수도수중 염소 소독부산물로 인한 건강위해성 평가에 관한 연구 : 서울시 수도수중 Trihalomethanes 및 Haloaceticnitriles을 중심으로

정용,신동천,양지연,박연신,김준성 한국환경독성학회 1997 환경독성보건학회지 Vol.12 No.2

Public concerns about hazardous health effect from the exposure to organic by-products of the chlorination have been increased. There are numerous studies reporting that chlorination of drinking water produces numerous chlorinated organic by -products including THMs, HAAS, HANs. Some of these products are known to be animal carcinogens. The purpose of this study was to estimate health risk of DBPs by chlorinated drinking water ingestion in Seoul based on methodologies that have been developed for conducting risk assessment of complex-chemical-mixture. The drinking water sample was collected seperately at six water treatment plant in Seoul at March, April, 1996. In tap water of households in Seoul, DBPs were measured with the mean value of 36.6 μg/L. Risk assessment processes, which include processes for the estimation of human cancer potency using animal bioassay data and calculation of human exposure, entail uncertainties. In the exposure assessment process, exposure scenarios with various assumptions could affect the exposure amount and excess cancer risk. The reference dose of haloacetonitriles was estimated to be 0.0023 mg/kg/day by applying dibromoacetonitrile NOAEL and uncertainty factor to the mean concentration. In the first case, human excess cancer risk was estimated by the US EPA method used to set the MCL (maximum contaminant level). In the second and third case, the risk was estimated for multi-route exposure with and without adopting Monte-Carlo simulation, respectively. In the second case, exposure input parameters and cancer potencies used probability distributions, and in the third case, those values used point estimates (mean, and maximum or 951!!i) upper-bound value). As a result, while the excess cancer risk estimated by US EPA method considering only direct ingestion tended to be underestimated, the -risk which was estimated by considering multi-route exposure without Monte-Carlo simulation and then using the maximum or 95% upper-bound value as input parameters tended to be overestimated. In risk assessment for Trihalomethanes, considering multi-route exposure with adopting Monte-Carlo analysis seems to provide the most reasonable estimations.

심한 척추후측만증 환자의 대퇴골절 복원술을 위한 부위마취 : 증례보고 A case report

김지은,박대용,유시현,강규식,권진형,김천숙,안기량 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Kyphoscoliosis is a disease manifested as lateral curvature of spine and accompanying rotation of the vertebrae, resulting in distortion of rib cage. Restrictive lung disease and pulmonary hypertension progressing to cor pulmonale are the major cause of mortality in patients with kyphoscoliosis. We had experienced a successful spinal and caudal epidural anesthesia for the open reduction and internal fixation with plate of fractured femur shaft in two patients with severe kyphosoliosis. We had chosen regional anesthesia as an anesthetic method because of there poor pulmonary function and severe deformities of thoracolumbar spine. We could achieve the adequate anesthetic sensory dermatome level, T_(5) and T_(8), for operation without any significant deterioration of blood pressure and respiration. We recommended that regional anesthesia is a useful anesthetic method for a patients with severe kyphoscoliosis when the operation on hip or lower extremity is required.

음용수 중 유해화학물질에 대한 위해성 평가에 관한 연구 : Ⅱ 비발암성 화학물질을 중심으로

정용,신동천,김종만,박성은,양지연,이자경,황만식,박연신 한국환경독성학회 1995 환경독성보건학회지 Vol.10 No.1

The purpose of this research is to estimate a safe environmental level of human exposure to thresholding acting toxicants in drinking water and recommend the acceptable levels and management plans for maintaining good quality of drinking water and protecting health hazard. This research has been funded as a national project for three years from 1992 to 1995. This study(the second year, 1993-1994) was conducted to monitor 39 species of non-carcinogenic chemicals such as volatile organic compounds(VOCs), polynuclear aromatic hydrocarbons(PAHs), pesticides and heavy metals of drinking water at some area in six cities of Korea, and evaluate health risk due to these chemicals through four main steps (hazard identification, exposure assessment, dose-response assessment and risk characterization) of risk assessment in drinking water. In hazard identification, 39 species of non-carcinogenic chemicals were identified by the US EPA classification system. In the step of exposure assessment, sampling of tap water from the public water supply system had been conducted from 1993 to 1994, and 39 chemicals were analyzed. Indose-response assessment for non-carcinogens, reference doses(RfD) and lifetime health advisories (HAs) of lifetime acceptable levels were calculated. In risk characterization of detected chemicals, the hazard quotients of noncarcinogens were less than one except those of manganese and iron in D city.

