신생아 집중치료를 받은 극소저출생체중아 치료성적의 시기에 따른 변화

김성신,김문희,심재원,고선영,이은경,장윤실,강이석,박원순,이문향,이상일,이흥재,Kim, Shung Shin,Kim, Moon Hee,Shin, Jae Won,Ko, Sun Young,Lee, Eun Kyung,Chang, Yun Sil,Kang, I Seok,Park, Won Soon,Lee, Mun Hyang,Lee, Sang Il,Lee, Heung J 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.7

목 적: 출생 체중 1,500 그램 미만의 극소저출생체중아(very low birth weight infant, VLBWI)의 치료성적은 신생아 집중치료술 향상여부를 모니터 하는 주요한 지표로 이용되고 있다. 이에 본 연구자들은 개원이래 최근 7년간 삼성서울병원 신생아 중환자실의 VLBWI 치료성적의 변화양상을 기간별로 관찰 분석하였다. 방 법: 1994년 10월부터 2000년 12월까지 삼성서울병원 신생아 중환자실로 생후 3일 이내 입원한 VLBWI 374명을 대상으로 기간을 나누어(I기 : 이미 성적이 보고된 1994. 10-1996. 9, II기 : 1996. 10-1998. 12, III기 : 1999. 1-2000. 12) 각 기별, 출생체중별, 재태기간별, VLBWI의 발생빈도와 생존율, 유병률 및 생존기간 등에 관해 의무기록지를 통한 후향적조사를 실시하였다. 생존율은(생존아/총출생 VLBWI)${\times}100$으 로 산출하였고 생존아는 신생아 중환자실에서 생존하여 퇴원한 경우로 정의하였다. 결 과 : VLBWI의 발생빈도는 기간별로 차이가 없었고(I기 : 1.3%, II기 : 1.5%, III기 : 1.4%), 생존율은 III기에 의미 있게 향상되었다. 출생체중별 생존율에서 III기에서 750 gm 미만군(vs II기)과, 1,250-1,499 gm 군(vs I기)의 향상이, 1,000-1,249 gm 군에서는 II기(vs I기)의 향상이 의미 있었고 최저출생 생존아는 I기 624 gm($26^{+5}$주), II기 667 gm($25^{+6}$주), III기 480 gm($26^{+2}$주)였다. 재태기간별 생존율에서 III기의 25-26주군과 29-30군이 I, II기에 비해 의미 있게 향상되었고 최저출생 재태기간의 생존례는 I기 26주(970 gm), II기 $23^{+5}$주(791 gm), III기 $24^{+1}$주(740 gm)였다. VLBWI의 주요 유병률 중 III도 이상의 심한 뇌실 내 출혈의 빈도가 III기 5%로 I기 13%, II기 10.5%에 비해 의미 있게 감소되었고, 전체 사망 중 7일 이전 사망률이 III기(15.4%)에 I기(55.5%)에 비해 의의 있게 감소되었다. 결 론 : 최근 VLBWI의 생존율이 주요 유병률의 증가 없이 현저히 향상되었고, 특히 26주 이하, 750 gm 미만의 초극소미숙아의 생존율 향상이 두드러졌다. Purpose : The outcomes of infants weighing less than 1,500 gm(very low birth weight infant : VLBWI) reflect recent progress in neonatal intensive care. In this study, we analyzed changes over time in survival rate and morbidity of VLBWIs during the past seven years. Methods : A retrospective review of medical records was analyzed for VLBWIs admitted to the neonatal intensive care unit of Samsung Medical Center within three days from birth. We compared the outcomes of previous corresponding data(period I : Oct. 1994 to Sept. 1996), with the outcomes of period II(Oct. 1996 to Dec. 1998) and period III(Jan. 1999 to Dec. 2000). Results : As shown in Tables 1 and 3, the distribution of birth weight, gestational age(GA), gender, and inborn admissions did not change during the 7-year study. The overall survival rate of VLBWI increased significantly over time(period I : 72% vs period III : 88.3%, P<0.05). Between period I and period II, the birth weight-specific survival rate increased by 23.6%(75% vs 92.7%, P<0.05) for infants 1,000 to 1,249 gm. Between period II and period III, the birth weight-specific survival rate increased three times(20% vs 66.7%, P<0.05) for infants <750 gm. The survivors of lowest birth weight included infants at 624 gm(GA : $26^{+5}$ weeks), 667 gm(GA : $25^{+6}$ weeks) and 480 gm(GA : $26^{+2}$ weeks) in each period. The gestational age-specific survival rate in period III increased significantly in GA 25-26 weeks and 29-30 weeks(vs period I & period II, P<0.05). The survivors of lowest gestational age included infants at GA 26 weeks(970 gm), GA $23^{+5}$ weeks(791 gm) and GA $24^{+1}$ weeks(740 gm) in each period. The incidence of severe IVH(grade III, IV) and the early death rate(< seven days) decreased in period III(vs period I; P<0.05), reflecting improvements in neonatal intensive care. Conclusion : The survival rate of VLBWI continues to increase, particularly for BW < 750 gm, GA < 26 weeks. This increase in survival is not associated by any increase in major morbidities.

