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( Myeong Jun Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Tae Hee Lee ),( Young Woo Kang ),( Ji Woong Jang ),( Seok Hyun Kim ),( Byung Seok Lee5 ),( Sea Hwan Lee ),( Hong Soo Kim ),( Ji Hoon Kim ),( S 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: We aimed to evaluate the efficacy and safety of Daclatasvir (DAV) and Asunaprevir (ASV) in patients with chronic hepatitis C virus (HCV) and chronic renal failure (CRF). Methods: 22 chronic hemodialysis patients with HCV infection at 12 medical centers have prospectively enrolled from Feb, 2016 to Feb, 2017 (NCT02580474). Of those, 9 patients who were followed 12 weeks after treatment ended were included. We evaluated the virological responses at each week 4, 12, 24 and the 12-week sustained virologic response (SVR12). The tolerability and safety of patients were also evaluated. Results: Of these 20 patients, there had no resistance-associated variant of NS5A (NS5A RAVs) and 2 patients showed indeterminate NS5A RAVs. 12 patients (54.5%) completed the 24 weeks treatment of DAV and ASV. 6 patients (27.2%) have continued, but 4 patients discontinued study prior to 12 weeks. Overall, all patients (n=9) achieved SVR12. Virologic response at week 4, 12 and 24 showed 94.4% (17/18), 93.3% (14/15), and 100% (12/12) respectively. DCV and ASV were well tolerated among the majority of patients and discontinuation of the treatment due to adverse events (hypertension, bradycardia, leukemia) was occurred in 3 patients. In two patients with indeterminate NS5A RAVs, one achieved SVR12 but the other showed viral breakthrough and discontinued treatment. Conclusions: In this study, DAV and ASV combination therapy for chronic hemodialysis patients with HCV infection achieved high sustained virological response with few adverse events. Close monitoring of safety and tolerability may be necessary when treating chronic hepatitis C patients with CRF receiving DCV and ASV.
체간안정화 훈련이 만성 뇌졸중 환자의 호흡기능에 미치는 효과
이경진(Kyeong-Jin Lee),정주현(Ju-Hyeoun Jeong),조명래(Myeong-Rae Jo),김세윤(Se-Yoon Kim),김난수(Nan-Soo Kim) 대한심장호흡물리치료학회 2019 대한심장호흡물리치료학회지 Vol.7 No.1
Purpose : The purpose of this study is to examine the effects of trunk stability training on improving trunk control, respiratory function, and respiratory muscle activation in stroke patients. Methods : The subjects were assigned to two groups: the intervention group (n=15) and the control group (n=15). Both groups participated in a conventional stroke rehabilitation program, but the intervention group also received trunk stability training for 30 minutes a day, 3 times a week, for 6 weeks. The main trunk stability exercise consisted of the dead bug exercise. Trunk control was assessed using a trunk impairment scale, and respiratory function (pulmonary function and respiratory muscle function) was assessed using spirometry. The data were analyzed using the Pearson correlation, independent t-test, and paired t-test. Results : Trunk control was significantly positively correlated with pulmonary function and respiratory muscle strength. Both groups showed a significant increase in trunk control and respiratory function. Conclusion : This study demonstrated that a conventional stroke rehabilitation program and trunk stability training have positive effects on respiratory function and respiratory muscle activation in stroke patients.
특수기능성섬유가 성장기 운동선수의 수면 중 성장호르몬 분비에 미치는 영향
이명수,이진희,고경찬,문성록 한국의류산업학회 2003 한국의류산업학회지 Vol.5 No.1
The purpose of this study was to investigate the effect of multi-functional fabric on EEG and growth hormone (GH) during sleep and quality of sleep with the 9 young female athletes. The subjects participated in separated experimental procedure; sleeping in multi-functional fabric wear (experimental group) and cotton wear (control group) for 450min. During the night (22:00-05:30), we recorded the changes of nocturnal polysomnographic sleep recording and GH were measured every 60min. The results show that there are significant differences in percentage of stage 1, 2 and slow wave sleep (SWS) between two groups(S1, p<.05;S2, SWS, p<.01). The SWS percentage of experimental group is 1.89 times higher than control group. The changes of GH secretion varied depending on two experimental procedures. The peak of GH secretion in experimental group is more than controls by 2.4time (p<.001). The quality of sleep in experimetal group is significantly higher than control (p<.01). These results suggest muti-functional fabric wear is effective in inducing the deep sleep and increasing GH and quality of sleep.
