Differential Manifestation of Ocular Phenotypes in TALEN-mediated p19arf Knockout FVB/N and C57BL/6J mouse lines

Jin‑Sung Park,Joo‑Il Kim,Hyun‑Jin Lim,Soo‑Kyung Ryu,Euna Kwon,Kang‑Min Han,Ki‑Taek Nam,Han‑Woong Lee,Byeong‑Cheol Kang 한국유전학회 2020 Genes & Genomics Vol.42 No.9

Background p19arf, primarily known as a tumor suppressor, has also been reported to play an essential role in normal development of mouse eyes. Consistently, lack of p19arf has been associated with ocular defects, but the mixed background of the knockout (KO) mouse strain used raised a concern on the accuracy of the phenotypes observed in association with the targeted gene due to genetic heterogeneity. Object We carried out a study to investigate into the efect of genetic background on the manifestation of p19arf KO associated phenotypes. Methods We characterized the phenotypes of novel p19arf KO mouse lines generated in FVB/N and C57BL/6J using a transcription activator-like efector nuclease (TALEN) system in comparison to the reported phenotypes of three other p19arf-defcient mouse lines generated using homologous recombination. Results Ninety-fve percent of FVB/N-p19arf KO mice showed ocular opacity from week 4 after birth which worsened rapidly until week 6, while such abnormality was absent in C57BL/6J-p19arf KO mice up to the age of 26 weeks. Histopathological analysis revealed retrolental masses and dysplasia in the retinal layer in FVB/N-p19arf KO mice from week 4. Besides these, both strains developed normally from birth to week 26 without increased tumorigenesis except for a subcutaneous tumor found in a C57BL/6J-p19arf KO mouse. Conclusion Our fndings demonstrated surprisingly variable manifestation of p19arf-linked phenotypes between FVB/N and C57BL/6J mice, and furthermore between our mouse lines and the established lines, indicating a critical impact of genetic background on functional study of genes using gene targeting strategies in mice.

Consumer Recognition Survey for Establishing the Reasonable Expiration Dates of Health Functional Foods

( Soo Jin Youn ),( Joo Youn Park ),( Hee Su Kim ),( Eun Jin Kang ),( Kil Jin Kang1 ),( Hye Kyung Park ),( Gun Hee Kim ) 한국식생활문화학회 2009 Food Quality and Culture Vol.3 No.2

This study investigated consumers` recognition on shelf life of health functional foods to set up their rational expiration date. For this study 107 male and female adults aged 20 to 59 years were randomly selected as major consumers of health functional foods. And their data were analyzed with SPSS 17.0. The questionnaire included questions asking a consumer`s recognition on the shelf life of health functional foods and how to treat health function food passing its shelf life. In this study, the consumers were found to pay attentions considerably to the shelf life. But most of them did not know an accurate meaning of the shelf life of health functional food and mistook it for expiry date. In addition, the consumers doubted safety of health functional foods passing the shelf life. Therefore, education for consumers about an accurate meaning of the shelf life was needed. The results of this study were considered to be helpful to set up a reasonable expiration date for health functional food.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

B 형 간염 에 있어서 IgM anti HBc 의 발현도 및 임상적 의의

김경희,강진경,문영명,송경순,김용범,최흥재,황용 대한내과학회 1986 대한내과학회지 Vol.30 No.1

Testing for IgM antiHBc was useful to detecting the patients with negative and positive HBsAg viral hepatitis and may improve serodiagnostic accuracy when acute NANB and delta agent hepatitis occur in previousely unrecognized HBsAg carriers. Moreover, it may be a useful test in defining potentially high risk sources of exposure to hepatitis B virus. But it is not useful in distinguishing recent from remote infection because IgM antiHBc occasionally was found in chronic liver diseases, IgM antiHBc was found by ELISA in 32 patients with acute viral hepatitis B, 61 with chronic hepatitis B, 18 patients with liver cirrhosis, 36 healthy HBsAg carriers and l49 patients with positive antiHBc alone. We continuously evaluated HBsAg and liver function of the patients who had negative IgM antiHBc acute hepatitis. The results are summarized as follows: 1) IgM antiHBc was positive in 84.4% of acute hepatitis B, 4% of chronic hepatitis B, 5.5% of positive HBsAg liver cirrhosis, 2. 8% of HBsAg healthy carriers but was all negative in patients with positive antiHBc alone. 2) Three patients with negative HBsAg acute viral hepatitis was diagnosed by positive IgM antiHBc as acute viral hepatitis R. 3) During the follow-up of 5 patients with negative IgM antiHBc acute hepatitis, 2 patients were diagnosed as type B acute viral hepatitis because of disappearance of HBsAg and normalization of liver function. And another 3 patients were diagnosed as non-B acute viral hepatitis superimposed on HBsAg carrier or natural course of chronic hepatitis.

