher in non-smokers, non-drinkers and exercise group (p<0.01). 2. Mean score of CES-D was 17.2 and the prevalence of depression was 19.8%. And those were significantly higher in female than in male(p<0.01). 3. Perceived health status, perceived weight, LSI-W, family size, weight and height were significant variables between high and low risk group of depression(p<0.05). 4. CES-D score was negatively correlated with LSI-W, age, duration of religious life, height, weight and po-sitively correlated with family size, sleeping time and economic status(p<0.01). 5. In the regression analysis significant predictors of the depression were sex, preceived health status, weight, smoking and drinking(p<0.05).