Metallocene compound for polymerization of ultra-high molecular weight polyolefin and method for producing ultra-high molecular weight polyolefin polymer using the same

성우영,강민경 한국공업화학회 2022 한국공업화학회 연구논문 초록집 Vol.2022 No.1

AHP를 활용한 병과선택 속성 분석 연구

성우영,강원석 한국군사학회 2017 군사논단 Vol.90 No.-

새로운 抗菌劑로서 1-(phenoxymethyl)benzotriazole 誘導體의 合成과 定量的 構造活性關係(QSAR) 分析

成洛道,林治煥,崔宇永,高東成,權奇星 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-

14종의 새로 합성된 1-(phenoxymethyl)benzotriazole(Ⅰ)(Y=0)과 1-(thiophenoxymethyl)benzotriazole (Ⅱ)(Y=S) 및 1-(azidomethy) benzotriazole(Ⅲ) 유도체의 구조와 in vitro에서 Pyricularia oryzae, Fusarium oxysporum f. sp. sesami, Valsa ceratosperma 및 Botrytis cinerea에 대한 균사 생장을 50% 저해하는 활성(pI_50)사이의 구조-항균활성 상관관계들을 QSAR방법으로 연구하였다. (Ⅰ)의 항균활성은 (Ⅱ)와 (Ⅲ)보다 우세하였으며 phenoxy group(Ⅰ)의 치환기 효과는 수소 결합성 (HB)과 포물선 관계의 electronic effect(σ), steric effect(B_1) 그리고 hydrophobic effect(π)로 설명된다. P. oryzae와 F. axysporum f. sp. sesami의 항균 활성에 대한 치환기의 적정값은 B_1=1.40A, (H)와 σ=0.07∼0.15, (H)이고 V. ceratosperma와 B. cinerea에 대하여는 각각 σ=0.23∼0.28, (C1)과 π=0.70, (C1)이었으며 가장 효과적인 화합물인 (Ia)와 (Id)의 구조-활성관계가 검토되었다 (1990년 5월 11일 접수, 1990년 9월 20일 수리). The structure-antifungal activity correlations between the structure of fourteen new 1-(phenoxymethyl)benzotriazoles (Ⅰ) (Y=0), 1-(thiophenoxymethyl)benzotriazoles (Ⅱ) (Y=S) and 1-(azidomethy)benzotriazole (Ⅲ) derivatives were synthesized, and their activity, fifty percent inhibition of mycelial growth(pI_50), in vitro against Pyricularia oryzae, Fusarium oxysporum f. sp sesami, Valsa ceratosperma and Botrytis cinerea were investigated using a generalized QSAR method. The activity of (Ⅰ) was superior to those of (Ⅱ) and (Ⅲ). The effect of the substituents (Ⅹ) on the phenoxy group (Ⅰ) was rationalized by a parabolic function of electronic (σ), steric (B_1) and hydrophobic parameter(π), and hydrogen bonding (HB). Where the optimal values of substituent on the fungicidal activity againt P. oryzae and F. axysporum f. sp. sesami are B_1=1.40A ; (H) and σ=0.07∼0.15;(H), and those of substituent on the fungicidal activity against V. ceratosperma and B. cinerea are σ=0.23∼0.28; (Cl), π=0.70; (C1), respectively. The most effective compound (Ⅰa) and (Ⅰd) were examined in this study.

N-[1-(benzotriazol-1-yl)aryl]arylamine 유도체의 항균성과 정량적 구조활성 관계(QSAR)

성낙도,김경훈,최우영,김홍기,Sung, Nack-Do,Kim, Kyoung-Hoon,Choi, Woo-Young,Kim, Hong-Ki 한국응용생명화학회 1992 Applied Biological Chemistry (Appl Biol Chem) Vol.35 No.1

