열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

병원영양사의 특성과 영양관리업무 수행과의 관련성에 관한 연구 : 서울시내 종합병원을 중심으로 in Seoul

최미영,장유경 漢陽大學校 韓國生活科學硏究所 1988 韓國 生活 科學 硏究 Vol.- No.6

The complexities of modern medicine and the demand for high quality nutrition care services challenge the adequacy of traditional function and roles of the clinical dietitian. This study was designed to examine the relationship between nutritional care services and characteristics of hospital dietitians in Seoul. Data were collected from 51 dietitians of 51 hospitals that occupy 62.2% of the total number of such hospitals in Seoul during the month of September, 1986. Informations were obtained by questionnaires and interviews. The findings are: (1) Current status and position of the hospital dietitians have been progressed in a little. The following go up according to the increase in bed capacity in the hospital: the working career of dietitians at the present position, the amount of salary, the number of dietitians, the frequency of food service by one dietitian per diem and the independence of the department of nutrition. The nutritional care services performed as follows: generally nutritional care services is unregular, nutritional education and counseling activities aren't performed. (2) The characteristics of dietians such as the bed capacity of the hospital, the number of dietitians, the number of food services per diem, independence of nutrition dept., year working at the present position, the exitence of independent nutrition counseling room were significantly correlated with nutritional care services. (3) Nutritional education and counseling activities showed relatively high correlation. Viewed in this light, the improvement of the status of dietitian and high quality nutritional care services that is more strongly supported by the appropriate laws and institutions, college of education curriculum and continuing education.

산업장 소음노출 실태에 관한 조사

최형일,정경훈,유현종 조선대학교 환경공해연구소 1999 環境公害硏究 Vol.15 No.2

This research conducted an analysis of instantaneous sound pressure levels by means of classifying 246 processes at 41 workplaces in 11 kinds of industries. This research aims reveal how much noise level of each enterprise are exposed to the environment. This study investigated the distribution of noise induced hearing loss and the instantaneous sound pressure level in the audible frequency band. It also investigated the exposure intensity and characteristic of noise frequency according to the classification of industries. A frequency analysis was conducted on the processes which exceeded 85 dB(A). In addition, it was analyzed that the result of special health checkups and survey the laborers knowledge about noise according to their general characteristics. The rate of wearing protectors was also survey and the following findings were obtained : 1. Among the 246 processes of survey objects, the processes which exceeded 90dB(A), which is the maximum permissible standard for noise exposure designated by the ministry of labor were, 55 places, which corresponded to 22.4%. 2. When the analysis on frequency characteristics of 120 processes which exceeded 85 dB(A) in surveyed industries was conducted, the processes at 20 places, 16.7% showed the highest sound pressure level in the high frequency band which represented higher than 2 kHz. 3. The laborers having opinions that they had noise induced hearing loss were 85, which was 10.6% of 802 laborers who were the survey objects. 4. As for the rate of noise induced hearing according to age and years of service of laborers, the rate of noise induced hearing loss appeared higher as their ages increased and their years of service increased. 5. As for the tendency of recognizing their working environment, 80% of the subjects stated that their working sites were noisy, 51.2% stated that they easily felt tired.

유지놀 처리된 상아질 표면의 상아질 접착제의 전단결합강도에 관한 연구

유화성,최경규,최기운,박상진 대한치과보존학회 2000 Restorative Dentistry & Endodontics Vol.25 No.4

In this study, shear bond strength of two bonding systems were measured and appearance of dentin surfaces were observed with SEM according to the storage time of eugenol on dentin surface, thus evaluated the effect of eugenol on bond strength of two dentin bonding systems. Control groups were directly bonded to dentin surface with One Step, Prime & Bond 2.1. Experimental groups were divided into experimental I and II according to dentin bonding agents. After eugenol application, dentin surfaces were bonded with One Step and Prime & Bond 2.1 according to the each storage time of immediately, 3min, 24hour, 48hour and 1week, and then control and experimental groups were filled with light cured composite resin(Z-100). After 24 hours water storage at 37℃, all samples were subjected to a shear load to fracture at a cross head 1.0mm/min with Instron universal testing machine(No. 4467) . Etched dentin surface storaged for each time of immediately, 3min, 24hour, 48hour and 1week after eugenol application were observed under Scanning Electron Microscope(Hitachi S-2300) at 20kvp. The data were evaluated statistically with two-way ANOVA and Tukey's HSD. The results were as follows; 1.Shear bond strengths were higher in control groups than in the experimental groups. 2.As storage time was increased after eugenol application, the shear bond strengths were decreased in experimental groups 3.In experimental I, II the shear bond strengths were the lowest in which storage time was 1week after eugenol application. 4.As storage time was increased after eugenol application, etched dentin surfaces showed obstructed dentinal tubule.

