TLD 방사선 센서용 판독장치의 제작

우홍,강희동,최희동,이상윤,도시홍,김도성 경북대학교 센서기술연구소 1992 센서技術學術大會論文集 Vol.3 No.1

생물막여과공정에 의한 고도정수처리시스템 구성에 관한 연구

강용태,양희천,김화석,김경동 동아대학교 환경문제연구소 1999 硏究報告 Vol.22 No.2

This study is to evaluate the characteristics of submerged biofilter process as pretreatment of raw water and alternative advanced water treatment system(AAWTS) composed with bioflitration, post-ozonation and GAC for Nakdong River by comparison of existing advanced water treatment system(EAWS), composed with pre-ozonation, flocculation, sedimentation, sand filtration, post-ozonation and GAC. In the biofiltration process, the removal of turbidity, color, KMnO₄consumption, NH₃-N and UV254 reached 98%, 95%, 70%, 72%, 79% respectively. The stable removal efficiency was obtained by the direct biofiltration after coagulant injection thought the influent was a muddy and highly polluted. The removal efficiency of the alternative advanced water treatment(AAWTS) using biofiltration process for turbidity, color, KMnO₄consumption, NH₃-N and UV254 was reached 98.5%, 98%, 82%, 90%, 92% respectively. It is equivalent to the removal efficiency of existing advanced water treatment system(EAWTS) though the demanded area and coagulant of the alternative advanced water treatment system using biofiltration process was decreased about 60% and 70% respectively.

전신 마취중 발생한 악성 고열증 1례

강봉진,김동희 단국대학교 1998 論文集 Vol.32 No.-

Malignant hyperthermia is a potentially fatal hypermetabolic syndrome characterized by hyper-pyrexia and skeletal muscle rigidity. It can be induced by all of the currently used anesthetics or by injection of succinylcholine. We experienced one case of malignant hyperthermia during tympanomastoidectomy under O_2-N_2O-enflurane anesthesia with induction by pentothal sodium and succinylcholine. At two and half hours after induction, tachycardia, generalized muscle rigidity, cyanosis of the extremities and skin mottling appeared. Body temperature was high as much as 42℃ and blood pressure was dropped to 50/38/32 mmHg. Anesthesia was terminated. Dantrolene, a specific drug for malignant hyperthermia, was not available immediately. So vigorous treatments to reduce the body temperature-external ice packs and iced saline massage, cold intravenous saline, gatric and urinary bladder lavage, intraperitoneal lavage-were attempted. After these vigorous treaments, the body temperature was lowered to 37℃ and vital signs were restored to normal ranges. We report a malignant hyperthermia case with review of clinical features and emergency treamens.

노인의 생활체육 참가와 여가만족 관계 연구

강관희,서동균 한국스포츠리서치 2001 한국 스포츠 리서치 Vol.12 No.4

The purpose of this study is to research into the influence of the old-aged-man's socio-economic variables and the characteristics of their participation in sport for all on their leisure satisfaction, and the influence of their socio-economic variables on the characteristics of their participation in sport for all, and thereby to provide some basic data for the activation of sport for all as leisure and the formation of the old-aged-man's proper leisure activity. For the achievement of such a study, data was collected through some questionnaires from 300 old people whose age is more than 60. And the collected data was statically processed through SPSS/WIN7.5, and with frequency and % calculated, One-way ANOVA were done. Result are as follows: First, it appeared that socio-economical characteristics educational background, age, method to provide living expenses, living together with husband or not - have a significant relation with their leisure satisfaction. Second, it appeared that the questioning items concerning the characteristics of participation in sport for all - the frequency of participation, the time of participation, factor influencing sport participation, and persons wishing to participate in sport for all - have a significant relation with leisure satisfaction.

한국인 지원자에서 니모디핀의 생체이용율연구

강원호,심희옥,남진경,김동출 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-

A reversed phase HPLC method was developed and validated for the determination of nimodipine in human plasma. Nitrendipine was used as an internal standard. Calibration curves were linear in the concentration range of 5~300 ng/ml. The coefficient of variation of the intra- and inter-day precision was below 15%. The coefficient of variation of the accuracy was below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Eight healthy male volunteers were orally administered 30 mg of nimodipine. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(24hr) was 64.0±31.3 ng·hr/ml, C_(max) was 46.5±31.2 ng/ml, T_(max) was 0.54±0.17 hr and t_(1/2) was 3.03±2.26 hr. The pharmacokinetic parameters and the HPLC method can be used for the design of bioequivalence study of nimodipine.

