흰쥐에서 탄수화물 종류가 운동시 당 및 지질대사에 미치는 영향

권태동,전중기,민경선,김형렬,장응찬 대구대학교 기초과학연구소 1998 基礎科學硏究 Vol.15 No.2

The purpose of this study was to investigate the effects of glucose, sucrose, and glucose polymer(GP) ingestion on the carbohydrate and lipid metabolism during treadmill running in rats. Rats were randomly assigned to normal, control and carbohydrate groups. Carbohydrate group was divided into glucose, sucrose and GP ingested rats. The experiment was carried out after overnight fasting. Rats were administrated either normal saline(control) or carbohydrates solutions of formulated glucose(6%), sucrose(6%) and GP(6%) via polyethlene tube to stomach before treadmill run. Exercise was loaded by a treadmill run at the speed of 1 km/hour for 30, 60 and 120 minutes. The results of experiment were as follows: Plasma glucose levels were decreased in proportion to the exercise time in control, but increased at treadmill run 30 minutes and then gradually decreased with the lapse of the exercise time in carbohydrates compared with normal rats. It decreased in control, glucose, sucrose and GP compared with normal rats in decreasing order at treadmill run 120 minutes(% change of plasma glucose level of control, glucose, sucrose and GP compared with normal rats were 67, 74, 87 and 91 in plasma glucose level at treadmill run 120 min., respectively). Plasma lactate levels were increased by the exercise loading compared with normal in control and carbohydrates ingested rats. It increased in control, sucrose and GP in increasing order compared with normal rats, at treadmill run 120 minutes(% change of plasma lactate level of control, glucose, sucrose and GP compared with normal rats were 167, 185, 149 and 114 in plasma lactate level at treadmill run 120 min., respectively). Plasma FFA levels had tendency to increase by the exercise loading compared with normal in control and carbohydrates ingested rats. It showed increase in the sucrose, glucose, GP and control rats in Increasing order compared with normal rats at treadmill run 120 minutes(% change of plasma FFA level of control, glucose, sucrose and GP compared with normal rats were 151, 153, 166 and 152 in plasma FFA level at treadmill run 120 min., respectively). Plasma acetoacetate levels were higher in control compared with carbohydrates ingested rats at treadmill run 30, 60 and 120 minutes. Plasma beta-hydroxybutyrate levels increased by exercise compared with normal rats in control and carbohydrates ingested rats at treadmill run 30, 60, 120 minutes. Plasma insulin levels were decreased in proportion to the exercise time in control compared with normal rats, but in carbohydrates ingested rats increased at treadmill run 30 minutes and then gradually deceased with the lapse of the exercise time compared with normal. In carbohydrates ingested rats, plasma insulin levies were higher than control. Hematocrit did not show any difference between control and carbohydrates rats at treadmill run 30, 60 and 120 minutes. From these experimental results, it is suggested that the exhaustion of skeletal muscle glycogen, the hypoglycemia, the overproduction of lactate and dehydration is delayed in carbohydrates ingested rats. GP of the carbohydrates is considered as the most effective for these effects. Therefore, intake of carbohydrates before exercise, especially GP seems to increase performance in the prolonged moderate exercise.

공급사슬에서의 리스크 대응이 공급사슬통합과 리스크 관리 성숙도, 기업경영성과에 미치는 영향

박찬권(Park, Chan-Kwon),박성민(Park, Sung-Min),김채복(Kim, Chae-Bogk) 한국경영교육학회 2021 경영교육연구 Vol.36 No.2

