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( Jae Ho Choi ),( Sun Woo Jin ),( Eun Hee Han ),( Bong Hwan Park ),( Hyung Gyun Kim ),( Tilak Khanal ),( Yong Pil Hwang ),( Minh Truong Do ),( Hyun Sun Lee ),( Young Chul Chung ),( Hee Suk Kim ),( Tae 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Purpose: The consequences of precipitously rising allergic skin inflammation rates worldwide have accelerated the risk of atopic dermatitis (AD). Natural product-based agents with good efficacy and low risk of side effects offer promising prevention and treatment strategies for inflammation-related diseases. We have already reported that Platycodon grandiflorum root-derived saponins (Changkil saponins, CKS) have many pharmacological effects, including anti-inflammatory and anti-allergic effects, but its influence on AD remains unclear. Therefore, we evaluated the inhibitory effect of CKS, mainly platycodin D, on AD-like skin symptoms in mice and the possible mechanisms in cells. Methods: Mice were sensitized and challenged with 2,4-dinitrochlorobenzene (DNCB). Four weeks after challenge, mice were treated with oral administration of CKS for 4 weeks. In addition, cells were used to evaluate the effect of CKS, mainly platycodin D, on the TARC expression regulated mechanism. Results: CKS attenuated DNCB-induced dermatitis severity, serum levels of IgE and TARC, and mRNA expression of TARC, TNF-α, IFN-γ, IL-4, IL-5, and IL-13 in mice. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells and mast cells in the ears. Moreover, CKS and platycodin D inhibited TNF-α/IFN-γ-induced TARC expression through the suppression of NF-κB and STAT1 and induction of Nrf2/ARE-mediated hemeoxygenase-1 (HO-1) expression in cells. Conclusion: We suggest that CKS and platycodin D inhibited the development of AD-like skin symptoms by regulating cytokine mediators and may be an effective alternative therapy for AD-like skin symptoms.ⓒ2014 Elsevler Gmbh. All rights reserved.
서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
Omeprazole 투여시 위산분비 억제능에 대한 CYP2C19 의 영향
박수헌(Soo Heon Park),김종원(Jong Won Kim),이수연(Soo Youn Lee),최명규(Myung Gyu Choi),김재광(Jae Kwang Kim),정인식(In Sik Chung),정규원(Gyu Won Chung),선희식(Hee Sik Sun),박두호(Doo Ho Park) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6
Background/Aims: CYP2C19 has an important role in the catabolism of several proton pump inhibitors. However, the relative contribution of CYP2C19-mediated metabolism varies among the different proton pump inhibitors. We investigate to determine the effect of CYP2C19 genotype status on intragastric pH during dosing with omeprazole. Methods: The subjects were 16 healthy volunteers. Their CYP2C19 genotype status was determined by a polymerase chain reaction-restriction fragment length polymorphism method. Twenty-four-hour monitoring of intragastric acidity were performed on the day without medication and day 4 after omeprazole administration. Results: A single dose of omeprazole significantly decreased 24 hour intragastric acidity (1.7±0.3 vs. 5.1±0.4). Subjects were divided into three groups on the basis of their CYP2C19 genotype status: homozygous extensive metabolizers (Ho-EMs, n=5), heterozygous extensive metabolizers (Ht-EMs, n=6), and poor metabolizers (PMs, n=5). Median 24 hour intragastric pH in the Ho-EM group was 3.1 compared with 5.5 in Ht-EM group and 5.9 in PM group(P<0.05). The median pH during omeprazole administration was influenced by CYP2C19 genotype. On the other hand, the Helicobacter pylori infection did not influence the median intragastric pH during omeprazole administration (p= NS). Conclusions: The effects of omeprazole on intragastric acidity is influenced by the CYP2C19 polymorphism. (Korean J Gastroenterol 2001;38:399-404)
규산 나트륨으로부터 THF에 의해 추출된 규산을 이용한 Mullite 전구체 제조시 촉매에 대한 영향
