젊은 남자에게 발생한 통상성 간질성 폐렴과 동반된 폐암 1예

박종숙,이준혁,박성우,장안수,박춘식,박재성,백상현,고은석,신화균 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Usual interstitial pneumonia(UIP) is relatively rare disease of lung parenchyme under the age of 50. Lung cancer is reported to occur as a complication of UIP, but has not been reported in young age patient with UIP in Korea. A 35-year-old man was admitted to the hospital because of dyspnea, cough and mild fever. He had been suffered from dyspnea during 3 years. The dyspnea worsened recent 1 month ago. He had been treated with pneumonia at another hospital during 4 months before this admission. Chest radiographs and High resolution CT showed subpleural and basal dominant reticular opacities in both lung with no change until now. He was smoker and his occupation was car engine-man dealing with benzene. UIP is suspected by history and radiologic findings. Operation for open lung biopsy was performed to obtain lung specimen via video-assisted thoracoscopic surgery. Patient's pathologic examination showed UIP combined with adenocarcinoma in RLL superior segment and posterobasal segment and RLL lobectomy was done. After operation, the patient has been in cancer free condition so far. We report a case of UIP combined with lung cancer in young man with brief review of the literature.

흰쥐 치아 재식 후 치수 치유 양상의 조직학적 관찰

고은진,정한성,김의성,정일영,이승종 大韓齒科保存學會 2010 Restorative Dentistry & Endodontics Vol.35 No.4

본 연구의 목적은 흰 쥐 (rat) 를 이용하여 미성숙 단계의 치아를 발치 후 즉시 재식 하였을 때 나타나는 치수의 치유 양상을 조직학적으로 관찰하고자 하는 것이다. 생후 4주된 암컷 Sprague-Dawley 계 흰쥐의 상악 우측 제1대 구치를 발거 후 원래의 치조골와 내로 위치시켰다. 재식 후 3일째부터 국소적으로 치수 내 염증 소견이 관찰되었으나, 치근 부위에서는 이미 치수의 재혈관화 및 치유가 진행되고 있는 소견이 관찰되었다. 재식 후 5일째 부터는 odontoblast-like cell이 관찰되기 시작하였다. 삼차 상아질의 형성은 재식 후 1주째 부터 관찰되기 시작하였으며, 2주째부터는 확실히 관찰할 수 있었다. Odontoblast-like cell 및 삼차상아질 형성은 4주째 까지도 계속 관찰되었다. 재식 후 4주째에는 bone-like tissue 및 cementum-like tissue이 형성되었음을 관찰하였다. 본 실험을 통하여 흰 쥐 치아 재식시 석회화 과정은 초기에는 삼차상아질 침착에 의해서 진행되나, 시간이 경과하면서 점차 bone-like tissue 또는 cementum-like tissue가 차지하는 비율이 증가하는 것을 관찰하였다. The objective of this study was to observe the histology of dental pulp healing after tooth replantation in rats. The maxillary right first molars of 4-week-old rat were extracted. and then the teeth were repositioned in the original socket. At 3 days after replantation. there was localized inflammatory reaction. But, pulp revasculization and healing had already begun in the root area. At 5 days after replantation. odonto blast-like cells were observed. Tertiary dentin deposition was observed beneath the pulp-dentin border from 1 week after replantation. And tertiary dentin was increased at 2 weeks after replantation. The presence of odontoblast-like cells and the formation of tertiary dentin were continued to 4 weeks after replantation. At 4 weeks after replantation. the deposition of bone-like tissues and cementum-like tissues was observed. This results show that there is a possibility of pulp healing after tooth replantation in rats and the mineralization of tooth can progress. The mineralization of tooth after replantation was initially occurred by the deposition of tertiary dentin. but as time passed. the deposition of bone-like tissues and cementum-like tissues was begun and increased.

