철카르보닐착물을 이용한 티오카프로락탐의 탈황 및 N-알킬화

심상철,이재수 경북대학교 산업기술연구소 1988 産業技術硏究誌 Vol.16 No.-

Thiocaprolactam reacts with ironpentacarbonyl in the presence of dibutylether solvent at 100℃ under nitrogen to give the corresponding desulfurized cyclic Schiff base. And then a variety of benzaldehyde derivatives react with reaction mixture including Schiff base in the presence of the synthesized tetracarbonyl-hydridoferrate at room temperature under an atmospheric carbon monoxide to give the corresponding N-substitute perhydroazepines in good yield. The mechanism of these reactions is investigated.

남조류의 체외 대사부산물이 다른 조류의 광합성에 미치는 타감작용

김범철,허우명,황길순,안태석,심재형 江原大學校 附設 環境硏究所 1994 環境硏究 Vol.11 No.-

The effect of cyanobacterial extracellular byproducts upon the aIgal photosynthesis was assessed to elucidate the allelopathic effect of algal blooms in eutrophic lake. Algal cultures were filtered with 0.2μm membrane filters to remove algal cells and sterilized. 0 to 30m1aliquots of filtrate were added to 25m1 culture suspensions of other algal species, and the (14)^C uptake rates wert measured. The filtrates of cyanobacterial cultures(Anabaena flos-aquae, Phormidium sp.) inhibited the photosynthesis of green algae(Selenastrum capricornutum and Scenedesmus brasiliensis), while the filtrate of Selenastrum capricornutum and Scenedesmuns brasiliensis did not inhibit Anabaena flos-aqiae. In the autoinhibition test Anabaena flos-aquae, Selenastrum capricornutum, and Scenedesmus brasiliensis showed positive, negative, and no effects, respectively.

간내 간충병에 대한 간절제술 1예

심민철,김홍진,권광보,노성균,이헌주,이태숙,장재천 영남대학교 의과대학 1990 Yeungnam University Journal of Medicine Vol.7 No.1

영남대학교 의과대학 외과학교실에서는 1989년 11월에 한국에서 발병한 간흡충병의 여섯 번째 증례로, 특히 간내 담관에 발생한 첫 증례를 우측 간엽 절제술 및 담낭 적출술로 좋은 결과를 얻었으며, 간내 담관에 발생한 경우에는 간암과의 구별이 요구되어야 한다는 점을 상기 시키면서 증례보고와 더불어 문헌적 고찰을 하였다. Human Fasciola hepatica infection is a rare entity involving infestation of the liver and biliary tree with adult flukes, which can result in hepatitis, cirrhos is and biliary tract inflammation, obstruction and lithiasis. The patient had the typical diagnostic tetrad of fever, eosinophilic leukocytos is, tender hepatomegaly and fluke ova in the stools. Theatment consistes of Emetine hydrochloride administration for hepatic involvement and common bile duct exploration for removal of flukes, with cholecystectomy for associated cholelithiasis. The combination of medical and surgical therapy cal be expected to produce an arrest of this infection. The removed liver revealed eggs of the fasciols species in the intrahepatic bile duct. The clinical history, pathological findings and treatment of this case were described.

KHFe(CO)_4-HCHO系를 利用한 Nitro 및 Nitroso化合物의 환원 N-메칠화 반응

沈相喆,閔庚隱,嚴在國,洪錫 경북대학교 1978 논문집 Vol.10 No.-

The reduction of nitro and nitroso compounds using tetracarbonylhydridoferrate-formaldehyde under mild conditions (at room temperature and then 60℃ under CO) gives the corresponding N, N-dimethylation via N-methylation in good to excellent yields. The reaction mechanism via immonium salt is assumed.