白鼠胎仔 골격발생과정에 미치는 Chlorambucil과 Tocopherol의 相互作用에 關한 實驗的 硏究

宋志南,全容赫 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.3

The effect of tocopherol to the teratogenecity due to chlorambucil have been studied on the developing skeleton in prenatal offsprings from 27 mothers of albino rat through macroscopic and microscopic observations. 1. None of the significant abnormality has been observed on either macroscopic or microscopic features in the fetal group treated with single dose of tocopherol administration the mother, except, the group treated with continuous 3 doses of it to the mother, of which the measures of the weight and stature of them are generally decreased than those of the normal contrast. 2. Though the degree of teratogenecity on the developing fetal skeletal frame due to the chlorambucil is mainly depend upon the amount of the drug and the time of administration during pregnancy of mother, the highest to teratogenetic effect could be elicitable on the fetuses at the day 12th, while, none of significant effect could be detectable in the fetuses after the time of day 14th of pregnancy on the administration of the chlorambucil. 3. The protective effectiveness of the tocopherol from the teratogenecity on the fetal skeletogenesis due to the chlorambucil appears not to be efficient. On the contrary, the concomitant use of tocopheral with chlorarmbucil tends to be facilitate the teratogenetic effect of the chlorambucil, furthermore, the rate is higher against with increase of the date of pregnancy.

지하수 중 자연방사성물질의 위해성 관리에 대한 고찰

신동천,김예신,문지영,박화성,김진용,박선구 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

At present, the health risks associated with the natural radionuclides of ground water have become a concern as potential social problems. However, there are no regulatory actions or control strategies for such risks. Therefore, we have investigated and discussed the risks and associated management strategies for radionuclides in other countries. US EPA has proposed MCL (300 pCi/L) and AMCL (4,000 pCi/L) for radon, and 30 ppb for uranium, 15 pCi/L for gross-alpha and 5 pCi/L for radium as final MCLs. Also, Canada, WHO and European countries have their inherent management levels. Finally, we suggested several criteria for setting guidelines in our countries including exposure related criteria such as geological distribution, occurrence, exposure probability distribution, exposure population and multimedia exposure assessment, acceptable risk, and cost-benefit analysis. The national-scale exposure and risk assessment, and economic analysis should be conducted for producing and aggregating the representative information on these criteria.

자외선 (UVB) 노출 증가에 대한 피부암 위해도 예측 모델의 적용

신동천,이종태,정용,강나경,양지연 한국환경독성학회 1996 환경독성보건학회지 Vol.11 No.1

A decrease in stratospheric ozone probably caused by chloroflurocarbons (CFCs) emissions, has been observed large parts of the globe. It is generally accepted that if ozone levels in the stratosphere are depleted, greater amounts of shortwave ultraviolet radiation-B (UVB) will reach the earth's surface, resulting in increased incidence of nonmelanoma skin cancer. In this study, we evaluated several mathematical models, such as a power and an exponential model, and a geometric model considering the surface area of a human body part and ages for the prediction of skin cancer incidence caused by exposure to the UVB radiation. These models basically estimated the risk of skin cancer based on those measurements of the local ozone in stratosphere and UVB. Both were measured at a part of Seoul with a Dobson ozone spectrometer and Robertson-Berger UV Biometer for 1995. As a result, we calculated the point estimation applying a biological amplification factor (BAF), UVB radiation and other factors. We used a Monte-Carlo simulation technique with assumption on the distribution of each considered factor. The sensitivity analysis of model by there components conducted using Gaussian sensitivity method. The annual integral of UVB radiation was 2275 MED (minimal erythema dose)/yr. Also, an estimate of the annual amount of UVB reaching the earth's surface at a korea's latitude and altitude was 3328 MED/yr. The values of the radiation amplification factor (RAF) were ranged from 0.9 to 1.5 in Seoul. To give the effective factors required to model the prediction of skin cancer incidence caused by exposure to the UVB radiation in Korea, we studied the pros and cons of above mentioned models with the application of those parameters measured in Seoul, Korea.