남자대학생의 흡연태도와 행동에 관한 연구

강경진,김정미,민혜영,안소진,오경숙,은경희,이현,이희선,홍주미,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

There have been so many researches about problems of cigarettes and relation of smoking and heath since 1950's and generally known that smoking is one of the worst factor of increasing disease and mortality. No matter what such many proofs about various problems of smoking have been researched, smoking rate of current male collage students has not been decreased. Besides, most of the researches about cigarette use and its addiction have been focused on the adolescent or adult women smokers or adult male, not male collage student. Therefore, the subject of this study is about smoking attitude and smoking behavior of male collage students by general features. Smoking attitude was analyzed by modifying 'Guidelines for the content of tobacco smoking surveys of the general population'(WHO, 1982). Two hundred of male collage students participated to the distributed questionnaire for one week in May. The smoking attitude was categorized into duration of smoking and number of cigarette per day(CPD), and nicotine dependency, investigated by Fagerstrom Tolerance Questionnaire(FTQ) (Fagerstorm & Schneider, 1989). All statistics were performed by procedure of SAS according to number, percentage, mean, standard deviation, and ANOVA. The results are as follows: 1. Smoking attitude level was mean 25.73±5.15 marks, ranging from 13 to 39 marks of the total 40 marks. 2. Duration of cigarettes, number of cigarette per day, and nicotine dependency were mean 5.14±2.84 years, 12.88±6.85 pieces, and 4.78±1.69, respectively. 3. Smoking attitude showed significance according to general features such as marital state and allowance, but the significance according to marital state is not valuable because the numerical difference is so big between married one and single that they cannot be compared with each other. 4. Duration of smoking was significant according to general features such as age and allowance. 5. Smoking amount showed significance the factors of age only. 6. ll1ere was no significance in nicotine dependency according to general features. As a result, smoking attitude of male collage student in this study shows moderate level. Smoking attitude and duration is significant according to allowance, and smoking amount is significant according to age. Nicotine dependency according to general features is not significant but comparing with the preceding study about adult male, male collage students in this study are respectively more nicotine-dependent than adult male smokers. In conclusion, the right allowance usage strategies and effective heath education focused on the young are needed. In addition, helpful programs and information spreading strategies are necessary for establishing higher level of smoking attitude. At last, systemic regulations in daily living for ""anti-nico-dependent"" and perspective reforming of male university student are needed for reducing nicotine dependency.

유기용제 중독에 의한 중추신경장애 1예

강성규,이경용,정호근,이영진 大韓産業醫學會 1992 대한직업환경의학회지 Vol.4 No.1

We report a case of demyelinating lesion in central nervous system in a 38-year-old female patient who suffered from muscle weakness and disability of standing by herself. She worked for 10 hours in a day at the small footwear factory about 1 year in 1990. Physical examinations showed normal except increased DTRs in the elbows and knees. Clinical laboratory findings were within normal limits. Brain CT and EMC findings were normal. But, brain MRI showed small multiple high signal intensity area on T2 weighted image in right frontal white matter, right fronto-parietal periventricular white matter with localized atrophy in genu and rostrum of corpus callosum. There were no ventilation system in the factory. By the evaluation of work environment 1½ months later, high concentration of toluene, MEK, n-hexane, MIBK, acetone and cyclohexane were detected. We suppose her demyelinating lesion was caused by toluene alone or mixed solvents with toluene and others.

P.C.를 이용한 作業管理시스팀(Ⅰ)

姜鎬郁,金炅模,徐有振 慶尙大學校 工科大學 附屬 生産技術硏究所 1986 生産技術硏究所論文集 Vol.2 No.-

The object of this research is to develop a personnel-computer program for THERBLIG analysis and FLOW-PROCESS analysis which are kinds of work methods design. All programs are written in BASIC language. The results of this research can be extended to other work methods design and reduce 50% in clerical effort.

