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문성록,박수경,정영표,김태요,최유선 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.2
Background: Radiation therapy in palliative cancer management leads mainly to nausea, vomiting, dyspepsia and anorexia. Several agents have been used to treat above symptoms and sings. We assessed the usefulness of continuous intravenous infusion of low-dose droperidol, compared to granisetron for the control of gastrointestinal symptoms due to radiation therapy. Method: We devided 30 patients who developed gastrointestinal symptoms after undergoing palliative radiation therapy due to metastatic bone pain in two groups. In group G(n=15), the patients were injected granisetron(3㎎) and then injected it, 3㎎ per day. In group D(n=15), the patients were injected low-dose droperidol(0.25㎎) and then infused continuously at low-dose(1㎎/day) by the disposable continuous infusion pump. Result: There were no significant differences in the patient's satisfaction, improvement of appetite and incidences of side effects between two groups. Conclusion: The continuous intravenous infusion of low-dose droperidol can substitute for serotonin-receptor antagonist for the treatment of gastrointestinal symptoms during radiation therapy for cancer patients.
고위험 예후인자를 가진 자궁경부암환자에서 방사선과 Cisplatinum의 동시병용요법
문성록,김홍곤,김혜정 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.1
Twelve patients with high risk group of uterine cervical carcinoma received concurrent chemoradiotherapy with weekly cisplatinum. A patient was FIGO stage Ⅰ-B barrel-shaped, two were stage Ⅱ-A. eight were stage Ⅱ-B, and one was Ⅲ-B. All patients responded to concurrent chemoradiotherapy with eleven complete and one partial responses. Nine of 11 with complete reponse are alive disease free on the completion of follow-up. Overall 3-year survival rate was 75% and 3-year local control rate was 92%. Toxicity for the combination therapy was not excessive. Although follow-up is short, this approach for patients with high risk uterine cervical carcinoma yielded excellent results and was well tolerated.
근접치료용 Ir-192선원의 선량분포에 대한 측정과 시뮬레이션
문성록,정동혁,이정혁,강정구 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.2
Background: As a fundamental study, measurement and Monte Carlo simulations for an Ir-192 source were performed to apply to the clinical dose calculations, and compared the results with recommended values for the source. Methods: The dose distribution as a function of radial distance from the axis of the source was measured using water phantoms and semiconductor detectors and calculated using Monte Carlo code with the input data prepared for the physical data for the source. Results: The measured data were higher than the data recommended from Meisberger et al. for all distances with the maximum differences of 30%, while the calculated data were in good agreement within 6% with recommended data. Conclusion: We found the Monte Carlo calculations for the adjacent area to the source are more suitable than measurement, because the measurement conditions were not satisfied in the region. As a result of this study, the application of Monte Carlo methods to the clinical dose calculation can be possible, but the calculated data should be evaluated accurately.
원광대학교병원 선형가속기를 이용한 뇌정위 방사선 수술장치의 개발
문성록,김태영,김종문 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.1
The purpose of this study is to develope LINAC based stereotactic radiosurgery system using ML-6M type linear accelerator which had been installed in Wonkwang University Hospital. Mechanical isocenter alignment, physical beam distribution and treatment simulation were evaluated. All the mechanical and physical data were acceptable and safe for clinical application. In the treatment simulation, Good agreement between the center of the radiation distribution and the localized target point was achieved. In conclusion, this type of radiosurgery system can be applied to clinical setting with acceptable accuracy and safety.