편측성 완전 구순구개열 환자의 포괄적 치료

이정근,황병남,최은주,김용빈 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.4

Cleft lip and palate is one of the congenital anomalies which need comprehensive and multidisciplinary treatment plan because 1) oral cavity is an important organ with masticatory function as a start of digestive tract, 2) anatomic symmetry and balance is esthetically important in midfacial area, and 3) it is also important to prevent psycho-social problems by adequate restoration of normal facial appearance. There are many different protocols in the treatment of cleft lip and palate, but our department has adopted and modified the Z□rich protocol, as published in the Journal of Korean Cleft Lip and Palate Association in 1998. The first challenge is feeding. Type of feeding aid ranges from simple obturators to active orthopedic appliances. In our department we use passive-type plate made up of soft and hard acrylic resin which permits normal maxillary growth. We use Millard's method to restore normal appearance and function of unilateral complete cleft lip. In consideration of both maxillary growth and phonetic problems, we first close soft palate at 18 months of age and delay the hard palate palatoplasty until 4 to 5 years of age. When soft palate is closed, posterior third of the hard palate is intentionally not denuded to allow normal maxillary growth. In hard palate palatoplasty the mucoperiosteum of affected site is not mobilized to permit residual growth of the maxilla. We have treated a patient with unilateral complete cleft lip and palate by Ajou protocol, which is a kind of modified Z□rich protocol. It is as follows: Infantile orthopedics with passive-type plate such as Hotz plate, cheiloplasty with Millard's rotation-advancement flap, and two stage palatoplasty. It is followed by orthodontic treatment and secondary osteoplasty to augment cleft alveolus, orthognathic surgery, and finally rehabilitation with conventional prosthodontic treatment or implant installation. The result was good up to now, but we are later to investigate the final result with longitudinal follow-up study according to master plan by Ajou protocol.

복식 전자궁적출술후 절단부에 발생한 난관탈출증 1예

송은석,이해혁,김태희,김정식,남계현,이권해,고은석 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Prolapse of the fallopian tube into the vaginal vault after hysterectomy is a rare complication. Since most of cases may resolve before detection or remain undiagnosed, the exact incidence is still unknown. Though most common sign of tubal prolapse is tender friable tissue in vaginal cuff, with the simptoms of lower abdominal pain, dysparenunia, vaginal discharge, or postcoital spotting. The definitive diagnosis should be confirmed histologically Recently, we experienced a case of fallopian tube prolapse after abdominal hysterectomy in a 41-year-old woman and report with a brief review of the literature.

효율적인 군 전직지원체제 정립 방안

정철영,고재관,황원채,윤희철,박가열,김재호,이성식,김동승,표성일,이건남,양안나,최수정,김은석 한국직업능력개발원 2008 직업능력개발연구 Vol.11 No.1

이 연구의 목적은 제대군인에 대한 효율적인 전직지원을 위해서 현행 전직지원 프로세스에 대한 개선 안과 이에 따른 국방부, 국가보훈처 등 제대군인 전직지원관련 기관 간의 역할분담 및 연계방안에 대해서 제안하는 것이다. 연구는 크게 세 가지 과정을 거쳤다. 첫째, 국내 군 전직지원 실태를 분석하여 문제점과 시사점을 도출하였다. 둘째, 이러한 문제점과 시사점, 군 전직지원 선행연구를 종합하여 효율적인 군 전직지원 프로세스 안을 제시하였다. 셋째, 구축한 군 전직지원 프로세스 안에 따라 주요 군 전직지원 관련 기관인 국방부, 국가보훈처의 역할 분담 안을 제안하였다. This study aims to suggest an improvement plan for the support process of effective occupation change for discharged soldiers and then role assignments among related institutions for supporting discharged soldiers such as Ministry of Defense, Ministry of Patriots and Veterans Affairs, Ministry of Labor and the cooperation plan among the institutions. The study was made in three steps. First, after analyzing currents support facts and status for discharged soldiers, it induced its problems and implications. Second, integrating the findings of previous studies related to support plan on occupation changes for the discharged soldiers, Problems and implications mentioned above, it constructed effective occupation change process for discharged soldiers. Then, according to the established process, it suggested role assignments such as Ministry of Defense, Ministry of Patriots and Veterans Affairs, Ministry of Labor.

