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용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1
To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.
Sleep status during pregnancy in Korea
( Jin Gon Bae ),( Jin-kyeong Ha ),( Yong Won Cho ),( Keun Tae Kim ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: For many pregnant women, pregnancy-related sleep disturbances arise as pregnancy progresses. Thus, the change of the sleep problems across pregnancy is of interest. However, there have been few surveillance of sleep problem during pregnancy in Korea. The aim of this study was to examine whether sleep problems and sleep quality increase or degenerate during pregnancy. Methods: As a prospective study, all pregnant women who visited our hospital was asked to fill out a series of questionnaire: the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and STOPBANG. Results: This is a cross-sectional study of 295 pregnant womens sleep and mood status. There were 30, 155, and 110 subjects in 1st, 2nd, and 3rd trimester, respectively. There is no significant difference in age; but body mass index, ISI, and BAI were gradually increased through the three trimesters. There were significant degenerations of BMI, ISI, ESS, PSQI, and BAI from the second trimester of pregnancy to the third (Table 1). There are 1 (3.3%), 6 (3.9%) and 16 (14.5%) subjects in 1st, 2nd and 3rd trimester showed clinically significant ISI (15.5) (Table 2). It suggests that the prevalence of insomnia increases as pregnancy continues. There are 1 (3.3%), 13 (8.4%), and 30 (27.3%) subjects in 1st, 2nd and 3rd trimester showed ESS above 10.5 (Table 3). It suggest that significant excessive daytime sleepiness increases progressively. There are 9 (30%), 62(40%), and 59 (53.6%) subjects in 1st, 2nd and 3rd trimester showed PSQI above 8.5 (Table 4). It suggest progressive worsening of sleep quality during pregnancy. There was no subjects of suspected sleep breathing disorders (STOPBANG above 3.5). Conclusion: This study suggests that pregnant women are complaining more sleep problems including insomnia, excessive daytime sleepiness, and poor sleep quality as their pregnancy period continues. Acknowledgements: This work was supported by NRF-2017R1C1B5076728 grant funded by National Research Foundation
( Jin Gon Bae ),( Jun Chul Park ),( Jong In Kim ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: We report the obstetrical outcomes in patients with twin pregnancies who underwent an emergency/physical exam-indicated cerclage and to compare them to patients with singleton pregnancies undergoing the same procedure. There is no evidence to support prophylactic cerclage in twin pregnancy 방법: Patients who underwent emergency/physical exam-indicated cerclage in the second trimester in Department of Obstetrics and Gynecology, School of Medicine, Keimyung University from Jan. 2013 to Dec. 2013 were reviewed. We defined an emergency/physical exam-indicated cerclage as any cerclage placed in a patient with a dilated cervix on examination or membranes visible at the external cervical os on speculum examination. We compared outcomes between patients with singleton and twin pregnancies using non-parametric testing. 결과: There were 98 patients (45 twin and 53 singleton pregnancies) who underwent emergency/physical exam-indicated cerclage placement. The median gestational age at cerclage placement, cervical dilation, maternal age, and cerclage type were similar between the groups. Comparing twins to singletons, the median time from cerclage placement to delivery was similar 0.330), as was the median gestational age at delivery=(102 vs. 126 days, p 0.244). The likelihood of delivery at=(35.5 vs. 38.0 weeks, p >32 weeks (87.0% vs. 91.0%, p>0.999) and the likelihood of neonatal survival to discharge (81.3% vs. 85.9%, p>0.999) were also similar. Emergency/physical exam-indicated cerclage in twin pregnancies can be associated with favorable outcomes, including a high likelihood of delivery at >32 weeks and a high likelihood of survival. Their outcomes appear similar to singleton pregnancies. 결론: Emergency or physical examination indicated cerclage should be considered an option for patients with twin pregnancies and a dilated cervix in the second trimester and is possible in twins and appears to be associated with favourable outcomes Keywords: Cerclage, Twin, Preterm birth, Physical examination, Emergency.
