Case Study of Urban Management in the Crossing Area of Urban and Rural Inhabitants in Beijing

Yao Yong-Ling 한국도시행정학회 2006 한국도시행정학회 학술발표대회 논문집 Vol.- No.-

Prediction of initiation time of corrosion in RC using meshless methods

Ling Yao,Lingling Zhang,Ling Zhang,Xiaolu Li 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.16 No.5

Degradation of reinforced concrete (RC) structures due to chloride penetration followed by reinforcement corrosion has been a serious problem in civil engineering for many years. The numerical simulation methods at present are mainly finite element method (FEM) and finite difference method (FDM), which are based on mesh. Mesh generation in engineering takes a long time. In the present article, the numerical solution of chloride transport in concrete is analyzed using radial point interpolation method (RPIM) and element-free Galerkin (EFG). They are all meshless methods. RPIM utilizes radial polynomial basis, whereas EFG uses the moving least-square approximation. A Galerkin weak form on global is used to attain the discrete equation, and four different numerical examples are presented. MQ function and appropriate parameters have been proposed in RPIM. Numerical simulation results are compared with those obtained from the finite element method (FEM) and analytical solutions. Two case of chloride transport in full saturated and unsaturated concrete are analyzed to test the practical applicability and performance of the RPIM and EFG. A good agreement is obtained among RPIM, EFG, and the experimental data. It indicates that RPIM and EFG are reliable meshless methods for prediction of chloride concentration in concrete structures.

Analysis of Uncertainty Influence on the Probabilistic Evaluation of Vortex-Induced Vibration Response of a Self-Anchored Suspension Bridge

Ling-yao Li 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.11

The uncertainty of the parameters involved in the bridge vortex-induced vibration (VIV) response is hard to be described accurately and the probabilistic description remains scarce. The present work aims at giving a contribution to the probabilistic evaluation of the bridge VIV response considering uncertainty influence of parameters. A self-anchored suspension bridge was selected as an example to analyze the uncertainty influence on the probabilistic evaluation of VIV response. The probability density function of the wind speed at the deck level of the bridge was established. The modal analysis was carried out and the natural vibration characteristics were checked. Then three performance functions involving different considerations of the maximum response models of bridge VIV were introduced. The numerical characteristics (coefficient of variation (COV), skewness and kurtosis) in the parameter space was propagated to access its influence on the exceeding probability of the bridge VIV response utilizing the second-order fourth-moment (SOFM) method. The influence from the different distribution type of the parameters was investigated. Results showed that the influence degree of COV, skewness and kurtosis of parameters on the exceeding probability of VIV response for the bridge is different and the distribution type of parameter has little effect based on the SOFM method.

Optimum Ca(NO3)2 Supply Develops Salt Tolerance in NaCl-stressed Cyclocarya paliurus Seedlings

Rui Ling Yao,Yin Wang 한국원예학회 2012 Horticulture, Environment, and Biotechnology Vol.53 No.1

The effect of varying Ca(NO3)2 supply (0, 6, 12, and 18 mM) on growth, ion uptake, leaf chlorophyll concentration and photosynthesis of NaCl-stressed (85 mM NaCl) Cyclocarya paliurus seedlings was investigated. Addition of Ca(NO3)2 stimulated the shoot growth more than root growth. Ca(NO3)2 supply increased K+ and Ca2+ concentration,whereas the Na+ transport to the leaves was inhibited. There was a strong increase in the K+/Na+ ratio in the leaves of Ca(NO3)2-treated seedlings. Leaf chlorophyll concentration and photosynthesis rate were low, but both factors were enhanced by 12 mM Ca(NO3)2. Therefore, moderate Ca(NO3)2 supply (12 mM) had optimal effects on growth and metabolism of NaCl-stressed C. paliurus seedlings.

Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs

Zhipeng Yao,Xiaochun Jiang,Hong Yao,Yafeng Wu,Fan Zhang,Cheng Wang,Chenxue Qi,Chenhui Zhao,Zeyu Wu,Min Qi,Jia Zhang,Xiaoxiang Cao,Zhichun Wang,Fei Wu,Chengyun Yao,Songqin Liu,Shizhang Ling,Hongping Xi 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

Background: Glioblastoma multiforme (GBM) is a fatal malignant primary brain tumor in adults. The therapeutic efficacy of chemotherapeutic drugs is limited due to the blood-brain barrier (BBB), poor drug targeting, and short biological half-lives. Multifunctional biomimetic nanodrugs have great potential to overcome these limitations of chemotherapeutic drugs. Methods: We synthesized and characterized a biomimetic nanodrug CMS/PEG-DOX-M. The CMS/PEG-DOX-M effectively and rapidly released DOX in U87 MG cells. Cell proliferation and apoptosis assays were examined by the MTT and TUNEL assays. The penetration of nanodrugs through the BBB and anti-tumor efficacy were investigated in the orthotopic glioblastoma xenograft models. Results: We showed that CMS/PEG-DOX-M inhibited cell proliferation of U87 MG cells and effectively induced cell apoptosis of U87 MG cells. Intracranial antitumor experiments showed that free DOX hardly penetrated the BBB, but CMS/PEG-DOX-M effectively reached the orthotopic ntracranial tumor through the BBB and significantly inhibited tumor growth. Immunofluorescence staining of orthotopic tumor tissue sections confirmed that nanodrugs promoted apoptosis of tumor cells. This study developed a multimodal nanodrug treatment system with the enhanced abilities of tumor-targeting, BBB penetration, and cancer-specific accumulation of chemotherapeutic drugs by combining chemotherapy and photothermal therapy. It can be used as a flexible and effective GBM treatment system and it may also be used for the treatment of other central nervous systems (CNS) tumors and extracranial tumors.

Effects of contact shape on ballistic phonon transport in semiconductor nanowires

Jing-Jing Yao,Wei-Qing Huang,Gui-Fang Huang,Yuan Chen,Ling-Ling Wang,Wangyu Hu,Anlian Pan 한국물리학회 2012 Current Applied Physics Vol.12 No.2

We study the effects of contact shape on ballistic phonon transport in semiconductor nanowires at low temperatures using an approximative scalar model of continuum elasticity. Five different contacts connected to two semiconductor nanowires with different transverse widths are discussed. Numerical results show that the contact shape acts as an ‘acoustic impedance adaptor’, playing a crucial role on the ballistic phonon transmission and thermal conductance. The phonon coupling in the contacts with certain length facilitates ballistic phonon transmission compared to the abrupt interface, in which the phonon scattering is the strongest. It is found that the more the contact is abrupt, the smaller the thermal conductance is. The catenoidal contact rather than the abrupt interface is also the competitive candidate to obtain bigger thermal conductance. These results indicate that choosing an appropriate contact shape is one of the most critical factors to accurately measure the thermal conductance with a very high precision and reliability in different temperature ranges at low temperatures.

Behavioral Response of Termites to Tunnel Surface Irregularity

Sang-Hee Lee,Rou-Ling Yang,Nan-Yao Su 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.05

Subterranean termites construct underground tunnels, tens to hundreds of meters in length, in order to search for and transport resources. Diverse soil conditions surrounding the tunnels, such as soil pores and differing moisture concentrations, may cause different sized- and shaped-irregularities in the tunnels. To understand how individual termites respond to the irregularities, the present study monitored the movement of termites, Coptotermes formosanus Shiraki, in artificially excavated tunnels with rectangular irregularities of varying sizes in twodimensional sand substrates. Termites tunneled at some of the irregularities and not at the others. The tunneling or non-tunneling behavior resulted from four different responses. The non-tunneling response may result from a behavioral adaptation that allows termites to avoid wasting energy that may be used in foraging.

