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RISS 인기검색어
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- 저자 : ( Beom Soo Shin ) (검색결과 504 건)
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‘제3세대’이후 국내 러시아 연구의 현황과 과제 : 사회과학을 중심으로
박수헌,신범식 서울대학교 러시아연구소 2006 러시아연구 Vol.16 No.2
Since the mid-1990s, Russian Studies in Korea have been in the stage of "relative stabilization" after undergoing the ups and downs in the previous years. The rise of the "third generation" scholars, many of which returned to Korea after earning their doctoral degrees in Russia, has contributed to this trend. The current research, based on a comprehensive review of social science works on Russia, published as M. A. and Ph.D theses, in book forms and monographs, and as articles in 12 academic journals during the past decade in Korea, shows the following developmental tendencies in the Russian Studies in Korea since the mid-1990s. First, the number of Korean specialists on Russia has consistently increased. Second, the scope of research has been extended in spatial dimension as well as in research topics. In the former, while CIS countries other than Russia have increasingly became the subject of research, the investigation of local politics and economy in Russia has also grown. In the latter, topics have been more diversified beyond the traditional fields of politics, economy, society, and history into education, law, media, anthropology, and political geography. Third, the cases of field researches and surveys have continued to increase, which can contribute to a qualitative progress in the Russian Studies in Korea. Fourth, more research efforts have been devoted to the analysis of various aspects of Russia from a comparative theoretical perspective. Fifth, new attention has been called to the methodological issues in understanding the Russian experiences. Despite these new developments and achievements, however, Russian Studies in Korea still offer the room for continuing improvement. First, compared with those countries with more advanced Russian Studies, the Russian Studies community in Korea is still much small, and there are very few specialists on other CIS countries than Russia. Second, Russian politics and economy still command a disproportionally high position in terms of research topic. Third, researches are lopsidedly tilting toward policy-oriented studies rather than contributing to strengthening the foundation of Russian Studies. Fourth, the previous tendency to approach the Russian experiences from the viewpoint of break with the past has not been fully overcome. Fifth, although efforts have been made for establishing a "Korean style of studying Russia", the Western approaches to the Russian realities still enjoy a disproportionately high popularity. Sixth, strenuous endeavor among the Russian Studies community is required for implementing interdisciplinary researches of Russia as subject of area studies.
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김권영,신수범 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3
Objective: To evaluate usefulness of the brain SPECT in brain dysfunction patients who showed low Mini-MentaI State Examination(MMSE) score. Method: Eighty four patients who were visited to a rehabilitation hospital for their brain dysfunction were retropectively studied. We investigated percent of positive finding in brain SPECT, brain CT, MRI, P-300 studies, and correlation of MMSE scores, brain SPECT, P-300 studies, and correlation of brain SPECT, brain CT and MRI, P-300 studies. Resutts: Percent of positive finding in brain SPECT was high than brain CT, MRI, P-300 studies. MMSE scores were positive correlation with brain SPECT, but no correlation with P-300 study(P>0.05). Brain SPECT were significant correlation with brain CT (P<0.05), but no correlation with brain MRI and P-300 studies (P>0.05). P-300 study was no correlation with brain CT, MRI (P>0.05). Conclusion: We concluded that brain SPECT is useful for reflection of brain dysfunction.
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들잔디 성숙종자로부터 캘러스배양 및 식물체 재분화에 미치는 몇 가지 요인의 영향
이상훈,김범수,원성혜,조진기,김기용,박근제,성병렬,이효신,이병현 Plant molecular biology and biotechnology research 2004 Plant molecular biology and biotechnology research Vol.2004 No.-
In an effort to optimize tissue culture responses of zoysiagrass (Zoysia japonica Steud.) for genetic transformation, factors affecting callus induction and plant regeneration were investigated. MS medium containing 3 ㎎/L 2,4-D was optimal for embryogenic callus induction from mature seed. The plant regeneration frequency of 73.3% was observed when embryogenic calli induced in this medium were transferred to N6 medium supplemented with 0.1 ㎎/L 2,4-D and 5 ㎎/L BA. Among several basic media, MS and N6 medium were optimal for callus induction and plant regeneration, respectively. Regenerated plants were grown normally when shoots transplanted to the soil. A rapid and efficient plant regeneration system established in this study will be useful for molecular breeding of turfgrass through genetic transformation.
