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민영주 ( Young Joo Min ) 대한내과학회 2014 대한내과학회지 Vol.87 No.5
Lung cancer is not only the most common cancer of the elderly but is also the leading cause of cancer related mortality in Korea. Therefore, the elderly form a large subgroup of patients with advanced lung cancer. Aging is associated with co-morbidities, poor performance status, and impaired organ function. These problems can cause uncertainty when selecting the optimal treatment for advanced lung cancer, and some elderly patients could be undertreated. Patients with non-squamous histology lung cancer, regardless of age or performance status, should be tested for epidermal growth factor receptor (EGFR) mutations; patients with EGFR mutations such as del 19 or L858R are able to receive EGFR tyrosine kinase inhibitors. The treatment options for elderly patients with lung cancer include best supportive care, single agent chemotherapy, platinum-based doublet chemotherapy, and targeted therapy. The optimum therapeutic option for elderly individuals with advanced lung cancer must be selected carefully, taking into account both the risks and benefits. (Korean J Med 2014;87:537-541)
유방암에서 Cyclophosphamide , Thiotepa , Carboplatin ( CTCb ) 고용량 복합항암화학요법 후 자가말초혈액 조혈모세포 이식술
민영주 ( Young Joo Min ),서철원 ( Cheol Won Suh ),이제환 ( Je Hwan Lee ),채영란 ( Young Ran Chae ),김신 ( Shin Kim ),배창황 ( Chang Whang Bae ),박진희 ( Jin Hee Park ),최성준 ( Sung Joon Choi ),김태원 ( Tae Won Kim ),윤환중 ( Wha 대한내과학회 1997 대한내과학회지 Vol.53 No.4
Objectives: Recently high dose chemotherapy with autologous peripheral blood stem cell transplantation (APBSCT) has been investigated with the hope of maximizing tumor response and increasing survival. The purpose of this study is to evaluate the effect, feasibility, and toxicity of high-dose cyclophosphamide, thiotepa, and carboplatin (CTCb) with APBSCT in patients with metastatic or high risk primary breast cancer. Methods: Four cases of high-risk primary breast cancer (with more than 10 involved axillary nodes) and three cases of metastatic disease in complete or partial response were enrolled. Peripheral blood stem cells were mobilized by G-CSF plus chemotherapy, and median number of collected mononuclear cells was 5.44×108/㎏(range, 1.95-7.08×108/㎏). High-dose chemotherapy of cyclophosphamide (1,500㎎/㎡/day), thiotepa (125㎎/㎡/day) and carboplatin (200㎎/㎡/day) was administered for 4 days and peripheral blood stem cells were reinfused to the patients 72 hours after the completion of chemotherapy. Results. The median days of recovery for neutrophil (over 500/㎣) and for platelet (over 50,000/㎣) were 10 (range, 8 to 33) and 30 (range, 10 to 40). One patient suffered from seizure attack and grade 3 hepatotoxicity during high dose chemotherapy, There were no treatment-related death. Four patients with high-risk primary breast cancer remained disease-free at 2, 8, 12 and 19 months post-transplant. In one patient with bone metastasis, complete response was induced following APBSCT. All three patients with metastatic disease remained progression-free at 8, 18 and 19 months post-transplant. Conclusion: High-dose chemotherapy and autologous peripheral blood stem cell transplantation was feasible and would be a potentially effective treatment modality in high risk and metastatic breast cancer.
박종호,민영주,윤제현,한동하,안종준,이기만,정윤성,이선호,박재후,김성률 대한내과학회 2002 대한내과학회지 Vol.63 No.3
Bone marrow necrosis is most frequently diagnosed at postmortem examination. Antemortem diagnosis is uncommon. However, organized studies using either bone marrow biopsy specimens or autopsy material showed that bone marrow necrosis can be demonstrated in approximately one third of specimens. Bone marrow necrosis has been observed during the course of a wide variety of diseases, most commonly in association with acute and chronic leukemia, carcinoma, malignant lymphoma, infections, and sickle cell disease. We report one case of bone marrow necrosis due to miliary tuberculosis. Although appropriate diagnosis and treatment were performed, the patient expired.
황성진,정병균,민영주,황 백 全南大學校 農漁村開發硏究所 1992 農業科學技術硏究 Vol.27 No.-
벼 현탁배양 세포로 부터 체세포 배발생에 의해 재분화 개체가 이루어졌다. 배발생에 의해 재분화 개체가 이루어졌다.배발생 캘러 스는 2.5mg/ℓ2.4-D 가 첨가된 MS 배지에서 유도되었으며,현탁배양은 5mM proline, 2.5mg/ℓ2.4-D 그리고 200mg/ℓcasein hydrolysate 가 첨가된 N6 medium 에서 계대배양하였다. 이와같은 현탁배양세포는 세포질이 충만된 세포들로 구성되었으며,액체배지에서 10개월이상 유지시켰을때,체세포 배 발생 빈도는 지속적으로 유지되었으며 현탁배양세포를 5mg/ℓkinetin, 1mg/ℓNAA, 1mg/ℓABA, 3% sucrose 와 1% sorbitol이 첨가된 MS 고체배지로 옮겨졌을때 높은 빈도의 식물체 재분화가 이루어졌다. This study was carried out to obtain the high frequency of plant regeneration from cultured cells of rice(Oryza sativa L. ev Taebaeg). Embryogenic callus was induced from matured-seed on MS medium conatining 2.5mg/ ℓ 2.4-D and used to establish embryogenic cell suspension culture. Embryogenic cell suspension cultures were subcultured every one week in N6 medium supplemented with 5 mM proline,200mg/ℓcasein hydrolysate and 2,5mg/ℓ2.4-D. Embryogenic suspension cultures were composed of cells that were densely cytoplasmic, potentially embryogenic and maintained for more than 10 months. Somatic embryo formed when embryogenic cell suspentions were transferred to solid medium which consisted of MS medium containing 5mg/ℓkinetin, 1mg/ℓNAA, 1mg/ℓABA,3% sucrose and 1% sorbitol and subsequently the high frequency of plant regeneration were achived.
확장성 심근병증을 나타낸 가족성 Becker 형 근이영양증 1 예 보고
김재중,박종훈,박성욱,박승정,민영주,이재균,장재원,김유호,임미경,박광재,이상암,이종구 대한내과학회 1997 대한내과학회지 Vol.52 No.5
Dilated cardiomyopaty is a rare occurrence in Hecker muscular dystropy. We report a case of Bec- ken muscular dystrophy in 28 old man who presented with dyspnea, progressive muscle weakness, and dilated cardiomyopathy with severe left ventricular dysfunction which was detected by echocardiograpy. Muscle biopsy demonstrated diffuse degenerated changes consistent with progressive muscular dystropy, His brother has also Becker muscular dystrophy and dilated cardiomyopathy, The patient is on NYHA Class II~III with medical therapy.