정신분열병 환자의 우울증에서 Paroxetine과 삼환계 항우울제 병용치료

심주철,공보금,박정환,윤영란,신재국,김정익,안동성,김용관,차인준,김영훈 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.4

저자들은 마산동서병원에 입원중인 우울증이 동반된 정신분열증 환자 10명을 대상으로 사용중인 항정신병약물에 paroxetine과 저용량의 삼환계 항우울제를 6주간 병용투여한 후 우울증상에 대한 효과와 치료의 안전성 및 약물상호작용을 알아보았다. Paroxetine은 고정량의 항정신병약물과 삼환계 항우울제에 부가하여 일일 20㎎을 6주간 병용하게 하였으며, 임상상태는 HDRS, HARS, UKU Side Effect Rating Scale등의 평가척도를 사용하여 평가하였다. 또한 약동학적 약물상호작용은 삼환계 항우울제들의 혈장농도를 HPLC로 측정하여 분석하였다. 결과는 다음과 같다. 1) 10명의 전체 대상환자에서의 HDRS 평균점수는 TCA와 paroxetine 병용투여 6주후에 통계적으로 유의하게 감소되었다. 이중 40%의 환자에서는 병용투여 6주후에 HDRS 점수상 50% 이상의 감소를 보여, 일부의 환자들에서는 정신분열병에 동반된 우울증상의 치료에 소량의 삼환계 항우울제와 paroxetine의 병용치료가 효과가 있음을 확인하였다. 2) 두 명의 환자에게서 심각한 약물독성이 발생하였다. 이중 한 명은 삼환계 항우울제의 높은 혈중농도로 인한 항콜린성 위기(anticholinergic crisis) 소견을 보였으며, 다른 한 명은 인지기능 및 의식수준은 명료하였으나 망상과 환각증상이 약화되는 소견을 보였다. 따라서 본 연구에서 시도된 복합적 약물치료의 경우, 삼환계 항우울제의 혈중농도의 측정을 포함한 세심한 임상적 추적이 필요하다고 생각된다. 3) 기저치의 amitriptyline과 그 대사물인 nortriptyline의 농도합. imipramine과 대사물인 desipramine의 농도합은 각각 47.8-226.5ng/㎖. 80.5-395.6ng/㎖였으며 일반적으로 이들 약물들의 단독사용시에 문헌에 보고된 혈중농도를 훨씬 상회하고 있었다. 이는 병용투여된 항정신병 약물 약시 강력한 CYP2D6 효소억제제로서 기저치의 삼환계 항우울제들의 혈장농도를 이미 상당히 증가시켰던 것으로 판단되며, 그러한 결과로 인해 본 연구에서는 paroxetine이 이전의 문헌보고들과는 달리 뚜렷하게 삼환계 항우울제들의 혈장농도를 증가시키지 못하였다. 본 연구는 SSRI와 삼환계 항우울제의 병합 투여가 우울증의 개선 효과를 빠르게 하고, 치료역을 넓히고, 약물상호작용의 결과 paroxetine이 삼환계 항우울제의 혈중농도를 증가시킨다는 기존의 연구결과를 이용하여 정신분열병 우울증상의 치료에 parotextine과 소량의 삼환계 항우울제를 병용하는 방법을 시도해 본 연구이다. 저자들은 이러한 약물치료가 일부의 환자들에게서 효과가 있음을 관찰하였으나, 항정신병약물과 삼환계 항우울제를 병용투여 할 경우는 물론 이에 paroxetine과 같은 선택적 세로토닌 재흡수 억제제를 병용할 경우 복합약물상호작용의 결과로 약물독성의 위험성이 크며 세심한 주의가 필요함을 경험하였다. Depression is well-known to comorbid with several psychiatric disorders. Many schizophrenics also suffer from depression in the course of their illness. Combined therapy of SSRI and tricyclic antidepressants were reported to have benefits in some depressed patients. Paroxetine, a potent CYP2D6 inhibitor, increases the blood levels of tricyclic antidepressant markedly. Using paroxetine, we tried this combined therapy in the treatment of depressive symptoms in 10 chronic schizophrenic inpatients and evaluated its efficacy and drug interactions between paroxetine and tricyclic antidepressants. The following results were obtained : 1) The mean score of Hamilton's Depression Rating Scale(HDRS) was reduced significantly after 6 weeks-trials of this combined therapy for the mild depressive symptoms in 10 chronic schizophrenics. In four patients, 50% or more reductions in the scores of HDRS were noticed at final evaluation. 2) Two among our 10 subjects experienced severe toxic behavioral problems. Anticholinergic crisis with toxic confusion due to high blood levels of tricyclics was found in one patient and the other showed rapid clinical deterioration in his psychotic symptoms such as delusion and hallucination without any consciousness alternation. 3) Baseline plasma levels of tricyclics before adding paroxetine were higher than expected in our chronic schizophrenic subjects maintained with their antipsychotic medications. Several antipsychotics were also known as a potent CYP2D6 inhibitors and to increase the blood levels of tricyclics. Because the blood levels of tricyclics had already increased significantly by the use of antipsychotics, adding paroxetine to antipsychotics and tricyclic antidepressant in our subjects could increase the blood levels of tricyclics not so much as previously reported in the literatures.