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난치성 외측 상과명에서 포동당 용액과 자가혈 주사치료의 효과
김종규,김권영,신수범 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1
Background and Objectives: To investigate the effect of hyperosmolar dextreose and autologous blood injection in the refractory lateral epicondylitis. Materials and Methods: The sunjects consisted of 39 patients suffering refractory lateral epicondylitis. All patients had failed previous nonsurgical treatments including all or combinations of physical therapy, splinting, nonsteroidal anti-inflammatory medication, and prior steroid injections, Sixteen subjects were injected with 15% dextrose solution under the extensor carpi radialis and tender points. Other subjects were injected with 2mL of autologus blood under same area. ResuKs: In the comparison of the VAS before and after treatment, Prolotherapy was 6.38 and 3.44, autologous blood injects was 6.12 and 2.54 respectively, which demonstrated statistically significant decrease..The effect of autologous blood injections was shown to be more effective than that of prolotherapy. Conclusion: After autologous blood injection therapy in whom nonsurgical modlalities had failed were relieved completely of pain even during strenuous activity. This study offers encouraging results of an alternative minimally invasive treatemnet that addresses the pathophysiology of latera epicondylitis that has failed traditional nonsurgical modalities.
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( Beom Soo Shin ),( Mary Grace C. Danao ) 한국농업기계학회 2012 바이오시스템공학 Vol.37 No.2
Purpose: Particle separation in solution is one of important process in a unit operation as well as in an extract preparation for biosensors. Contrary to centrifuge-type of mesh-type filter, using an ultrasonic standing wave make the filtering process continuous and free from maintenance. It is needed to investigate the characteristics of particle movement in the ultrasonic standing wave field. Methods: Through the computer simulation the effects of major design and driving parameters on the alignment characteristics of particles were investigated, and a cylindrical chamber with up-stream flow type was devised using two circular-shape PZTs on both sides of the chamber, one for transmitting ultrasonic wave and the other for just reflecting it. Then, the system performance was experimentally investigated as well. Results: The speed of a particle to reach pressure-node plane increased as the acoustic pressure and size of particle increased. The maximum allowable up-stream flow rate could be calculated as well. As expected, exact numbers of pressure-node planes were well formed at specific locations according to the wavelength of ultrasonic wave. As the driving frequency of PZT got close to its resonance frequency, the bands of particles were observed clearer, which meant the particles were trapped into narrower space. Higher excitation voltages to the PZT produced a greater acoustic force with which to trap particles in the pressure-node planes, so that the particles gathered could move upwards without disturbing their alignments even at a higher inlet flow rate. Conclusions: This research showed the feasibility of particle separation in solution in the continuous way by an ultrasonic standing wave. Further study is needed to develop a device to collect or harvest those separated particles.
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Shin, Beom-Soo,Seo, Jin-Hyuk,Hur, Man-Wook,Lee, Min-Nyung,Yoo, Sun-Dong 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.9
This study examined the absorption and pharmacokinetic disposition of $^{125}I-GST-TatdMt$, a recombinant Tat protein possessing potent anti-obesity activity, in mice after vascular and extravascular administration. GST-TatdMt was over-expressed in E. coli, purified, and radioiodinated using the IODO-GEN method. $^{125}I-GST-TatdMt$ was administered to mice by i.v., i.p. and oral administration at doses of 652.7 nCi (102.3 ${\mu}g$). Upon i.v. injection, the average terminal elimination half-life ($t_{1/2,{\lambda}z}$), AUC and AUMC were 6.4 h, 318.2 $nCi{\cdot}h/mL$ and 2518 $nCi{\cdot}h^{2}/mL$, respectively. The highest radioactivity was observed in lung followed by liver, spleen, heart and kidney. The $t_{1/2,{\lambda}z}$ values obtained from i.v., i.p., and oral administration were comparable from each other (range 5.8-6.4 h). The absolute bioavailability of $^{125}I-GST-TatdMt$ was 42.8% and 60.5% after p.o. and i.p. administration, respectively. Given the cell-penetrating nature, $^{125}I-GST-TatdMt$ may be absorbed into the systemic circulation to a relatively high extent after extravascular administration.