濟大 學生生活指導의 改善方向 探索

玄惠慶,姜志勇,許鐵洙,梁奇千 濟州大學校 學生生活硏究所 1982 學生生活硏究 Vol.5 No.-

A. The necessity and purpose of the study Since 1960s the number of university and college students has increased due to the rapid industrial development which requires more technical and intellectual persons. Also the upward spreading effects of education with generalization of secondary education have increased the social demands of liberal education, which expedite university students' diversity and heterogeneity. Therefore, the problems of students are no longer those of school authorities, but expand into social and national problems. Recently most of university in Korea have put more emphasis on the rearrangement and reinforcement of Student Guidance System. Especially, in case of Jeju National University, taking into considerations the special geographical conditions far away from the Korean mainland, and transitional stage on which JNU was promoted to national full-university status, along with the unification of campuses, the more careful interests and efforts are required for student guidance. This study was conducted with a view to providing the opportunities of educational and social specialization of student guidance. The following are the purpose of this study: 1) To set up directions for student guidance which can carry out the role and function of the university. 2) To consider, in the aspect of education, the main factors which influence the problems of university students. 3) To find out the difference between the problems of students' demand and abilty and realities of guidance, by comparing and analyzing present guidance realities between universities. 4) To offer improvement directions for efficient student guidances. B. The scope and contents of the study 1) The problem of student guidance in view of the purpose and function of a university. 2) The fundamental viewpoint of guidance in university 3) A theoretical investigation for efficient student guidance 4) A root cause of student problems 5) The present condition and problems of student guidance 6) Improvement directions for guidance C. The method of the study 1) To analyze the domestic data as well as foreign data 2) To analyze the questionnaire 3) To analyze the results of guidance through the actual result reports of student guidance 4) To analyze various data of student guidance 5) To represent by percentage(%) the realities and problems of student guidance D. The problematic factors of student guidance in the light of purpose and function of a university 1) The original purpose and functions of university are the acquisition of knowledge the transmission of knowledge, and application of knowledge. They are based on the wholemen community of intellectuals in which research, education, and service are determined to be prime mission, but hasn't well been fulfilled because of the present special situations of Korea. 2) In the expectations of university's roles, it is becoming important to harmonize the real desire of administrative officials, intellectual desire of professors, and idealistic of students with each other. 3) A university's research function of creating academic atmosphere is very unsatisfactory. 4) The relationship between professors and students, and even among students hasn't well progressed because of excessive solicitude of omission by graduation quota system as well as full classes. And cultural education is not conducting effectively because it is very fragmentary and formal. 5) The chaos is being produced about the establishment of concept of community service given to university education, the ways and limitations of participation in society and actual world. E. The viewpoint of student guidance The contents and methods of student guidance are decided according to the view of students to be the subject of guidance. In the reformative viewpoint of student guidance by educative instruction methods, main method of guidance are authority, blind obediance, cramming, subjectivity, control, rectification. From the educative viewpoint of student guidance, self-direction can be possible by means of students' interest, desire and ability. Future student guidance must be conducted to develop their potentiality and natural ability of growth without external force or blind gramming. F. Following theoretical investigation were enforced in order to establish effective directions for student guidance. 