특수교육 교육과정 국제동향 분석

강경숙,김진숙,정해진,황윤한 국립특수교육원 2004 연구보고서 Vol.- No.2

본 연구는 세계 여러 국가의 특수교육 교육과정의 개발 및 운영에 대한 정보를 수집하여 국제동향을 분석하기 위해 시행되었다. 해외 9개국과 국내의 특수교육 교육과정 개발 및 운영에 대한 동향을 살펴보고, 일반교육과정과 특수교육 교육과정의 연계성을 탐색하여 국제비교하여 향후 우리나라 특수교육 교육과정 수립 시 필요한 방향성에 대한 시사점을 도출하고자 하는 것이다. 제1장에서는 연구의 필요성 및 목적, 연구의 문제 및 내용, 연구방법. 연구의 제한점을 비롯한 연구의 개요를 기술하였다. 연구의 내용으로는, 첫째 특수교육 교육과정의 전체 교육적인 맥락을 파악하기 위해 각 국가의 교육제도 및 일반교육과정에 대한 개요를 파악하고. 둘째 특수교육 교육과정의 국가수준ㆍ지역수준ㆍ학교수준 개발에 대한 실태를 파악하고, 셋째 특수교육 교육과정의 운영 및 실제에 대한 실태를 분석하고, 넷째 특수교육 교육과정의 개발 운영에 대한 국제동향을 권역별로 비교ㆍ분석하고 시사점을 도출하여 향후 교육과정 개발을 위한 방향성을 모색하는 것이다. 이처럼 전반적인 교육제도와 일반교육과정을 함께 연구한 것은 특수교육 교육과정을 연구하는 특수교육관련 전문가만이 아니라 일반교육 교육과정 관계자와 교사들에게도 유용한 정보를 제공할 수 있을 것이며 일반 교육과정과의 관계성 정립을 통해 장애학생의 교육과정적 통합을 위한 토대를 구축할 수 있을 것이다. 연구방법 및 절차로는 우선, 일반교육과정 및 특수교육 교육과정 관련자료를 분석하여 동향 분석 준거를 설정한 후 외국의 한국교육원, 해외 거주 박사과정 및 해외연구원을 활용하여 국외 특수교육 교육과정 개발 및 운영측면에 대한 자료를 수집하였다. 또한, 해외 현지외국인 교사 및 관리자를 통한 설문조사와 면담조사, 국내 교육과정 운영자료를 수집 하기 위해 설문조사와 현장방문 및 면담조사를 실시하였다. 제2장에서는 선행연구 및 특수교육 교육과정 고찰을 위해 첫째, 교육과정 국제동향비교 관련 선행연구 고찰, 둘째 기존 특수교육과정의 변천 및 제7차 교육과정 고찰, 셋째 특수교육과정 개발 및 운영에 대한 내용을 소개하였다. 제3장부터는 각 장을 구성하고 있는 본 연구의 주요부분으로 특수교육 교육과정 국제동향에 대해 미국, 캐나다, 영국, 독일, 호주, 뉴질랜드, 일본, 중국, 홍콩을 중심으로 자료를 조사하였으며, 한국에 대해서는 교육과정 개발 및 운영 면에 대해 특정 교육청으로부터 수집한 자료와 특정 학교의 사례를 중심으로 기술하였다. 본 연구의 큰 주제는 특수교육 교육과정의 개발 및 운영이지만, 특수교육 교육과정은 그 나라의 교육제도 및 일반교육과정과 밀접한 연관성을 지니고 유기적으로 개발ㆍ운영되기 때문에 교육 전반적인 맥락을 알아보기 위해 각 국가의 교육제도, 일반교육과정의 개발 및 운영, 특수교육의 개관에 대해 먼저 살펴보았다. 본 연구의 주 핵심인 특수교육 교육과정의 개발과 운영은 면담 및 설문자료를 토대로 했을 뿐 아니라, 사진 및 교실구조도와 같은 교실현장의 자료를 토대로 특수교육의 장면 특히, 통합장면의 교육사례를 중심으로 구성하였다. 위 국가에서 연구된 내용을 중심으로 연구결론에서는 권역별로 나누어 특수교육 교육과정을 중심으로 국가간 비교를 하였다. 비교할 내용의 틀로는 첫째, 특수교육의 방향 및 관련법규, 특수교육 서비스전달체제와 같은 특수교육개관, 둘째, 특수교육 교육과정 개발 측면으로 특수교육 교육과정의 결정방식, 국가ㆍ지역ㆍ학교 수준의 교육과정 개발, 표준 및 가이드라인, 교육과정철학ㆍ목표ㆍ내용ㆍ평가 등 교육과정의 요소, 학급의 교육과정 운영 시 상위수준 교육과정과의 연계성 여부, 교육과정 적용 절차 및 시기, 교육과정 재구성에 대한 교사의 자율성 및 의사결정에 대한 국가간 비교를 하였다. 셋째, 특수교육 교육과정 운영 측면으로는 교사의 교육과정 운영에 대한 자율성 부여정도, 교육과정적 통합을 위한 일반교사와 특수교사의 협력, 일반교육과정으로의 접근 혹은 연계성, 개별화교육 계획과의 연계 측면, 교육방법과 교재활용과 같은 내용을 권역별로 비교하였다. 각 국가간 권역별 비교를 통해 향후 특수교육 교육과정 수립 및 일반교육과정과의 연계를 위한 시사점 및 제언을 도출하였다. 본 연구에서는 특히 거스를 수 없는 추세인 통합교육을 위해 어떻게 일반교육과정과 연계를 맺어야 하는지, 교사 간 협력을 어떻게 이뤄가야 하는지에 대해 초점을 맞추어 시사점을 도출해내었다. 각 국가의 특수교육 교육과정을 조사한 결과를 토대로 시사점을 도출하여 간단히 정리해보면 다음과 같다. 첫째, 세계 각국의 교육과정은 나름대로 국가수준ㆍ지역수준ㆍ학교수준의 교육과정 체제의 틀을 갖추고 있지만, 중앙 집중적이기보다는 지방 분권화되어가는 경향을 강하게 보이고 있다. 미국, 캐나다, 독일과 같은 경우는 각 주에서 독자적으로 개발한 교육과정에 따라 독창적으로 운영되고 있었다. 영국, 뉴질랜드, 중국, 일본, 우리나라의 경우는 국가교육 과정의 틀에 따라 교육과정이 구성되어 전달된다고 볼 수 있다. 특수학급의 경우 각국 공통적인 현상은 국가수준의 일반교육과정과 특수교육 교육과정이 있는 경우에도, 특수학급을 위한 학교교육과정 개발을 찾기 어려웠다. 특수학급을 위한 교육과정 개발은 지역수준 교육과정 지침에 의해 학급교육과정, 개별화지도계획 등으로 교사에게 일임되어 있는 상태이다. 둘째, 교육과정 개발 및 운영에 대한 교사의 자율권을 상당부분 제공하고 있다. 미국과 영국, 캐나다, 호주는 교육과정의 기준(standards)과 성취수준을 제시할 뿐 구체적인 교육내용이나 방법을 제시하고 있지는 않기 때문에 교사의 자율권을 상당부분 허용하고 있었으며, 독일은 주 수준에서 교육과정 내용을 제시한다 하더라도 구속력은 거의 없었다. 영국은 교사들의 교육과정 구성능력이 중시된 국가로서 교사가 스스로 개발ㆍ운영하는 데 무리가 없는 국가라고 자처하지만, 장애학생의 교육성과가 교사의 질에 전적으로 의존해야 하는 상황은 신중하게 검토해야 할 부분이다. 셋째, 전 세계적인 특수교육이 분리교육에서 통합교육의 방향으로 이동해 감에 따라 일반교육과정을 근간으로 특수교육 교육과정이 구성되어 운영되는 국가가 많았다. 캐나다, 영국, 홍콩, 호주, 뉴질랜드와 같이 유럽, 미주 지역과 그 영향권 하의 학교중심 교육과정 개발의 전통이 강한 나라들이 그러하다. 일본, 중국, 우리나라와 같이 기본교육과정이라는 특수교육 교육과정이 별도로 개발되어 있는 국가는 찾아보기 어려웠다. 즉, 많은 국가에서 일반교육과정으로의 접근, 혹은 일반교육과정과 특수교육 교육과정과의 연계성 측면을 상당부분 모색하고 있는 것으로 사료된다. 넷째, 특수교육 요구학생의 개별적인 필요에 맞게 고안된 교육과정이라 할 수 있는 개별화된 교육계획을 구성하여 운영하고 있었다. 미국, 캐나다, 영국, 호주, 뉴질랜드, 우리나라에서는 특수교육 요구학생의 교육과정이 IEP에 의해 이루어지도록 제도화되어 있었다. 