문성록,김혜정,김귀언 圓光大學校 醫科學硏究所 1992 圓光醫科學 Vol.8 No.1-2
From January 1984 to December 1987, 66 patients with Modified Astler Coller stage C rectal cancer were retrospectively analysed. All patients received complete surgical resection followed by postoperative radiotherapy. The patients were divided into two groups as follows : Ⅰ.Low-dose irradiation group (28 patients received less than 5500 cGy in 6 weeks ; Mean 48.7 Gy). Ⅱ.High-dose irradiation group (38 patients received more than 5500 cGy in 6-8 weeks ; Mean 57.7 Gy). Main purpose of this study is to determine whether or not there was differences in local control and survival between low-dose and high-dose postoperative irradiation group. Low-dose postoperative irradiation group had a 45.0% of 3-year local recurrence free survival and 30.3% of 3-year disease free survival. On the other hand, High-dose postoperative irradiation group had a 69.0% of 3-year local recurrence free survival and 60.2% of 3-year disease free survival. The complications for postoperative radiotherapy had no significant difference between two groups and were acceptable in all patients. On the basis of this study, when considering adjuvant postoperative radiotherapy in stage C rectal cancer, at least minimum of 5500 cGy or more should be delivered in order to have maximum benefit.
문성록,이형식,김귀언,안기정,서창옥,노준규,민진식,이경식,김병수,노재경,고은희,Moon, Sun-Rock,Lee, Hyung-Sik,Kim, Gwi-Eon,Ahn, Ki-Jung,Suh, Chang-Ok,Kyu, John-Juhn,Min, Jin-Sik,Lee, Kyung-Sik,Kim, Byung-Soo,Noh, Jae-Kyung,Koh, Eun-Hee The Korean Society for Radiation Oncology 1990 Radiation Oncology Journal Vol.8 No.1
유방암의 일차 치료후 흉벽이나 국소임파절에 국한된 재발은 비교적 흔하게 관찰된다. 방사선치료는 이러한 국소재발유암 환자에게 효과적인 치료법으로 사용되어 왔으나 국소병변의 관해에도 불구하고 많은 경우에서 이차개발 또는 원격전이로 인해 불량한 예후를 보이므로 최근에는 다방면 병용요법을 시도하여 환자의 수명을 연장시키고 관해율을 증가시켰다는 고들이 있다. 이에 저자들은 국소 재발유암 환자의 특성과 치료결과, 치료후 실패양상, 생존율에 영향을 미치는 예후인자를 분석하여 향후치료의 지침으로 삼고자, 1974년 부터 1986년까지 연세대학교 의과대학 치료방사선과에서 방사선치료를 받은 53명을 대상으로 후향적분석을 통해 다음과 같은 결과를 얻었다. 32예 ($60.4\%$)가 단일 병소에, 21예 ($39.4\%$)가 다발병소에 재발하였다. 방사선치료후 31예 ($58.4\%$)에서 완전관해를 보였으나 그 중 7예는 치료부위에 다시 재발하였다. 전체환자의 5년 생존율과 무병생존율은 각각 $27\%,\;15\%$였다. 각각의 예후인자에 대한 단일변량분석에서는 최초 수술당시의 액와임파절전이 숫자, 보조적 화학요법의 시행 유무, 경도의 유무 등이 통계적 유의성을 보였고, 다변량분석법을 통한 분석에서는 최초수술당시의 액와임파절전이의 수, 경도의 유무, 재발시 병변의 크기, 치료후 관해기간 등이 생존율에 통계적으로 유의한 영향을 끼치는 예후인자였다. Between January,1974 and December 1980, fifty eight patients with locoregional recurrent breast carcinoma who did not have evidence of distant metastasis after initial treatment of surgery with or without adjuvant chemotherapy were treated with radiation therapy. Among them, five patients were excluded from this study because of incomplete record or incomplete treatment. The 5-year overall survival and disease free survival from the time of locoregional recurrence was $27\%\;and\;15\%$ respectively. In univariate analysis of prognostic variables, the clinical stage at initial diagnosis, recur duration, number of recurrence sites, size of recurrences, response to the treatment, remission duration were all found to have no significant effect on survival or disease free survival. On the other hand, menopausal status at initial diagnosis, number of positive node at initial surgery, whether or not the use of adjuvant chemotherapy after initial mastectomy had definite prognositc significance. In multivariate analysis of prognostic variables, remission duration, menopausal status at diagnosis, number of axillary node at mastectomy had definite prognostic significance. On the other hand, remission duration more than 12 months, premenopaus at initial mastectomy, less than four positive axillary lymph nodes at mastectomy predicted a good prognosis.