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RISS 인기검색어
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- 저자 : Zhipeng Yao (검색결과 5 건)
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Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs
Zhipeng Yao,Xiaochun Jiang,Hong Yao,Yafeng Wu,Fan Zhang,Cheng Wang,Chenxue Qi,Chenhui Zhao,Zeyu Wu,Min Qi,Jia Zhang,Xiaoxiang Cao,Zhichun Wang,Fei Wu,Chengyun Yao,Songqin Liu,Shizhang Ling,Hongping Xi 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: Glioblastoma multiforme (GBM) is a fatal malignant primary brain tumor in adults. The therapeutic efficacy of chemotherapeutic drugs is limited due to the blood-brain barrier (BBB), poor drug targeting, and short biological half-lives. Multifunctional biomimetic nanodrugs have great potential to overcome these limitations of chemotherapeutic drugs. Methods: We synthesized and characterized a biomimetic nanodrug CMS/PEG-DOX-M. The CMS/PEG-DOX-M effectively and rapidly released DOX in U87 MG cells. Cell proliferation and apoptosis assays were examined by the MTT and TUNEL assays. The penetration of nanodrugs through the BBB and anti-tumor efficacy were investigated in the orthotopic glioblastoma xenograft models. Results: We showed that CMS/PEG-DOX-M inhibited cell proliferation of U87 MG cells and effectively induced cell apoptosis of U87 MG cells. Intracranial antitumor experiments showed that free DOX hardly penetrated the BBB, but CMS/PEG-DOX-M effectively reached the orthotopic ntracranial tumor through the BBB and significantly inhibited tumor growth. Immunofluorescence staining of orthotopic tumor tissue sections confirmed that nanodrugs promoted apoptosis of tumor cells. This study developed a multimodal nanodrug treatment system with the enhanced abilities of tumor-targeting, BBB penetration, and cancer-specific accumulation of chemotherapeutic drugs by combining chemotherapy and photothermal therapy. It can be used as a flexible and effective GBM treatment system and it may also be used for the treatment of other central nervous systems (CNS) tumors and extracranial tumors.
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Zhipeng Ma,Fengyang Jing,Liyin Hou,Lukai Fan,Yao Zhao,Yuqian Fan,Xiujuan Qin 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2020 NANO Vol.15 No.03
Manganese-based oxides are one of the most promising high-performance supercapacitor (SC) electrode materials. In this work, a stable MnOx nanowires@MnOx nanosheets core–shell heterostructure electrode material consisting of MnOx nanosheets grown uniformly on the surface of MnOx nanowires has been prepared by a simple liquid phase method followed by thermal treatment. The electrode displays a specific capacity of 336 F g -1 at 1 A g -1 and exhibits a good cycling life of 83% capacitance retention after 5000 cycles. This is mainly due to the synergy effect between the one-dimensional MnOx nanowires as the backbone structure and the two-dimensional MnOx nanosheets with large specific surface area provide more active sites and the rapid transmission of electrons.
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A helix slope deviation compensation model for milling small modulus copper electrode gears
Zhipeng Feng,Zhao-Yao Shi,Shoujin Lin,Aijun Tong,Peng Wang,Guoqing Wu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.7
When a milling tool is used to mill small modulus copper electrode gears (SMCEG), the deformation is inevitable, thus leading to the helix slope deviation (HSD) of copper electrode gears (CEG). To compensate the influence of milling tool deflection (MTD) on the HSD, a universal HSD compensation model was established for different sizes of milling tools. First, using the principle of orthogonal experiment, a linear regression model of milling parameters and milling tool radius is established. Secondly, the average value of the HSD obtained by the gear measuring instrument is converted into the maximum of MTD according to the principle of helix line formation. The maximum deflections of the milling tools are used as the response value of the regression analysis to fit the maximum deflection curve of the milling tool. Through the reverse adjustment of the rotation angle of the rotating motor, the HSD compensation is realized. Finally, the model was verified by the milling tests. The results showed that the helix deviation reached the requirements of level 4 to 5 in GB/T 38192-2019, and proved the correctness of the established MTD model. The model is significant for milling SMCEG.
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Detection for Operation Chain: Histogram Equalization and Dither-like Operation
( Zhipeng Chen ),( Yao Zhao ),( Rongrong Ni ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.9
Many sorts of image processing software facilitate image editing and also generate a great number of doctored images. Forensic technology emerges to detect the unintentional or malicious image operations. Most of forensic methods focus on the detection of single operations. However, a series of operations may be used to sequentially manipulate an image, which makes the operation detection problem complex. Forensic investigators always want to know as much exhaustive information about a suspicious image`s entire processing history as possible. The detection of the operation chain, consisting of a series of operations, is a significant and challenging problem in the research field of forensics. In this paper, based on the histogram distribution uniformity of a manipulated image, we propose an operation chain detection scheme to identify histogram equalization (HE) followed by the dither-like operation (DLO). Two histogram features and a local spatial feature are utilized to further determine which DLO may have been applied. Both theoretical analysis and experimental results verify the effectiveness of our proposed scheme for both global and local scenarios.
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Yinan Wang,Zhi Wang,Xiongliang Yao,Nana Yang,Zhipeng Chen 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.2
In this paper, the attitude changes of projectile and its influence parameters during the process of penetration on the ship plate structure are studied by material point method. The method is firstly verified by comparing with experimental results. The numerical results agree well with the experimental results. The failure behavior of the plate is similar to the actual situation, and the failure mode is basically the same. With the change of different parameters, the attitude of projectiles will change differently. The greater the penetration velocity, the weaker the influence of other related parameters on the projectile attitude. When other parameters are not changed, the relative size of the strength of stiffener and the thickness of target plate determines the change of the projectile attitude. Analyze from the perspective of energy and force, and finally projectile attitude can be divided into four types.
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