봉독약침이 류마티스 관절염 환자의 관절 통증, 종창 및 급성 염증 반응에 미치는 영향

이상훈,이현종,백용현,김수영,박재경,홍승재,양형인,김건식,이재동,최도영,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients. Methods Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender Joint counts, swollen joint counts, Visual analog scale(VAS), morning stiffness, ESR. C-reactive protein(CRP) were analyzed before and after BV therapy. Results The results as follows. 1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy(9.0±7.9 vs 15± 11.4, p=0.002). 2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy(50±61 vs 15±23, p=0.001). 3. VAS in patients after BV therapy was significantly lower than those before BV therapy(608± 17.6 vs 380± 159, p=0.000). 4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy(119.1± 112.6 min vs 59.0±89.7 min, p=0.009). 5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect. Conclusions BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed on long-term effect of BV therapy.

濟州道 菜蔬·花卉園藝의 生産實態, 育成方案 및 流通構造改善에 관한 硏究

李宗錫,吳現道,蘇寅燮,張田益,姜志勇 濟州大學校 亞熱帶農業硏究所 1986 亞熱帶農業硏究 Vol.3 No.-

濟州道의 施設을 理用한 菜蔬類와 球根切花類 및 洋蘭類의 재배실태를 調査한 結果는 다음과 같이 要約할 수 있다. 1. 作目이 토마토와 오이에 編重되어 있어 딸기等을 첨가하여 作目이 多樣化하여야 할 것으로 思料되었다. 2. 施設內의 土壤管理에 대한 認識이 不足하며, 均衡施肥가 施行되지 않고 있었고 土壤酸度도 矯正해야 할 농가가 많았다. 3. Mg이 缺乏된 施設이 대부분이므로 이의 是正이 時急한 課題였다. 4. 施設內 土壤에서 鹽類集積의 被害가 우려되는 곳은 거의 없었으나 裁培年限이 5年以上된 施設에서는 土壤改良이 이뤄저야 할 것으로 思料되었다. 5. 作付體係를 改善해서 年 2期作 體係가 確立되어야 겠으며 施設管利技術이 普及, 育苗技術의 改善 및 共同育苗를 施行해서 健全苗의 養成이 重要課題였다. 6. 濟州道內에서 産業的으로 栽培되고 있는 蘭類 中에서 熱帶産 Cymbidium類가 全體 洋蘭 栽培量의 67.8%로 가장 많았는데 그 中에서도 Eiko, sharnell-5, Kenny가 數的으로 많았다. 7. 溫帶産蘭(東洋蘭)類 中에서는 새우난초類가 數的으로 가장 많았고, 나도풍난, Dendrobrum moniliforme, Cymbidium 風蘭의 順位이었으며, 自生寒蘭은 대 40,396촉이 栽培되고 있었다. 8. 供試 5種의 球根類들은 virus 감염이 甚하여 全量이 virus 無病株로 대체되어야 할 것으로 판단되었다. 9. 서귀포지역의 土壤은 害蟲이 많이 分布하여 球根切花栽培에 큰 위협조건으로 나타났으며 앞으로 도양소독에 대하여 보다 집약적이고 효율적인 方法이 개발되어야 하겠다. 10. 한라산의 고냉지를 利用한 球根의 低溫處理 效果에 對하여 많은 적응시험이 요망되며 道當局은 고냉지의 개발과 利用에 적극적인 지원을 투여하여야 할 것이다. 11. 植栽되고 있는 5種의 球根類 모두 50% 以上이 外國수입에 의존하고 있으므로 國內의 組織培養技術을 利用한 virus 無病良質球根의 生産이 절실히 요망된다. Studies on various cultural practices of vegetable crops, and orchids have been conducted in Chejudo. Followings are the results of such studies. 1. Too much importance has been given to Tomato and Cucumber crops. An additional crop such as Strawberry should be included to broaden the studies. 2. In general, lack of informations on soil managements appear to be prevailing; scheduled fertilization, for instance, has not been performed and pH level must be adjusted on many farm lands. 3. Mg deficiency has been very much in common, therefore, is corection are matter of utmost importance. 4. Problems arising from salt accumulation were nearly unimportant, however, soil improvements through various cultural practices are recommended for those soils which have been continuous cropping for more than 5 years. 5. Planting system should be improved so as to establish 2-crops/year system. In addition, proper extention of various soil management techniques and improvement on nursing techiques are of inportant matters. Commonly sharing community nursing practices must be accompanied in order to provide healthy-seedlings. 6. Among commercially growing orchid species in Chejudo, the tropical Cymbidium species found to be the most widely grown, nearly 67.8% 'Kiko', 'Sharnell-5', 'Kenny' appear to be most in common. 7. Among oriental orchids, Calanthe spp are found to be most prevalent followed in the order of Aerides japonica, Dendrobium moniliforme, Cymbidiums, respectively. 8. The total number of the shoots of Cymbidium kanran being cultivated in Chejudo were found to be 40,396. 9. Virus infections appear to be universal in all 5 species of bulbs studied therefore, virus-free stocks must be essential. 10. Sogwipo-soil, in general, heavily infected by soil-born insects of various kinds are badly affecting bulb productions. More efficient methods of soilsanitations must be studied and introduced in the future. 11. The studies of low temperature treatment on bulb crops by utilizing the high altitude growing in the area of mountain Halla are in great need. An extensive assistance from the provincial government are very much in need in order for the development and utilization of the high-altitude cultivation. 12. More than 50% of the bulbs of the 5 species grown are being imported. Domestic production utilizing 'meristem culture' which enable the virus free stocks are in great demand.