미국과 캐나다에서는 학생의 학업 및 사회적 기능에 초점을 맞추어 IEP가 개발되고 있는 것으로 나타났다. 영국에서는 일반학생의 교육과정을 특수교육 요구학생의 수준에 맞게 수정ㆍ보완하거나 현저한 차이가 있는 경우, 다른 것으로 대체할 수 있도록 하였다. 다섯째, 일반교육과 특수교육의 팀 형성 및 교사간 협력관계를 토대로 특수교육 교육과정이 운영되는 것을 주목할 수 있었다. IEP를 구성할 때도 일반교사와 함께 논의하고, 학급운영에 있어서도 보조원의 지원을 받을 수 있을 뿐 아니라 교사간 팀 교수를 통해 통합 장면에서의 수업이 진행되는 것을 볼 수 있었다. 독일의 경우, 특수학교에 적을 둔 특수교육 대상학생이 일반학급에 통합되어 특수교사가 함께 일반학급에서 수업을 지도하였다. 홍콩은 통합교육을 국가주도적인 정책 방향으로 삼아 '전체학교접근'을 시도하였는데, 이는 학교전체적인 차원에서 협력하여 통합교육을 지지하는 것이라 할 수 있다. 이제 통합장면에서의 특수교육 교육과정의 운영은 협력을 떼어서는 생각할 수 없는 주제처럼 생각된다. 이 외, 영국에서는 일반학교에 특수교사 대신 특수교육코디네이터(SENCO)를 두고 있으며, 일본에서도 최근 이러한 유형의 코디네이터를 학교에 배치할 것을 계획하고 있는 것으로 나타났다. 이는 일반교육 안에서 특수교육이 함께 가기 위한 노력의 일환으로 보인다. 이처럼 일반교육과 특수교육의 일원화된 체제를 지향하기 위해 독일의 특수교사 양성 교육과정에서는 교육학 일반 및 일반교과가 특수교육 전공보다 많았으며, 홍콩과 같이 일반 교사 및 특수교사 양성체제가 이원화되어 있지 않고 일반교육을 교육받은 후 이를 토대로 특수교육을 전공하거나 연수를 통해 특수교육을 이수하게 하는 경우는 처음부터 일반교육 과정과 특수교육과정이 별개로 운영되지 않을 수 있다는 단초를 제공한다. 그리고 특수학교에서의 통합교육을 모색하고 있는 중국의 경우, 지역사회에서 특수교육적 자료를 제공 하고 상담하는 리소스센터로 거듭나기 위해 학교를 개방하고 있었는데, 통합장면만이 아닌 특수학교에서의 교육과정의 개발 및 운영도 일반교육의 그것과 더불어 함께 논의되어야 한다는 점을 강하게 시사한다. 끝으로, 본 연구에서는 향후 일반교육과정과의 연계성을 고려한 특수교육 교육과정의 개발 및 운영을 위해 일반교육과정의 개정 작업 시 특수교육전문가가 참여할 것을 제안하는데, 이는 경도장애학생의 경우 당초부터 특수교육 요구학생으로 낙인되지 않고 구제될 수 있도록 모든 학생을 고려한 보편적인 교육과정을 개발하는데 특수교육적 고려를 포함 할 수 있기 때문이다. 교육의 내용 뿐 아니라 교육방법 면에서도 차별화된 교수법 등의 제안으로 일반학급에서 장애학생이 통합되어 교육과정이 운영될 수 있도록 다양한 노력이 요구된다. The purpose of this study was to analyze international trends of development and management of special education curriculum in nine countries. The results of this study will help establish direction for the development of special education curriculum in Korea. Chapter 1 describes the needs for and purposes of this research, research questions, research methods, and limitations of this study. Sections on each country have the following structure : the education system and general education curriculum ; the development of special education curriculum at the national, local, and school level ; the management of special education curriculum and current practices in local schools: and implications for establishing direction for the development of special education curriculum. This study will serve professionals in both general education and special education field since it emphasized the perspective by which special education was viewed as part of the general education system. The focus was on investigating the relationship between general education curriculum and special education curriculum. This study attempted to establish foundation for curricular integration of students with disabilities. In terms of research methods and procedures, first, researchers developed a framework for the analysis of international trends based on literature review. Second, researchers collected data on the development and management of special education curriculum through local research assistants from the countries. Third, for the nine countries, school teachers were surveyed and interviewed on special education curriculum. Chapter 2 reviews existing literature on international trends of curriculum, current special education curriculum, and the history of the development of special education curriculum. Also information on the development and management of special education curriculum in Korea was provided. In the following chapters, data on special education curriculum from nine countries including USA, Canada, UK, Germany, Australia, New Zealand, Japan, China, and Hong Kong were