급성기 뇌경색 환자에서 화열 관련 증상과 증후의 변화에 관한 연구

곽승혁,박수경,우수경,이은찬,박주영,정우상,문상관,조기호,조승연,박성욱,고창남,Kwak, Seung-hyuk,Park, Su-kyung,Woo, Su-kyung,Lee, Eun-chan,Park, Joo-young,Jung, Woo-sang,Moon, Sang-kwan,Cho, Ki-ho,Cho, Seung-yeon,Park, Sung-wook,Ko, Ch 대한중풍순환신경학회 2011 대한중풍.순환신경학회지 Vol.12 No.1

Objective : Fire and heat related symptoms and signs are considered common in acute stage of diseases. The purpose of this study is to evaluate the occurrences and changes of fire and heat related symptoms and signs in acute cerebral infarction patients. Method & subjects : 40 acute cerebral infarction patients hospitalized in Oriental medicine hospital, Kyung-Hee University, who had examined and diagnosed 2 or 3 times based on oriental medical diagnosis were selected. We chose 23 as fire and heat related symptoms and signs from 94 diagnostic articles, and we added all those scores together of each patient. We analysed the scores of fire and heat related symptoms and signs as the time passed, and depending on oriental medical diagnosis. Result : In acute cerebral infarction patients of this study, 4 of fire and heat related symptoms and signs were took 1st, 2nd, 4th and 8th places in most changeable 10 articles of total 94 articles. The mean score of fire and heat related symptoms and signs of all patients were decreased significantly over the 3 times of measurements. The 8 patients diagnosed as fire and heat diagnosis at visit1 were samely diagnosed as fire and heat diagnosis at visit2, and at visit3 5 patients of them except for 3 patients excluded between visit2 and visit3, were still diagnosed as fire and heat diagnosis. At all of 3 measuring times, the scores of fire and heat related symptoms and signs of fire and heat diagnosis group were higher than non-fire and heat diagnosis group. Conclusion : This study indicated that fire and heat related symptoms and signs were very changeable phenomenon in acute cerebral infarction patients. And they decreased as time goes on.

구강에 발생한 편평상피암종의 MMP-2, MMP-9, TIMP-1, TIMP-2 발현과 EGFR 및 E-cadherin 발현의 상호연관성

조성재,권창석,김용환,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : Matrix metalloproteinases(MMPs) are involved in the degradation of extracellular matrix, which is related to infiltrative growth and metastasis of tumor. Positive correlation between MMPs expression and clinico-pathologic parameters were reported, and MMPs expressions were regulated by tissue inhibitor of metalloproteinases(TIMPs) or cell adhesion molecules such as E-cadherin and epidermal growth factor receptor EGFR). The aim of this study is to evaluate the relationship between MMP-2, MMP-9 expressions and clinico-pathologic factors such as clinical stage. recurrence. histologic grade and invasion pattern, and between MMP-2 and MMP-9 Expressions and TIMP-1, TIMP-2, and E-cadherin expressions. Methods and Material : The materials were 55 cases of squamous cell carcinoma of the oral cavity, and immunohisdtochemical studies for MMP-2, MMP-9, TIMP-1, TIMP-2, E-cadherin and EGFR were performed. Clinico-pathologic factors such as clinical stage, recurrence, histologic grade and invasion pattern were recorded through microscopic examination and clinical record review. Statistical analyses between MMP-2, MMP-9 expressions and clinico-pathologic factors, TIMP-1, TIMP-2 expressions and EGFR and E-cadherin expressions were done. Results : 1. MMP-2 and MMP-9 expressions were noted in 30(54.5%) and 22(40.0%) of 55 cases, respectively. TIMP-1 and TIMP-2 expressions were observed in 21(38.2%) and 33(60.0%), and E-cadherin and EGFR expressions were found in 35(63.6%) and 26(47.3%) of 55 cases, respectively. 2. MMP-2 expression rate was slightly higher in cases without recurrence, and TIMP-2 expression rate was slightly higher in cases showing more infiltrative growth pattern. However, there were no significant differences of MMP-2, MMP-9, TIMP-1, and TIMP-2 expression rates according to other clinico-pathologic parameters were noted. 3. The expression rate of EGFR was higher in cases with well differentiation (p=0.0047), but no positive relationship between the expression rate of E-cadherin and histologic grade was found. There were no significant differences of the expression rates of E-cadherin and EGFR according to other clinico-pathologic parameters. 4. Cases with positive reaction for MMP-9 showed an increasing tendency of negative reaction for TIMP-1. However, signigicant relationships between MMP-2, MMP-9 expressions and TIMP-1, TIMP-2 expressions were not noted. 5. The expression rate of MMP-2 was higher in cases with positive reaction for Ecadherin and EGFR with no statistical significance. The expression rate of MMP-9 was significantly higher in cases with positive reaction for E-cadherin(p=0.0221), but there was no significant relationship between MMP-9 and EGFR expression. Conclusion : These results suggest that MMP-2, MMP-9, TIMP-1 and TIMP-2 expressions are involved in the development of oral squamos cell carcinomas, but MMP-2, MMP-9, TIMP-1, and TIMP-2 expressions might not seem to be a sueful prognostic factors because there were no significant relationship between clinicopathologic parameters, EGFR expression showed positive correlation with low histologic grace, so EGFR expression could be regarded as a good prognostic factor. In the progression of squamous cell carcinoma of oral cavity, MMP-9 and E-cadherin might be involved with positive correlation, but there were no significant correlations between MMP-2, MMP-9 and TIMP-1, TIMP-2 and EGFR expressions rate. Further study for other factors such as cytokines or growth factors except TIMP-1, TIMP-2 and EGFR will be needed.