[연구목적] 본 연구는 공급사슬에서 발생할 수 있는 리스크를 규명하고, 리스크에 대응하기 위한 과정에서 공급사슬통합의 필요성과 함께 리스크 관리 성숙도 제고가 기업경영성과 역시 제고할 수 있다는 것을 규명하는 것이다. 이를 위해 리스크 대응과 공급사슬통합, 리스크 관리 성숙도, 기업경영성과 간의 관계구조를 분석하고 시사점을 제공하는 것이다. [연구방법] 본 연구는 공급사슬에서 발생할 수 있는 리스크 유형, 공급사슬통합, 리스크 관리 성숙도, 기업경영성과에 대한 기존 선행연구들과 논의를 충분히 검토하였고 최종적으로 6개의 가설을 도출하였다. 연구목표 달성을 위해 국내 제조업체들을 대상으로 124개의 설문 자료를 수집하였다. 수집된 자료에 대해 신뢰성과 타당성을 검토하였고, Smart PLS 2.0을 활용하여 경로분석 방식으로 연구가설을 검증하였다. [연구결과] 내부리스크대응, 외부리스크대응, 공급사슬리스크대응은 공급사슬통합에 유의한 정(+)의 영향을 미치며, 내부리스크대응과 공급사슬리스크대응은 리스크관리성숙도에 정(+)의 영향을 미친다. 공급사슬통합과 리스크 관리 성숙도는 기업경영성과에 정(+)의 영향을 미친다. 또한 공급사슬통합은 외부리스크대응 및 공급사슬리스크대응과 기업경영성과 사이에서 매개변수의 역할을 하는 것으로 검정되었다. [연구의 시사점] 공급사슬에서의 리스크 대응, 공급사슬통합, 리스크 관리 성숙도, 기업경영성과 간의 전체적인 관계구조에 대하여 연구를 진행하였으며, 우리나라의 기업들에게 리스크 대응과 관련한 이론적, 실무적 시사점을 제공하였다. [Purpose] This study is to identify risks that may occur in the supply chain, and to identify that supply chain integration is necessary in the process of responding to the risks, and that corporate management performance can also be improved by enhancing risk management maturity. The purpose of this study was to analyze the relationship structure between risk response, supply chain integration, risk management maturity, and corporate management performance and to provide implications. [Methodology] This study has sufficiently reviewed the previous studies and discussions on the types of risks that can occur in the supply chain, supply chain integration, risk management maturity, and business management performance, and finally derived six hypotheses. For the study, 124 data were collected from domestic manufacturers. The reliability and validity of the collected data were reviewed, and the research hypothesis was verified through a path analysis method using Smart PLS 2.0. [Findings] Internal risk response, external risk response, and supplier chain integration have a significant positive (+) effect on supply chain integration, while internal risk response and supplier chain risk response have a positive (+) effect on risk management maturity. Supply chain integration and risk management maturity have a positive (+) effect on corporate management performance. In addition, it was verified that supply chain integration plays a role as a parameter between external risk response and supplier chain risk response and corporate management performance. [Implications] A study was conducted on the overall relationship structure between risk response in the supply chain, supply chain integration, risk management maturity, and corporate management performance, and provided theoretical and practical implications for risk response to Korean companies.

중학생들의 인터넷 중독 위험수준에 따른 신체활동량과 비만도의 관련성

정민기(Jeong, Min-Ki),김권민(Kim, Gwon-Min),권유찬(Kwon, Yoo-Chan) 한국체육과학회 2015 한국체육과학회지 Vol.24 No.4

The purpose of this study was to examine the association perceived physical activity pattern and body mass index according to habitual internet usage among middle school student. Data were analyzed for 969 students who responded to self-reported base cross-sectional survey relating to socio-demographic variables, internet usage status, and a short version of the international physical activity questionnaire. Prevalence rate of physical activity status showed that 53.5% at 150 min/week under, 46.5% at 150min/week over. Prevalence rate of internet usage showed that 95.6% at normal group, 2.6% at potential group, 1,9% at addiction group. Prevalence rate of body mass index status of over weight according to internet usage status shoed that 83.1% at normal, 5.1% at potential, 11.9% at addiction. Prevalence rate of physical activity levels of 150 min/week under according to internet usage status showed that 93.8% at normal, 3.5% at potential, 2.7% at addiction. In comparison with the physical activity levels was significantly more likely potential internet usage (OR, 2.62; 95% confidence interval [95%CI], 1.09-6.47; p〈.05) and addiction usage (OR, 3.82; 95% confidence interval [95%CI], 1.24-11.75; p〈.05). The results revealed that physical activity levels and body mass index correlates of internet usage status. This finding suggest the necessity of developing specific strategies for physical activity intervention by internet addiction among middle school students.

대학생들의 인터넷 사용정도에 따른 신체활동량과 신체구성의 관련성

김권민(Kim, Gwon-Min),박상갑(Park, Sang-Kab),권유찬(Kwon, Yoo-Chan) 한국체육과학회 2015 한국체육과학회지 Vol.24 No.3

The purpose of this study was to examine the association perceived physical activity patten and body composition according to habitual internet usage among university students. Data were analyzed for 500 students who responded to an self-reported based cross-sectional survey relating to socio-demographic variables, internet usage status, and a long version of the international physical activity questionnaire. Prevalence rate of physical activity status showed that 40.2% at 150 min/week over, 59.8% at 150 min/week under. Prevalence rate of internet usage showed that 94.6% at normal group, 3.0% at potential, 2.4% at addiction. Prevalence rate of physical activity levels of 150 min/week under according to internet usage status showed that 92.0% at normal, 4.3% at potential, 3.7% at addiction. In comparison with the physical activity levels was significantly more likely potential internet usage (OR, 4.82; 95% confidence Interval [95%CI], 1.07, 21.86; p〈.05) and addiction usage (OR, 8.00; 95% confidence interval [95%CI], 1.02, 62.56; p〈.05) The results revealed that physical activity levels correlates of internet usage status. This findings suggests the necessity of developing specific strategies for physical activity intervention by internet addiction among university students.