인체 자궁암 세포에서 천연 성분이 P-당단백질의 활성에 미치는 영향

정수연,고은정,김나형,성민경,장정옥,이화정 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.15

Multidrug resistance (MDR) of cancer cells is, at least in part, associated with the overexpression of P-gly-coprotein (P-gp). Many studies hve demonstrated that natural compounds obtained from fruits, vegetables, teas and medicinal plants may modulate P-gp activity. The objective of the present investigation was to examine the effect of seven natural compounds on the P-gp activity in human uterine sarcoma cell line, MES-SA/DX5. Daunomycin uptake was significantly increased by biochanin A and silymarin (p<0.0001) whereas it was reduced by morin (p<0.01). The efflux of daunomycin from the cells was significantly inhibited by biochanin A, morin, cephalotaxine, berberine (p<0.05) and silymarin (p<0.0001). Biochanin A, berberine and silymarin significantly decreased IC_(50) value of daunomycin (p<0.05) while morin increased it (p<0.05). These results suggest that some natural compounds such as biochanin A and silymarin may inhibit P-gp funciton and can by developed as MDR reversing agents to improve the efficacy of chemotherapeutic drugs when administered concomitantly.

간세포암환자에서 간동맥 화학 색전술 후 발생한 리피오돌에 의한 폐렴 1예

김소이,김유리,허현미,배서은,이명원,최윤정,김고흔,김태헌,유 권,문일환 이화여자대학교 의과대학 2009 EMJ (Ewha medical journal) Vol.32 No.2

Hepatocellular carcinoma(HCC)is one of common causes of cancer-related death in Korea where the majority of HCC patients were Hepaitc B virus(HBV)carriers and have cirrhosis. Transarterial chemoembolization(TACE)is commonly applied to the treatment of multinodular HCC in Korea and careful selection of candidate is important for the risk of various side effects. Besides common side effects as fever, nausea, abdominal pain and elevation of liver enzyme, TACE may predispose to hepatic failure, ischemic cholecystitis, pulmonary embolism, cerebral embolism and pneumonitis. In previous studies, some cases of pulmonary and cerebral embolism cases were reported but lipiodol pneumonitis after TACE was rarely reported. A 65-year-old woman with a multinodular HCC associated with HBV infection, was treated with TACE. Seven days after the procedure, nonspecific respiratory symptoms such as dyspnea and dry cough developed. Chest X-ray and chest computed tomography showed diffuse ground glass opacities in whole lung fields, suggestive of lipiodol pneumonitis. After several days of supportive care with steroid administration, radiologic abnormalities and subjective symptoms were much improved, considered that the disease was compatible with lipiodol pneumonitis.

뇌하수체 종양 제거술 시행 후 뒤늦게 발생한 횡문근 융해증과 동반된 중추성 열

장제혁,최규남,김일환,노은지,김윤정,유충헌,고정해,박봉수,김태균,권민정,이순희,박정현 인제대학교 2008 仁濟醫學 Vol.29 No.-

Body temperature is controlled by thermoregulatory center of the hypothalamus. We report a case of 24 years old man with central fever. He was subjected to a partial excision of pituitary tumor compressing optic chiasm four years ago. He has received hormonal therapy for panhypothyroidism after removal of pituitary tumor. And He received gamma knife operation for partially contrast-enhancing masses in suprasellar and both hypothalamic areas that is probably postoperatively remnant or recurrent tumor of pituitary adenoma. One year after gamma knife operation, he presented with a febrile syndrome of unknown origin including rhabdomyolysis. All usual investigations proved negative. We diagnosed him as central fever with rhabdomyolysis. He received medical ICU care with cooling bed, ice pack. And his symptom improved. Postoperative hyperthermia may result following resection of the pituitary tumor. When central fever is suspected taking note of past history, a quick recognition of course of fever can help reduce the using of unnecessary antibiotics and hospital stay.

