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한인호,이인섭,최재혁,백홍수 한국생체재료학회 2006 생체재료학회지 Vol.10 No.2
Since middle of 20 century, so many efforts have been conducted to make excellent biocompatible biomaterials especially for quick and firm osseointegration. SiO2-CaO-NaO-P2O5 system was proposed with the name of 멊ioglass? Bioglasses provide the convenient surface for hydroxyapatite formation when they are immersed in the body fluids. Bioglasses are the first artificial materials which can make direct bonding to the bone. Alkali treatment to metals and zeta-potential experiment are reviewed to investigate the essential component for the hydroxyapatite formation. It is uncovered that the essential component is not Si, Ca nor P but hydroxyl group.
이성미,노인섭 한국생체재료학회 2002 생체재료학회지 Vol.6 No.2
서구화와 문명화에 따라 발생되는 손상•손실된 장기들의 수가 급증하고 이들을 복원하기 위한 다양한 노력에도 불구하고 기증되는 장기부족과 이식술의 제한으로 인하여 이식을 필요로 하는 장기의 수는 심각할 정도로 부족하다. 이러한 장기부족 문제점을 해결하기 위한 방법으로, 조직공학기법을 이용하여 환자조직과 유사한 생화학적 및 생기계적 기능을 가진 조직공학 인공장기를 개발하고자 하는 연구노력이 활발히 이루어져, 조직공학 제품의 시장성은 매우 빠르게 증가하고 있다. 1960년 대 중반에 화상환자 치료를 위하여 합성섬유를 이식재료로 하는 인공피부 개발이 처음 시도된 이래로, Transcyte , IntegraTM, TerudermisTM, EpicelTM 등과 같은 조직공학제품이 출시되었다. 최근에는 궤양치료용 Apligraft 인공피부 상품과 Carticel㉯繭遮 연골치료용 세포의 상품화와 함께, 혈관, 방광, 뼈, 건, 간, 심장 등과 같은 기타 인공장기 개발연구로 상품화가 점진적으로 이루어지고 있다. 그러나 조직공학이라는 학문이 미래의 핵심산업으로 성장하기 위해서는 수많은 과제들을 극복해야 할 것이다. 구체적으로 조직공학의 핵심요소인 지지체 개발측면에서, 환자에게 필요한 특정조직의 구조와 표면생화학을 정확히 모방할 수 있는 보다 생체적합한 조직공학용 지지체의 개발이 필요하다. 이와 함께 조직공학의 또 다른 핵심요소인 세포측면에서, 미분화된 줄기세포와 특정세포들을 이용한 조직공학제품의 개발이 필요하다. 제품 출시와 함께 제품에 대한 품질관리와 추적검사를 함으로써, 개발되는 제품의 안전성 보장과 새로운 제품개발에 필요한 데이터베이스로 활용하려는 노력 또한 조직공학회사들을 중심으로 진행되고 있다. 조직공학제품의 개발에 필요한 지지체, 세포 및 제품의 안전성 문제와 함께, 조직공학제품 다양화•세분화로 산업의 확대도 시도되고 있다. 이러한 시장성과 사회적 필요성을 가진 조직공학제품의 현황과 미래의 핵심 바이오산업이 되기 위하여 조직공학 산업이 극복하여야 할 과제들을 본 고에서 고찰하고자 한다.
박노형,김동현,김창목,정의섭,이준우 한국생체재료학회 2013 생체재료학회지 Vol.17 No.2
Recently, the research paradigm for plastics has been moved from petrochemical polymers to either biodegradable plastics, bioplastics, produced from plant-derived raw materials or both. Bioplastics are highlighted as materials to solve the environmental regulations from petrochemical dependence and applied to many fields such as vehicles, electronics, architectures and commodities etc. Although bioplastics have begun to achieve some degrees of commercial success, the industry is still in an embryonic stage. For bioplastics, the market will continue to evolve as products become more widely available and their performances are improved closely to those of the conventional polymers such as PE, PP, PET and PS. According to Frost & Sullivan Report (Global Bio-based Plastics Market), it is expected that bioplastic market and CAGR at 2014 be approximately $ 2.1 billion and 21.2%, respectively. For bioplastics industry, market success will depend mostly on lowering production costs and performances to compete with those of conventional polymers.
노인섭 한국생체재료학회 2008 생체재료학회지 Vol.12 No.3
Hyaluronic acid has been studied for tens of years in biomedical society due to its excellent biocompatibility and specific biological activities. To improve its mechanical, chemical and biological properties in its specific biomedical applications, numerous methods of the chemical derivatizations of hyaluronic acid have been reported. We have reviewed its diverse applications in biomedical materials by analyzing mainly derivative chemistries of hyaluronic acid via its functrional groups such as carboxylic acid, alcohol and others.