Acute Exacerbation of Interstitial Pneumonia Other Than Idiopathic Pulmonary Fibrosis

Park, I-Nae,Kim, Dong Soon,Shim, Tae Sun,Lim, Chae-Man,Lee, Sang Do,Koh, Younsuck,Kim, Woo Sung,Kim, Won Dong,Jang, Se Jin,Colby, Thomas V. American College of Chest Physicians 2007 Chest Vol.132 No.1

<P>BACKGROUNDS: Acute exacerbation (AE) in idiopathic pulmonary fibrosis (IPF) is increasingly recognized as a relatively common and highly morbid clinical event. However, clinical data on AE in non-IPF interstitial pneumonia are sparse. This study was performed to find the frequency, clinical features, and outcome of AE in non-IPF interstitial pneumonia. METHODS: Retrospective analysis of 10 patients who satisfied the modified Akira criteria for AE during follow-up of 74 patients with surgical lung biopsy-confirmed idiopathic nonspecific interstitial pneumonia (I-NSIP) and 93 patients with biopsy-confirmed interstitial pneumonia associated with collagen vascular disease (CVD-IP). RESULTS: AE occurred in six patients with I-NSIP (1-year frequency, 4.2%) and in four patients with CVD-IP (rheumatoid arthritis [RA], n = 3; scleroderma, n = 1), with 1-year frequency of 3.3%. Median age was 58 years (range, 47 to 75); six patients were female. AE occurred in two patients immediately after surgical biopsy. Median duration of acute symptom before hospital admission was 10 days (range, 1 to 30). Median ratio of Pao(2) to the fraction of inspired oxygen (Fio(2)) was 172 (range, 107 to 273), and Pao(2)/Fio(2) ratio was < 200 in six patients. Surgical lung biopsy performed at the time of AE in two patients revealed diffuse alveolar damage superimposed on nonspecific interstitial pneumonia pattern. Four patients with I-NSIP survived to discharge and were followed up for 24 months (range, 6 to 121). CONCLUSION: AE occurred in the patients with I-NSIP with apparently better prognosis. In patients with CVD-IP, AE occurred mostly with RA-usual interstitial pneumonia in our small series with poor outcome.</P>

Radiosynthesis and <i>in vitro</i> evaluation of 1‐(tetrahydro‐5‐hydroxy‐6‐(hydroxymethyl)‐2H‐pyran‐3‐yl)‐5‐[¹²⁵I]iodouracil: A new potential agent for HSV1‐tk

Jo, Nam Hyun,Kim, Jung Young,El‐,Gamal, Mohammed I.,Choi, Won‐,Kyoung,Park, Jin‐,Hun,Kim, Eun Jung,Cho, Jung‐,Hyuck,Ha, Hyun‐,Joon,Choi, Tae Hyun,Oh, Chang‐,Hyun John Wiley Sons, Ltd. 2011 Journal of labelled compounds & radiopharmaceutica Vol.54 No.2