analyzed. Particularly, for Korea, the description centered around the analysis of data from a District Office and case studies of local schools. Main topic of this study was the development and management of special education curriculum. However, special education curriculum can not be discussed without considering the context of general education system and curriculum. Therefore, first, reviewed were education system in general and development and management of general education system for the nine countries. The development of special education curriculum was presented at the national, local, and school level, and management of special education curriculum was described based on interview data, survey responses, pictures, and case studies. In the results section, international data on special education curriculum was compared and contrasted by the region. The framework for the comparison include (1) special education overview including special education trends, law and policy, special education service delivery system, (2) the development of special education curriculum including curriculum decision-making process, the national, local, and school level curriculum, standard and guideline, curriculum philosophy, elements of curriculum such as objectives, contents, methods, and assessment, link to the upper level curriculum, curriculum implementation procedures, teacher autonomy in curriculum restructuring, (3) the management of special education curriculum including teacher autonomy in the management of curriculum, collaboration between special education and general education teachers, link to general education curriculum, link to IEP, instructional methods, and use of text books. Based on the regional comparisons among countries, implications and suggestions were drawn. In particular, the focus was on how to connect general education curriculum with special education curriculum, and how to encourage collaborative relationships between teachers. The implications are as follows. First, although curriculum in the countries had different levels of curriculum such as the national, local, and school-level curriculum, the international trends moved toward localization from centralization. Countries including USA, Canada, Germany implemented the state-developed curriculum while countries such as UK, New Zealand, China, and Korea developed curriculum within the framework of the national level curriculum. With regard to curriculum in special education classrooms, reviewed countries appeared to share a similar trend. That is, even in the cases that had the national-level general and special education curriculum, the national-level curriculum for students in special education classrooms were not found. In most cases, curriculum for students in special education classrooms was often developed by teachers based on local curricular guidelines. Second, autonomy in the process of the development and management of curriculum was provided for teachers. For example, in USA, UK, and Canada, standards and achievement objectives were presented in the curriculum leaving out contents and instructional methods. In Germany, even though curriculum was presented at the state level, it was not mandatory. In UK where teachers' ability of curriculum development was traditionally valued, careful considerations were needed : because outcomes of students with special education needs solely depended on teacher quality. Third, as