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김보배,노은경,박서영,박영,오승희,전영란,차현진,윤희상,김수지,이자형 이화여자대학교 간호과학대학 2004 이화간호학회지 Vol.- No.38
This study surveyed and analyzed comparatively college students-knowledge' attitude, was to cultivate the right knowledge and attitude on sex, and serve the foundational data for the suitable sex education. The purpose of the study was to identify and examine: 1) students; sexual knowledge and sexual attitude; 2) the differences between variables of gender, age, and self-perceived sexual knowledge in relation to sexual knowledge and sexual attitude; and 3) the relationship between sexual knowledge and sexual attitude. For this study the questionaires were given to 300 students from five different universities located seoul areas. the questionaires were collected Jenuary 8th to 15th in 2004. Two hundred and nigty one samples were analyzed for the study. The adapted SKAT(saxual knowledge & attitude test; Lief & Reed, 1986) was used to determine sexual knowledge and the students' sexual attitude. Collected data were analyzed statistically by means of percentage, t-test, ANOVA test, and pearson correlation analysis with SPSS 12.0 package program. The main results of this analysis are as follows: Participants consisted of male(48.1%) and female(51.9%) which were mainly between the ages of 21.25(71.8%) with an age range of 19 to 30. Knowledge of sexual disease was scored highest of 92.4%, and konwledge of the knowledge of the male and female's anatomy was the lowest at 60.9%. The respondents' level of sexual attitude was tolerant as on average 3.66(on the basis of 5) Relating to the items, the respondents' score of the sexual curiosity was 4.16, sexual behavior 3.85, self-consolation 3.81, aborthon 3.23, virgine 3.19, extramarital experiences 3.17. There were no significant differences in sexual knowledge between male and females, between younger and older students, residence, sexual experience, and how students mainly obtained their sexual knowledge. But a significant difference was also found religion in their sexual attitude(p<.005). In addition, results showed the relationship between sexual knowledge and sexual attitude(P=0.332).
Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics
Bae, Jung-woo,Choi, Chang-ik,Kim, Mi-jeong,Oh, Da-hee,Keum, Seul-ki,Park, Jung-in,Kim, Bo-hye,Bang, Hye-kyoung,Oh, Sung-gon,Kang, Byung-sung,Park, Hyun-joo,Kim, Hae-deun,Ha, Ji-hey,Shin, Hee-jung,Kim, Springer Science and Business Media LLC 2011 Acta pharmacologica Sinica. Vol.32 No.10
Prenatal diagnosis of a 7q21.13q22.1 deletion detected using high-resolution microarray
( Kyoung Bo Kim ),( Jung Sook Ha ),( So Jin Shin ),( Chun Soo Kim ),( Jin Gon Bae ) 대한산부인과학회 2014 Obstetrics & Gynecology Science Vol.57 No.4
We report a case of de novo 7q interstitial deletion detected by conventional karyotyping and by microarray of amniotic fluid sampled during the prenatal period. A 32-year-old pregnant woman was evaluated at our hospital following detection of increased nuchal translucency at 12 weeks and 5 days of gestation. Conventional karyotyping revealed 46,XX,del(7)(q21q22) in 20 interphase mitotic cells, and high-resolution microarray revealed 12.8 Mb (90,625,014·103,430,901) deletion in the region 7q21.13q22.1. Both parents had normal karyotypes. After birth, the neonate displayed several anomalies, including palatine cleft, upslanted and wide palpebral fissure, low-set ears, micrognathia, microcephaly, ventriculomegaly, subglottic tracheal stenosis, hearing loss, and hand/foot deformities, including brachydactyly, polydactyly, and cutaneous syndactyly. This case study helps explain the phenotype-genotype relationship in patients with 7q21.13q22.1 deletion.
구강질환 원인균에 대한 자몽종자추출물과 법제유황수 함유 치약시제품의 항균효과
이보배(Bo-Bae Lee),하유미(Yu-Mi Ha),신수화(Su Hwa Shin),제경모(Kyoung Mo Je),김순래(Soon Rae Kim),최재석(Jae-Suk Choi),최인순(In Soon Choi) 한국생명과학회 2009 생명과학회지 Vol.19 No.7
구강질환 원인균에 대한 자몽종자추출물(GSE)과 법제유황수(PSS)의 항균활성을 확인하기 위해, 평판배지확산법 및 액체감수성실험법으로 Streptococcus mutans, Prevotella intermedia, Porphyromonas gingivalis 및 Candida albicans에 대한 항균활성을 측정하였다. 평판배지확산법의 경우, GSE의 농도가 40 ㎕/disk일 때, S. mutans, P. intermedia, P. gingivalis 및 C. albicans에 대한 항균활성은 각각 11.0, 9.5, 8.0, 9.0 ㎜로 나타났으며, PSS의 농도가 40 ㎕/disk일 때에는 각각 2.0, 3.5, 0.0, 1.5 ㎜로 나타났다. 또한 액체배지감수성실험에서 GSE에 대한 MIC 값은 0.24, 0.06, 0.10, 15.63 ㎕/㎖이었으며, PSS에 대한 MIC 값은 각각 0.12, 3.91, >125, 7.81 ㎕/㎖이었다. 치약 시제품의 항균효과를 확인하기 위해, GSE와 PSS가 농도별로 함유된 치약시제품 원액과 2배 및 4배 희석액을 제조하여 평판배지확산법을 수행한 결과, 0.5% 치약 시제품의 2배 희석액에서 각각 7.3, 4.3, 2.2 그리고 1.5 ㎜로 나타났다. 치약 시제품의 물리ㆍ화학적 특성을 확인한 결과, pH, 점도, 굴절 및 색도 변화에 있어서 모두 안정성을 보였고, 이상의 결과를 바탕으로 기능성 치약과 같은 구강질환 예방 및 치료제 개발 가능성을 확인하였다. The aim of this study was to assess the effects of dentifrice-contatning grapefruit seed extract (GSE) and processed sulfur solution (PSS) on antimicrobial effects against oral pathogens. We first evaluated the antimicrobial effects of GSE and PSS against oral microbes: Streptococcus mutans (Sm), Prevotella intermedia (Pi), Porphyromonas gingivalis (Pg) and Candida albicans (Ca). When antimicrobial activity against Sm, Pi, Pg and Ca was tested, at 40 ㎕/disk, the inhibition zones of GSE were 11.0, 9.5, 8.0 and 9.0 ㎜, respectively. With the same method, the inhibition zones of PSS were 2.0, 3.5, 0.0 and 1.5 ㎜, respectively. In the micro broth dilution method, the MIC values of GSE against Sm, Pi, Pg and Ca were 0.24, 0.06, 0.10 and 15.63 ㎕/㎖, respectively. The MIC values of PSS were 0.12, 3.91, >125 and 7.81 ㎕/㎖, respectively. When pH, refractive index, viscosity and color value of dentifrice-containing GSE and PSS were measured, there were no significant changes in these physical properties compared to the control samples. Antimicrobial activities of dentifrice products containing 0.5% GSE and 0.5% PSS against oral pathogens were 7.3, 4.3, 2.2 and 1.5 mm, respectively. According to these results, we conclude that there may be a role for GSE and PSS in the development of new oral supplies.