Rational finite element method for plane orthotropic elastic problems

Ling Mao,Weian Yao,Qiang Gao,Wanxie Zhong 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.51 No.6

The rational finite element method is different from the standard finite element method, which is constructed using basic solutions of the governing differential equations as interpolation functions in the elements. Therefore, it is superior to the isoparametric approach because of its obvious physical meaning and accuracy; it has successfully been applied to the isotropic elasticity problem. In this paper, the formulation of rational finite elements for plane orthotropic elasticity problems is deduced. This method is formulated directly in the physical domain with full consideration of the requirements of the patch test. Based on the number of element nodes and the interpolation functions, different approaches are applied with complete polynomial interpolation functions. Then, two special stiffness matrixes of elements with four and five nodes are deduced as a representative application. In addition, some typical numerical examples are considered to evaluate the performance of the elements. The numerical results demonstrate that the present method has a high level of accuracy and is an effective technique for solving plane orthotropic elasticity problems.

Curcumin Inhibits the Proliferation, Migration, Invasion, and Apoptosis of Diffuse Large B-Cell Lymphoma Cell Line by Regulating MiR-21/VHL Axis

Ling Chen,Cheng-Zhi Zhan,Tao Wang,Hua You,Rui Yao 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.1

Purpose: Curcumin exerts its anti-cancer effects, partly by targeting special microRNAs, in human cancers. MiR-21 is a key oncomirin carcinogenesis of multiple human cancers. Here, we aimed to further explore the mechanistic insight into the link betweencurcumin and miR-21 on diffuse large B-cell lymphoma (DLBCL). Materials and Methods: Quantitative real-time PCR assays were performed to assess the levels of miR-21 and Von Hippel-Lindau(VHL) mRNA. In situ hybridization assay was used for miR-21 expression visualization in lymphoma tissues. Western blot was usedfor determination of VHL protein, Ki-67, caspase-3, and cleaved caspase-3 levels. Dual-luciferase reporter assay and RNA immunoprecipitationassay were employed to confirm the direct target of miR-21. MTT assay, flow cytometric analysis, and transwell assaywere used to evaluate cell proliferation, apoptosis, and migration and invasion capacities, respectively. Results: Curcumin repressed the proliferation, migration, and invasion abilities and promoted apoptosis in SU-DHL-8 cells. Curcumininhibited miR-21 expression and curcumin exerted its anti-proliferation, anti-migration, anti-invasion, and pro-apoptosiseffects by miR-21 in SU-DHL-8 cells. VHL was a direct target of miR-21. Moreover, curcumin exerted its regulatory effects on SUDHL-8 cells by VHL. Conclusion: Curcumin exerted its anti-proliferation, anti-migration, anti-invasion, and pro-apoptosis functions, at least partly, byrepressing miR-21 and regulating VHL expression in DLBCL cell line. Our findings provided a possible molecular mechanism ofcurcumin-mediated anti-cancer effect.

Genetic Differentiation of Chinese Indigenous Meat Goats Ascertained Using Microsatellite Information

Ling, Y.H.,Zhang, X.D.,Yao, N.,Ding, J.P.,Chen, H.Q.,Zhang, Z.J.,Zhang, Y.H.,Ren, C.H.,Ma, Y.H.,Zhang, X.R. Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.2

To investigate the genetic diversity of seven Chinese indigenous meat goat breeds (Tibet goat, Guizhou white goat, Shannan white goat, Yichang white goat, Matou goat, Changjiangsanjiaozhou white goat and Anhui white goat), explain their genetic relationship and assess their integrity and degree of admixture, 302 individuals from these breeds and 42 Boer goats introduced from Africa as reference samples were genotyped for 11 microsatellite markers. Results indicated that the genetic diversity of Chinese indigenous meat goats was rich. The mean heterozygosity and the mean allelic richness (AR) for the 8 goat breeds varied from 0.697 to 0.738 and 6.21 to 7.35, respectively. Structure analysis showed that Tibet goat breed was genetically distinct and was the first to separate and the other Chinese goats were then divided into two sub-clusters: Shannan white goat and Yichang white goat in one cluster; and Guizhou white goat, Matou goat, Changjiangsanjiaozhou white goat and Anhui white goat in the other cluster. This grouping pattern was further supported by clustering analysis and Principal component analysis. These results may provide a scientific basis for the characteristization, conservation and utilization of Chinese meat goats.