the international trends of special education moved toward inclusive education, more countries developed special education curriculum based on general education curriculum. For example, countries such as Canada, UK, Hong Kong, Australia, and New Zealand did not have separate special education curriculum at the national level. Many countries appeared to exert their effort to integrate special education into general education. Fourth, individualized curriculum for students with special education needs were used in many countries including USA, UK, Canada, Australia, New Zealand, and Korea. In USA and UK, curriculum for students with special education needs tended to focus on academics and social function, while in UK, general education curriculum was accommodated to meet the needs of students, or alternative curriculum was used in case the academic gap was too large. Fifth, it was noted that the management of special education curriculum was based on the collaborative relationship between general education teachers and special education teachers. It was observed that the collaboration was in place in the development of IEP, support of teacher aides, and co-teaching. In Germany, students enrolled in special education schools were integrated in general education classes, and special education teachers from the special school taught in the general education classroom. In case of Hong Kong, a national policy called 'whole school access' was tried in which inclusion was supported at the whole school level. That is, the management of special education curriculum can not be successful without collaboration among educators. In U.K, there was a SENCo, special education needs coordinator instead of special education teacher in general education schools. This system was scheduled to be in place in Japanese schools. This seemed to be an effort to integrate special education into general education. Another effort could be found in Germany where special education teacher training programs included more general education courses than special education courses. In Hong Kong, the teacher education systems were not even separated. That is, teachers who have completed course requirements for acquiring general education teacher certificate can major special education or attend to special education in-service to be special education teachers. This system appeared to provide head start for the integrated education system. In case of China where inclusive education in special education schools were considered, educators strongly indicated that the development and management of curriculum for students enrolled in special education schools should also be discussed. Finally, this study suggests special education professionals participate into the process of the general education curriculum revision in order to develop and manage special education curriculum that is well-connected with general education curriculum. By doing this, the development of universally designed curriculum can be empowered by widening the range of audience the curriculum covers. This, in turn, will eliminate the needs for the identification of students with mild disabilities since the universally designed general education curriculum would meet these students' needs. Successful implementation of curriculum for students with disabilities in inclusive settings requires consistent efforts from all stakeholders in education.