OB-13 : Outcomes of twin pregnancies with single fetal death: management, maternal and fetal outcome
( Jin Gon Bae ),( Jun Chul Park ),( Jong In Kim ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: We investigated the management and maternal and fetal outcome in single fetal death in twin pregnancies. 방법: We studied 156 (9.5%) twin deliveries out of a total of 1,655 deliveries in Department of Obstetrics and Gynecology, School of Medicine, Keimyung University at 2013. 결과: Out of them, 19 (12.1 %) were complicated with single fetal death in the second or third trimester. These cases were managed conservatively with regular monitoring of maternal coagulation profile along with intensive fetal surveillance for the surviving twin. The cases were studied for antenatal complications and placental chorionicity. Neonatal and maternal outcome in the postpartum period was also studied. No antenatal complications were present in 14 out of 19 cases with one having PIH which could be extended to term( 38 week G/A) and had no maternal complications. Four pregnancy ended in preterm labor with delivery of a preterm baby which could not be saved. One resulted in death of the other fetus also where pregnancy was remote from term. 결론: Although our study was small, it indicates that in case of twin pregnancy with single fetal death with good surveillance, the live fetus can be salvaged.
( Jin Gon Bae ),( Jun Chul Park ),( Jong In Kim ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
Hemolysis, elevated liver enzymes, and low platelet(HELLP) syndrome is a rare complication and occurs in 0.5-0.9% of pregnant women . A 28-year-old women was admitted to our hospital due to abrupt onset of convulsion with normal blood pressure after normal delivery(male, 3200gm). There are no antepartum abnormal laboratory findings and no history of hypertension and other illness. After 3 hours after admission, abrupt onset of high blood pressure was occurred with low level of platelet( 50.00×103/ul), elevated LDH( 3974/ UL), elevated liver enzymes( AST 1325/ UL ,ALT 670/UL,) ,urine albumin(3+) and myoglobulin(+) where HELLP syndrome was diagnosed. she developed disseminated intravascular coagulation (DIC), mild cerebral infarction with postpartum blue. She discharged after one week with careful observation and rapid and massive management. Here we report a case of postpartum HELLP syndrome without antepartum pregnancy induced hypertension. Keywords: Postpartum HELLP syndrome
Case Report : An Orbital Hemangioendothelioma Of Fetus Detected By Prenatal Ultrasonography
( Jin Gon Bae ),( Su Yeon Lim ),( Jeong Ho Rhee ),( Jong In Kim ),( Joon Cheol Park ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.8
Most orbital tumors of infants include retinoblastoma, dermoid cyst (teratoma), optic nerve glioma and nevus, and hemangioendothelioma is found in rare cases. Hemangioendothelioma, the tumor of intermediate malignancy between angiosarcoma and hemangioma, is commonly recognized in soft tissue of extremities, skin, lung and liver with symptoms of ulceration and hepatomegaly in neonates and infants. However it seldom localizes in the orbit. Although there have been two case reports of orbital hemangioendothelioma in neonate and adult in Korea, there was no case report of prenatally diagnosed orbital hemangioendothelioma in fetus. We found hemangioma-like orbital tumor in a fetus at 36 weeks of gestation by prenatal ultrasonography and confirmed hemangioendothelioma by microscopic examination after birth. This is the first case of orbital hemangioendothelioma in fetus.
임신 제 3 삼분기에 발생한 자발성 혈복강의성공적인 보존적 치료
배진곤 ( Jin Gon Bae ),박준철 ( Joon Cheol Park ),이정호 ( Jeong Ho Rhee ),김종인 ( Jong In Kim ) 대한주산의학회 2014 Perinatology Vol.25 No.1
At early stage of pregnancy, hemoperitoneum often occurs in heterotopic ectopic pregnancy or bleeding of hyperstimulated ovary and can be managed easily by laparoscopic surgery while maintaining pregnancy. But in the 3rd trimester pregnancy, surgical management without delivery is very difficult and preterm birth is inevitable because of life-threatening complications not only for mother but fetus. We present a woman with 31 weeks and 3 days` gestation and spontaneous hemoperitoneum that was treated by conservative management without preterm delivery successfully. A review of the literature was undertaken.