슬관절 내측부 인대 손상의 보존적 치료

임홍철,심재학,남혁우,왕준호,노영진 대한스포츠의학회 2000 대한스포츠의학회지 Vol.18 No.2

Purpose : The medial collateral ligament injury is the most common injury of the knee. Recently Non-operative treatment has been preferred than operative treatment and most of patients have satisfactory clinical results after non-operative treatment. But a few patients have continuous instability after non-operative treatment, so the purpose of this study is to fine out the cause of persistent symptom. Methods and Materlals : We performed a retrospective study of one hundred thirty seven patients with medial collateral ligament injury treated non-operative from January 1990 to December 1997. W divided patients into two groups: isolated medial collateral ligament injury (groupⅠ): medial collateral ligament injury with concomitant anterior cruciate ligament injury (groupⅡ) and we analysed MRI finding, valgus instability, and Lysholm knee score. Result : At the follow up, three of group Ⅰ, five of group Ⅱ had persistent grade Ⅲ valgus instability. In group Ⅰ, we could find two case of rupture of the proper of medial collateral ligament with inward inversion and one case of concomitant posteromedial compartment injury. We could find the proper rupture of medial collateral ligament with inversion inward in two patients, the injury of posteromedial compartment in one patient. Two patients of group Ⅱ with grade Ⅲ valgus instability had anterior instability with laxity of grafted tendon after anterior cruciate ligament reconstruction. Conclusion : Most of isolated injury of the medial collateral ligament heals wthout operative intervention. But in case of rupture of the proper portion of medial collateral ligament with inversion inward or concomitant injury of posteromedial compartment, we should consider the operative treatment of medial collateral ligament. In case of medial collateral ligament injury with anterior cruciate ligament, it would better to consider the delicate reconstruction of anterior cruciate ligament.

지역사회획득 폐렴의 치료지침 권고안

송재훈,정기석,강문원,김도진,배현주,서지영,심태선,안중현,안철민,우준희,이남용,이동건,이미숙,이상무,이영선,이혁민,정두련,지역사회획득 폐렴 치료지침 제정위원회 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

A successful therapy of community-acquired pneumonia requires appropriate empirical antimicrobial therapy. Etiology and antimicrobial susceptibility of major pathogens of pneumonia can differ by country. Therefore, an ideal treatment guideline of community-acquired pneumonia should be based on the studies performed in each country. We developed a treatment guideline for community-acquired pneumonia in immunocompetent adults in Korea. This guideline was developed by the joint committee of the Korean Society for Chemotherapy, the Korean Society of Infectious Diseases, and the Korean Academy of Tuberculosis and Respiratory diseases.