일련의 새로운 N-[1-(benzotriazol-1-yl)-X-치환-aryl]-Y-치환-arylamine 유도체를 합성하고 Pyricularia oryzae, Fusarium oxysporum f. sp. sesami, Valsa ceratosperma 및 Botrytis cinerea에 대한 항균활성$(pI_{50})$을 한천 희석법으로 측정하여 정량적인 구조-활성 관계$(QSAR_S)$를 분석한 바, X 및 Y-치환기들의 ${\pi}$와 ${\sigma}$ 및 $M_R$ 파라미터가 항균 활성을 결정하는 중요한 요소이었다. 4-bromo 치환체(1d 및 2b)가 항균활성이 제일 큰 화합물이었으며, 중성 pH에서 1의 가수분해 반응에 대한 반감기$(T_{1/2})$는 약 1.5일 이었다. 기질 화합물의 분자궤도(MO) 함수와 항균 반응에 대한 자유에너지 관계$(LFER_S)$ 그리고 분자 설계의 결과들이 검토되었다. A series of new N-[1-(benzotriazol-1-yl)aryl]arylamine derivatives were synthesized and their antifungal activities $(pI_{50})$ in vitro against Pyricularia oryzae, Fusarium oxysporum f. sp. sesami, Valsa ceratosperma and Botrytis cinerea were dertermined by the agar medium dilution method. From the results of the quantitative structure-activity relationships $(QSAR_S)$ analysis, $hydrophobicity({\pi})$, $electronic({\Sigma\sigma})$ and molar $refractivity({\Sigma}M_R)$ parameter of X & Y-substituents on the phenyl group were also shown to be important factor in determining the variation in the antifungal activity. 4-Bromo group substituents (1d & 2b) were the most effective compounds and the $half-life(T_{1/2})$ on the hydrolysis of X(1) at netural pH was about 1.5 day. Molecular orbital(MO) functions of substrate compound, linear free energy relationships$(LFER_S)$ on the antifungal reactivity arid the results of molecular design were also discussed.

Micro orifice를 이용하여 발생시킨 미세기포의 2D-PIV 측정

성진영(Jinyeong Sung),이한얼(Han-eol Lee),오우영(WooYoung Oh),이재호(Jaiho Lee),신원규(Weon Gyu Shin) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.12

N - [1 -(benzotriazol - 1- yl) aryl] arylamin 유도체의 항균성과 정량적 구조활성 관계(QSAR)

최우영,성낙도,김경훈,김홍기 한국농화학회 1992 Applied Biological Chemistry (Appl Biol Chem) Vol.35 No.1

A series of new N-[1-(benzotriazol-1-yl)aryl]arylamine derivatives were synthesized and their antifungal activities (pI_(50)) in vitro against Pyricularia oryzae, Fusarium oxysporum f. sp. sesami, Valsa ceratosperma and Botrytis cinerea were dertermined by the agar medium dilution method. From the results of the quantitative structure-activity relationships (QSAR_S) analysis, hydrophobicity(π), electronic(Σσ) and molar refractivity(ΣM_R) parameter of X & Y-substituents on the phenyl group were also shown to be important factor in determining the variation in the antifungal activity. 4-Bromo group substituents (1d & 2b) were the most effective compounds and the half-life(T_(1/2)) on the hydrolysis of X(1) at netural pH was about 1.5 day. Molecular orbital(MO) functions of substrate compound, linear free energy relationships(LFER_S) on the antifungal reactivity arid the results of molecular design were also discussed.

투약프로세스 개선을 통한 투약오류율 감소

성일순,김소희,송미라,정미아,황지원,연미향,유애리,김윤경,백목련,김진영,정주희,제우영,안용원 한국의료QA학회 2008 가을학술대회 Vol.2008 No.3

배추좀나방(Plutella Xylostella Linnaeus)에 대한 새로운 살충활성 분자의 설계

조윤기,최우영,성낙도 충남대학교 농업과학연구소 2007 농업과학연구 Vol.34 No.2

The new insecticidal active molecules from the based on the holographic quantitative structure-activity relationships (HQSAR) between a series of 1-(R₁)-2-(n-octyl)-3-(R₂), 3-(R₃)-pseudothiourea derivatives and their insecticidal activities against Diamond-back moth (Plutella Xylostella Linnaeus) were designed and discussed quantitatively. The most active molecule from the based graphical analyses of atomic contribution maps with the optimized HQSAR C-1 model (q²=0.764 & r²_(ncv)=0.942) was 1-(n-butyl)-2-(t-butyl)-3,3-diisopropylpseudothiourea (P1: pI_(50)=5.30, IC_(50)=1.397 ppm). Therefore, it is suggested that the new designed molecule would increased the activity as much as 23.5 times as compared to X=n-octyl substituent 17(pI_(50)=4.00, IC_(50)=32.86 ppm) which was the highest active molecule in training set compounds.