한국인의 정당관에 대한 실험적 고찰

조일문,윤경우 건국대학교 1970 學術誌 Vol.11 No.1

This article is prepared to serve the purpose of experimentally analyzing the nature and changes of Korean attitude toward political party in recent years. It is based on a sample study about political parties in Korea and analyses of relevant literatures and materials. The sample study had been conducted in a most selective way in view of the limited number of personnel, expenses and the pressure of time. In order to eliminate any bias or prejudice on the part of interviewers, however, special efforts had been made in selecting samples adequate enough to represent the sex, occupation, age, educational background and the compositive ratio among the population. The results of sample study on the basis of 1,002 respondents might be summarized as follows : 1. The necessity of political party is particularly emphasized by male population, urban residents, younger generation, intellectuals and propertied classes. Though in small number altogether, those who think political party unnecessary are found in a relatively greater number in urban areas than in rural areas. 2. There are now many political parties registered in Korea. The results of the survey about what group regards political system composed of how many political parties as most desirable are as follows ; two or three parties‥‥‥‥Supported by females, rural dwellers, the aged, the lower-educated. three or four parties‥‥‥‥Supported by males, urban residents and intellectuals. In general, the degree of recognizing the value of political parties is considerably high with regard to the two major parties, especially with regard to the government party. High degree of recognition for government party is attributable to the fact that the ruling party is in a position to penetrate deeply into the masses with the support of the government. Those who are more familiar with political party tend to insist upon the greater necessity of political party. But this has no direct bearing with the ruling that only party nominees can be candidates for the Presidency and the National Assembly membership, and that independents without party affiliation are prohibited from running as candidate. 3. In selecting Presidential candidates and National Assembly candidates, more emphasis is usually placed upon their personality and public pledges than upon their party affiliation. Respondents who synthetically considered the following three elements-political party, public pledges and personality-amounted to 36.7%. Among them, about 70% considered primarily in terms of personality. The degree in which continuous support to the same party is very low and this tendency seems to have something to do with Korean tradition of taking into serious consideration the personality itself rather than political party. 4. Half of the respondents are in favor of the measure that independents without party affiliation and consequently without party recommendation may become candidates for the member of National Assembly, while one-thirds of them are againt it. They think independents should be given opportunities to run as candidates for National Assemblymen. Though they admit the very necessity of political parties, they still seem to be of the opinion that corruptions accompanying party politics have to be dispensed with. 5. Arguments in favor of plural party system are that it is the very foundation of democracy and performs the function of integrating and coordinating the general will of the people. In particular, party members among the respondents favor the existence of political parties and oppose independent candidates running in the National Assembly election. 6. The most important reason why some of the respondents are against the existence of multiple political parties is that their activities accelerate political corruptions and sacrifice national interests through partisan causes. 7. Whether people support any particular political party or oppose it depend more upon the leading figures of the party than the degree of social representation, policy or accomplishments of that party. The dominant tendency to rely upon personality in selecting public candidates reveals the backward attitude of the Korean people towards political party. 8. On the question of adequate number of political party required, half of the interviewers support the bipartisan system and one-thirds the three-party system. Members of the New Democratic Party are overwhelmingly in favor of the two-party system , while members of minor parties are unanimously in support of multi-party system. 9. Most respondents think that only if a man filed an application he is fully qualified to be a party member and that political party is more concerned with formalities than with the exercise of rights or fulfilment of duties on the part of party members. 10. Many respondents consider it to be legitimate to raise political fund through the party members' contribution or from the sources of national treasury so as to use it as a safeguard against political corruptions and injustices. Those respondents who possess high consciousness as party member emphatically argue in favor of the need of party members' contribution. However, it reflects their view only and it is doubtful whether this argument could be realized. 11 Many respondents, more among party members than among nonparty members, expressed opinions in a negative way about intra-party democratic practices. Though many of them favor in principle the democratic order among political parties, they anticipate that it is hardly feasible because it is completely left to the voluntary ruling in each party's constitution. More party members than non-party members, and more intellectuals than illiterates support the possibility of democratizing intra-party order. 12. Looking into the changes in Korean attitude toward political party in the past and present, one can learn that gradual changes have taken place ranging from complete distrust of it in the immediate aftermath of the Liberation to a relatively general trust in it in the later stage. The present tendency suggests us that there will be a possibility of significant transition into a total trust in the political party system among Korean people in the future. Nonetheless, there is also a tendency for many people to discredit party members and policies, event though there are a few who trust political party. The expectation for political party does not seem to be improved. For the future of party politics, many people bear an opinion that supra-party movement is likely to emerge in order to overcome the bad influence of plutocracy. Yet, many people still expect that party-centered vote and peaceful change of regime shall be eventually made possible despite the inactivity of National Assembly.