인공 혈관용 나노 섬유 지지체에 관한 연구 : 세포 부착 및 조직 형성
신정욱,신호준,이용재,김인애,이창훈,조은희,김은정 한국생체재료학회 2004 생체재료학회지 Vol.8 No.2
The purpose of this study is to examine the potential of the nanofiber scaffold as a substrate for forming an artificial vascular graft. Aligned and randomly aligned polylatic-co-glycolic acid (PLGA) and polyurethane(PU) nanofiber scaffolds fabricated by electrospinning were used as square sheets. Fibroblasts harvested from human foreskin were seeded and cultured over 1 week period on a nanofiber scaffold, followed by seeding of endothelial cells harvested from human vessel. Thereafter the new tissue was analyzed for DNA, collagen and stained for immunohistochemistry with von Willebrand factor. DNA and collagen analysis of the seeded scaffold demonstrated that the human fibroblasts and endothelial cells attached to the polymeric fibers had begun to spread out (day 7) and extracellular matrix was saturated after 2 week. The immunohistochemistry examination demonstrated the seeded endothelial cells formed a monolayer on the fibroblasts and no endothelial cell invasion or new formation of capillaries could be detected. Indeed, there's no significant difference between aligned and randomly aligned nanofiber scaffold in all analyses. These results demonstrated that nanofiber scaffold used in this study might be a promising base material for tissue-engineered blood vessels.
Recent Advances of Biodegradable Polymers for Medical Applications
성정석,성용결 한국생체재료학회 2006 생체재료학회지 Vol.10 No.3
The recent advances of biodegradable polymers for medical applications have been reviewed on the basis of biodegradability, functionality, and biocompatibility. These include the functional biodegradable polymers synthesized in our research laboratory and some injectable biodegradable polymers developed for biomedical applications. The biodegradable polymers synthesized from Krebs cycle acid derivatives, injectable biodegradable block copolymers, biodegradable polymers for RNA interference and DNA matrix-based biopolymeric systems for tissue engineering have been also discussed briefly.
Chemical Modifications of Chitosan as Gene Carriers
김태희,조종수,나재운,강호림,박인영,김유경,조명황,Toshigiro Akaike 한국생체재료학회 2006 생체재료학회지 Vol.10 No.3
Among the cationic polymers, chitosan has emerged as a promising candidate for gene delivery because it has several advantages such as biocompatibility, biodegradability, low toxicity and favorable physicochemical properties. However, low specificity and low transfection efficiency of chitosan as a DNA carrier need to be overcome for clinical trials. In this review paper, chemical modifications for enhancement of cell specificity and transfection efficiency were explained
김문선,강길선,이진호,이해방 한국생체재료학회 2006 생체재료학회지 Vol.10 No.3
Over last three decades, various biomaterials have been developed for the utilization in biomedical industry. The practical utilization of biomaterials in industry depends on the study about an appropriate physical and biological response of biomaterials referred as its biocompatibility. The surface modification of biomaterials has recently become an interesting topic in the field of surface engineering. We recently developed a “gradient surface”. The gradient surface is the surface on which a gradually varying chemical composition exists along its length. Such gradient surface is of particular interest for basic and applied studies of the interactions between biological species and surfaces since the effect of a selected property like wettability or chemical composition can be examined in a single experiment on one surface. The present review focuses on the preparation and characterization of gradient surfaces, and their interactions with biological species.
Fabrication and Characterization of Pore Size Gradient Scaffolds By a Novel Centrifgarion Method
임성묵,이진호,박일규,오세형 한국생체재료학회 2006 생체재료학회지 Vol.10 No.3
It is well recognized that the pore size of polymer scaffolds plays an important role for tissue ingrowth and regeneration: different kinds of cells were shown to have different optimal pore size ranges in the scaffolds for effective cell growth. So, if the tissue scaffold with pore size gradient (i. e., the scaffold with gradually increasing pore size along one direction) can be prepared, it will become a powerful tool for basic studies of the interactions between cells or tissue and scaffolds with different pore size since the effect of pore size can be effectively examined using one scaffold. In recent years, several techniques have been used to fabricate porous polymer scaffolds having 3-dimensional pore structure. However, it is not possible from those techniques to fabricate scaffolds with pore size gradient. Recently, we developed a new method to fabricate pore size gradient cylindrical scaffolds by a simple centrifugation. In this method, the pore size ranges of the scaffold can be easily controlled by adjusting centrifugal speed. The fabrications of pore size gradient cylindrical scaffolds made by alginate, chitosan and polycaprolactone, and their characterizations in terms of scaffold pore sizes are discussed in this article.
원심분리법을 이용한 다양한 형태의 조직공학용 다공성 알지네이트 지지체의 제조 및 분석
오세행,이진호,석경록,박일규 한국생체재료학회 2003 생체재료학회지 Vol.7 No.1
In recent years, several techniques have been used to fabricate porous polymeric scaffolds having 3-dimensional pore structure. However, it is not easy to fabricate the porous scaffolds with complicated shapes by conventional methods and thus the prepared scaffolds usually have simple shapes, such as sheet, disc, cylinder and tube. In this study, we developed a new porous scaffold fabrication method (centrifugation method) to prepare scaffolds with uniform surface and interior pore structures as well as various shapes. The porosity and pore size of the scaffolds could be controlled by adjusting centrifugation speeds. The pore sizes of the prepared alginate scaffolds decreased with the increasing centrifugation speed: as the centrifugation speed increased from 1,000 rpm to 3,000 rpm, the pore size of the scaffolds decreased from 250 m to 130 m. The alginate scaffolds were impregnated into chitosan solution with the different concentration (0~1.0 wt%) to improve mechanical strengths as well as cell adhesiveness. The maximum load and modulus analog of the scaffolds gradually increased by the chitosan impregnation. This study demonstrate that the centrifugation method is an effective method for preparing porous 3-dimensional scaffolds with complicated shapes for tissue engineering applications.