중환자의 욕창 예방 연구 : 욕창 예방 QI팀을 중심으로

강소영,최은경,김진주,주미정 한국의료QA학회 1997 한국의료질향상학회지 Vol.4 No.1

Background : A pressure sore was defined as any skin lesion caused by unrelieved pressure and resulting in damage to underlying tissue. The health care institutions in the United States were reported the incident rate of pressure sores ranging from 6 to 14%. United states were reported the incident rate of pressure sores in patients rate of pressure sore. Also, Annual expenditures for the care of pressure sores in patients in the United States have been estimated to be $7.5 billion; furthermore, 50 percent more nursing time is required to care for patients with pressure sore in comparison to the time needed to implement preventive measures against pressure sore formation. However, In Korea, there were little reliable reports, or researches, about incidence rates of pressure sore in health care institution including intensive care unit and about the integrated approach like CQI action team for risk assessment, prevention and treatment of pressure ulders. Therefore, this study was to develop pressure sore risk assessment tool and the protocol for prevention of pressure sore formation through CQI action team activities, to monitor incident rate of pressure sore and the length of sore formation for patients at high risk, and to approximately estimate nursing time for sore dressing during research period as the effect of CQI action team. Method : CQI action team in intensive care unit, launched since early 1996, reviewed the literature for the standardized risk assessment tool, developed the pressure sore assessment tool based on the Braden Scale, tested its validity, compared on statistics including incidence rate of pressure sore for patients at high risk. Throughout these activities, CQI action team was developed the protocol.called as St. Marys hospital Intensive Care Unit Pressure Sore Protocol, shifted the emphasis from wound treatment to wound prevention, After applied the protocol to patients at high risk, the incident rate and the period of prevention against pressure development were tested with those for patients who received care before implementation of protocol by Chi-square and Kaplan-Meier Method of Survival Analysis. Result : The CQI action team found that there was significant difference of incidence rate of pressure sores between patients at high risk( control group) who received care implementation of protocol (p<.05). 25% possibility of pressure sore formation was shown for the patients with 6th hospital day in ICU in control group. In experimental group, the patients with 10th hospital day had 10% possibility of pressure sore. Therefore, there was significant difference(p< .05) in survival rate between two groups. Also, nursing time for dressing on pressure sore in experimental group was deceased as much as 50% of it in control group. Conclusion : The collaborative team effort led to reduced incidence, increased the length of prevention against pressure sore, and declined nursing care times for sore dressing. However, there have had several suggestions for future study. The preventive care system for pressure sore should be appleed to patients at moderate, or low risk throughout continuous CQI team activities based on Bed sore Indicator Fact Sheet. Hospital-wide supports, such as incentives, would be offered to participants for keeping strong commitment to CQI team. Also, Quality Information System monitoring incidents and estimation cost of poor quality. like workload(full time equivalence) or financial loss, regularly in a hospital has to be developed first for supporting CQI team activities as well as empowering hospital-wide QI implementation. Being several limitations, this study would be one of the report cards for the CQI team activities in intensive care unit of an acute hospital and a trial of quality improvement of health care in Korea.

한국인 지원자에서 니모디핀의 생체이용율연구

강원호,심희옥,남진경,김동출 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-

A reversed phase HPLC method was developed and validated for the determination of nimodipine in human plasma. Nitrendipine was used as an internal standard. Calibration curves were linear in the concentration range of 5~300 ng/ml. The coefficient of variation of the intra- and inter-day precision was below 15%. The coefficient of variation of the accuracy was below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Eight healthy male volunteers were orally administered 30 mg of nimodipine. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(24hr) was 64.0±31.3 ng·hr/ml, C_(max) was 46.5±31.2 ng/ml, T_(max) was 0.54±0.17 hr and t_(1/2) was 3.03±2.26 hr. The pharmacokinetic parameters and the HPLC method can be used for the design of bioequivalence study of nimodipine.