1) The concept and purpose of the orientation for freshmen and its basic policy and contents 2) The necessity and contents of department arrangement guidance 3) The practice of alloted academic adviser system 4) The educational functions, necessity, and meaning of campus extracurricular activity 5) The role and function of student government(SNDC) 6) The welfare and scholarship system for students G. As a result of a selection of root causes of student problems from the introspection, the following were important order of immediate and expected problems 1405 freshmen; 1. Studies Problem(40.3%) 2. Course problem(36.4%) 3. Economic life problem(36.9%) 4. Social fitness Problem(26.7%) 5. Health Problem(16.0%) The investigation consequence for sophomore and junior are following; 1. A course Problem(35.2%) 2. Economic life problem(35.4%) 3. Human relation problem between professor and student(35.2%), and a good use problem of spare time(35.2%) 4. Studies problem(26.4%) H. The problems were revealed by a statistics which were investigated and analyzed realities of student guidance as follows, respectively: 1. In the orientation for fresh, it is emphatic to give only a information, the program of a important purpose in an orientation that are helpful to initiation of university life with a safety emotionally by withdrawing from strain from strange environment is making light of. 2. In the guidance of a department choice, department allocation by a record is making without giving a chance searching for self-characteristic like aptitude or hobbies, the guidance plan and materials of objectivity are not prepared, and the chance choosing carefully comes very short of. 3. In the management of partial charge professors system, the relation position between professor and student is very formal because, as a matter of fact, it is meaningfulness to guide students from a professor is responsible for guidance of so many students, director of professors are in want of the whole recognition about guidance contents. 4. Though the circle activities are very important as an educational function, a director professors of a circle has charge of guidance for so many students, the activities without purpose consciousness are unfolding, the activities with interest and recreation mainly are rich in, and the activities for enlightenment sound activity model which gets a value experience are situation insufficiency itself. 5. In the activities and management of Student Body, he is not accomplishing plan and function by nature, the activities and management individual and new are very lack owing to emphasis of events centre and actual results centre. And the appearance of making heteronomy now that he is not also chose relation to the circles in SNDC is more and more deepening. 6. The lower organization taking charge of students guidance specially in managent of the students guidance institute are in need, the number of specialists are for want of, it is just so formal to run the students guidance institute because the institute's finance is in very poverty, its originally functions are not accomplishing due to the consultation mood in consultation room is stiff. 7. Our university lacks in research facilities and mental incentive with regard to student welfare function. I. I am directing the way of student guidance for withdrawing from and getting rid of the problems revealing, concerning the students guidance to the best of his ability by the realities of students problems as follows; First, the investigation and research activities and assistance understanding and helping students have to provide in the side of prevention of problems by understanding university students' nature consciousness and characteristic regularly. Second, students' spontaneous participation, the development of interesting and useful programmes, and faculty members' active supports & guidance should be given to obtain effective result of fresh's orientation. Third, school authorities should provide freshmen with opportunity to judge their aptitudes from the time of entrance by holding orientation several times, and by offering detailed informations on the department selection. Fourth, The academic & human relations between professors and students should be maintained through proper enforcement of alloted academic professor system. Fifth, every circle and club should established proper and patent objectivities of activity, and try, to create and introduce useful and interesting programmes in order to promote an educational function of each circle and club. Sixth, in order to eleminate the gap between students and Students Government, students should take deep interests in Student Body's activity, while Student Body should develop academic and literary activity to promote students research activities. Seventh, in order to promote the function of Student Guidance Institute, there should be secured expert staff for smooth counselling, investigation and employment guide as well as financial and administrative support of school authorities. Finally, university authorities should organize several institute such as student welfare committee(institute) so that they might grasp what student opinions & desire are and make students lead comfortable campus lives.

