중증 재생불량성 빈혈 환자의 동종골수이식 후에 병발한 간정맥폐색질환(Hepatic Veno-Occlusive Disease)의 임상 경과 및 혈액응고 인자들의 변화

이제환,이규형,최성준,민영주,김신,이정신,김상희,박찬정,지현숙,김우건 대한조혈모세포이식학회 1999 대한조혈모세포이식학회지 Vol.4 No.2

연구배경: 재생불량성 빈혈 경우에는 조혈모세포 이식 후 VOD의 발생에 관한 보고가 거의 없는 실정이다. 저자 등은 cyclophosphamide와 antithymocyte globulin으로 전처치 후에 동종골수이식을 시행한 재생불량성 빈혈 환자들을 대상으로 하여 VOD의 발생과 임상 양상, 혈액응고 인자들의 변화에 관하여 분석하여 보았다. 방법: 재생불량성 빈혈로 동종골수이식을 시행 받은 13예 환자를 대상으로 하였다. 임상적 기준에 따라 VOD를 진단하였으며 임상 경과에 따라서 경중을 분류하였다. Protein C, protein S, antithrombin Ⅲ, tPA, PAI-1 등의 혈액응고 인자들을 전처치 투여전, 골수 주입당일, 이식 후 제7, 14, 21일에 측정하였다. 결과: 7예(53.8%)에서 VOD가 발생하였으며, 경증 5예, 중등도 2예였다. VOD군에서 혈소판치가 20.000/㎕ 이상을 유지하는 데까지 걸리는 시간이 더 길었다(p=0.026). 또한 VOD군에서 적혈구 및 혈소판의 수혈 요구량이 각각 유의하게 많았다(p=0.025, 0.015). 혈액응고 인자들의 변화를 보면, 제 0일에 VOD군에서 PAI-1의 혈중 농도가 유의하게 더 높았다.(p=0.034). 결론: 재생불량성 빈혈환자에서도 조혈모세포 이식 후에 VOD의 높은 발생률을 관찰하였으며, 대부분이 경증이었다. VOD 환자에서의 혈액응고 인자들의 변화는 PAL-1이 VOD의 감별 진단을 위하여 이용될 수 있음을 시사하고 있다. Background: There are few reports about the occurrence of hepatic veno-occlusive disease(VOD) after bone marrow transplantation (BMT) for severe aplastic anemia (SAA). We analyzed the incidence and clinical outcomes of VOD and changes of coagulation factors in patients with SAA who were conditioned with cyclophosphamide plus ATG and underwent allogeneic BMT. Methods: Thirteen patients with SAA who underwent allogeneic BMT were included. A diagnosis of VOD was made according to clinical criteria, and severity of VOD was classified according to clinical course. Plasma levels of protein C, protein S, antithrombin Ⅲ, t-PA, and PAI-1 were determined before preparative chemotherapy, in the day of marrow infusion, and days 7, 14, and 21. Results: VOD occurred in 7/13(53.8%). Five were mild VOD and two were moderate VOD. Time to platelet ≥20,000/L was slower (p=0.026) and red cell and platelet transfusion requirements were higher (p=0.025,0.015) in patients with VOD . The mean plasma level of PAI-1 at 0 were higher in patients with VOD (p=0.034). Conclusion: We observed the high incidence of VOD after allogeneic BMT in patients with SAA. A majority of cases of VOD were mild. The changes of PAI-1 after BMT may be useful marker of hepatic VOD

동종 골수이식을 시행받은 환자에서 폐색성 세기관지염에 의하여 발생한 자발성 기종격동과 피하 기종

이병환,이제중,이연경,안재숙,김여경,황호인,박무림,조상희,정익주,김형준 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2