건설공사 업무프로세스재설계(BPR) 기법 연구

강인석,곽중민,박서영,이동희,김창학 경상대학교 생산기술연구소 2001 工學硏究院論文集 Vol.1 No.-

The current trend of If (Information Technology) in 21st century demands management innovation, that is Business Process Reengineering (BPR) in all the industry including construction project. The solution of its demand is proposed by IT based on Internet. And also, in order to meet this objective, from 1997 domestic construction industry is accelerating to systematize CALS (Continuous Acquisition and Life-cycle Support) which is being planned to apply by government. These efforts give much weight to build computer systems rather than to improve and redesign construction business process that is more important for system application. This research develops a model for applying the BPR to construction industry, especially construction site that is a base to build a system for CALS. And the research suggests performing method, process and modeling technique of BPR to be applicable in business process redesign of construction field. Also, focusing on the research of execution step of business in construction site will be helpful for the site worker to perform BPR in construction site.

레이저 박피술의 피부면적 감소효과와 레이저 punch out 병변의 치유에 대한 실험적 연구

강동희,윤을식,구상환,안덕선,박승하 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

An experimental study was designed to analyze the surface reduction effect of ultrapulse carbon dioxide laser on the skin of guinea pigs receiving laser resurfacing. Two squares of skin measuring 3x3 ㎠ were designed on each side of the abdomen of guinea pigs(n=10). Five animals received laser resurfacing on their abdomen at energy of 250mJ/5 watt, and five other animals received 500 mJ/5 watt. On each animal, the left side square was treated with one pass of a CO2 laser, and the right side q=square was treated with two passes using a C.P.G. scanner. The size of the resurfacing area was determined by celluloid overlays at 1,2,3,4 and 6 weeks. Immediately following laser resurfacing, the area was decreased to 69%(left side) and 56%(right side) of the designed area in the 250 mJ/5 watt group, and 59% and 40% in the 500mJ/5 watt group. After 6 weeks, the resurfaced area had been reduced to 70% and 56% of the designed area in the 250mJ/5 watt group, and 60% and 40% in the 500mJ/5 watt group. As a result, the effect of surface reduction by CO2 laser resurfacing increased at a higher power and when more passes of the ultrapulse carbon dioxide laser were applied. The laser treated skin continued to maintain its contracted dimensions. These findings suggest that ultrapulse carbon dioxide laser may be an effective treatment method for rhytides. Another experiment was performed on multiple punch-out lesions on guinea pig skin(n=2) with 1,2,3 mm collimated hand pieces for the purpose of determining a new laser treatment method. After 4 weeks, on gross and histological examination, there were no differences in the healing of multiple punch-out lesions and the healing of punch-out lesions was complete without any scarring. These findings suggest that the laser punch-out method can be used for the treatment of acne scars.

Polystyrene 입자 수용액에서 프랙탈 차원에 관한 광산란 실험 연구

강명화,김두철,강창희,현동걸 제주대학교 1994 논문집 Vol.39 No.-

Using light scattering technique, we measured intensities of scattered light from aggregation of polystyrene particles of 114nm in a solution of NaCl in the concentration from 0.15 to 2mol/ℓIntensity data give direct information that aggregated cluster are built with fractal structure ; We find that the value for fractal dimension of aggregation in the fast regime 1.25≤c≤2mol/ℓis 1.55 ±0.05 that is nearly consistent with diffusion-limited-aggregation model, whereas in the slow regime (0.3≤c≤0.5mol/ℓ)the value of fractal dimension is 2.12±0.05 agreed with reaction-limited-aggregation model.

