http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
성낙도,이상호,송종환,김형래 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8
새로운 quinclorac계 제초성 화합물을 탐색하기 위하여 기질 화합물로 3-phenyl-5-(3,7-dichloro-8 quinolinyl)-1,2,4-oxadiazole 유도체들의 벼(Ory)와 논피(Ech) 줄기 및 뿌리에 대한 생장 저해활성에 관한 비교 분자장 분석(CoMFA)과 분자 홀로그램 구조-활성관계(HQSAR)를 분석하였다. 두 초종의 부위 별 생장 저해 활성에 대한 PLS 계산에 따른 교차 확인된 예측성(q²)과 Pearson 상관계수(r²)를 비교한 바, HQSAR 모델이 CoMFA 모델보다 양호한 결과를 나타내었다. 논피에 대한 선택성 조건은 입체적으로 큰 치환기로서 phenyl 고리상에 양하전을 생성하는 전자 끌게가 도입되어야 할 것으로 판단되었으며 2,6-dichloro, U5 및 2,4,6-trichloro-치환체, U6(△pI_50=CoMFA: 1.18 및 HQSAR: 1.82) 등은 두 초종에 대하여 선택성과 고활성이 예측되는 화합물이었다. A series of new quinclorac family, herbicidal 3-pheny1-5-(3,7-dichloro-8- quinolinyl)-1,2,4-oxadiazole derivatives as substrate were synthesized and their growth inhibition activity (PI_(50)) against root and shoot of rice plant (Oryza sativa L) and barnyard grass (Echinochtoa crus-galli) were determined. And then comparative molecular field analysis (CoMFA) and molecular holographic quantitative structure- activity relationshiP (HQSAR) were compared in terms of their potential for predictiability. The statistical results were suggested that HQSAR based model had better predictability than CoMFA model. The selective factors to remove barnyard grass take electron withdrawing groups which can be created positive charge and steric bulky on the phenyl ring. Results revealed that the unknown 2,6-dichloro-substituent, U5 and 2,4,6-trichloro-substituent, U6(△pI_(50)=CoMFA: 1.18 & HQSAR: 1.82) were predicted as compound with higher activity and selectivity.
인공 DNase의 리간드 화합물로써 2,9-(N,N-Dimethylethylenedi-aminomethyl)-1,10-phenanthroline 분자내 수소결합들의 역할
성낙도,박경용 한국응용생명화학회 2005 Journal of Applied Biological Chemistry (J. Appl. Vol.48 No.4
In the catalytic hydrolysis of 2',3'-cAMP by the Cu(II) complexes of 2,9-(N,N-di-methylethylenediamino)- 1,10-phenanthroline (A) and 2,9-(N,N-dimethylethylenediaminomethyl)-1,10-phenanthroline (B) that are designed as a new ligand molecule of artificial DNase, due to the four intramolecular H-bonds forming between amino groups of ligand molecule and phosphoryl group of 2',3'-cAMP.It is anticipated that Cu(II) complexes of (A) and (B) are able to promote a rate that is as much as seventy thousand times faster than the catalytic hydrolysis rate of 2',3'-cAMP by Cu(II) complexes of 2,9-dimethyl-o-phenanthroline. 인공 DNase의 새로운 리간드 분자로 설계된 2,9-(N,Ndimethylethylenediamino)-1,10-phenanthroline(A) 및 2,9-(N,NDimethylethylenediaminomethyl)-1,10-phenanthroline(B)의 Cu(II) 착 화합물에 의한 2',3'-cAMP의 촉매 가수분해 반응에서 리간드 분자의 아미노기들과 2',3'-cAMP의 인산기 사이에 형성되는 분자내 4개의 수소결합들로 인하여 (A) 및 (B)의 Cu(II) 착 화합물은 2,9-dimethyl-o-phenanthroline의 Cu(II) 착 화합물에 의한 2',3'-cAMP의 촉매 가수분해 반응 속도를 7만배 이상 빠르게 촉진 할 것으로 예측되었다.
새로운 N-치환 benzotriazol-1-yl 유도체의 항균활성에 미치는 치환기 효과
성낙도,유성재,성민규,김대황 ( Nack Do Sung,Seong Jae Yu,Min Gyu Sung,Dae Whang Kim ) 한국응용생명화학회 1997 Applied Biological Chemistry (Appl Biol Chem) Vol.40 No.1
Series of new chiral N-substituted benzotriazol-1-yl derivatives were synthesized and their fungicidal activities in vitro against gray mold(Botrytis cinerea), black spot(Alternaria kikuchiana) and phytophthora blight(Phytophthora capsici) were measured by the agar medium dilution method. The substituents effects between the fungicidal activities (obs. pI_(50)) and a various physicochemical parameters of phenoxy or thiophenoxy group(X) & alkyl or phenyl group(Y) were analyzed by the multiple regression technique. From the analyzed substituent effects, the structure-activity relationship(SAR) equations shows that the antifungal activities depend on the parameters for the optimal molecular hydrophobicity((∑logP)_(opt.)), Van der Waals (∑Vw$gt;0) volume(Å^(-3)) and inductive constant with electron withdrawing group(σ_IY$gt;0). The activity in affected by the inductive effect (σ_IY$gt;σ_RX) of Y-group rather than the X-group. The phenoxy substituents, 1, showed higher antifungal activity than the thiophenoxy substituents, 2. For 1, polar substituent constant(σ^*) was an important factor in determining the activity. And the tribromomethyl substituent, 1g showed the highest activity against the three fungi.
살충성 Imidacloprid의 가수분해 반응 메카니즘
성낙도,유성재,강문성 ( Nack Do Sung,Seong Jae Yu,Moon Sung Kang ) 한국응용생명화학회 1997 Applied Biological Chemistry (Appl Biol Chem) Vol.40 No.1
The rate of hydrolysis of insecticidal 1-(6-chloro-3-pyridylmethyl)-2-nitro-iminoimidazolidine (common name; imidacloprid) have been investigated in 15%(v/v) aqueous dioxane at 45℃. From the kinetics and non-kinetics data such as pH-effect, solvent effect(m=0.04, n=0.30 & m≪ℓ), thermodynamic parameter(△H^*=16.14㎉·㏖^(-1) & △S^*=-0.03e.u.), rate equation (k_(obs.)=4.56×10^(-3)[OH^-]) and analysis of hydrolysis product, 1-(6-chloro-3-pyridylmethyl-2)-imidazolidinon, the hydrolysis mechanism of imidacloprid is proposed that the specific base catalyzed hydrolysis(k_(OH)) through nucleophilic addition-elimination (Ad_N-E) mechanism proceed via intermediate, 1-(6-chloro-3-pyridylmethyl)-2-hydroxy-2-imidazolidinylisonitraminate (Ⅰ) and β-3-(6-chloro-3-pyridylmethyl)aminoethyl-1-nitrourea(Ⅲ). And the half-life(t½) of hydrolytic degradation at pH 8.0 and 45℃ was about 4.5 months.