이온빔 보조 증착법으로 형성된 SiO₂박막의 특성

이헌주,장도현 濟州大學校工科大學産業技術硏究所 1996 尖端技術硏究所論文集 Vol.7 No.1

In the conventionally formed thin films, it is difficult to solve many of the problems created by the columnar structure. The IAD (Ion Assisted Deposition) is a technique for improving the properties of thin films by ion bombardment. The objective of this study is to analyze the properties of thin films prepared by the IAD method. The ion beam energy extracted from the Kaufman type ion source can vary from 100 to 3000 eV. To minimize the deterioration of film by sputtering, it was maintained below 500 eV. In this experiment, the SiO₂is deposited by the resistance evaporator on the glass or silicon wafer substrate. To investigate the properties of thin films, various test methods such as scotch tape test, pull-off test (for adhesive test), 3% NaCl test (for corrosive test), XRD test (for the understanding of crystal structures) and RBS test (for the examination of density) have been carried out. From the results of these tests, it is found that the film made by IAD method is superior to one by conventional method.

보존적 치료로 호전된 요로감염에 의한 자발성 신파열

홍소현,김도연,김태오,배지윤,이신아 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.S

자발성 신파열은 외상 혹은 수술 등의 병력 없이 신장 피막 혹은 신장 주위 혈종이 자발적으로 발생하는 드문 질환으로, 원인으로는 요로 결석[1], 결핵, 신우신염, 신농양 같은 감염성 질환이나[2] 신장의 종양 및 신장 이식 수술 후[3], 후천성 낭성 신환[4] 등이 관련이 있다. 그 중 복막 투석 환자에서 낭성 신질환에 의한 자발성 신파열은 국내 보고가 있었으나 요로감염에 의한 자발성 피막하 혈종을 동반한 신파열은 문헌 보고가 없었다. 저자들은 요로감염으로 진단된 환자에서 피막하 혈종을 동반한 신파열 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

土工을 中心으로 한 林道網 配置 計劃에 關한 硏究 : 白雲山 演習林 地區를 對象으로 Application in Mt. Baekwoon Research Forest

鄭道鉉,禹保命,李峻雨 서울대학교 농과대학 농업개발연구소 1992 서울대농학연구지 Vol.17 No.2

This study was aimed at determining the rational forest road networks in mountainous terrain forests by using the developed computer model. The computer model used for this study is composed of two major subroutines for digital terrain analysis and road-route selection, and the road-route selection subroutine uses the area-partitioning method in order to fully investigate alternative roading routes and to determine the layout of forest roads. The developed computer model was applied to designing a road network for the Research Forest of Seoul National University. The forest having an area of about 11,000 hectares is located in Mt. Baekwoon region of Kwangyang-gun and Gurye-gun in Chulanam-do. To evaluate the optimality of the determined road networks in this study, such factors as the average skidding distance, accessibility to forest stands, development index and circulated road network index were measured. The results of the optimality analysis of the road network is good and practicable.