탄광부 진폐증의 운동지수

조영선,김세곤,문우기,유재인,정치경 가톨릭대학 산업의학 센타 산업의학연구소 1984 韓國의 産業醫學 Vol.23 No.3

Exercise index(EI) was measured on 933 pneumoconiosis patients (865 patients with small rounded opacities and 68 patients with large opacities) and 176 suspected pneumoconiosis patients from Korean anthracitic mines, in order to evaluate the ventilatory impairment of pulmonary function according to the chest radiographic findings of pneumoconiosis. Exercise index was obtained from the maximum breathing capacity (MBC) and the exercise ventilation volume(EV) which were measured by spirometer and two step-test. Classification of pneumoconiosis was based on the international classification of ILO U/C. The results were as follows: 1. The mean value of E1 was significantly increased in pneumoconiosis patients with large opacities(46.0%) than in patients with small rounded opacities(26.5%) and with suspected pneumoconiosis(25.0%). The number of jpatients in substandard EI was 97.1% in patients with large opacities but 49.4% in patients with small rounded opacities and 40.3% in patients with suspected pneumoconiosis. 2. The mean values of EI and the number of patients in substandard EI were markedly increased in pneumoconiosis patients with small rounded opacities and suspected over 50 years of age. However, the number of patients in substandard EI showed no association with age in pneumoconiosis patients with large opacitis. 3. In pneumoconiosis patients with small rounded opacities, the mean values of EI and the number of patients in substandard EI showed significant association with the profusion (category) but no significant association with the type of small rounded opacities. 4. In pneumoconiosis patients with large opacities, the mean values of EI and the number of patients in substandard EI showed no significant difference between patients complicated with and without pulmonary tuberculosis. 5. No significant association of EI and the number of patients in substandard EI with the size of large opacities was observed in pneumoconiosis patients with large opacities, however, the mean values of EI showed increasing tendenccy in category B and C compared to category A.