서울지역 복지회관의 결식아동의 영양적 건강상태

최윤정;박유신;장유경 한양대학교 2004 韓國 生活 科學 硏究 Vol.- No.24

This study was carried out to investigated the growth development and nutritional health of poorly-fed children in Seoul Welfare Center. All subjects underwent a structured interview for general characteristics, anthropometric measurement and nutritional status. The results are as follows : The subjects were 30(male : 14, female : 16), among 7 to 12 years old. In higher grade boy, physical growth and development were decreased. Among the subjects, 37.7% were skipped the breakfast. In food group frequencies, subjects had animal protein such as meats(82.1%), fish(58.6%), and vegetable protein such as legumes(73.3%) 2 times and less a week. The average intakes of energy, vitamin B2, calcium were below 75% of the recommended dietary allowance. More than half of the subjects were under-nutrition (deficient of RDA, below 75%) in energy, vitamin A, vitamin B2, niacin, calcium and iron. Consequently, for balanced growth and development, it is necessary for school or community based nutritional support to supply dairy products that are major source of vitamin B2 and calcium for poorly-fed children.

가족성 정신분열병 환자에서 임상 특성의 가족내 연관성

최경숙,이유상,장용이,조은영,전현옥,김창현,김상욱,홍경수 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : This study aims at examining familial associations of symptoms and clinical characteristics in affected sibling or relative pairs of schizophrenia as an effort to identify genetically homogeneous phenotypes. Methods : Forty-seven relative pairs with DSM-IV diagnosis of schizophrenia from thirty-five Korean families multiply affected with schizophrenia were ascertained. Direct interviews were done using the Korean version of Diagnostic Interview for Genetic Studies (DIGS). The Krawieka Rating Scale and the Schedule for the Deficit Syndrome were also applied for further evaluation of psychopathologies. Intra-familial concordances and correlations of clinical characteristics and symptoms were tested using χ² -test and Spearman's correlation. Results : Significantly high concordance rate within relative pairs was found for the diagnosis of paranoid vs. non-paranoidsubtype (χ²=7.623, P=0.006, df=1). Deficit vs. non-deficit syndrome also showed significant concordance (χ² =3.850, p=0.0497, df=1). Among single symptom items in DIGS, only 'auditory hallucination' showed significant concordance rate ( χ² =5.503, P=0.019, df=1). Factor analysis for symptoms items in the Rrawiecka Rating Scale indicated three symptom dimensions ; negative, psychotic and affective, Psychotic (P =0.442, P=0.003) and affective dimension scores (p =0.427, P=0.004) showed significant intra-familial correlations. Age at onset of recognized psychotic symptoms showed significant correlation only within the male sibling pairs. Conclusion : Familial factors, Possibly genetic factor contribute to the phenotypic characteristics of paranoid vs. non-para-noid subtype, deficit vs. non-deficit syndrome, auditory hallucination, and affective syndrome, It supports their use in the delineation of homogeneous subgroups for future genetic studies.