한국인의 체력연령 추정식 개발

옥정석,박우영,안근옥,홍지영,성종환,신혁수,김우원,정덕조,신승윤 대한운동학회 2012 아시아 운동학 학술지 Vol.14 No.3

[INTRODUCTION] The purpose of this study was to develop a regression equation of health-related physical fitness age(HPFA) of Korean adults. The subjects of the study were 646 males and females with ages ranging from 20 to 69 years. The items measured were %bodyfat, VO2max, Hand grip strength, Sit-ups, Sargent jump, Sit and reach, BMI, and PACER. during the analysis, we developed the regression equation against 394 subjects (60% of total subjects; group for equation development) and analyzed a cross validation against 252 subjects (40% of total subjects; group for cross-validation). We grouped subjects of ages 20 to 40 as "adults" and subjects of ages 40 to 69 as "middle-aged adults". [METHOD] Regarding data analysis, first, %bodyfat, VO2max, hand grip strength, sit-up, Sargent jump, sit and reach were set as variables and a principle component score (PCS) was yielded through principal component analysis. Second, sit-up, Sargent jump, sit and reach, BMI, and PACER were set as explanatory variable and the reverse score of PCS as response variable to develop a regression equation through multiple regression analysis. Third, we executed an independent t-test against the group for cross-validation to verify the difference in chronological age, VO2max, and %bodyfat between below-average HPFA group and above-average HPFA group for cross-validation. [RESULT] The resulting regression equations by sex and age were as the following; HPFAma=45.054+.324X1-.089X2-.142X3-.153X4-.228X5(R2=.954) for male adults, HPFAmm=75.123+.090X1-.095X2-.382X3-.009X4-.233X5(R2=.909) for male middle-aged adults, HPFAfa=49.031+.328X1-.121X2-.423X3-.260X4-.144X5(R2=.913) for female adults, and HPFAfm=76.004+.026X1-.150X2-.651X3-.010X4-.271X5(R2=.865) for female middle-aged adults (X1=BMI, X2=PACER, X3=Sargent jump, X4=sit and reach, X5=Sit ups). Regarding the results of the independent t-test against the group for cross-validation, there were statistically significant differences in all groups except %bodyfat of male adults. [CONCLUSION] As a result, the development of regression equation of HPFA through VO2max, BMI, PACER, Sargent jump, Sit-ups, Sit and reach has been proven to be valid. [서론] 본 연구의 목적은 성인과 중년층을 대상으로 체력요인을 활용하여 각 개인의 건강관련체력연령을 추정할 수 있는 추정식을 개발하는 것이다. [방법] 본 연구에 참여한 대상은 수도권에 거주하는 20세에서 65세의 남녀 645명이며, 검사항목은 %bodyfat, BMI, VO2max, PACER, hand grip strength, sit-ups, Sargent jump, sit and reach등 이었다. 주성분분석을 통하여 주성분점수를 산출하고, 주성분점수를 반응변수로 하고 BMI, PACER, sit-ups, Sargent jump, sit and reach를 설명변수로 하는 회귀분석을 실시하여 건강관련체력연령을 추정하기 위한 추정식을 개발하였다. [결과] 개발된 한국인의 건강관련체력연령 추정식은 다음과 같다. 남자 40세 미만 : HPFAma = 45.054+.324X1-.089X2-.142X3-.153X4-.228X5(R2=.954), 남자 40세 이상 : HPFAmm = 75.123+.090X1-.095X2-.382X3-.009X4-.233X5(R2=.909), 여자 40세 미만 : HPFAfa = 49.031+.328X1-.121X2-.423X3-.260X4-.144X5(R2=.913), 여자 40세 이상 : HPFAfm = 76.004+.026X1-.150X2-.651X3-.010X4-.271X5(R2=.865). (X1=BMI, X2=PACER, X3=Sargent jump, X4=sit and reach, X5=sit-ups). [결론] 본 연구를 통하여 개발된 건강관련체력연령 회귀추정식은 집단에 관계없이 보편적으로 적용할 수 있는 방식으로 확인되었다.

N - [1 -(benzotriazol - 1- yl) aryl] - aniline 유도체의 항균성과 정량적 구조 - 활성 관계(QSAR)

김경훈,성낙도,김현이,최우영 한국농화학회 1991 Applied Biological Chemistry (Appl Biol Chem) Vol.34 No.2

일련의 새로운 N-[(benzotriazol-1-yl)aryl]-anilille 유도체를 합성하고 한천희석법으로 측정된 벼 멸구균(Pyricularia oryzae), 참깨 시들음병균(Fusarium oxysporum. F. sp. sesami) 및 사과 부란병균(Valsa ceratasperma)에 대한 항균활성(pI_50)과 X(1) 및 Y(2) 치환기 변화에 따른 physicochemical parameters로부터 정량적인 구조-활성 관계(QSAR)를 분석한 바, π>0으로부터 비극성 치환체일수록 fungus cell 속으로 침투가 촉진되거나 receptor 작용점과의 소수성결합 형성에 기여함으로써 4-치환기들의 hydrophobicity (π)가 항균활성을 증가시키는 가장 중요한 요소이었다. 특히, 4-bromo 치환체(Id)가 항균활동이 가장 큰 화합물이었으며, 중성 pH에서 비치환성(4-H)의 반감기는 약 1.5일이었다.