Productivity S/W 학습용 웹 코스웨어에서 상황맥락적 오류교정 패드백이 학업성취도에 미치는 영향

김도윤,배영권,백장현,이태욱 한국컴퓨터교육학회 2004 컴퓨터교육학회 논문지 Vol.7 No.1

현재 웹 코스웨어에서의 형성평가와 이에 대한 피드백 시스템은 많이 구축되어 있다. 그러나 대부분 웹 코스웨어의 형성평가와 사용자 반응에 따라 제공되는 피드백은 실제의 문제 상황과 거리가 먼 상태에서 단순한 텍스트 형태로 정오의 표시, 정답 표시, 관련 정보의 표시 등을 제공하고 있다. 이는 자칫 피드백의 교정적 기능을 약화시켜 학습자의 학습 내용에 대한 이해와 학습 전이의 가능성을 감소시킬 수 있다. 또한 구성주의 학습이론에 따르면 학습은 그 것이 발생하는 상황에 영향을 받고 지식이 어떤 맥락에서 학습했느냐에 따라 다르게 학습되며 전이된다고 한다. 이런 배경에서 본 연구는 웹 코스웨어에서 형성평가를 실시할 때 학습자의 반응에 따라 피드백을 문제 상황과 밀접하고 유사하게 상황맥락적으로 제시할 수 있는 상황맥락적 오류고정 피드백시스템을 설계하고 구현하였다. 그리고 실제 Productivity S/W를 학습할 수 있는 웹 코스웨어에 ‘정오/정답제공형 피드백', ‘관련정보제공형 피드백’‘상황맥락적 오류교정 피드백’을 적용한 후 ‘상황맥락적 오류교정 피드백’이 학업 성취에 있어서 다른 두 가지 유형의 피드백보다 더 효과적인지를 검증하였다. Today there are many Web courseware systems for formative evaluation and feedback. Formative evaluation and feedback provided according to users’ response in most Web courseware systems, however, are simple texts showing only whether correct or wrong, correct answers, relevant information, etc., far deviated from actual context. Thus such a system may weaken the corrective function of feedback and, as a result, reduce learners’ understanding of contents and the possibility of leaming transfer. In addition, according to the learning theory of constructivism, learning is influenced by the situation, in which it happens, and knowledge is learned and transferred differently depending on the context in which it is learned. In the background, this study designed and implemented a contextual error-correction feedback system that can provide feedback in a context closely related and similar to the relevant situation according to the response of learners when formative evaluation is carried out in Web courseware. In addition, it applied ‘correction/correct-answer-providing feedback’, ‘relevant information providing feedback’ and ‘contextual error-correction feedback’ to Web courseware for learning actual productivity S/W and verified if ‘contextual error-correction feedback’ is more effective than other two types of feedback for learners’ academic achievement.

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

濟州道 菜蔬·花卉園藝의 生産實態 育成方案 및 流通構造改善에 관한 硏究

張田益,李宗錫,蘇寅燮,姜志勇,吳現道 濟州大學校 亞熱帶農業硏究所 1986 亞熱帶農業硏究 Vol.3 No.-

The increasement of products and the technological development in Cheju's floriculture can be easily derived from the appropriate climate to the cultivation and the high level of farmer's education. And the economical and social condition around the floriculture have come to maturity. Therefore, if the questions that confronts us are solved and the reasonable supporting method to floriculture rearing is established, the cultivation of flowers will be florished. The rearing methods of Cheju's floriculture are as follows. Fist, the creation of production complex Second, the increasement of modern production facilities Third, the establishment of production and diffusion system of excellent seeds Fourth, the reinforcement of research institutes Fifth, the improvement of flowers distribution structure Sixth, the reinforcement of supporting policy of Cheju provincial administration

p-Anisaldehyde가 조골세포 분화에 미치는 영향

김경민 ․ 이도원 ․ 김현준 ․ 김아랑 ․ 장원구 대구대학교 산업기술연구소 2018 産業技術硏究 Vol.29 No.2

p-Anisaldehyde is a natural fragrance extracted from Pimpinella anisum L., and used as a preservative. This study examined the effect of p-anisaldehyde on osteoblast differentiation. First, cytotoxicity tests were carried out after examining the concentrations that did not show toxicity to the cells. The expression of osteoblast differentiation marker gene was confirmed by RT-PCR and was not effective in the treatment with p-anisaldehyde alone. However, p-anisaldehyde decreased the expression levels of inhibitor of differentiation-1 (Id1), distalless related homeobox (Dlx5), and runt-related transcription factor 2 (Runx2), which are osteogenic differentiation marker genes, which are increased in osteogenic condition. alkaline phosphatase (ALP) activity was also confirmed by ALP staining that p-anisaldehyde reduced ALP activity. These results show that p-anisaldehyde is effective in reducing osteoblast differentiation.

退行性關節炎 韓方治療에 對한 最近 硏究 動向 : 臨床硏究 方法論을 中心으로 Herbal Medicines in the Treatment of Osteoarthritis in Pubmed and Chinese Medical Journals

서병관,류성룡,이송실,허정은,백용현,이재동,최도영,조윤제,김남재,박동석 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : The aim of this study was to review systemically clinical trials on the effectiveness and safety of herbal medicines in the treatment of osteoarthritis. Methods : Computerized literature searches were carried out on seven electronic databases, and hand-searching on some chinese medical journals in library of Kyung Hee Medical Center. Trial data were extracted in a standardized, predefined manner and assessed independently. Results : 1. Thirty reports of clinical trials and two reports of meta-analyses concerning herbal medicine were collected and reviewed Among these reports three medical herbs were applied as topical medicine and others as internal medicine. 2. The western studies established NSAIDs or placebo as their control group. Five chinese reports established formulated herb pill(Ruanshnagshenjin pill) as their control group and Six did not establish a control group at all. 3. ACR was the most highly used diagnostic criteria in the western studies while the Chinese used their official criteria established by their government or the criteria of their text books. 4. 20 reports chose the Lequesne functional index, SHAQ, WOMAC OA index, AIMS, and their own unique scoring system as the criteria of analysing the effect. Others chose clinical symptoms, articular functions, and lab finding as their criteria. 5. 7 single herbs and 19 formulated herbs were studied. Among the formulated herbs, Achyranthes japonica was studied in 10 of the studies and Angelica gigantis Radix in 8, making them the most often studied herbs among the studies.