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Shin, Beom Soo,Bulitta, Jü,rgen B.,Hong, Deok Ki,Kim, Hye Youn,Kim, Min Ki,Choi, Yohan,Lee, Jong Bong,Hwang, Sang Wook,Lee, Mann Hyung,Yoo, Sun Dong S. Karger AG 2011 Chemotherapy Vol.57 No.3
<P>Abstract</P><P><I>Background:</I> This study assessed the population pharmacokinetics and metabolic conversion of a novel histone deacetylase (HDAC) inhibitor, SD-2007, into its active metabolite, apicidin, in rats. <I>Methods:</I> SD-2007 was given to rats by intravenous injection (4 mg/kg) and oral administration (40 mg/kg). Serum concentrations of SD-2007 and apicidin were determined by LC-MS/MS. All concentrations were analyzed using a population pharmacokinetic model with 9 compartments in S-ADAPT. <I>Results:</I> The area under the curve for apicidin was 96 ± 16 mg·h/ml after 4 mg/kg administered intravenously and 2,455 ± 1,211 mg·h/ml after 40 mg/kg given orally. The population pharmacokinetic model described all profiles well. After oral administration of SD-2007, the median absolute bioavailability of SD-2007 was 6.67% (range 3.83–9.89) and the median apparent bioavailability was 22.3% (range 15.7–35.8) for apicidin, whereas only a median of 8.85% (range 7.57–9.34) of an intravenous SD-2007 dose was converted to apicidin. <I>Conclusions:</I> Oral SD-2007 displayed a substantial presystemic metabolism to active apicidin. The high serum concentrations of apicidin after oral administration of SD-2007 may cause significant HDAC inhibition.</P><P>Copyright © 2011 S. Karger AG, Basel</P>
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Beom Lee,Jun-Gyu Park,Won-Beom Shin,Beom-Soo Kim,Byoung-su Byun,Hang-Bae Jun 대한환경공학회 2019 Environmental Engineering Research Vol.24 No.4
Anaerobic digestion is a popular sewage sludge (Ss) treatment method as it provides significant pollution control and energy recovery. However, the low C/N ratio and poor biodegradability of Ss necessitate pretreatment methods that improve solubilization under anaerobic conditions in addition to anaerobic co-digestion with other substrates to improve the process efficiency. In this study, three pretreatment methods, namely microwave irradiation, ultrasonication, and heat treatment, were investigated, and the corresponding improvement in methane production was assessed. Additionally, the simplex centroid design method was utilized to determine the optimum mixture ratio of food waste (Fw), livestock manure (Lm), and Ss for maximum methane yield. Microwave irradiation at 700 W for 6 min yielded the highest biodegradability (62.0%), solubilization efficiency (59.7%), and methane production (329 mL/g VS). The optimum mixture ratio following pretreatment was 61.3% pretreated Ss, 28.6% Fw, and 10.1% Lm. The optimum mixture ratio without pretreatment was 33.6% un-pretreated Ss, 46.0% Fw, and 20.4% Lm. These results indicate that the choice of pretreatment method plays an important role in efficient anaerobic digestion and can be applied in operational plants to enhance methane production. Co-digestion of Ss with Fw and Lm was also beneficial.
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Pharmacokinetics of SD-0542, a Novel Histone Deacetylase Inhibitor, in Rats
Shin, Beom-Soo,Yoo, Sun-Dong The Korean Society of Pharmaceutical Sciences and 2005 Journal of Pharmaceutical Investigation Vol.35 No.5
This study reports the pharmacokinetics of a novel histone deacetylase inhibitor, SD-0542, in rats after i..v. and oral administration. SD-0542 was injected intravenously at doses of 10, 20, and 40 mg/kg. The terminal elimination half-life $(t_{1/2})$, systemic clearance (Cl), and steady-state volume of distribution $(V_{ss})$ remained unaltered as a function of dose, with their values ranging from 2.0-2.5 hr, 157.2-214.1 ml/min/kg, and 11.1-17.5 L/kg, respectively, whereas, the initial serum concentration $(C_0)$ and AUC increased linearly as the dose was increased. Renal excretion of SD-0542 was minimal. Oral pharmacokinetic studies were conducted in rats at a dose of 20 mg/kg. The $T_{max}$, Cl/F, $V_{z}/F$, and $t_{1/2}$ were 2.0 hr, 92864 ml/min/kg, 16331 L/kg, and 2.0 hr, respectively. Taken together, SD-0542 showed linear pharmacokinetics over the i.v. bolus dose range studied. SD-0542 was poorly absorbed, with the absolute oral bioavailability of 0.9%.
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