<P><B>Abstract</B></P><P>Synthesis, radiolabelling, and <I>in vitro</I> evaluation of a new <SUP>125</SUP>I‐labelled iodouracil hexitol nucleoside analogue are reported. The target compound was successfully synthesized by an iodination–destannylation method and then purified by reverse phase HPLC. The radiochemical purity of the product was >99% with decay‐corrected yields of 48±3%. <I>In vitro</I> cellular uptake testing was carried out using MCA and MCA‐tk cell lines for comparison of compound 1 with [<SUP>18</SUP>F]FHBG. The newly synthesized compound 1 showed higher accumulation in herpex simplex virus type 1 thymidine kinase (HSV1‐tk) gene expression cell line (MCA‐tk cell line) than in the wild type MCA cell line compared with [<SUP>18</SUP>F]FHBG. The MCA‐tk to MCA cellular uptake ratio for compound 1 was higher than that of [<SUP>18</SUP>F]FHBG from 2 h after incubation. The radioiodine‐labelled compound 1 (I‐125, <I>t</I><SUB>1/2</SUB>=59.37 days) has a longer physical half‐life than F‐18‐(<I>t</I><SUB>1/2</SUB>=110 min) labelled FHBG. Radioiodine‐labelled compound 1 could be used for monitoring gene expression for a long time. The selectivity for MCA‐tk cell line makes compound 1 a promising imaging agent for HSV1‐tk expression. Copyright © 2010 John Wiley & Sons, Ltd.</P>

Albumin 밀도 경사를 이용한 정자분리가 정자운동특성 및 수태율에 미치는 영향

원유석,이성수,박노형,김덕임 한국축산학회 1999 한국축산학회지 Vol.41 No.5

The 16 ejaculates from 3 Hanwoo sires were used to study whether the sperm separation by 6, 8 and 10% of bovine serum albumin (BSA) gradients increase the motional characteristics relating sperm fertility and pregnancy rate in Hanwoo. The motional characteristics of sperm were analysed by Computer-assisted sperm analyser (CASA). The sperm separated by each 6, 8, 10% of BSA gradients showed significantly hid value in motility, curvillinear velocity, straight-line velocity, average-path velocity, and beat-cross frequency as compared with control sperm(P$lt; 0.05). Artificial insemination was performed with sperm separated by 6% BSA gradients, which was revealed the highest sperm recovery. The pregnancy rate of sperm separated by 6% BSA gradients was 15.4% higher than that of the control sperm (P = 0.22). Therefore, the sperm separation by BSA gradients may be used to increase the motional characteristics of sperm relating the fertility of sperm and the pregnancy rate of artificial insemination in Hanwoo.

엘크사슴의 냉동정액 생산과 인공수정

원유석,이성수,박노형,김덕임,정지원,이봉식,김찬규 한국동물자원과학회 2000 한국축산학회지 Vol.42 No.5

To establish the system for frozen-semen production, oestrus synchronization, and artificial insemination (AI) in Elk deer, the characteristics of frozen-semen and conception rate by artificial insemination were observed. Semen were collected from 2 heads of elk (Cervus Elaphus canadensis) sire by an electroejaculator and diluted to 0.9- 1.1 X 10^9 sperms/straw with the extender containing glycerol, hydroxymethyl amino methane, citric acid, fructose, and 20% egg yolk. The diluted semen were chilled at 4℃ for 3-4 hours, prefrozen at -140㎏ for 30-40 minutes, and preserved at liquid nitrogen (-196℃). The motility, viability, and abnormality of frozen-thawed semen were 62.4-70.5%, 73.7-75.3% and 6.8-7.3%, respectively. Oestrus was synchronized in 48 heads of hind with progesterone- impregnated intravaginal devices (CIDRs). The CIDRs were removed on Day 14, and 10-250 IU pregnant mare's serum gonadotrophin (PMSG) were given to each hind. Oestrus exhibition rate was 95.8% (46/48). Forty-six hinds, showing oestrus, were artificially inseminated with frozen-thawed semen 60-62 hours after PMSG injection. Pregnancy was detected by ultrasonography at 40 days after Al. The overall conception rate was 78.3% (36/46). These results indicate that the system for frozen-semen production and AI established in this study may be adapted to deer industry.