다시마 푸코이단추출물과 지질대사의 연관성

강금석,남천석,김인덕,권륜희,이동찬,허예영,하배진 신라대학교 자연과학연구소 2007 自然科學論文集 Vol.16 No.-

The effects of Laminaria japonica fucoidan extract (LJFE) on the biochemical parameters of lipid-related function were investigated in liver and serum of CCl_(4)-treated rats. LJFE of 100 mg/kg concentration was intraperitoneally administered into rats at dose of 1.5 ml/kg for 14 days. On the day 15, 3.3 ml/kg of CCl_(4) dissolved in olive oil (1:1) was injected 12 hours before anesthetization. We examined the lipid-related functions and enzyme activitys by measuring the levels of total cholesterol (TC), triglyceride (TG), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in serum. The results showed that CCl_(4) treatment increased the high values of TG, LDH and ALP decreased the low values of TC but LJFE pretreatment decreased the high values of TG, LDH and ALP to the low values, increased the TC. It was suggested that LJFE can be used as the potential candidate for the lipid-metabolism natural supplement.

천궁의 GABAА-Benzodiazepine 수용체 복합체와의 상호작용

강지현,이동웅,하정희 대한생물치료정신의학회 1997 생물치료정신의학 Vol.3 No.2

요약천궁(Cnidium Officinale)는 미나리과 다년생초본식물로서 대뇌 억제 및 진정 작용이 있다는 여러 문헌 등을 참고하여 볼 때 천궁은 항불안작용을 나타낼 가능성이 시사되었다. 이에 본 연구는 천궁을 사용하여 실험 동물에서 천궁의 항불안 작용을 검색하고 그 작용기전의 일부를 밝히고자 천궁을 극성 및 비극성 용매로 추출하여 분획을 만들고 이들 분획의 GABA-benzodiazepine 수용체 복합체 결합반응에 미치는 영향을 관찰하고자 하였다. 실험 결과 천궁 표준추출물 경구투여는 생쥐의 elevated plus maze 검사에서 그 효과는 diazepam 1 mg/kg 투여 후 실시한 elevated plus maze 검사 결과보다 낮았으나, 개방통로에로의 진입회수 및 개방통로에서의 체류시간을 증가시킴으로써 불안해소작용을 나타내었다. 또 천궁의 표준추출물은 benzodiazepine 수용체 길항제인 [3H]Ro15-1788 결합을 억제함으로써 수용체 활성물질의 존재 가능성이 관찰되었다. 이러한 행동검사상의 불안해소작용 및 benzodiazepine 수용체 활성도를 나타내는 구성성분을 추적하고자 천궁의 표준추출물의 분획화를 실시하였는데, 이를 통하여 얻은 각 분획들을 사용하여 수용체 활성도를 검색한 결과, 모든 분획에서 활성도를 나타내었으나 그 중 chloroform분획의 활성도가 crude한 추출물인 methanol 추출물이나 다른분획에 비하여 가장 높은 활성도를 나타냄을 관찰하였다.천궁의 chloroform분획은 [3H]flunitrazepam의 흰쥐대뇌피질조직에 있는 benzodiazepine 수용체에 대한 결합반응을 억제시켰으며, 이러한 억제도는 GABA 및 chloride 존재에 의해 더욱 항진되는 positive GABA shift 현상이 관찰되었다. 이상의 결과를 종합해볼 때, 천궁의 chloroform분획내에는 benzodiazepine 수용체에 대해 효현제 활성을 지니는 물질이 있음을 추측할 수 있으며, 이는 천궁의 항불안작용의 중요한 한 기전으로 생각된다. C. Officinale is a medicinal plant which has been known to have anxiolytic and sedative activity. A survey of the relevant literature has indicated that the putative anxiolytic activity of C. Officinale has not been scientifically investigated. Therefore, the present study was designed to assess anxiolytic property and interaction with benzodiazepine receptor of C. Officinale. The putative anxiolytic activity of methanol extract of C. Officinale was performed in mice using an elevated plus maze paradigm. Chronic oral administration of C. Officinale showed anxiolytic action in mice. The interaction of C. Officinale with benzodiazepine receptor was investigated using rat cortices. Methanol extract of C. Officinale inhibited the binding of [3H] Ro 15-1788, a selective benzodiazepine receptor antagonist to benzodiazepine receptor of rat cortices. Chlorform fraction of methanol extract showed higher binding activity to benzodiazepine receptor than crude extract by methanol. GABA significantly enhanced the potency of C. Officinale in inhibiting [3H] flunitrazepam, a selective benzodiazepine receptor agonist, binding to benzodiazepine receptor. From these findings, it can be concluded that substance or substances with neurochemical properties characteristic of a benzodiazepine receptor agonist may contribute to the anxiolytic property of C. Officinale.