사후분해 시체에 대한 법의학적 접근

최영식,이상용,김유훈,조갑래,이봉우,양경무,정낙은,서중석,이한영,이원태,강현욱 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2

Disposal of a homicide victim by dismemberment is rare, but individual cases are on record in most major medicolegal departments. Recognition of postmortem mutilation may be of importance in the interpretation of certain murders committed by sexual perverts and other mentally deranged individuals and sometimes performed for the sole reason of easier disposal of the body. Postmortem dismemberment is usually readily recognizable as such; The edges of the injuries are dry and lack evidence of bleeding. The joints may be disarticulated without fracture, or the use of an axe or saw may be evident from examination of bones. Parallel horizontal or oblique furrows in the bone surface are caused by skipping of the saw prior to establishing depth. Such patterns on the bone may assist in identifying the particular saw involved. So we report 25 dismembered corpses that autopsied in National Institute of Scientific Investigation. This paper can help in attempting to establish not only the first criminal investigation steps but also the medicolegal approach methods in unidentified and dismembered deaths.

벼꽃으로부터 두 개의 calmodulin cDNA 유전자의 분리 및 특성 연구

고보경,고명수,김유정,정일선,최영주 신라대학교 자연과학연구소 2005 自然科學論文集 Vol.14 No.-

Ca^(2+)은 신호전달과정에서 중요한 작용을 하는데 CaM은 이러한 Ca^(2+)이은의 modulator로서 중요한 작용을 하는 것으로 알러져 있다. 벼꽃의 cDNA library로부터 rice genomic DNA(RCaM-2)를 probe로 사용하여 30여개의 Positive clones을 얻어 이 중 두 개의 벼꽃 calmodulin CDNA clone을 분리하였다. RFCaMs CDNA clone의 총염기수는 RFCaM-3은 831p, RFCaM-4는 751bp이고 open reading frame은 각각 149개의 아미노산으로 구성되어 있다. RFCaM-3 과 RFCaM-4의아미노산은 동일하지만 nucleotide 순서는 상당한 차이를 나타내고 있다. RFCaMs CDNA clone의 open reading flame은 protein serine/threonine kinase에 보존되어 있는 catalytic domain을 가지고 있다 RfCaM-3은 5'-untranslated region은 105bp, 3'-untranslated region은 270bp이고 RfCaM-4는 5'-untranslated region은 78bp, 3'-untranslatedregion은 283bp이다. RFCaMs는 Arabidopsis와 70%, potato와는 92%, carrot과는 98%의 유사성을 보였다. Genomic southern blot분석에 의하면 벼의 clamodulin 유전자들이 7-8개의 multigene family로 존재하는 것으로 나타났다. Two different calmodulin (CaM) cDNAs (RFCaM-3 and RFCaM-4) were isolated from a rice flower cDNA library by screening with a rice genomic probe (RCaM-2). Both cDNAs are 90% sequence homologous inside the coding region but are highly divergent outside this region. The polypeptides encoded by RFCaM-3 and RFCaM-4 show identical sequence homology. Comparison of the deduced amino acid sequence of the RFCaMs cDNA clone have identity to Arabidopsis (70%), potato (92%), carrot (98%), and barley and soybean (98%). Southern analysis revealed that both cDNAs are encoded by different genes. Four intense and a few weaker bands were observed in the restriction fragments. Most restriction fragments showed high intensity hybridization signals under stringent conditions, suggesting the presence of a small multigene family for CaM in the rice genome as in other plants.

Stent삽입을 이용한 관동맥성형술로 치료한 내장역위가 동반된 우심증의 급성 심근경색증환자 1예

황경화,김태용,김준영,최유정,최홍엽,오재인,임상욱,차동훈 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

peat moss를 이용한 폐수중의 중금속 제거

이경화,김정섭,유현철,최성우,윤철종,우성훈,박승조 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1

Adsorption equilibrium of heavy metals ion on the peat moss was confirmed Frundlich isotherm Removal efficiency of heavy metals ion was increased from pH 2 to 10 and heavy metal removal efficiency was increased in the sequence of Cu(Ⅱ) > Pb(Ⅱ) > Cd(Ⅱ) > Mn(Ⅱ) on the PM(Peat Moss). The PM is likely to be more effective adsorption than the PAC to removal of metal ions in the solution, since PM's weakly acidic functional groups which is not founded on the PAC, in addition to its high surface area and porosity. But, the PM is not separated from the solution water by sedimentation process. So, a liquid and solid seperation between the PM and the solution water could be considered for the PM's field application. But peat moss was low cost adsorbent. Thus author propose to adopt PM as a adsorbent for heavy metal removal.