食品 中 殘留農藥에 관한 硏究 : Monitoring Program for Pesticide Residues in Food

元敬豊,洪茂基,郭寅信,李熹德,朴建相,尹熙俓,文在辰,姜仁鎬 국립보건연구원 1994 국립보건원보 Vol.31 No.2

TMS320C31을 이용한 얼굴 검출용 하드웨어 구현

박일용,진경찬,채승표,원철호,손병기,신장규,조진호 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

The real-time pattern recognition is widely used in the image recognition or auto sentry systems to be implemented by the DSP chip which is adequate for real-time processing. The pattern recognition can be performed by two methods, i.e. the feature-based matching and template one mainly. Generally, the feature-based matching, such as DLM(dynamic linking matching), is very difficult to utilize as a software for the development of real-time processing system. So as to be possible for real-time processing is the template matching desirable. In this paper, we have proposed the image acquisition and processing system for face detection. By applying the PCA(principal component analysis), we made the template to be matched with the input image acquired by the implemented system. And then the face region could be extracted from the input image by the computations of the Euclidean distances between the template and the sub-images. The system, which is based on the TMS320C31 DSP chip, consists of the video signal A/D, D/A converter, image acquisition part, and DSP part.

의료자문을 신청한 골절치료 자체의 합병증에 대한 분석

정인희,원예연,전창훈,안재인,박병문,김병석 대한골절학회 1995 대한골절학회지 Vol.8 No.2

The authors analysed 220 patients (225 cases) of complications including implant failure and refracture in fracture treatment which had been requested for medical consultation by the Korean Automobile, Fire k Marine Insurance Co., Ltd. from July 1984 to December 1992. The results were as follows: 1. The patients were consisted of 178(81%) males and 42(19%) females. 2. The average age of patients was 36.9 years. 3. There were 140(60%) cases of femur, 63(29%) cases of tibia and 12(5%) cases of humerus. 4. The most common previous mode of treatment was plate and screw fixation (183 cases, 83%). 5. There were 171(78%) cases of metal failure, 14 cases of secondary fracture and 14 cases of refracture. 6. Among the causes of complications, improper postoperative care (156 cases, 71%) was the most common causes of complications. 7. It is recommended that in the operative treatment of fracture, orthopaedic surgeon should obey the AO principles and proper postoperative care and also consider the conservative treatment as a good counter part of the operative treatment.

꼭지절단 원추형 페라이트 전파흡수체의 최적설게 및 제작에 관한 연구

김동일,박종구,정세모,원영수,이영구 한국해양대학교 산업기술연구소 2001 연구논문집 Vol.18 No.-

The remarkable progress of electronics and radio communications technology has made our life abundant. On the other hand, the countermeasure of EMC becomes more important socially according to the increased use of electromagnetic waves. It had been required that the absorbing ability of an electromagnetic wave absorber is more than 20 dB, the bandwidth of which is require through 30 MHz to 1,000 MHz for satisfying the international standard about an anechoic chamber for EMI/EMS measurement. From November of 1998, however, the CISPR11 has accepted the extended frequency band from 30MHz to 18 GHz in the bandwidth of EMI measurement. In this paper, we propose the cutting corn-shaped type satisfying the above requirments and carried out broadband design using the equivalent material constants method. Moreover, we have fabricated it and compared its characteristics with simulated one.

Data Reconciliation and Gross Error Detection for Data Intensive Modeling and Optimization

Eom, T.-I 한국화학공학회 1995 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.33 No.5