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Pengfei Wu,Zhichun Fang,Xue Wang,Guangyi Zhu 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.6
Deep buried tunnel has a complex stress environment and large stress level. At present, it is difficult to dynamic monitoring for such tunnels. In order to make the safety evaluation and prediction of tunnel closer to the engineering practice, this paper deduces the tunnel reliability evaluation algorithm. The time-varying reliability of deep tunnel excavation process is analyzed and predicted. Based on the similarity theory, the actual deep tunnel excavation is simulated by indoor model test, the stress and deformation are monitored. The results show that after the tunnel excavation, the reliability of the structure does not decrease gradually, but increases slowly first and then decreases sharply. With the increase of the buried depth of the tunnel, the structural reliability decreases gradually. When the buried depth reaches a certain depth, the structural reliability will decrease rapidly. The influence of different parameters on the structural reliability has different sensitivity. The sensitivity of friction angle is the highest, and the sensitivity of gravity is the lowest. The sensitivity has little effect with the change of tunnel excavation time and tunnel buried depth. The accuracy of this method is verified by the comparative analysis of model box tests.
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Research on Calculation Method of Suspension Bridge Internal Force under Random Traffic Load
Pengfei Wu,Zhichun Fang,Xue Wang,Renyuan Wang,Qiang Xu 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.11
Suspension bridge is a flexible structure. The weight, location and number of traffic on the bridge will affect the geometric alignment of the bridge. Although the finite element software can analyze the geometric nonlinearity of the bridge, the calculation of random load combination in finite element software is huge. In this paper, based on the deformation coordination, static equilibrium and constitutive model of the bridge, the force expression considering the geometric nonlinearity of the bridge is derived. Finite element software is used to simulate the internal force of components of suspension bridge under train load and vehicle load. The accuracy is verified by comparing the finite element results. Considering the random number of traffics, the random location of traffics, and the random weight of traffics, this paper analyzes the stress state of bridge under the random process of train load and vehicle load respectively. The method in this paper can be well used to analyze the actual stress state of the bridge, and provide a theoretical basis for related calculations.
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Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs
Zhipeng Yao,Xiaochun Jiang,Hong Yao,Yafeng Wu,Fan Zhang,Cheng Wang,Chenxue Qi,Chenhui Zhao,Zeyu Wu,Min Qi,Jia Zhang,Xiaoxiang Cao,Zhichun Wang,Fei Wu,Chengyun Yao,Songqin Liu,Shizhang Ling,Hongping Xi 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: Glioblastoma multiforme (GBM) is a fatal malignant primary brain tumor in adults. The therapeutic efficacy of chemotherapeutic drugs is limited due to the blood-brain barrier (BBB), poor drug targeting, and short biological half-lives. Multifunctional biomimetic nanodrugs have great potential to overcome these limitations of chemotherapeutic drugs. Methods: We synthesized and characterized a biomimetic nanodrug CMS/PEG-DOX-M. The CMS/PEG-DOX-M effectively and rapidly released DOX in U87 MG cells. Cell proliferation and apoptosis assays were examined by the MTT and TUNEL assays. The penetration of nanodrugs through the BBB and anti-tumor efficacy were investigated in the orthotopic glioblastoma xenograft models. Results: We showed that CMS/PEG-DOX-M inhibited cell proliferation of U87 MG cells and effectively induced cell apoptosis of U87 MG cells. Intracranial antitumor experiments showed that free DOX hardly penetrated the BBB, but CMS/PEG-DOX-M effectively reached the orthotopic ntracranial tumor through the BBB and significantly inhibited tumor growth. Immunofluorescence staining of orthotopic tumor tissue sections confirmed that nanodrugs promoted apoptosis of tumor cells. This study developed a multimodal nanodrug treatment system with the enhanced abilities of tumor-targeting, BBB penetration, and cancer-specific accumulation of chemotherapeutic drugs by combining chemotherapy and photothermal therapy. It can be used as a flexible and effective GBM treatment system and it may also be used for the treatment of other central nervous systems (CNS) tumors and extracranial tumors.
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