이상의 <오감도>에 나타난 현대디자인적 사고

이고은 ( Go Eun Lee ),김덕순 ( Deok Sun Kim ) 한국기초조형학회 2013 기초조형학연구 Vol.14 No.5

문학의 텍스트는 하나의 이미지로서 기능을 하고 있어 다양한 표현으로 수용자의 감성을 자극하는 디자인 요소와 상관성이 크다. 이상의 <오감도>는 현대성에 대한 고찰을 통해1930년대 식민지 상황, 서구 문화의 수용 과정 속에 고뇌하는 자아의 성찰과 그만의 독특한 시 의식으로 풀어낸 것이다. 이를 디자인적 관점에서 분석하는 과정은 우리의 시각문화가 불안한 사회현상 속에 과거를 통한 동시대의 모습을 해석하는 것이라고 할 수 있다. 이에 이상과 이상 문학의 기존연구 검토를 통해 그동안 진행되었던 연구 방법론을 정리하였고, 이상 문학의 전반적인 고찰을 통해 <오감도>이해의 틀을 마련하였다. 본 연구를 통해 현대성과 현대 디자인에 대한 이론적 정리를 통해 이상 문학과 현대디자인의 상관성을 밝혔으며, <오감도>에 나타난 다섯 가지로 요약된 모더니즘의 요소가 13편의 시에서 표현되고 있다는 것을 볼 수 있었다. 이러한 현대 디자인적 사고에 대한 분석이 21세기 현대사회의 불안한 사회현상에서 이상 문학을 다각도로 분석하고 다양한 학문으로서의 접근이 필요한 이상 문학의 가치이며 디자인에 있어서도 간과할 수 없는 연구과제로 인식되기를 바라는 바이다. As literary texts function as an image, they are largely correlated with design elements that stimulate consumers with various expressions. Through consideration of modernity, by Lee, Sang expresses self-examination in the process of accepting Western culture under the colonial period of 1930s, based on his own unique spirit of poetry. The whole process of analyzing this in the aspect of design could be an interpretation of the contemporary looks through the past, in social phenomenon with unstable visual culture. Through the review of the existing researches on Lee, Sang and his literature, this study summarized their research methodologies, and also established the framework of understanding through overall consideration of Lee, Sang`s literature. This study revealed not only the correlation between Lee, Sang`s literature and modern design, through theoretical summarization of both modernity and modern design, but also the fact in which the elements of modernism summarized into five elements shown in are expressed in 13 poems. Such an analysis on thinking of modern design should be recognized as a research subject that cannot be ignored in design and value of Lee, Sang`s literature that needs to be approached by various studies and to be analyzed from various angles, in such unstable social phenomenon of the 21st modern society.

The rates in developmental dysplasia of the hip in breech presentation in twins and triplets

( Eun Ji Oh ),( Seong Been Kim ),( Ye Hyon Park ),( Young Eun Lee ),( Su Been Hong ),( Jee Yoon Park ),( Kyung Jun Oh ),( Joon-seok Hong ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: To determine the incidence of developmental dysplasia of the hip (DDH) in breech presentation among multifetal pregnancies. Methods: This retrospective cohort study included 1256 consecutive live births who were born through cesarean section with at least one baby had been presented as non-cephalic presentation in each pregnancy from April 2013 to October 2018. Only births after 23+0 weeks of gestation were included. During analysis, neonates who had been presented as transverse lie in twins and triplets were excluded (n=39). In out institution, every baby is physically examined to assess the possibility of DDH by pediatricians and for the babies confirmed to be breech presentation during antenatal period, consultation to the orthopedists is routinely performed. The primary outcome was the diagnosis of DDH through ultrasonography. Results: The incidences of DDH diagnosed in neonates who had been presented as breech presentation antenatally were 5.1% (19/371) in singletons, 4.3% (20/463) in twins, and 8.1% (3/37) in triplets. In those three groups, the incidence of DDH was not significantly different. In twin pregnancy, the rate of DDH was significantly higher in breech presentations than cephalic presentations (4.3% vs. 0.3%, p<0.001). In the multivariate logistic regression analysis for the association between the incidence of DDH and various factors, breech presentation was the strongest and independent risk factor for the diagnosis of DDH (Odds ratio (OR) 8.9, 95% Confidence interval (CI) 2.1-38.3, p=0.003). Oligohydramnios and twin pregnancy were not statistically significant risk factors. however triplet pregnancy was found to be associated with DDH (OR 6.7, 95% CI 1.7-26.5, p=0.007). Conclusion: Pos Breech presentation is the strongest risk factor for the diagnosis of DDH even in the multifetal pregnancies.