정흥호,박은희,김도수,정호승,노재성 공주대학교 자원재활용신소재지역협력센터 2000 2차년도 센터 사업 성과집 Vol.2000 No.1
Sol-Gel법으로 Aluminum isopropoxide[Al(i-OC3H7)3]와 규산나트륨로 부터 THF로 추출한 규산을 사용하여 mullite 겔 분말 제조시 산염기촉매의 영향에 관하여 XRD, TGA. SEM, 및 BET를 이용하여 연구하였다. 산성촉매로는 염산 (HCl)과 질산(HNO3)을, 염기성촉매로는 암모니아 (NH4OH)를 사용하였다. 촉매에 따른 중량 감소는 HCI=32.6% > HNO3=25.43% > Non=24.0% > NH4OH=22.5% 순서로 나타났다. 입자의 형태는 산성촉매인 경우 구형의 입자를, 염기능촉매의 경우는 구형이 아닌 입자형태를 나타내었다. 1400℃에서 하소한 분말은 촉매의 종류에 관계없이 0.05∼0.1㎛ 크기의 매우 미세한 입자들의 응집체임을 알 수 있었다. 그리고 촉매의 종류에 관계없이 온도가 증가할수록 흡착할 수 있는 세공이 줄어듬을 알 수 있었고, 염기 촉매를 사용하는 경우의 mullite 비표면적 변화가 거의 없는 내열성을 가지고 있었다. Effect of catalysts, which was catalyzed by acid(HCl and HNO3) and base(NH4OH), on characteristics of the mullite powders prepared by sol-gel method was investigatad by XRD, TGA, SEM and BET. As a result, weight loss as a function of catalysts was in order of HCI=32.6% > HNO3=25.43% > Non=24.0% > NH4OH=22.5%. The mullite powder dried at 100℃ appeared spherical shape in acid catalyst and different shape in base catalysts but sintering powder at 1400℃ appeared very fine particle of 0.05~0.1 ㎛ ragardless of catalysts. In all case, the pore quantity, which was capable to adsorption, was decreased with increasing temperature. In base catalyst, no change of special surface area in mullite appeared.
정규성,조기섭,정재용,조영호,민영돈,박찬국,김만우 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.1
Double pyrolus, one of the relatively rare anomalies of the gastrointestinal tract, is a fistulous communication between the gastric antrum and the duodenal bulb. The first case of a double Pylorus was reported in 1969 by Smith, since then several cases have been reported. Recently, as the frequency of examining upper gastrointestinal series and endoscopy increases, it occurs more frequently and a few cases have been described in our country. According to the reports previously published, it resulted only from cysts, diverticla, atresia, band, membrane malformation of the pylorus, however, it might be also caused by penetration, complication of peptic ulcer. We report a case of double pylorus in a 67-year old man with prolonged administration of corticostetoids due to lumbago who has complained epigastric pain which was confirmed by endoscopy and biopsy.
정재화,강여진,최호진 대진대학교 2001 大眞論叢 Vol.9 No.-
The Purpose of this study is to test of the hypothesis that is the difference in the cognition of the male and female sex civil servants on training and transfer of the civil servants. The contents of this study consists of the explanation on conception and purpose of the civil servants's training-transfer, the examination on pre-researches of several scholars, the build of several hypothesises, and the experimental outcomes result from the questions to the male and female sex civil servants of Kyonggi provincial office. In conclusion, We knows that is a clear difference in cognition of the male and female sex civil servants on training and transfer of the civil servants, finds that the female sex civil servants have more positive cognition than the male sex civil servants on training and transfer of the civil servants. Also, this study provide us with a point of current events that is important a use of the female sex civil servants to improvement or development of the public organization.
정용호,김명윤,김재홍 서강정보대학 1999 산업과학연구 Vol.1 No.-
The thermoelectric refrigeration technologies have no moving parts, compressor, or piping required. In this study, the basic capacity of thermoelectric devices and developement on some thermoelectric refrigerator were reviewed and basic technical concepts related with many kinds of thermoelectric materials were discussed. Especially the result of performance test on thermoelectric refrigerator whose minimum temperature of -2℃ was introduced briefly.