저자들은 만성골수성백혈병으로 동종 골수이식과 이식편 부전으로 인하여 추가적인 말초혈액 조혈모세포이식을 시행 받은 환자에서 만성 이식편대숙주질환과 그 폐 합병증인 폐색성 세기관지염에 동반된 자발성 기종격동과 피하 기종이 병발한 1예를 경험하였기에 이를 보고하는 바이다. Obstructive lung disorders following after allogeneic bone marrow transplantation (BMT) in association with graft- versus-host disease (GVHD) contribute significant morbidity and mortality. We report a case of a 28-year-old man who developed spontaneous pneumomediatinum and subcutaneous emphysema complicating bronchiolitis obliterans after allogeneic BMT. He received an allogeneic BMT for chronic phase of chronic myeloid leukemia. Five months after BMT, he was boostered by allogeneic peripheral blood stem cells from the same donor due to graft failure. One month after the boostering, chronic GVHD developed and were treated with cyclosporine and steroid. The patients developed spontaneous pneumomediatinum and subcutaneous emphysema secondary to severe bronchiolitis obliterans 4 months after boostering donor cells. The air-leak syndromes were recovered by conservative management, including high-flow oxygen.

WIPO의 전통지식 등의 지재권 설정 논의에 관한 개략적 방안 모색

이제현,김용진,최환수 대전대학교 한의학연구소 2004 혜화의학회지 Vol.12 No.2

The international government committee is progressing their agreements about intellectual property protection of traditional knowledge(TK1, gene resource(GR), folklore(FL) in WIPO. It is in the course of selection with precedence of TK, GR, FL in WIPO, focused on discussions about listing of TK documents, standardization of DB construction, sharing and profit distribution of GR. There are disagreements between developed countries and developing countries about intellectual property protection agreements of TK, GR. The developed countries insist on using the existing intellectual property protection, but the developing countries ask new ones on character of TK, GR. It causes intangible assets to be valuable trade properties in future world trade. This research Groped for a summary program about intellectual property protection of traditional knowledge(TK) etc. debating in WIPO. This program confirms that such as TK, GR etc. not only to be the cultural property accumulated in human history, but also to be the original resource may be using at present. Therefore, we suggest that the focus of discussion should transfer to UNESCO instead of WIPO which only deal with the intellectual property protection. Besides, the main body which protecting and supporting TK should become its holding organization so as to achieve more effective management about it. In order to protect and support TK, the government should have firstly the recognition that TK is the property belongs to the country. By this viewpoint, it needs to setup DB through overall excavation of the unofficial knowledges in order to protect and support these TK, GR. Because the positive dealing with those WIPO's discussion means to support our TK, GR, so there should have some reorganization about existing related ones, and also needs systemic supporting policies & management system.

X-線粉末廻折法에 의한 Cadmiun Sufide 試料의 定量定性分析

徐日煥,金永銓,鄭濟永 충남대학교 자연과학연구소 1983 忠南科學硏究誌 Vol.10 No.1

The 32 X-ray diffraction intensity peaks for the cadmium sulfide powder (99.999% purity),which is an industrially important semiconductor, were obtained rotating 2θh㎘ Bragg angle of X-ray diffractometer with Cu Kα radiation from 20 to 120 degrees by θ-2θ scan technique. Each reflecting plane identified by means of the graphical and analytical methods indicated that there are two different kinds of phases : hexagonal close-packed structure with a=4.13Å, c=6.75Å and face-centered cubic structure with a=5.82Å. In order to account for the result of two molecules per unit hexagonal cell and four molecules per unit cubic cell, they should have the wurtzite form and zinc blende form respectively. The quantitative analysis by the direct comparison method has shown that this sample contains approximately 86.3 percent wurtzite form and the rest 13.7 percent zinc blende form of CdS. The correct result has been proved by the good agreement between the experimental and theoretical integrated intensities.