스마트폰 사용정도가 수면의 질과 좌식행동에 미치는 영향

김권민(Kim, Gwon-Min),정민기(Jeong, Min-Ki),권유찬(Kwon, Yoo-Chan) 한국체육과학회 2016 한국체육과학회지 Vol.25 No.1

The purpose of this study was to examine the association perceived physical activity pattern and body mass index according to habitual internet usage among middle school student. Data were analyzed for 969 students who responded to self-reported base cross-sectional survey relating to socio-demographic variables, internet usage status, and a short version of the international physical activity questionnaire. Prevalence rate of physical activity status showed that 53.5% at 150 min/week under, 46.5% at 150min/week over. Prevalence rate of internet usage showed that 95.6% at normal group, 2.6% at potential group, 1.9% at addiction group. Prevalence rate of body mass index status of over weight according to internet usage status showed that 83.1% at normal, 5.1% at potential, 11.9% at addiction. Prevalence rate of physical activity levels of 150 min/week under according to internet usage status showed that 93.8% at normal, 3.5% at potential, 2.7% at addiction. In comparison with the physical activity levels was significantly more likely potential internet usage (OR, 2.62; 95% confidence interval [95%CI], 1.09-6.47; p<.05) and addiction usage (OR, 3.82; 95% confidence interval [95%CI], 1.24-11.75; p<.05). The results revealed that physical activity levels and body mass index correlates of internet usage status. This finding suggest the necessity of developing specific strategies for physical activity intervention by internet addiction among middle school students.

지속성 외래복막투석 환자들의 예후에 영향을 미치는 요인들에 관한 고찰

권혁만,김찬덕,조지형,장민화,최혁준,이현철,박자용,박선희,김용림 대한신장학회 2004 대한신장학회잡지 Vol.23 No.2

프리미돈의 한국인에서의 생체이용율시험

권광일,윤민혁,윤희열,박희찬,권준택,심희옥,김동출 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-

A reversed phase HPLC method was developed and validated for the determination of primidone in human plasma. Propylthiouracil was used as an internal standard. Calibration curves were linear in the concentration range of 10-120 ng/㎖. The coefficient of variation of the intra- and inter-day precision were below 15%. The coefficient of variation of the accuracy were below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Twenty four healthy human male volunteers were orally administered 20 mg of primidone. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(LAST) was 85.0±17.7 ㎍ hr/㎖, C_(max) was 4.22±1.04 ㎍/㎖, T_(max) was 1.85±1.13 hr, t_(1/2) was 17.7±2.4 hr. The pharmacokinetic parameters and the HPLC method can be used for the desigm of bioequivalence study of primidone.

경구면역을 통한 항원 특이적 IgA 항체 합성에 있어 Cholera Toxin과 Alginate-Microsphere의 효과

송민형,유진수,권명상,성승룡,김용희,권익찬,정서영,양재명,김평현 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.3

Secretory (S-IgA) isotype antibody (Ab) is known to play an essential role in the primary defense against various infectious agents in mucosal tissue. However, it has been mostly unsuccessful in the induction of antigen (Ag)-specific IgA Ab response in this site by peroral vaccination. In the present study, we investigated the effect of cholera toxin (CI) as a mucosal adjuvant and alginates-microspheres as a carrier on BSA-specific IgA Ab response in gut-associated lymphoid tissue`(GALT). Peroral immunization of BSA plus CT conferred a great BSA-specific IgA response but IgG response on intestinal fluid (IF). In contrast, intraperitoneal immunization of BSA with Freund's adjuvant readily induced BSA-specific IgG response but IgA response in IF. Further, number of CT specific IgA-secreting cells was substantially increased in mesenteric lymph node when CT-encapsulated-VI alginates-microspheres was administered perorally. Taken together, these results indicate that peroral immunization of soluble antigen in combination of CT or microspheres significantly enhances antigen-specific IgA response in GALT.

