http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
남해성,이숙영,김승준,권순석,김영균,김관형,문화식,송정섭,박성학,김석찬,김주상 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.4
Purpose: Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that has been implicated in many aspects of the airway pathology in asthma. TNF-α blocking strategies are now being tried in asthma patients. This study investigated whether TNF-α blocking therapy inhibits airway inflammation and airway hyperresponsiveness (AHR) in a mouse model of asthma. We also evaluated the effect of TNF-α blocking therapy on cytokine production and adhesion molecule expression. Meterials and Methods: Ovalbumin (OVA) sensitized BALB/c female mice were exposed to intranasal OVA administration on days 31, 33, 35, and 37. Mice were treated intraperitoneally with soluble TNF-α receptor (sTNFR) during the OVA challenge. Results: There were statistically significant decreases in the numbers of total cell and eosinophil in bronchoalveolar lavage fluid (BALF) in the sTNFR treated group compared with the OVA group. However, sTNFR-treatment did not significantly decrease AHR. Anti-inflammatory effect of sTNFR was accompanied with reduction of T helper 2 cytokine levels including interleukin (IL)-4, IL-5 and IL-13 in BALF and vascular cell adhesion molecule 1 expression in lung tissue. Conclusion: These results suggest that sTNFR treatment can suppress the airway inflammation via regulation of Th2 cytokine production and adhesion molecule expression in bronchial asthma.
P-97 폐암환자의 악성흉수와 혈청의 중성구/림프구의 비율을 이용한 새로운 예후인자의 임상적 중요성
남해성,임준혁,전상훈,김정수,조재화,류정선,곽승민,이홍렬,문연숙 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.0
목적: 혈청의 중성구와 림프구의 비율은 (neutrophil-to-lymphocyte ratio, sNLR) 다양한 암에서 유용한 예후인자로 알려져 있다. 그러나 악성흉수의 NLR에 (mNLR) 관한 연구는 없다. 따라서 악성흉수를 지닌 폐암환자에서 mNLR의 역할을 조사하고, 악성흉수와 혈청의 NLR을 (smNLR) 활용한 새로운 예후인자 시스템을 만들어 임상적인 중요성을 조사하였다. 방법: 폐암진단 당시 흉수를 동반한 환자를 후향적으로 조사하여, 악성흉수로 확인된 환자들만을 조사하였다. 이들의 mNLR의 역할을 조사하고, sNLR과 mNLR을 활용한 새로운 smNLR score을 정의하여 임상적 변수와 생존율과의 관계를 분석하였다. 성적: 총 158명의 환자들이 새로운 smNLR score에 따라 3그룹으로 분류되었다 (score 0: 84명, score 1: 58명, score 2: 16명). 단변량 분석에서 sNLR (p < 0.001), mNLR (p = 0.004), smNLR score (p < 0.001)이 높으면 짧은 생존율을 보였으며, 다변량 분석에서는 수행능력 (p < 0.001), 조직학적 분류 (p = 0.001), 그리고 smNLR score (p < 0.012)만이 독립적인 예후인자로 확인되었다. 결론: 새로운 smNLR score의 임상적인 활용에 있어 더 많은 연구가 필요하나, smNLR score는 악성흉수를 지닌 폐암환자에서 비용-효과적인 유용한 예후인자로 치료의 계획 등에 있어 임상의와 환자에게 더 많은 정보를 제공해 줄 수 있을 것이다.
지속성 급성호흡곤란증후군 환자에서 "저용량" 글루코코르티코이드 치료 효과에 대한 예비연구
남해성,박소영,김수아,송재욱,전경만,김호중,권오정,서지영,박맹렬,임소연 대한중환자의학회 2009 Acute and Critical Care Vol.24 No.2
Background: The role of glucocorticoids for treating persistent acute respiratory distress syndrome (ARDS) is matter of debate. In the previous studies, the side effects of moderate doses of glucocorticoids might have negated positive effects of glucocorticoids. This study aimed at determining the feasibility of administering "low-dose" glucocorticoid to treat the patients who suffer with persistent ARDS. Methods: We retrospectively reviewed the medical records of twelve patients with ARDS of at least seven days` duration and who were treated with "low-dose" glucocorticoid (starting dose of 1 mg/kg) between June 2007 to December 2008. The patients were divided by whether or not they were successfully weaned from the ventilator after glucocorticoid therapy. The baseline characteristics and physiologic parameters were recorded for up to 7 days after starting glucocorticoid therapy. Results: Five patients (42%) were included in the weaned group. There was no significant difference in the clinical characteristics and the physiologic parameters between the two groups on the day of ARDS. Yet the weaned group had a significantly lower Sequential Organ Failure Assessment (SOFA) score, as compared to that of the failed group [3 (3-6) vs 8 (5-12), p = 0.009)] at start of glucocorticoid treatment. After 3 days of glucocorticoid therapy, there was significant improvement in the PEEP, the PaO2/FIO2 ratio, the PCO2, the SOFA score and the Murray Lung Injury Score of the weaned group, as compared to that of the failed group. There were no major neuromuscular side effects from the therapy. Conclusions: This study suggests that the "low-dose" glucocorticoid therapy is feasible and that the SOFA score and the physiologic parameters may assist in determining whether or not to initiate and to continue glucocorticoid therapy for the patients who are suffering with persistent ARDS.
일부 농촌지역 사망신고자료에 기재된 사인에 관한 연구 -사망신고사인과 조사사인의 비교-
남해성,박경수,선병환,신준호,손석준,최진수,김병우,Nam, Hae-Sung,Park, Kyeong-Soo,Sun, Byeong-Hwan,Shin, Jun-Ho,Sohn, Seok-Joon,Choi, Jin-Su,Kim, Byong-Woo 대한예방의학회 1996 예방의학회지 Vol.29 No.2
This study was conducted to evaluate the accuracy of the official death registry in rural area. The base data used for the study was 379 deaths registered during the period of 1993 and 1994 in 4 rural townships of Chonnam province. The interview survey for cause-of-death was performed on the next of kin and/or neighbor. Additional medical informations were collected from hospitals and medical insurance associations for the purpose of verification. The underlying cause-of-death of 278 cases presumed by the survey was compared to the cause on official death registry. There was a prominent disagreement of cause-of-death between the survey data and the registry data(agreement rate: $38.9\sim44.6%$, according to disease classification method). These results may be caused by extremely low rates of physicians' certification, which were mostly confined to the poisoning and injury. Symptoms, signs, and ill defined conditions on death registry could be classified into circulatory disease(32.3%), neoplasm(21.2%), digestive disease(7.1%), injury and poisoning(7.1%) and so on. These results suggest that careful attention and verification be required on utilization of death registry data in rural area.
Escherichia coli 패혈증 환자에 합병된 대칭적 하지 말단 괴사증 1예
남해성,유진홍,권순석,민준기,조현선,박민경,심병주,남유정,이지인,김진수,길욱현,조근종,신완식 대한감염학회 2005 감염과 화학요법 Vol.37 No.6
We have encountered a rare case of symmetrical peripheral gangrene complicating Escherichia coli sepsis in a 47-years-old male. He was successfully treated with antibiotics, anticoagulants, and vasodilator. To our knowledge, this is the first report on symmetrical peripheral gangrene complicating E. coli sepsis in Korea.