대학생 내담자가 호소하는 문제유형과 성격유형과의 관계 연구

박제일,임승환 한국심리유형학회 2002 심리유형과 인간발달 Vol.9 No.-

본 연구는 대학교 학생생활연구소를 내방하여 상담을 받은 537명의 학생들을 대상으로, 학생들이 호소하는 문제유형과 성격유형과의 관계를 분석하여, 이를 토대로 내담자의 성격특성에 따른 적절한 상담대처방식을 적용하기 위한 기초연구로 진행되었다. 이를 위하여 내담자들이 호소하는 문제유형과 성적유형과의 관계를 분석하였다. 그 결과를 종합해보면, 내담자들이 호소라는 문제유형은 "학업 및 진로문제", "성격문제", "정서문제"의 순으로 나타났다. 성격유형 분포는 전체 분포에 비추어볼 때, "내향형"과 "직관형"의 비율이 높게 나타나고 있고, 성격유형과 내담자들이 호소하는 문제유형과의 관계에서는 ISTJ, ISTP, INFP, INTJ, INTP 유형에서 공통적으로 빈도가 높게 나타나고 있는 것을 알 수 있다. 따라서 이들 유형에게서 문제를 호소하는 비율이 증가하는 이유와 그 대책에 대한 논의가 필요하다. 또한 상담장면에서 성격유형별 대처방식에 대한 적용가능성에 대해 좀더 확대된 연구가 필요하다고 하겠다. This study was proceeded with 537 students who had counseling sessions in university students counseling center as the groundwork of applying appropriate counseling strategies according to the client's personality type, on the basis of the analyses of relations between the types of problems students complained about and their personality types. For this purpose, analyses were proceeded to figure out the relations between the reffered problem types and personality types of student clients in university. In summary, the problem types clients complained about appeared as "problems in schoolwork and career", "problems in personality", and "emotional problems" in order. Compared with the whole personality type distributions, "Interversion" and "iNtuition" types occupied higher rates than other types, concretely, ISTJ, ISTP, INFP, INTJ, and INTP types showed higher frequencies in common than others. So, it is necessary to discuss the reason why the problem complaining rates showed higher levels in these types and the strategies of the counselors to cope with these types of clients appropriately. And further study is needed to research the applicability of strategies of counselors according to the personality type of client's in counseling setting.

합성섬유보강 콘크리트의 구속수축균열 제어특성연구

박제선,윤경구,이주형,최성용,김태환 강원대학교 부설 석재복합신소재 제품연구센터 1999 석재연 논문집 Vol.4 No.-

최근에 폴리프로필렌 섬유를 첨가하여 콘크리트의 인성을 증가시키고, 균열에 대한 저항성을 향상시키고자 하는 노력이 계속되어 왔다. 그러나 첨가된 섬유의 구조에 대한 이해부족으로 인하여 연구자들간에 실험결과에 대한 해석이 상이한 경우가 많았다. 이러한 연구의 일환으로 섬유의 첨가에 따른 건조수축 균열의 조절 가능성을 분석하기 위하여 섬유의 첨가에 따른 유동성과 건조수축의 변화를 조사하였다. 섬유의 첨가에 따른 유동성의 변화와 건조수축을 측정하기 위한 강제링 시편을 제작하였다. 본 연구에서는 섬유를 첨가한 콘크리트의 역학적 거동특성인 압축강도, 휨강도, 인성, 그리고 균열특성을 실험적으로 규명하고자 하였다. 본 연구는 강도 및 건조수축특성을 규명하기 위하여 수행되었고 섬유의 영향으로 인한 건조수축특성을 예견할 수 있다. Polypropylene Fibers have been used to increase the toughness of concrete and to increase the resistance to crack formation. However, there are many contradictory argument about the effectiveness of the fiber due to the lack of knowledge about the mechanism of fiber in concrete. In order to study the effect of fibers on possible crack control, the effects of fibers on workability and drying shrinkage have been studied. The workability change due to the addition of fibers has been studied, and full size concrete steel ring specimen have been cast at field to investigate the effect of fibers on the shrinkage properties. This laboratory have been performed to obtain the properties of pp fiber reinforced concrete such as compressive, flexural strength, toughness, slump, drying shrinkage crack and drying shrinkage characteristics. The present study was performed clarify the strength and drying shrinkage properties. From these results, we can expect the effect of the admixtures of polypropylene fiber for concrete and mortar about strength and drying shrinkage properties.