삼출성 늑막액에서 양악성 감별지표로서 CEA, TPA, SCC Ag 측정의 의의

김경찬,김민수,김미정,권두영,한승범,전영준 啓明大學校 醫科大學 1998 계명의대학술지 Vol.17 No.4

상피 세포에서 기원한 대표적인 종양표지자인 carcinoembryonic antigen (이하 CEA로 약함)은 삼출성 늑막액 환자의 양악성 감별에 보고적으로 사용되고 있다. CEA 이외에 혈청에서 양악성감별의 보조적 지표로 알려진 tissue polypeptide antigen (이하 TPA로 약함)과 squamous cell carcinoma antigen (이하 SCC Ag으로 약함)을 혈청과 늑막에서 동시 측정하여 늑막삼출액의 악성 감별에 어느 정도의 임상적인 유용성이 있는지를 알아보기 위하여 이 연구를 시행하였다. 1997년 1월 1일부터 동년 8월 31일까지 계명대학교 동산의료원에 입원한 환자들 중 삼출성늑막액을 가진 61명을 대상으로 하여 혈청과 늑막액에서 CEA, TPA, SCC Ag의 수치를 방사면역법으로 측정하였다. 각각의 조양표지자들은 악성과 양성군으로 구분한 뒤 분석하였으며 악성군이 28례, 양성군이 33례이었다. 그리고 진단양성기준치를 설정한 뒤 종양표지자들의 특이도, 민감도를 산출하였고 상기 지표들을 종양표지자와 늑막액 세포검사르 조합한 경우에도 산출하여 비교 분석하였다. 혈청 CEA 와 TPA는 각각 7.0 ng/ml, 80.0 ng/ml, 늑막액 CEA와 TPA는 각각 50. ng/ml, 4700.0 ng/ml로 진단양성기준치를 설정하였을 때 특이도를 낮추지 않으면서 가장 높은 민감도를 보였다. 늑막액 세포검사와 동시에 혈청 TPA 도는 늑막액 CEA를 측정하였을 때 특이도는 떨어뜨리지 않으면서 민감도를 높이는 좋은 조합인 것으로 나타났으며 혈청 CEA 및 TPA수치를 늑막액 세포검사와 도시에 시행하였을 때 특이도를 떨어뜨리지 않으면서 가장 높은 민감도를 얻었다. 늑막액 세포검사가 음성인 경우에도 혈청 CEA와 TPA를 동시에 측정하여 높은 민감도와 특이도를 얻을 수 있었다. 따라서 CEA와 TPA는 늑막삼출액의 양악성 감별 진단 유용한 보조적 지표로서 사용할 수 있을 것으로 판단된다. Carcinoembryonic antigen(CEA), the most widely used tumor marker was measured in pleural fluid of patients with exudative pleural effusions in order to differentiate malignant from benign effusions. This study was performed to find out if there is any clinical utility in differential diagnosis of malignancy by measuring simultaneously CEA, tissue polypeptide antigen(TPA) and squamous cell carcinoma antigen(SCC Ag) in serum and pleural fluid. The study population was 61 patients with exudative pleural effusions who were admitted to Keimyung University Hospital from January 1 to August 31, 1997. Each CEA, TPA and SCC Ag level in serum and pleural fluid were measured using radioimmunoassay method. These patients were divided to malignant and benign group. Malignant group consists of 28 cases and benign group consists of 33 cases. And the sensitivity and specificity of each tumor marker was obtained using cut-off value and that combining tumor markers and pleural fluid cytology were also obtained and analyzed. When the cut-off value was applied to CEA and TPA in serum using 7.0 ng/ml and 80.0 ng/ml respectively, the highest sensitivity was obtained without specificity being lowered. The same result was obtained when the cut-off value was applied to CEA and TPA in pleural fluid using 5.0 ng/ml and 4700.0 ng/ml respectively. When CEA in pleural fluid or TPA in serum were measured in combining with pleural fluid cytology sensitivity was increased without decreasing specificity than measured in pleural fluid cytology alone. When CEA in serum and TPA in serum were measured in combining with pleural fluid cytology simultaneously, the highest sensitivity was produced without decreasing specificity than measured in any other combinations. In addition, when serum CEA and TPA in serum were measured in the negative group of pleural fluid cytology, high sensitivity and specificity were obtained. These data suggest that CEA and TPA can be used as useful tumor markers for the differential diagnosis of malignancy and benign condition in patients with exudative pleural effusions.

조세부담수준에 관한 고찰

박찬,박민권 대구산업정보대학 1995 논문집 Vol.9 No.1

This study aims at suggesting a proper level of tax burden in Korea. To this end, I conducted an extensive literature survey on the theories of tax burden analysis on the determinants of tax burden ratio against GNP for a number of selected countries. The most important factor that affects the tax burden ratio turned out to be the level of national income. Based on the overall result of theoretical analysis findings, I propose the following policy suggestions with regard to the desirable directions of tax system and tax policy in korea : First, it is desirable that expenditures on social welfare should be increased and income redistribution function of tax system should be enhanced. Second, it is necessary that the burden of income and property taxes should be increased while the burden of indirect taxes decreased in order to achieve a more equitable structure of tax burdens. In particular, an amendment of tax system is called for to solve the problem of inequitable tax burden among different occupations and income groups.