最大酸素攝取量에 의한 運動 後의 心博數 恢復率에 關한 硏究

趙庚旭,金泰完,張鳳愚,金奎鎭,金榮男 忠北大學校 平生體育硏究所 1985 平生體育硏究所 論文集 Vol.1 No.-

The purpose of this study is to research the relative effectiviness of heart rate of recovery after exercise and the estimated maximal oxygen uptake by physical work capacity. The subjects of this study were 22 conditioned non-athletes in Chung Buk University. The result of the measurement is summarized as follows : 1. The percentage of the increase of heart rate during work loads is 13% higher in second work load than in the first work load and is 9% higher in the second work load than in the third work load. 2. The percentage of heart rate of recovery after exercise by physical work capacity shows recovery of 23.8% at 30 seconds and of 82.3% at 300 seconds. 3. The relationship between heart rate of recovery and maximal oxygen uptake is r≒0.4∼0.6 except at 30 seconds.

推出 分光光度法에 의한 水銀의 定量法에 關한 硏究

趙庚烈,禹美熙 대구효성 가톨릭 대학교 1988 연구논문집 Vol.36 No.1

Extraction-spectrophotometric determination of mercury(Ⅱ) was studied by associated complex formation using antipyrine, antipyretics and eosin, halogenated xanthenes. K₂SO₄was added for the promotion of complex formation and it's optimal concentration was 0.3M. Optiaml conditions for the quantitative analysis of trace of mercury(Ⅱ) were investigated. Molar ratio of Hg(Ⅱ)-antipyrine-eosin complex was presumed as 1:4:2. Linear calibration curve was obtained in the range of 6~28㎍/㎖ at 485nm. Mercury(Ⅱ) determination of this method was interfered in the presence of metals such as ??, ??,, ??, ?? and ??, halides an dthiocyanate, but the interferences of metals except ?? were masked with 0.01M-sod. tartrate.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

상부 조기 위암 환자의 복강경하 상부 위절제술 3례 경험

조규석,김형철,박경규,이문수,송옥평,임철완,신웅진,주종우,유기원 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Background : The reported incidence of early gastric cancer located in the upper portion of the stomach has been increasing with the recent advances in its diagnosis and screening. Recently, we have successfully performed laparoscopic assisted proximal gastrectomy and gastric tube reconstruction without pyloroplasty on three patients with early gastric carcinoma localized to the upper third of the stomach. We describe our modification of this procedure in this report. Method : After creating an surgical pneumoperitoneum, the stomach was mobilized using laparoscopic coagulating shears. Upper half of the greater curvature and three-quarters of the lesser curvature were then dissected along with regoinal D2 lymphadenectomy. This was followed by a 5 cm, longitudinal mini-laparotomy in the upper abdomen, and the construction of the exteriorized stomach with a gastric tube measuring 20 cm long and 4 cm wide. Reconstruction with an esophagogastrostomy was performed using a circular stapler. Result : No post-operative morbidity or mortality was observed in this small series of patients. The average operative time was 250 minutes (range 220-300 minutes), and the average blood loss was 150 ml (range 90-180 ml). The mean number of lymph nodes harvested during these laparoscopic proximal gastrectomies was 24 nodes (range 22-25 lymph nodes). The average postoperative hospital stays was 7.5 days (range 7-8 days). Conclusion : Our technique of laparoscopic assisted proximal gastrectomy and gastric tube reconstruction without phloroplasty offers a minimally invasive technique with the potential of impoving the post-operative quality of life patients with an early-stage proximal gastric cancer.

新銀行經營論(Ⅲ) : 우리나라 시중은행의 인터넷뱅킹서비스 사례를 중심으로

조대우,황경연 충남대학교 경영경제연구소 2000 경영경제연구 Vol.23 No.1

은행은 서비스 점검(service encounter)에 기술을 도입함으로써 서비스 특성중 이질성(heterogenity)과 소멸성(perishability)의 효과를 통제할 수 있고, 고객은 시간절약, 비용절감, 편리성 등의 효과를 얻을 수 있다. 최근 인터넷의 성장과 더불어 세계 은행들은 인터넷기술을 이용한 서비스에 많은 관심을 갖고 투자하고 있다. 인터넷기술을 이용한 서비스인 인터넷뱅킹은 현재 정보전달수단, 거래채널, 고객관계향상수단으로 활용되고 있으며, 앞으로 매우 중요한 수단으로 인식되고 있다. 본 연구에서는 우리나라 시중은행의 인터넷뱅킹서비스 현황을 분석하고 향후 발전방향을 제시해보고자 한다.