비선형 캐리어 제어 부스트 정류기 특성에 관한 연구

이제환,전기영,조정민,한홍일,한경희 明知大學校 産業技術硏究所 2000 産業技術硏究所論文集 Vol.19 No.-

Average-current mode controlled boost rectifier is most universally used at present, While the method gives high power factor, low harmonics distortion, has drawbacks such as 3-feedback loop, complex component, difficulty of control-circuit design, and high cost. Research for improving these problem has been carried out, and Nonlinear Carrier(NLC) Control method is representative. This control method has easy algorithm for control, and its feedback loop and control components are reduced. In this paper, the control method was evaluated by simulation through Matlab/Simulink, and experimented with 550W boost rectifier. As the result, that can get high power factor above 0.95 and low harmonic distortion was confirmed. Also, a good dynamic response on line and load variation was confirmed.

대인관계 자아개념 척도의 개발 연구

박제일,임승환 [용인대학교 학생생활연구소] 2003 학생생활연구 Vol.11 No.-

This study was proceeded to develop a scale for self-concept which assesses the interpersonal relationships with social interactions in the center, affecting such great Influences on one's self-concept. In the process, a novel scale has been developed through integrating and extracting items related to interpersonal relationships from those scales for self-concept up to now. This study was executed two times. In the first period, among the whole subjects of 279, staff members of 'H' group, 'J' hospital, and 'S' group were included in, with 28 males and 247 females. When classified into age, they were constituted of 234 in twenties, 32 in thirties, and 8 in forties. In the second period, the subjects were 218 of undergraduate students in 'K' university and 450 of high school students in Busan. The whole 668 subjects were constituted of 233 males and 435 females. In the results, five items had been deleted in the first analysis and 3 items has been deleted to remain final twelve items. The final confirming scale for interpersonal self-concept is constituted of three factors, self-value, self-affirmation, and self-efficacy. The factor 'Self-Value' can be explained as the understanding himself and that he is contented with himself, 'Self-Affirmation' can be the factor that explains the tendency to recognize himself as positive, and the 'Self-Efficacy' as the tendency of acknowledging his own abilities of problem solving skills in the process of interactions with other persons. The limitation of this study is that to reconsider the possibilities of the use of this scale, such broad validation processes are remained.

當歸의 種類에 따른 四物湯이 白鼠의 胸部大動脈 血管弛緩에 미치는 影響

김형환,이주호,이제현,안덕균,박성규 대한본초학회 2001 大韓本草學會誌 Vol.16 No.2

We have examined the relaxational reponse to the water extract of Angelica gigas Nakai (AG), A. sinensis(Oliv.) Diels (AS), A. acutiloba Kitagawa (AA), and Four-Substance Decoctions (AG-FSD, AS-FSD, AA-FSD) in isolated thoracic aorta from sprague dawley(SD) rat in the presence and absence of endothelium. Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to AG, AS, AA and AG-FSD, AS-FSD, AA-FSD were investigated in vessels precontracted with 5-hydroxytryptamine(5-HT) were compared in vasodilation effect. We found that the thoracic aorta segments responded to AG, AS, AA and AG-FSD, AS-FSD, AA-FSD with a dose-dependent vasodilation. The 5-hydroxytryptamine induced contraction at 10-4M were inhibited by 26.3%, 2.7%, 2.1% and 24.6%, 1.1%, 3.2% after addition of the 0.1 g/㎖ water extract of AG, AS, AA and AG-FSD, AS-FSD, AA-FSD. The 5-hydroxytrptamine induced contraction at 10^-4M with and without endothelium were inhibited by 24.6% and 6.9% after addition of the 0.1 g/㎖ water extract of AG-FSD. In conclusion, AG, AS, AA and AG-FSD, AS-FSD, AA-FSD-induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation. AG-FSD has very potent vasodilation.

신경 회로망을 이용한 Discrete Cosine Transform Chip 설계

류제광,여지환 대구대학교 산업기술연구소 1991 産業技術硏究 Vol.10 No.-

Many Kinds of fast algorthm for DCT(Discrete Cosine Transrorm) that has been adopted in a wide range of digital image processing were developed. This paper describes that the general DCT algorithm appropriate to systolic array consists of the hardware by combining basic circuits using neutral network and existent digital circuits. In the neutral network used for this paper, decoder using single layer perceptron model and adder, subtractor and multiplier using UFT(Unidirectional Feedback Type) model proposed by Kyungpook national university VLSI & CAD lab.