칠절봉 신갈나무(Quercus mongolica)림의 군락구조와 토양환경

이호준,배병호,전영문,정흥락,홍문표,김용옥,길지현 建國大學校基礎科學硏究所 1998 理學論集 Vol.23 No.-

칠절봉 신갈나무림의 군락구조와 토양환경과의 관계를 파악하기 위해 식물사회학적 조사와 토양 환경을 분석하였다. 조사지역의 신갈나무림은 신갈나무군락, 철쭉꽃하위군, 큰개별꽃하위군으로 구분되었으며, 철쭉꽃하위군과 큰개별꽃하위군에서의 방형구당 평균출현종수는 각각 30종(24∼46종), 43종(31∼52종) 이었다. 피복지수치에 의한 계층별 우점순위는 교목층에서 신갈나무(6750.0), 아교목층에서 당단풍(2364.0) 관목층에서 철쭉꽃(988.5), 초본층에서 쌀새(1040.5)가 가장 높게 나타났다. 신갈 나무림의 DBH 분포는 2∼10㎝ 범위의 소경목이 전체의 29.7%를 차지하였으며 전체적으로 정규분포를 나타내어 교란 후 재생과정에 있는 것으로 조사되었다. 또한 후계목의 발달로 인한 극상상태로의 천이가 가능할 것으로 조사되었다. 전반적인 토양환경은 두 하위군 간에 뚜렷한 차이가 없었으며, 큰개별꽃하위군이 철쭉꽃하위군에 비하여 다소 양호한 것으로 조사되었다. 환경구배분석에서 까치박달, 물푸레나무, 함박꽃나무 등은 습한 곳에 분포하고 철쭉꽃, 전나무, 국수나무 등은 건조한 곳에 분포하는 것으로 나타났다. A relationship between the community structure composition and soil environmental factors of the Quercus mongolica forest on Mt. Chiljelbong was investigated from June 1996 to August 1997. The Q. mongolica community was classified into two subcommunity of Rhododendron schlippenbachii and Pseudostellaria palibiniana. The 30(24-46) species per quadrat were appeared in R. schlippenbachii subcommunity and 43(31-52)species in P. palibiniana subcommunity. The dominant sequences on each stratum determined by the coverage index showed that Q. mongolica was the most dominant in tree-1 layer with 6750.0, Acer pseudo-sieboldianum in tree-2 layer with 2364.0, R. schlippenbachii in shrub layer with 988.5, and Melica onoei in herb layer with 1040.5 value. The value of diameter breast height(DBH) showed a normal distribution displaying a highest value in the range of 2∼10㎝(29.7%) in Q. mongolica forest and it was investigated being at restoration phase after disturbance. It also was investigated that the succession to climax state would be possible due to growth of successive tree. Overall, which the soil conditions make little difference between two subcommunities, P. palibiniana subcommunity was favorable than those of R. schlippenbachii subcommunity. It was shown that in an environmental gradient analysis, Carpinus cordata, Fraxinus rhynchophylla, and Magnolia sieboldii were distributed in a mesic area, but R. schlippenbachii, Abies holophylla, and Stepanandra incisa in a xeric area.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

Identification of Polymorphisms in CYP2E1 Gene and Association Analysis among Chronic HBV Patients

Chun, Ji-Yong,Park, Byung-Lae,Cheong, Hyun-Sub,Kim, Jason-Y.,Park, Tae-Joon,Lee, Jin-Sol,Lee, Hyo-Suk,Kim, Yoon-Jun,Shin, Hyoung-Doo Korea Genome Organization 2009 Genomics & informatics Vol.7 No.4

Cytochrome P450 2E1 (CYP2E1) is a member of the cytochrome P450 superfamily, and it is a key enzyme responsible for the metabolic activation of many smallmolecular-weight compounds such as alcohol, which is classified as a human carcinogen. In this study, we identified 19 single nucleotide polymorphisms (SNPs) in CYP2E1 in Korean population. In these SNPs, we examined possible genetic association of CYP2E1 polymorphisms with HBV clearance and the risk of hepatocellular carcinoma (HCC). Five common polymorphic sites were selected, CYP2E1 polymorphisms at rs381-3867, rs3813870, rs2070673, rs2515641 and rs2480257, considering their allele frequencies, haplotype-tagging status and LDs for genotyping in larger-scale subjects (n=1,092). Statistical analysis demonstrated that CYP2E1 polymorphisms and haplotypes show no significant association with HBV clearance, HCC occurrence and onset age of HCC (p>0.05). Previous studies, however, have shown contradictory findings on associations of CYP2E1 polymorphisms with CYP2E1 activities and HCC risk. Comparing the contrasting results of previous researches suggest that CYP2E1 polymorphism is associated with CYP2E1 activity induced by ethanol, but is not directly associated with HCC risk. CYP2E1 variation/haploype information identified in this study will provide valuable information for future studies on CYP2E1.