이명수,장혜숙,류훈,문성록 한국정신과학학회 2002 韓國精神科學學會誌 Vol.6 No.2
The oriental idea that health begins in mind is currently being applied in the clinical field by mind-body medicine. In the past decade. we have seen an increase 10 the popularity of mind-body medicine as an alternative or complement to traditional health care interventions. This paper explores the scientific idea of mind-body medicine and how particular mind-body intervention focusing on stress reduction and relaxation can be useful methods to Improving health state. On the basis of the psycho- neuroendocrine-immune triangular circuit, the mind-body pathway has been Investigated. Among many mind-body intervention, Qi-training and Qi-therapy are described, research on their effectiveness is reviewed, conclusions are drawn, and the applicability to clinical practice is discussed. Given existing empirical support for the effectiveness of these interventions, the authors provide Korean scientists With an overview of the psychoneuroimmunological effects of Qi-training and Qi-training, and possibility of their medical benefits.
통계적 공정 관리(SPC)와 엔지니어링 공정 관리(EPC)의 비교 조사 : 통합 방안을 중심으로
이명수,김광재 한국품질경영학회 2005 품질경영학회지 Vol.33 No.1
With the common objective to improve process productivity and product quality, statistical process control (SPC) and engineering process control (EPC) have been widely used in the discrete-parts industry and the process industry, respectively. The major focus of SPC is on process monitoring, while that of EPC is on process adjustment. The emergence of the hybrid industry necessitates a synergistic combination of the two methods for an effective process control. This paper investigates the existing studies on SPC, EPC, and the integration of the two methods. This paper also presents future research issues in this field.
이명수,허화정,김병기,류훈,정현택 한국정신과학학회 1998 韓國精神科學學會誌 Vol.2 No.2
심장박동간격은 최근 교감신경과 부교감신경의 안정을 알아보는 척도로 쓰이고 있다. 본 연구는 4~12개월 천도선법 기수련을 행한 20대의 20명의 기수련자와 동일 연령층의 20명의 일반인을 대상으로 하여 1시간 동안 천도선법을 수행하게 하여 전, 참선, 후의 심장박동을 생리 기록계로 측정을 하여 빠른 퓨리에 변환 (FFT)을 통하여 심장박동간격을 조사하였다. 그 결과 자율신경제의 안정척도인 저주파수 적분 값과 고주파수 적분 값의 비(LF/HF)가 수련전과 수련 중에서 천도선법 기수련생들의 값이 일반인과 비교하여 통계적으로 유의한 차이가 났으며 (p<0. 01) 특히 두 그룹 모두 HF 의 값이 유의하게 변화하는 것을 보았을 때 천도선법 기수련이 부교감신경의 활동을 조절하여 자율신경계를 안정화 시킨다는 것을 보여주었다. The effects of ChunDoSunBup (CDSB) Qi-training on the power spectrum of heart rate variability were studied in 20 healthy subjects and 20 CDSB Qi-trainee (subjects with CDSB Qi-training for 4-12 months) Continuous ECG signals were recorded during 1) 10 min of rest in sitting position, 2) 1 hour of CDSB Qi-training , 3) 10 min of post-training. Fast Fourier transformation was used to determine the power spectrum of heart rate variability While CDSB Qi-training, there were significant decrease in the ratio of low to high frequency power spectrum. And value of pre and mild-training in CDSB Qi-trainees were lower than that of control subjects There was a significant changes in high frequency power of both group, but net in low frequency These results suggest that CDSB Qi-training may stabilize autonomic nervous system by modulate parasympathetic nervous system.