Temporal and Spatial Variation of Chlorophyll a Concentration in Lake Soyang

김범철·심재형·조규송 江原大學校 附設 環境硏究所 1989 環境硏究 Vol.6 No.-

폭이 좁고 길며 수심이 깊은 나뭇가지형 인공호인 소양호에서 하류로 부터 상류에 이르기까지 10개 정점에서 클로로필 농도의 계절적 변화와 수평적 변이를 조사하였다. 하루에서는 계절적으로 식물플랑크톤의 최대 번성기가 일정치 않아 불규칙한 시간적 변화를 보였으먀, 대체로 늦은 봄부터 초가을 까지 가장 높은 클로로필 농도를 보였다. 그러나 지류하천이 유입되는 수역에서는 매년 늦은 가을에 주기적으로 연중 최고의 클로로필 농도를 보였다. 조사 정점간의 수평적 변이를 보면 크로로필 농도는 지류 하천의 유입부에서 가장 높게 나타났으며 하류쪽으로 갈수록 농도가 낮아지는 경향을 보였다. 하류댐 앞에서의 농도는 5μg/l 이하로 빈영양호 수준인데 반하여 지류의 유입부에서는 때로는 100μg/l를 넘는 부영향호 이상의 농도를 보여 주었다. 상류 수역에서 식물플랑크톤 밀도가 높은 현상은 유입 하천의 영양염류 농도가 호수보다 높다는 것으로 입부 설명될 수 있으나, 극심한 대량번식을 유발할 정도로 높지는 않은 것으로 보아, 식물플랑크톤을 유입부에 밀집시키는 또 다른 지작이 존재하는 것으로 생각되며, 이는 지류 하천의 중층으로의 유입과 소양호에서 겨울과 초뭄을 제외하고는 항상 우점종으로 나타나는 쌍편모조류의 주광성에 기인하는 것으로 보인다. Seasonal and horizontal variations of chlorogphyll a concentration were surveyed in Lake Soyang, a long, narrow and deep artificial lake in a mountainous sistrict. Pattern of seasonal variation at the dam site did not show regular blooms, but irregular blooms occurred through late spring to early autumn, and at the stream inlet sites a yearly regular bloom could be observed in late autumn. Chlorophyll a concentration varied greatly with the distance from the inflowing stream inlet. Though the concentration was in the range of oligotrophic level (5μg/l) at the dam site, peak value at the inlet sites far exceeded eutrophic level (up to more than 100μg/l). Such high density of phytoplankton in the upstream area can be partly explained by the high phosphate concentration in the inflowing stream water. In addition phytoplankonm aggregation may be attributed to a physical process which could trap dinoflagellates coupled with their phototactic moveattributed to a physical process whic could trap dinoflagellates coupled with their phototactic movement. These dinoflagelates are dominant species in the research lake throughout the warm season.

경화제 주입에 의한 치핵치료의 후유증

이동식,심민철,김재황 대한대장항문학회 1997 Annals of Coloproctolgy Vol.13 No.3

RCGKA를 이용한 최적 퍼지 예측 시스템 설계

방영근,심재선,이철희 江原大學校 産業技術硏究所 2009 産業技術硏究 Vol.29 No.B

In the case of traditional binary encoding technique, it takes long time to converge the optimal solutions and brings about complexity of the systems due to encoding and decoding procedures. However, the ROGAs (real-coded genetic algorithms) do not require these procedures, and the k-means clustering algorithm can avoid global searching space. Thus, this paper proposes a new approach by using their advantages. The proposed method constructs the multiple predictors using the optimal differences that can reveal the patterns better and properties concealed in non- stationary time series where the k-means clustering algorithm is used for data classification to each predictor, then selects the best predictor. After selecting the best predictor, the cluster centers of the predictor are tuned finely via RCGKA in secondary tuning procedure. Therefore, performance of the predictor can be more enhanced. Finally, we verifies the prediction performance of the proposed system via simulating typical time series examples.